END STAGE RENAL DISEASE

This study is testing a home support program for people on the kidney transplant waitlist who are currently 'inactive' or at risk of becoming inactive. A team of nurses, occupational therapists, and handy workers will visit participants at home over four months to help them overc…

This study is testing whether a blood-filtering procedure called rheopheresis can help heal painful skin ulcers caused by calciphylaxis in people on dialysis. About 138 participants will be randomly assigned to receive either the real treatment or a sham procedure, in addition to…

This study aims to learn about the safety and effectiveness of kidney transplants from donors with HIV to recipients who also have HIV. Researchers will follow 30 adults with HIV who need a kidney transplant and receive one from either a living or deceased donor who also has HIV.…

This study is testing an investigational drug called DCR-PHXC in children under 6 years old who have a rare, inherited disease called Primary Hyperoxaluria Type 1 (PH1). PH1 causes kidney damage and often leads to kidney failure, requiring dialysis or transplant. The main goals a…

This study is testing a web-based app designed to help people waiting for a kidney or liver transplant. The app helps patients create and share their story on social media to find a living donor. The goal is to see if using social media makes it easier for patients to identify po…

This study is testing whether a new, low-glucose dialysis solution called XyloCore is as effective and safe as standard glucose-based solutions for people with end-stage kidney disease. About 170 patients who perform daily peritoneal dialysis at home will use either the new solut…

This study is testing whether an investigational drug called pegcetacoplan can help prevent a common complication called delayed graft function (DGF) after a kidney transplant. DGF means the new kidney doesn't work right away, often requiring temporary dialysis. The trial will en…

This study aims to find out which of two common blood pressure medications works better for people receiving dialysis. It will compare metoprolol, which is filtered out during dialysis, to carvedilol, which is not. The goal is to see which drug more effectively prevents heart att…

This study is testing a new type of dialysis machine called the Solv System for people with end-stage kidney disease. It aims to see if the machine is safe and works as well as standard dialysis at cleaning the blood. The study will involve 46 people who receive their dialysis tr…

This study is testing a small, external support device called VasQ that is placed around a surgically created blood vessel connection (fistula) used for dialysis. The goal is to see if the VasQ implant helps the fistula become ready for use faster and work better than the standar…

This study is testing if empagliflozin, a medication usually for diabetes, can help people who have just started kidney dialysis. Researchers want to see if it safely helps control body fluid levels and blood pressure in 60 adults. The goal is to see if this drug could improve ma…

This study is testing a new, dissolvable wrap called SelfWrap that is placed around a surgically created blood vessel connection (fistula) used for dialysis. The goal is to see if the wrap helps the fistula develop properly and last longer while reducing complications, compared t…

This study is testing a medical device that creates a connection between an artery and vein for dialysis access using a minimally invasive approach. The research involves 280 adults with kidney failure who need dialysis. Doctors will track how well the access works for dialysis a…

This study is testing whether a home monitoring system can help people with advanced kidney disease avoid emergency room visits and hospital stays. About 340 patients will use a tablet app to track their blood pressure, weight, and symptoms daily, sharing the data with their care…

This study is testing if a combination of high-intensity exercise and a supplement called CoQ10 can improve muscle strength and energy levels in people with advanced kidney disease on dialysis. The goal is to see if this approach helps fight frailty and muscle loss better than ex…

This study is testing whether adjusting sodium levels during dialysis can help patients with end-stage kidney disease. Researchers want to see if this personalized approach reduces fluid weight gain between treatments and prevents dangerous blood pressure drops during dialysis. T…

This study is testing a new, personalized strategy for managing fluid in veterans on dialysis. It aims to see if using a patient's own recent blood pressure patterns to guide how much fluid is removed is better than the standard approach. The goal is to better control fluid overl…

This study is testing a new automated ultrasound system designed to help doctors monitor a special type of blood vessel connection (an arteriovenous fistula) used for dialysis in people with kidney failure. The goal is to see if using this device regularly can help the connection…

This study is testing if a special ultrasound probe placed inside a vein (IVUS) can give doctors a better picture of vein damage in people on dialysis. The goal is to see if this method is more accurate than the standard X-ray test (venogram) at finding and measuring blockages. R…

This study is testing whether taking amino acid supplements during dialysis treatments can help reduce severe fatigue and improve strength and thinking skills in people with kidney failure. Researchers will compare two different supplement formulas in about 28 patients who receiv…

This large French study is testing whether regularly asking dialysis patients about their symptoms and automatically alerting their care teams leads to better management and improved quality of life. It involves over 2,200 patients with kidney failure. One group will report sympt…

This study is testing whether wearing special light therapy glasses during dialysis treatments can help reduce severe fatigue in people with end-stage kidney disease. Researchers will compare bright light to dim light in 60 participants over four weeks. The main goal is to see if…

This study is testing whether a treatment using magnetic stimulation can help reduce low back pain and prevent muscle loss in people with end-stage kidney disease who are on dialysis. Researchers will enroll 18 adult patients who experience significant back pain. The goal is to s…

This study is creating a large database to track 60,000 patients who have both heart and kidney disease. Researchers want to understand why these patients often receive different treatments and have worse outcomes than people with only heart problems. By analyzing real-world pati…

This early-stage study aims to understand how a new drug called MK-2828 is processed by the body in people with impaired kidney function. Researchers will compare blood levels of the drug in 24 participants—some with kidney disease and some healthy—after they receive one or two d…

This study aims to understand how chronic inflammatory diseases like type 2 diabetes, irritable bowel disease, and kidney failure might change how the body processes medications. Researchers will collect blood samples and health records from 150 patients with these conditions to …

This study investigates whether sounds coming from dialysis fistulas can reveal problems with blood flow. Researchers will record sounds from 15 patients with kidney failure who need new dialysis access and compare them to detailed blood flow measurements. The goal is to understa…