END-STAGE KIDNEY DISEASE

This study tests whether a personalized dialysis schedule (starting with fewer sessions based on remaining kidney function) is safer and improves quality of life compared to the standard fixed schedule. About 350 adults with new kidney failure will be randomly assigned to one of …

This study compares two common heart medications (metoprolol and carvedilol) in people on dialysis to see which one better prevents heart attacks, strokes, heart failure, and death. About 2,540 participants will be randomly assigned to one of the two drugs. The goal is to find ou…

This early-phase study tests whether a stem cell infusion from the same donor can allow kidney transplant recipients to safely stop their daily anti-rejection medications. Ten adults with a stable, well-functioning kidney from a matched living donor will receive a conditioning tr…

This study tests a drug called CSL300 in about 2,300 adults with end-stage kidney disease who are on dialysis and have signs of inflammation. The goal is to see if the drug can reduce the risk of heart attacks or heart-related death. Participants will receive either the drug or a…

This study is testing a new dialysis machine called Moda-flx in 50 adults with end-stage kidney disease who are already on stable dialysis. The goal is to see if it is safe and works well both in a clinic and at home when used by trained patients or care partners. The study will …

This study tests whether a tablet-based symptom tracker, called SMaRRT-HD, helps dialysis patients feel better. About 2,400 adults with end-stage kidney disease at up to 36 U.S. clinics will either use the tracker or receive usual care. The goal is to see if regular symptom repor…

This study tests whether using social virtual reality (VR) during dialysis sessions can reduce loneliness and other symptoms in people with end stage kidney disease. Sixty participants will use VR glasses for 30-45 minutes during dialysis, three times a week for four weeks. The g…

This study tests a small, battery-powered headband that delivers a gentle electrical stimulation to the scalp to reduce chronic pain in people with end-stage kidney disease who are on dialysis. About 125 adults will use the device at home and report their pain levels. The goal is…

This study looks at how the drug eloralintide is processed by the body in people with severe kidney disease or kidney failure compared to healthy people. About 28 adults will receive a single injection under the skin. The study lasts about 14 weeks and aims to understand drug lev…