Steroid showdown: low dose vs. no dose in rare disease trial

NCT ID NCT01940094

Completed Disease control Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Apr 02, 2026 · Last updated May 19, 2026 · Updated 6 times

Summary

This study looked at 159 people with a rare autoimmune disease called granulomatosis with polyangiitis (GPA). Half slowly lowered their prednisone to 5 mg per day, while the other half stopped completely. The goal was to see which approach better prevented disease flares over about six months.

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Contacts and locations

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Locations

Brigham and Women's Hospital

Boston, Massachusetts, 02215, United States
Cleveland Clinic

Cleveland, Ohio, 44195, United States
Mayo Clinic

Rochester, Minnesota, 55905, United States
Mount Sinai Hospital

Toronto, Ontario, M5T 3L9, Canada
St. Joseph's Healthcare

Hamilton, Ontario, Canada
University of Kansas Medical Center

Kansas City, Kansas, 66160, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh

Pittsburgh, Pennsylvania, 15261, United States
University of Utah

Salt Lake City, Utah, 84112, United States

Conditions

Explore the condition pages connected to this study.

GRANULOMATOSIS WITH POLYANGIITIS