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Pee power: urine test may spare kids painful kidney biopsies

NCT ID NCT03719339

First seen Jan 08, 2026 · Last updated Jun 20, 2026 · Updated 26 times

Summary

This study is testing whether a simple urine test can detect signs of kidney transplant rejection in children. Researchers are looking for specific molecules in urine that signal the body is attacking the new kidney. If the test works, it could help doctors spot problems early without needing a needle biopsy. The study involves 445 children aged 2 to 18 who have had a kidney transplant.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Ann & Robert H. Lurie Children's Hospital of Chicago

    Chicago, Illinois, 60611, United States

  • CHOP

    Philadelphia, Pennsylvania, 19104, United States

  • Children's Hospital Los Angeles

    Los Angeles, California, 90027, United States

  • Children's National Medical Center

    Washington D.C., District of Columbia, 20010-291, United States

  • Cincinnati Children's Hospital Medical Center

    Cincinnati, Ohio, 45229, United States

  • Joan & Sanford I. Weill Medical College of Cornelle University

    New York, New York, 10065-4805, United States

  • Seattle Children's Hospital

    Seattle, Washington, 98105, United States

  • Stanford University

    Palo Alto, California, 94304, United States

  • University of California

    Los Angeles, California, 90095, United States

  • University of California-San Diego, Rady Children's Hospital

    La Jolla, California, 92093-0894, United States

  • University of Minnesota

    Minneapolis, Minnesota, 55455, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • Vancouver Children's Hospital

    Vancouver, British Columbia, V6T 1Z3, Canada

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to

If successful, this could lead to a non-invasive urine test to monitor kidney transplant health in children, replacing some painful biopsies.

What could go wrong

This is an observational study, not a treatment trial. The urine test may not be accurate enough to replace biopsies, and results may not apply to all children.

Conditions

The condition(s) this trial relates to.

acute transplant rejection chronic kidney disease kidney disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.