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New test could predict dangerous blood pressure drops in dialysis patients

NCT ID NCT05214729

Diagnosis Sponsor: Hospices Civils de Lyon Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether a fast removal of 250 ml of fluid during dialysis can predict which ICU patients with acute kidney injury are at risk of unstable blood pressure. Twenty adults on mechanical ventilation and continuous dialysis underwent two different speeds of fluid removal. The goal was to see if this test could identify preload dependence, a condition where the heart relies on adequate blood volume to pump effectively.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
fast ultrafiltration challenge (rapid removal of 250 ml of fluid over 15 or 30 minutes)
What this could lead to
If successful, this test could help doctors predict which ICU patients on dialysis are at risk of unstable blood pressure, allowing safer fluid management.
What could go wrong
This is a small, early study with only 20 participants, so results may not apply to all patients. The test itself involves rapid fluid removal, which could cause temporary drops in blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Jul 2022

Finished

Jan 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * adult patient, aged 18 year or older * under mechanical ventilation and continuous general anesthesia, with a positive end-expiratory pressure of 5 cmH2O or more * with stage 3 KDIGO acute kidney injury * treated with continuous renal replacement therapy for less than 14 days * ongoing continuous cardiac output monitoring * with a predicted intensive care length of stay of 24 hours or more at time of screening Exclusion Criteria: * High arterial lactate concentration, \> 4.0 mmol/L at time of screening * Calibrated cardiac index \< 2.0 L/min/m2 or \> 4.0 L/min/m2 at time of screening * Positive postural change maneuver in the last 2 hours preceding screening * Patient under extracorporeal membrane oxygenation * Patient with active bleeding requiring emergent transfusion * Patient under chronic maintenance dialysis or renal transplant recipient * Acute ischemic or hemorrhagic stroke complicated with coma and requiring mechanical ventilation * Fulminant hepatitis (acute liver injury, hepatic encephalopathy, icterus and a drop in prothrombin \< 50% in less that 15 days * Impossible postural change maneuver * Pregnant or lactating patient * Imminent death * Patient under legal protection measures as by French regulation * Patient already enrolled in the present study * Patient already participates in a study with protocolized net ultrafiltration, ongoing at time of screening

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Conditions

The condition(s) this trial relates to.

acute kidney injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Acute kidney injury

Contacts and locations

Locations

  • Department of Intensive Care, Croix Rousse hospital, Hospices Civils de Lyon

    Lyon, 69004, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.