END-STAGE KIDNEY DISEASE

This study compared two ways to do dialysis at home for people with end-stage kidney disease: overnight automated dialysis (APD) and daytime continuous dialysis (CAPD). The goal was to see if the overnight method cleans the blood just as well as the daytime method, and if it impr…

This study looked at whether a 12-week cycling program during hemodialysis sessions can reduce heart muscle stress (called stunning) in adults with end-stage kidney disease. 111 participants either cycled during dialysis or received standard care. The main goal was to see changes…

This study tested a special implant that slowly releases the drug sirolimus around a new dialysis fistula (a surgically created blood vessel connection). The goal was to see if it helps the fistula mature and stay usable for dialysis in people with end-stage kidney disease. The t…

This study tested a special collagen implant that slowly releases a drug called sirolimus. It was placed around a new blood vessel connection (fistula) during surgery in 136 people aged 65+ with kidney failure on dialysis. The goal was to see if the implant helps the fistula matu…

This study tested an experimental drug called MK-2060 in 506 people with end-stage kidney disease who need dialysis through a special tube (graft) in their arm. The goal was to see if the drug could prevent dangerous blood clots from blocking the graft. Researchers compared two d…

This study tested a drug called PLS240 in 412 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). The goal was to see if the drug can safely lower high parathyroid hormone levels. Participants received eith…

This study looked at how the drug MK-5684 is processed in the bodies of men with severe kidney disease or end-stage kidney disease compared to healthy men. Researchers measured drug levels in the blood over time and checked for side effects. The goal was to understand how kidney …

This early-phase study tested a single injection of a new drug called MK-2060 in 14 people with advanced chronic kidney disease. The main goal was to check safety and how the drug moves through the body. Only the first part was completed; later parts were not started for reasons …

This study tested a decision-making tool for people waiting for a kidney transplant. 100 participants used an online education tool and discussed their donor preferences with a doctor. The goal was to see if the tool helps patients make more informed choices about accepting donor…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…