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Could a common NSAID replace opioids for kidney stone surgery pain?

NCT ID NCT03888144

Symptom relief Sponsor: The Cleveland Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether ketorolac, a non-steroidal anti-inflammatory drug (NSAID), works as well as the opioid oxycodone for pain after kidney stone removal. 81 adults who had ureteroscopy and received a ureteral stent took part. For five days after surgery, they recorded their pain levels and how much medication they used. The goal was to see if ketorolac could provide similar pain relief with fewer opioid-related side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

81 people

The number who actually took part.

Started

Oct 2017

Finished

Aug 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients with kidney or ureteral stones confirmed on imaging (CT of the abdomen pelvis) and who elect for definitive treatment via unilateral ureteroscopy at one of two hospital sites within a tertiary care institution * Patients who post-operatively receive a unilateral ureteral stent * Capable of giving informed consent * Capable and willing to fulfill requirements of the study Exclusion Criteria: * Active or history of peptic ulcer disease, gastrointestinal bleeding or perforation * History of coronary artery bypass graft surgery * History of a bleeding disorder * GFR less than 60 mL/min/1.73m2 (MDRD equation) * Chronic use of opioid or other pain medication including NSAIDs (greater than 12 weeks) * Known allergy to either ketorolac or oxycodone * Known or suspected pregnancy * Solitary kidney * Patients taking anticoagulant medication or antiplatelet medication (e.g. warfarin, clopidogrel, pradaxa, rivaroxaban, apixaban etc). * Inability to give informed consent or unable to meet requirements of the study for any reason

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Conditions

The condition(s) this trial relates to.

Kidney Calculi nephrolithiasis Ureteral Calculi ureterolithiasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Kidney calculi Ureteral calculi

Contacts and locations

Locations

  • Cleveland Clinic Foundation

    Cleveland, Ohio, 44195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.