New hope for dialysis patients: drug targets hormone imbalance

NCT ID NCT05836220

Completed Disease control Sponsor: Pathalys Pharma Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 21, 2026 · Updated 27 times

Summary

This study tested a drug called PLS240 in 412 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). The goal was to see if the drug can safely lower high parathyroid hormone levels. Participants received either PLS240 or a placebo for 27 weeks, followed by an open-label phase where everyone could get PLS240 for another 26 weeks. The study is complete, and results will show if PLS240 helps control this common complication.

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Contacts and locations

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Locations

Site Number: BGR001-2

Gabrovo, 5300, Bulgaria
Site Number: BGR002-2

Rousse, 7002, Bulgaria
Site Number: BGR003-2

Lom, Montana, 3600, Bulgaria
Site Number: BGR004-2

Varna, 9000, Bulgaria
Site Number: ESP003-2

Córdoba, Cordoba, 14004, Spain
Site Number: ESP005-2

Manises, Valencia, 46940, Spain
Site Number: POL001-2

Lodz, Lódzkie, 90-242, Poland
Site Number: POL002-2

Poznan, Greater Poland Voivodeship, 60-214, Poland
Site Number: POL004-2

Tomaszów Mazowiecki, Lódzkie, 97-200, Poland
Site Number: POL005-2

Warsaw, Masovian Voivodeship, 02-758, Poland
Site Number: PRT001-2

Carnaxide, 2790-134, Portugal
Site Number: PRT002-2

Covilha, Castelo Branco District, 6200-000, Portugal
Site Number: PRT003-2

Lisbon, 1250-203, Portugal
Site Number: SRB001-2

Kruševac, 37000, Serbia
Site Number: SRB002-2

Niš, 18000, Serbia
Site Number: SRB003-2

Belgrade, 11000, Serbia
Site Number: SRB004-2

Užice, 31000, Serbia
Site Number: SRB005-2

Belgrade, Belgrade, 11080, Serbia
Site Number: USA001-2

Chula Vista, California, 91910-3813, United States
Site Number: USA002-2

Hollywood, Florida, 33024-2776, United States
Site Number: USA003-2

San Diego, California, 92111-3636, United States
Site Number: USA004-2

Fort Myers, Florida, 33908-4154, United States
Site Number: USA005-2

La Mesa, California, 91942-3017, United States
Site Number: USA006-2

Waxahachie, Texas, 75165-1399, United States
Site Number: USA007-2

Amherst, New York, 14228-2792, United States
Site Number: USA008-2

San Antonio, Texas, 78251-4125, United States
Site Number: USA009-2

Toledo, Ohio, 43606-1171, United States
Site Number: USA010-2

Greenville, South Carolina, 29605-4019, United States
Site Number: USA011-2

El Paso, Texas, 79925-4828, United States
Site Number: USA012-2

San Antonio, Texas, 78221-3019, United States
Site Number: USA013-2

Columbus, Georgia, 31904-3603, United States
Site Number: USA015-2

Newark, Delaware, 19713-2081, United States
Site Number: USA016-2

Minneapolis, Minnesota, 55404-1212, United States
Site Number: USA017-2

Middlebury, Connecticut, 06762-2843, United States
Site Number: USA018-2

San Dimas, California, 91773-3539, United States
Site Number: USA019-2

Granada Hills, California, 91344-7407, United States
Site Number: USA020-2

Escondido, California, 92025-4402, United States
Site Number: USA021-2

Tarzana, California, 91356-3647, United States
Site Number: USA022-2

Moorpark, California, 93021-3352, United States
Site Number: USA023-2

Arvada, Colorado, 80002-3714, United States
Site Number: USA024-2

Wichita, Kansas, 67214-2944, United States
Site Number: USA025-2

Kalamazoo, Michigan, 49007-3889, United States
Site Number: USA026-2

Durham, North Carolina, 27704-2147, United States
Site Number: USA027-2

Knoxville, Tennessee, 37923-3624, United States
Site Number: USA028-2

Mishawaka, Indiana, 46545-3519, United States
Site Number: USA029-2

Live Oak, Texas, 78233-4767, United States
Site Number: USA030-2

Los Angeles, California, 90022-4302, United States
Site Number: USA031-2

Aurora, Colorado, 80045-7202, United States
Site Number: USA033-2

Northridge, California, 91324-3528, United States
Site Number: USA034-2

Fullerton, California, 92832-3037, United States
Site Number: USA035-2

South Miami, Florida, 33143-5522, United States
Site Number: USA037-2

Norfolk, Virginia, 23507-1901, United States
Site Number: USA038-2

St. George, Utah, 84790-5898, United States
Site Number: USA039-2

Anaheim, California, 92801-6731, United States
Site Number: USA041-2

Orlando, Florida, 32801, United States
Site Number: USA042-2

Fresno, California, 93720-3389, United States
Site Number: USA043-2

Los Angeles, California, 90033, United States
Site Number: USA044-2

Lancaster, California, 93534-2831, United States
Site Number: USA045-2

Roseburg, Oregon, 97471-6214, United States
Site Number: USA046-2

Glendale, California, 91205-3313, United States
Site Number: USA048-2

Detroit, Michigan, 48236-2169, United States
Site Number: USA049-2

Northridge, California, 91324-2927, United States
Site Number: USA051-2

Fairfax, Virginia, 22033-1907, United States
Site Number: USA052-2

Victorville, California, 92395-8322, United States
Site Number: USA053-2

Charlotte, North Carolina, 28208-3876, United States
Site Number: USA054-2

New Orleans, Louisiana, 70112, United States
Site Number: USA055-2

Prosper, Texas, 75078-1411, United States
Site Number: USA056-2

Tarzana, California, 91356-2806, United States

Conditions

Explore the condition pages connected to this study.

END STAGE KIDNEY DISEASE END-STAGE KIDNEY DISEASE SECONDARY HYPERPARATHYROIDISM SECONDARY HYPERPARATHYROIDISM