END STAGE RENAL DISEASE

This study tested whether kidneys from deceased donors with hepatitis C could be safely transplanted into patients without the virus. After transplant, recipients took antiviral medication to cure the hepatitis C infection. The goal was to expand the donor pool and reduce wait ti…

This study looked at whether taking vitamin C by mouth can safely lower the amount of erythropoietin (a drug for anemia) needed by people with end-stage kidney disease on regular dialysis. Sixty adults completed the trial. Researchers checked hemoglobin, iron levels, and any chan…

This study tested a lab-made blood vessel (Human Acellular Vessel, or HAV) against the standard surgically-created fistula (AVF) for people with kidney failure who need dialysis. The goal was to see which one works better and is safer for connecting to the dialysis machine. The t…

This study tested a special implant that slowly releases the drug sirolimus around a new dialysis fistula (a surgically created blood vessel connection). The goal was to see if it helps the fistula mature and stay usable for dialysis in people with end-stage kidney disease. The t…

This study looked at the safety of a home hemodialysis system for people with end-stage kidney disease. 25 patients who had already used the system in a previous study continued using it at home. The main goal was to track any side effects or device problems.

This study tested a device called Carry Life UF that adds sugar to dialysis fluid already in the belly to help remove more fluid during peritoneal dialysis. 28 adults with end-stage kidney disease who were on standard dialysis tried the device at home. The goal was to see if it c…

This study checked the safety of a new dialysis filter called ELISIO™-HX in 22 adults with kidney failure who were already on dialysis. The main goal was to make sure the filter did not lower blood protein (albumin) levels, while also improving removal of certain waste products. …

This study tested a special collagen implant that slowly releases a drug called sirolimus. It was placed around a new blood vessel connection (fistula) during surgery in 136 people aged 65+ with kidney failure on dialysis. The goal was to see if the implant helps the fistula matu…

This study tested an experimental drug called MK-2060 in 506 people with end-stage kidney disease who need dialysis through a special tube (graft) in their arm. The goal was to see if the drug could prevent dangerous blood clots from blocking the graft. Researchers compared two d…

This study tested a new dialysis filter called Clearum HS in 20 adults with end-stage kidney disease who were already on dialysis. The filter was used for 6 weeks and compared to a standard filter to see how well it removes waste products like urea from the blood. The goal was to…

This study tested whether teaching dialysis clinic staff and encouraging patients to speak up could reduce dangerous drops in blood pressure during treatment. Over 1,400 people with kidney failure took part across multiple clinics. The goal was to make dialysis sessions safer and…

This study tested two drug-free methods to help people on dialysis sleep better and feel more comfortable. Sixty patients in Cyprus received either reflexology (a special foot massage) or sleep hygiene education. Both approaches improved sleep and comfort, but reflexology worked …

This study tested whether doing hand grip exercises with a dynamometer for six weeks helps the surgically created blood vessel connection (fistula) mature and stay open in adults on hemodialysis. 34 patients were randomly assigned to either the exercise program or standard care. …

This study looked at whether a 26-week exercise program can reduce symptoms and improve quality of life for people on long-term hemodialysis. 133 participants were randomly assigned to either the exercise program or usual care. The main goal was to see if exercise lessened sympto…

This study looked at how kidney doctors (nephrologists) think about choosing the right type of dialysis for patients with kidney failure. Researchers interviewed 25 active nephrologists to understand their beliefs and attitudes. The goal is to find out if doctors' views affect wh…

This early-phase study tested a single injection of a new drug called MK-2060 in 14 people with advanced chronic kidney disease. The main goal was to check safety and how the drug moves through the body. Only the first part was completed; later parts were not started for reasons …

This study tested a program to improve how older adults (65+) with advanced kidney disease talk with their doctors about dialysis. The program trained doctors in communication and coached patients to share their values and questions. The goal was to see if the program was feasibl…

This study tested a communication tool called "Best Case/Worst Case" to help older adults with end-stage kidney disease and their doctors talk about treatment options, including palliative care. Over 400 patients from ten kidney clinics took part, with some doctors trained to use…

This study tested a program called KidneyTIME that uses videos and text messages to teach kidney patients about getting a transplant from a living donor. Over 400 adults waiting for a kidney took part. The goal was to see if the program helped patients learn more and led to more …

This study tested a program called SPIRIT that helps people with end-stage kidney disease and their families plan for end-of-life care. The program involves two face-to-face sessions to improve understanding and agreement between patients and their chosen decision-makers. Researc…

This study tested a program that helps people with end-stage kidney disease find a living kidney donor. Patients on the transplant waitlist were encouraged to bring family and friends to educational sessions. These 'champions' then helped spread the word about the patient's need …

This study tested whether trained transplant navigators could help kidney failure patients complete the steps needed to get a kidney transplant. About 167 adults on dialysis took part, with some receiving navigator support and others usual care. The goal was to see if personalize…