END STAGE KIDNEY DISEASE

This study tested whether a drug called PLS240 could safely and effectively treat a hormone disorder called secondary hyperparathyroidism in people with kidney failure who are on dialysis. For the first 27 weeks, 412 participants were randomly assigned to receive either the drug …

This early-stage study tested a single injection of an experimental drug called MK-2060 in people with advanced kidney disease. The main goals were to check the drug's safety, see how long it stays in the body, and measure its effect on blood clotting. Only 14 people with stage 4…

This study tested a small, drug-releasing implant placed during surgery to create a dialysis access point (called a fistula). The goal was to see if the implant, compared to standard surgery, could help the fistula develop better and last longer for patients on kidney dialysis. A…

This study tested whether a small, drug-releasing implant placed during surgery could improve the success of creating a usable dialysis access point (called a fistula) in the arm. It involved 269 people with kidney failure who needed to start or were recently on dialysis. Researc…

This study tested whether an experimental drug called MK-2060 could prevent dangerous blood clots from forming in the artificial grafts used for dialysis in people with kidney failure. Over 500 participants received either one of two doses of the drug or a placebo to see which wo…

This early-stage study tested how the experimental drug AZD4144 is processed by the body in people with different levels of kidney function. Researchers gave a single dose to 41 participants, including healthy volunteers and people with mild to severe kidney impairment or end-sta…

This study aimed to understand how the experimental drug MK-5684 is processed by the body in men with severe or end-stage kidney disease. Researchers compared drug levels in the blood of 24 men—some with kidney disease and some healthy—after a single dose. The goal was to see if …