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Steroids for kidney disease: do they prevent failure Long-Term?

NCT ID NCT05434325

Knowledge-focused Sponsor: The George Institute Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 10, 2026 · Updated 2 times

Summary

This study follows 211 people with IgA nephropathy who previously took a 6-9 month course of the steroid methylprednisolone in the TESTING trial. Researchers want to see if the steroid helped prevent end-stage kidney disease (needing dialysis or a transplant) over the long term. The goal is to understand how well the treatment works based on dose, ethnicity, and kidney function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
methylprednisolone (a steroid)
What this could lead to
If successful, this could clarify whether a short course of steroids can prevent kidney failure in IgA nephropathy patients.
What could go wrong
This is an observational follow-up, not a new treatment test. Results may not apply to all patients, and long-term steroid risks (e.g., infections) remain a concern.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

211 people

The number who actually took part.

Started

Dec 2022

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The population for this study will consist of all TESTING participants who do not meet any of the exclusion criteria.

Ages

18 to 100 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1\) Only participants who were randomised into the TESTING trial Exclusion Criteria 1. Participants who have reached kidney failure requiring maintenance dialysis or kidney transplantation during the TESTING trial 2. Participants who died during the TESTING trial 3. Participants who had withdrawn their consent during the TESTING trial 4. Participants who are unable to provide consent for some other reason

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Conditions

The condition(s) this trial relates to.

chronic kidney disease end stage renal failure glomerulonephritis IgA glomerulonephritis kidney disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ESRD Glomerulonephritis IgA nephropathy Kidney diseases

Contacts and locations

Locations

  • Beijing Anzhen Hospital, Capital Medical University

    Beijing, 100029, China

  • Calicut Medical College

    Kozhikode, Kerala, 673008,, India

  • Chinese PLA General Hospital (301 Hospital)

    Beijing, Beijing Municipality, China

  • Concord Repatriation General Hospital

    Concord W., New South Wales, 2137, Australia

  • Guangdong Provincial People's Hospital, Guangzhou

    Guangzhou, Guangdong, China

  • Hangzhou Hospital of Traditional Chinese Medicine,

    Hangzhou, Zhejiang, China

  • Hospital Kuala Lumpur

    Kuala Lumpur, Kulala Lumpur, 50586, Malaysia

  • Hospital Raja Permaisuri Bainun

    Ipoh, Perak, 30990, Malaysia

  • Hospital Sultanah Aminah

    Johor Bahru, Johor, 80100, Malaysia

  • Hospital Tuanku Jaafar Seremban

    Seremban, Negri Seremban, 70300, Malaysia

  • Hospital Umum Sarawak

    Kuching, Samarahan, 93586, Malaysia

  • Hôpital Maisonneuve-Rosemont

    Montreal, Quebec, H1T 2M4, Canada

  • Inner Mongolia People's Hospital

    Hohhot, Inner Mongolia, 010017, China

  • Jilin Province FAW General Hospital [Jilin University Fourth Hospital]

    Changchun, Jilin, 130011, China

  • Jinan Military General Hospital

    Jinan, Shandong, China

  • London Health Sciences Centre

    London, Ontario, Canada

  • Madras Medical College

    Chen, Tamil Nadu, 600037, India

  • Nepean Hospital

    Kingswood, New South Wales, 2747, Australia

  • Ningbo Urology & Nephrology Hospital

    Ningbo, Zhejiang, China

  • Nizams Institute of Medical Sciences

    Hyderabad, Andhra Pradesh, 500082, India

  • Osmania General Hospital

    Hyderabad, Andhra Pradesh, 500012, India

  • Peking University First Hospital

    Beijing, 100034, China

  • Peking University People's Hospital

    Beijing, 100035, China

  • Peking University Shenzhen Hospital

    Shenzhen, Guangdong, 518036, China

  • Peking University Third Hospital

    Beijing, China

  • Post Graduate Institue of Medical Education and Reasearch

    Chandigarh, Punjab, 160 012, India

  • Princess Margaret Hospital

    Kowloon, Kowloon, Hong Kong

  • Qilu Hospital of Shandong University

    Jinan, Shandong, 250012, China

  • Renji Hospital, Shanghai Jiaotong University School of Medicine

    Shanghai, 200001, China

  • Renmin Hospital, Wuhan University

    Wuhan, Hubei, 430060, China

  • Royal Adelaide Hospital

    Adelaide, South Australia, 5000, Australia

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065, Australia

  • Ruijin Hospital, Shanghai Jiaotong University, School of Medicine

    Shanghai, 200025, China

  • Shandong Provincial Hospital

    Jinan, Shandong, 250021, China

  • Shengjing Hospital Of China Medical University

    Shengyang, Liaoning, China

  • Sichuan Academy of Medical Science, Sichuan Provincial People's Hospital

    Chengdu, Sichuan, 610072, China

  • St Pauls Hospital

    Vancouver, British Columbia, V6Z 1Y6, Canada

  • St. Joseph's Healthcare

    Hamiliton, Ontario, L8N 4A6, Canada

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

  • The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology,

    Baotou, Inner Mongolia, 014010, China

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang, Henan, 471003, China

  • The First Affiliated Hospital of Shangdong First Medical University,Shangdong Provincial Qianfoshin

    Jinan, Shandong, 250014, China

  • The First Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450052, China

  • The First Affiliated Hospital with Nanjing Medical University

    Nanjing, Jiangsu, 210029, China

  • The First Affiliated Hospital, Sun Yat-Sen University

    Guangzhou, Guangdong, 510080, China

  • The First Affiliated Hospital, Zhejiang University of Medicine

    Hangzhou, Zhejiang, 310003, China

  • The Second Hospital of Hebei Medical University

    Shijiazhuang, Hebei, 050005, China

  • The Second Hospital of Shanxi Medical University, Taiyuan

    Taiyuan, Shanxi, 030001, China

  • The Third Hospital of Hebei Medical University

    Shijiazhuang, Hebei, 050051, China

  • Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology

    Wuhan, Hubei, 430022, China

  • Toronto General Hospital,

    Toronto, Ontario, M5G 2N2, Canada

  • Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology

    Wuhan, Hubei, 430022, China

  • University Malaysia Medical Centre

    Kuala Lumpur, Kuala Lumpur, 59100, Malaysia

  • University of Alberta Hospitals

    Edmonton, Alberta, T6G 2B7, Canada

  • University of Calgary/Alberta Health Services

    Calgary, Alberta, T2R 0X7, Canada

  • West China Hospital of Sichuan University

    Chengdu, Sichuan, 610041, China

  • XinQiao Hospital, Third Military Medical University

    Chongqing, 400037, China

  • Zhejiang Provincial People's Hospital

    Sangzhou, Zhejiang, China

  • he First Affiliated Hospital of Dalian Medical University, Dalian

    Dalian, Liaoning, 116011, China

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Other studies related to the condition(s) this trial covers.