Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New shot may keep dialysis grafts open longer in kidney patients

NCT ID NCT05027074

Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called MK-2060 in 506 adults with end-stage kidney disease who need regular dialysis through a special tube (graft) in their arm. The goal was to see if the drug could prevent dangerous blood clots from blocking the graft, which would require emergency procedures. Participants received either a low dose, a high dose, or a placebo shot, and researchers tracked how long it took for a clot to happen. The study is complete, and results will help decide the best dose for future research.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

506 people

The number who actually took part.

Started

Sep 2021

Finished

Feb 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Current diagnosis of ESRD. * Receiving hemodialysis (including hemodiafiltration) ≥3 times per week for a minimum of 3 hours per session via a mature normally functioning, uninfected AVG with at least 75% of the sessions meeting these criteria over the 4 weeks prior to randomization. * A female participant is not pregnant or breastfeeding, not a woman of child-bearing potential (WOCBP) or is a WOCBP and agrees to follow contraceptive guidance during the intervention period and for at least 90 days after the last dose of study intervention. Exclusion Criteria: * Recent history of cancer (\<1 year). Non-melanoma skin cancers are allowed. * Mechanical/prosthetic heart valve. * Recent hemorrhagic stroke or lacunar stroke (\<1 month). * Recent evidence (\<1 month) of bleeding requiring hospitalization or unplanned medical attention, a history (≤2 years) of recurrent bleeding episodes including epistaxis, gastrointestinal (GI) bleeds or genitourinary (GU) bleeds requiring medical treatment or events requiring treatment with blood products. * Recent history (\<1 year) of drug or alcohol abuse or dependence. * Currently receiving or planning to receive anticoagulants or antiplatelet medications (intradialytic heparin and aspirin are permitted). * Planning on receiving a living donor renal transplant within 12 months (participants are permitted to be candidates for deceased donor renal transplants). * Planning on receiving an arteriovenous fistula (AVF) placement within 12 months.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for End-stage kidney disease are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

chronic kidney disease chronic renal failure syndrome end stage renal failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

End-stage kidney disease End-stage renal disease Kidney failure, chronic

Contacts and locations

Locations

  • AKDHC MEDICAL RESEARCH SERVICES, LLC-Maryvale ( Site 0723)

    Phoenix, Arizona, 85035, United States

  • AKDHC Medical Research Services, LLC ( Site 0629)

    Tucson, Arizona, 85741, United States

  • ASST Grande Ospedale Metropolitano Niguarda ( Site 0953)

    Milan, 20162, Italy

  • ATTIKON GENERAL UNIVERSITY HOSPITAL-2nd Dep. of Int. Medicine. Research Unit & Diabetes Center ( Sit

    Chaïdári, Attica, 124 62, Greece

  • Academic Medical Research Institute ( Site 0533)

    Los Angeles, California, 90022, United States

  • Akademiska sjukhuset-Njurmottagningen ( Site 0453)

    Uppsala, Uppsala County, 751 85, Sweden

  • Albert Einstein College of Medicine-Department of Medicine-Nephrology Einstein ( Site 0628)

    The Bronx, New York, 10461, United States

  • CEREHA ( Site 0004)

    Sarandí, Buenos Aires, B1872JBA, Argentina

  • California Institute Of Renal Research ( Site 0660)

    Chula Vista, California, 91910, United States

  • California Institute Of Renal Research ( Site 0679)

    El Centro, California, 92243, United States

  • California Institute of Renal Research ( Site 0566)

    Escondido, California, 92025, United States

  • California Institute of Renal Research - Kearny Mesa ( Site 0678)

    San Diego, California, 92111, United States

  • California Institute of Renal Research - La Mesa ( Site 0682)

    La Mesa, California, 91941, United States

  • Capital District Renal Physicians ( Site 0633)

    Albany, New York, 12209, United States

  • Capital Nephrology ( Site 0596)

    Greenbelt, Maryland, 20770, United States

  • Centro de Educación Médica e Investigaciones Clínicas (CEMIC) ( Site 0010)

    Buenos Aires, Buenos Aires F.D., C1431FWO, Argentina

  • Citrus Dialysis Center ( Site 0609)

    Covina, California, 91723, United States

  • Clinical Research Consultants, LLC ( Site 0542)

    Kansas City, Missouri, 64111, United States

  • Clinical Research Strategies ( Site 0625)

    Houston, Texas, 77090, United States

  • Clínica de Nefrología, Urología y Enfermedades Cardiovasculares ( Site 0001)

    Santa Fe, 3000, Argentina

  • DaVita Anaheim West Dialysis-Davita Anaheim West Dialysis - Ismail ( Site 0562)

    Anaheim, California, 92801, United States

  • DaVita Bakersfield Oak Street Dialysis-Clinical Research ( Site 0547)

    Bakersfield, California, 93304, United States

  • DaVita Clinical Research ( Site 0502)

    Minneapolis, Minnesota, 55404, United States

  • DaVita Clinical Research - Columbus ( Site 0532)

    Columbus, Georgia, 31904, United States

  • DaVita Clinical Research - El Paso ( Site 0505)

    El Paso, Texas, 79925, United States

  • DaVita Clinical Research - Hartford ( Site 0507)

    Hartford, Connecticut, 06112, United States

  • DaVita Clinical Research - Houston ( Site 0508)

    Houston, Texas, 77004, United States

  • DaVita Clinical Research - Middlebury ( Site 0511)

    Middlebury, Connecticut, 06762, United States

  • DaVita Clinical Research - Milwaukee ( Site 0512)

    Wauwatosa, Wisconsin, 53226, United States

  • DaVita Clinical Research - Norfolk ( Site 0513)

    Norfolk, Virginia, 23502, United States

  • DaVita Clinical Research Germany GmbH ( Site 0901)

    Düsseldorf, North Rhine-Westphalia, 40210, Germany

  • DaVita Clinical Researh ( Site 0501)

    The Bronx, New York, 10461, United States

  • DaVita Crescent Heights Dialysis Center ( Site 0574)

    Los Angeles, California, 90048, United States

  • DaVita East Georgia Dialysis Unit ( Site 0536)

    Statesboro, Georgia, 30458, United States

  • DaVita Five Star Dialysis Center ( Site 0509)

    Las Vegas, Nevada, 89128, United States

  • DaVita Glendale Heights ( Site 0604)

    Glendale, California, 91201, United States

  • DaVita Kidney Center - East LA Plaza Dialysis ( Site 0548)

    Los Angeles, California, 90033, United States

  • DaVita North Glendale ( Site 0552)

    Glendale, California, 91206, United States

  • DaVita Van Nuys Dialysis ( Site 0538)

    Van Nuys, California, 91405, United States

  • DaVita West Glendale Dialysis ( Site 0579)

    Glendale, California, 91205, United States

  • Desert Cities Diaylsis-Clinical Research ( Site 0615)

    Victorville, California, 92392, United States

  • Dialýza ( Site 0256)

    Beroun, 266 01, Czechia

  • Durham Nephrology Associates ( Site 0655)

    Durham, North Carolina, 27704, United States

  • Dyalisis Center - Clinic NephroCare Lumiar -Fresenius ( Site 0853)

    Lisbon, Lisbon District, 1750-130, Portugal

  • East Carolina University-Department of Nephrology & Hypertension ( Site 0663)

    Greenville, North Carolina, 27834, United States

  • Elixia Clinical Research Collaborative (CRC) - Southeast Florida ( Site 0728)

    Hollywood, Florida, 33020, United States

  • Elixia at Clinical Renal Associates ( Site 0677)

    Upland, Pennsylvania, 19013, United States

  • Elixia at Florida Kidney Physicians - Southeast ( Site 0602)

    Fort Lauderdale, Florida, 33308, United States

  • FME Mansilla ( Site 0007)

    Ciudad Autonoma de Buenos Aires, Buenos Aires, C1425BPM, Argentina

  • First Dialysis Services Bulgaria ( Site 0158)

    Montana, 3400, Bulgaria

  • Floridian Clinical Research, LLC ( Site 0684)

    Miami Lakes, Florida, 33016, United States

  • Fondazione Salvatore Maugeri clinica del lavoro ( Site 0955)

    Pavia, 27100, Italy

  • Fresenius Clinical Trials Perdizes ( Site 0101)

    São Paulo, São Paulo, 05024-030, Brazil

  • Fresenius Kidney Care - Charlotte ( Site 0686)

    Charlotte, North Carolina, 28208, United States

  • Fresenius Kidney Care Bakersfield Northeast ( Site 0647)

    Bakersfield, California, 93306, United States

  • Fresenius Kidney Care Brookhaven ( Site 0693)

    Brookhaven, Mississippi, 39601, United States

  • Fresenius Kidney Care Meadows Field ( Site 0618)

    Bakersfield, California, 93308, United States

  • Fresenius Kidney Care Newhope Fountain Valley ( Site 0617)

    Fountain Valley, California, 92708, United States

  • Fresenius Medical Care ( Site 0253)

    Pardubice, 532 03, Czechia

  • Fresenius Medical Care - Dialyzační středisko ( Site 0254)

    Prague, Praha 4, 142 00, Czechia

  • Fresenius Medical Care - Moron ( Site 0008)

    Morón, Buenos Aires, B1708DPO, Argentina

  • Fresenius Medical Care - NephroCare Almada ( Site 0854)

    Corroios, Lisbon District, 2855-227, Portugal

  • Fresenius Medical Care - NephroCare Amadora ( Site 0851)

    Amadora, Lisbon District, 2700-391, Portugal

  • Fresenius Medical Care - NephroCare Covilha ( Site 0852)

    Covilha, Castelo Branco District, 6200-000, Portugal

  • Fresenius Medical Care - Nephrocare Portimao ( Site 0855)

    Portimão, Faro District, 8500-311, Portugal

  • Fresenius Medical Care - San Fernando ( Site 0013)

    San Fernando, Buenos Aires, 1646, Argentina

  • Fresenius Medical Care Ciudad Evita ( Site 0006)

    Buenos Aires, B1778IFA, Argentina

  • Fresenius Medical Care Humacao ( Site 0354)

    Humacao, 00971, Puerto Rico

  • Fresenius Nephrocare - Brașov ( Site 0409)

    Brașov, Brăila County, 500152, Romania

  • Fresenius Nephrocare - Bucharest ( Site 0408)

    Bucharest, Bucharest, 013217, Romania

  • Fresenius Nephrocare - Cluj-Napoca ( Site 0410)

    Cluj-Napoca, Cluj, 400528, Romania

  • Fresenius Nephrocare - Iași ( Site 0406)

    Iași, Iaşi, 700523, Romania

  • Fundação Faculdade Regional de Medicina de São José do Rio Preto-Centro Integrado de Pesquisa ( Site

    São José do Rio Preto, São Paulo, 15090000, Brazil

  • G. Papanikolaou General Hospital-Nephrology Department ( Site 1052)

    Thessaloniki, 570 10, Greece

  • Gamma Medical Research ( Site 0688)

    McAllen, Texas, 78503, United States

  • Genesis Clinical Research, LLC ( Site 0585)

    Tampa, Florida, 33603, United States

  • Genesis Clinical Research, LLC ( Site 0594)

    Tampa, Florida, 33603, United States

  • Genesis Clinical Research, LLC ( Site 0680)

    Tampa, Florida, 33603, United States

  • Hemomed ( Site 0159)

    Sofia, 1618, Bulgaria

  • Henry Ford Hospital-Nephrology and Hypertension ( Site 0694)

    Detroit, Michigan, 48202, United States

  • Horizon Research Group ( Site 0578)

    Coral Gables, Florida, 33134, United States

  • Horizon Research Group ( Site 0581)

    Coral Gables, Florida, 33134, United States

  • Hospital do Rim e Hipertensão ( Site 0106)

    São Paulo, 04038-002, Brazil

  • Ippokrateio General Hospital of Thessaloniki ( Site 1053)

    Thessaloniki, Central Macedonia, 546 42, Greece

  • Karolinska Universitetssjukhuset Huddinge-ME Njurmedicin ( Site 0451)

    Stockholm, Stockholm County, 141 86, Sweden

  • Kidney and Hypertension Center ( Site 0571)

    Roseburg, Oregon, 97471, United States

  • Knoxville Kidney Center ( Site 0689)

    Knoxville, Tennessee, 37923, United States

  • La Puente Dialysis Center ( Site 0610)

    La Puente, California, 91744, United States

  • Limited Liability Company -Nefroline-Novosibirsk ( Site 0810)

    Novosibirsk, Novosibirsk Oblast, 630064, Russia

  • MHAT Dobrich-Department for dialysis treatment ( Site 0161)

    Dobrich, 9300, Bulgaria

  • Multiprofile Hospital for Active Treatment - "Dr. Cherven Bryag"-Department of dialysis treatment (

    Cherven Bryag, Lovech, 5980, Bulgaria

  • Nephrology Consultants ( Site 0681)

    Huntsville, Alabama, 35805, United States

  • Nephrology Specialists - Merrillville ( Site 0537)

    Merrillville, Indiana, 46410, United States

  • Nephrology Specialists - Michigan City ( Site 0541)

    Michigan City, Indiana, 46360, United States

  • North America Research Institute ( Site 0587)

    Lynwood, California, 90262, United States

  • North America Research Institute ( Site 0611)

    San Dimas, California, 91773, United States

  • North America Research Institute ( Site 0612)

    Lynwood, California, 90262, United States

  • Northeast Clinical Research Center ( Site 0653)

    Bethlehem, Pennsylvania, 18017, United States

  • Omega Research Orlando ( Site 0645)

    Orlando, Florida, 32808, United States

  • P.O. San Carlo Borromeo- ASST SANTI PAOLO E CARLO ( Site 0954)

    Milan, Milano, 20153, Italy

  • Pines Clinical Research ( Site 0605)

    Hollywood, Florida, 33024, United States

  • Renal Disease Research Institute ( Site 0621)

    Dallas, Texas, 75235, United States

  • Renal Medicine Associates ( Site 0690)

    Albuquerque, New Mexico, 87109, United States

  • Renal Physicians of Georgia ( Site 0577)

    Macon, Georgia, 31217, United States

  • Research Physicians Network Alliance ( Site 0563)

    Boca Raton, Florida, 33431, United States

  • Ridgewood Dialysis Center ( Site 0725)

    Ridgewood, New York, 11385, United States

  • Skånes Universitetssjukhus Malmö ( Site 0454)

    Malmö, Skåne County, 205 02, Sweden

  • Somnos Clinical Research ( Site 0669)

    Lincoln, Nebraska, 68505, United States

  • South Carolina Nephrology & Hypertension Center-Research ( Site 0672)

    Orangeburg, South Carolina, 29118, United States

  • South Florida Research Institute ( Site 0656)

    Fort Lauderdale, Florida, 33313, United States

  • Southwest Houston Research ( Site 0649)

    Houston, Texas, 77099, United States

  • St. Clair Nephrology Research - Roseville ( Site 0597)

    Roseville, Michigan, 48066, United States

  • Texas Institute for Kidney and Endocrine Disorders ( Site 0626)

    Lufkin, Texas, 75904, United States

  • Toronto General Hospital ( Site 1002)

    Toronto, Ontario, M5G 2C4, Canada

  • UMBAL Plovdiv AD-Deparment of Hemodialysis ( Site 0162)

    Plovdiv, 4003, Bulgaria

  • Unipharm LLC ( Site 0804)

    Krasnogorsk, Moscow Oblast, 143403, Russia

  • University Of Alberta Hospital ( Site 1001)

    Edmonton, Alberta, T6G 2B7, Canada

  • University of Chicago Medical Center-Medicine - Section of Nephrology ( Site 0595)

    Chicago, Illinois, 60637, United States

  • Valley Renal Medical Group Research-Clinical Research ( Site 0651)

    Northridge, California, 91343, United States

  • Western Health-Sunshine & Footscray Hospitals-Renal Services ( Site 0054)

    St Albans, Victoria, 3021, Australia

More trials for these conditions

Other studies related to the condition(s) this trial covers.