END STAGE RENAL DISEASE

This study compares two common heart medications (metoprolol and carvedilol) in people on dialysis to see which one better prevents heart attacks, strokes, heart failure, and death. About 2,540 participants will be randomly assigned to one of the two drugs. The goal is to find ou…

This study tests a new automated ultrasound system (EchoMark/EchoSure) to see if it can help blood vessel connections (fistulas) mature faster in people with kidney failure who need dialysis. About 304 adults will be randomly assigned to get the automated scans or standard care. …

This study tests whether kidney transplants from HIV-positive donors are safe and effective for HIV-positive patients with kidney failure. About 30 adults with well-controlled HIV will receive a kidney from an HIV-positive donor. Researchers will track patient survival and kidney…

This study tests whether a special smartphone app (VIEWER) can help people with advanced chronic kidney disease (stage 5) or end-stage kidney disease stay healthier at home and avoid emergency room visits or hospital stays. About 340 adults will be split into two groups: one gets…

This study tests a special wrap called SelfWrap placed around blood vessels during fistula creation surgery for dialysis. The goal is to help the fistula mature faster and work without needing extra procedures. About 600 adults with chronic kidney disease will take part, and they…

This study tests a new dialysis solution called XyloCore that uses less sugar than standard fluids. It is for adults with end-stage kidney disease who are on continuous peritoneal dialysis. The goal is to see if XyloCore works as well as current solutions and may improve blood su…

This study tests a drug called pegcetacoplan in adults who are getting a kidney transplant from a deceased donor and are at high risk for delayed graft function (when the kidney takes a while to start working). The goal is to see if the drug helps the kidney work sooner and reduc…

This study tests a new method for removing fluid during dialysis in people with kidney failure. Instead of standard care, doctors will use each patient's recent blood pressure patterns to decide how much fluid to remove. The goal is to lower the risk of dangerously low blood pres…

This study tests a device called VasQ, which is placed around a surgically created blood vessel connection (fistula) used for dialysis. The goal is to see if VasQ helps the fistula work better and sooner for dialysis. About 300 adults with end-stage kidney disease will be randoml…

This study looks at whether adding a supplement called CoQ10 to high-intensity interval training can improve muscle function in people with end-stage kidney disease on dialysis. Researchers believe that mitochondrial problems limit the benefits of exercise in these patients. The …

This study tests an experimental drug called DCR-PHXC in 28 people with primary hyperoxaluria type 1 (PH1) who have severe kidney damage, some of whom are on dialysis. The goal is to see if the drug can safely lower high levels of oxalate in the blood, which causes kidney stones …

This study tests whether a blood-filtering procedure called rheopheresis can help heal severe skin ulcers caused by calciphylaxis, a rare complication in people on dialysis. About 138 adults with end-stage kidney disease and at least one open ulcer will receive rheopheresis along…

This study compares a new, individualized sodium management feature on dialysis machines to standard treatment for people with end-stage kidney disease. The goal is to see if it reduces weight gain between sessions, improves blood pressure stability, and lowers complications duri…

This study is testing a device called the BD WavelinQ EndoAVF System, which creates a connection between an artery and a vein in the arm to make dialysis easier. About 280 adults with end-stage kidney disease who need dialysis will take part. The goal is to see if the device work…

This study is testing a new dialysis system called Solv Multi-Pass for people with end-stage kidney disease. The goal is to see if it safely and effectively removes waste from the blood during in-center dialysis sessions. About 46 adults who are either new to dialysis or already …

This study compares a once-daily anti-rejection drug (Envarsus XR) to a twice-daily drug (tacrolimus) in 78 adults receiving a first kidney transplant. The goal is to see if Envarsus XR reduces hidden rejection and improves immune system markers in the blood. Participants will be…

This study tests whether empagliflozin, a drug used for diabetes, is safe and helps control fluid balance in people who are starting hemodialysis for end-stage kidney disease. About 60 adults will receive either empagliflozin or a placebo for 12 weeks. The goal is to see if the d…

This study looks at whether a special ultrasound placed inside the vein (IVUS) can better detect blockages in dialysis patients compared to the usual X-ray method. About 50 adults with kidney failure who are on dialysis and have access problems will take part. The goal is to see …

This study tests whether magnetic stimulation can reduce low back pain and help maintain muscle mass in people with end-stage kidney disease who are on dialysis. About 18 adults with moderate to severe back pain will receive the treatment. The goal is to improve pain, physical fu…

This study tests a program called CAPABLE Transplant to help people with kidney failure who are waiting for a transplant. The program aims to solve problems like depression, physical weakness, or lack of support that keep them from being active on the waitlist. About 43 adults wi…

This study tests if wearing special glasses that give off bright light during dialysis can help reduce fatigue in people with end-stage kidney disease. 60 adults on dialysis will use the glasses for one hour during each session for four weeks. The goal is to see if this simple, d…

This study tests whether regularly monitoring symptoms in dialysis patients and automatically notifying their care teams can improve quality of life. About 2,293 adults with end-stage kidney disease will participate across French dialysis centers. The goal is to help doctors addr…

This study tests whether taking amino acid supplements during dialysis can help reduce fatigue, frailty, and improve thinking in people with end-stage kidney disease. About 28 adults on dialysis will take either a single amino acid (valine) or a mix of essential amino acids. The …

This early-stage study looks at how the drug MK-2828 behaves in people with different levels of kidney function, including those with severe kidney failure or on dialysis. About 24 adults will receive one or two doses, and researchers will measure drug levels in the blood over ti…

This study is testing a web-based app that helps people on the kidney or liver transplant waiting list share their story on social media to find a living donor. The goal is to see if this approach brings in more potential donors and leads to more transplants. The study involves 1…

This study is a large registry that will collect health information from up to 60,000 people with both heart and kidney disease. The goal is to understand what factors lead to worse outcomes and to improve how doctors predict and manage these conditions. No new treatments or proc…

This study looks at how inflammation from type 2 diabetes, end-stage kidney disease, or irritable bowel syndrome can change the way the body processes certain drugs. Researchers will measure inflammation markers and immune cells in blood samples from 150 adults and children with …

This study looks at whether the sound made by blood flowing through an arteriovenous fistula (AVF) can tell doctors about its condition. Researchers will measure sound patterns and compare them to blood flow disturbances in 15 adults with end-stage kidney disease who need a new A…