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Chocolate tested for kidney effects – but Don't get excited yet

NCT ID NCT05755217

Knowledge-focused Sponsor: Gregoire Wuerzner; MD Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 30, 2026 · Updated 4 times

Summary

This study looks at whether eating a single dose of dark chocolate (70% cocoa) changes blood flow to the kidneys and blood pressure, compared to white chocolate. Researchers will use ultrasound to measure kidney blood flow two hours after eating. The study includes 32 people: healthy volunteers and those with mild-to-moderate chronic kidney disease. It's a small, early-stage study that aims to gather basic knowledge, not to prove any treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
dark chocolate (70% cocoa) and white chocolate (4% cocoa)
What this could lead to
If it works, this could help us understand whether dark chocolate has any short-term benefits for kidney function and blood pressure.
What could go wrong
This is a very small, early study (32 people) looking only at immediate effects after a single dose. It won't prove any long-term health benefits or risks.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

33 people

The number who actually took part.

Started

Feb 2023

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for healthy volunteers: * Age ≥ 18 years old * ability to understand the study protocol and to sign an informed consent. Inclusion criteria for CKD patients: * Age ≥18 years old, * CKD stage 1-3, * ability to understand the study protocol and to sign an informed consent Exclusion Criteria: * Lactose or cocoa intolerance, * Diabetes, * any severe digestive issue and liver disease, * history of kidney stones, * inability to follow the procedures of the study, e.g. due to language problems, dementia, etc. * pregnant women * healthy volunteers taking antihypertensive medication * healthy volunteers having a known kidney malformation or abnormality * healthy volunteers with albuminuria and/or hematuria in the urine sample. * CKD patients with an eGFR\<30ml/min/1.73m2 * CKD patients with measured kalemia of \> 5.5mmol/l in the last three months.

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Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chocolate consumption

Contacts and locations

Locations

  • Department of Nephrology, Centre Hospitalier Universitaire Vaudois

    Lausanne, Canton of Vaud, 1011, Switzerland

  • University Hospital of Lausanne (CHUV)

    Lausanne, Canton of Vaud, 1011, Switzerland

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