Deep dental cleaning may protect kidneys in diabetics, new study suggests
NCT ID NCT07256613
First seen Jun 27, 2026 · Last updated Aug 25, 2026 · Updated 2 times
Summary
This study looks at whether deep cleaning for gum disease can improve kidney health in people with uncontrolled type 2 diabetes. 46 adults with both conditions will either get gum treatment right away or after a delay. Researchers will measure kidney markers like creatinine and urea in blood tests at the start and after 90 days to see if gum care makes a difference.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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46 people
The number who actually took part.
- Started
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May 2025
- Finished
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Aug 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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30 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults between 30 and 65 years of age * Men and women previously diagnosed with type 2 diabetes mellitus for at least one year * Participants with uncontrolled diabetes, defined as HbA1c ≥ 7% * Presence of moderate to severe gum disease, Stage II or Stage III periodontitis, as determined by dental examination * Estimated glomerular filtration rate (eGFR) of 60 mL/min/1.73 m² or higher * Willing and able to provide written informed consent Exclusion Criteria: * Critically ill individuals or those unable to communicate effectively * Pregnant or breastfeeding women * Women currently using hormone replacement therapy or oral contraceptives within the past six months * Individuals taking steroidal drugs, nonsteroidal anti-inflammatory drugs (NSAIDs), or other anti-inflammatory medications within the past three months, except low-dose aspirin up to 75 mg daily * Participants with a recent history of major blood loss, trauma, or gastrointestinal bleeding * Use of antibiotics within the last month * History of fever or vomiting lasting more than one week within the last month * Regular tobacco or alcohol users * Individuals with any other chronic disease or condition that could interfere with study outcomes * Individuals unwilling or unable to comply with study procedures or follow-up visits
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Dow University of Health Scinces
Karachi, Sindh, 75330, Pakistan