Protein and exercise may boost muscle before dialysis

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1. In order to be eligible to participate in this study, a patient with CKD must meet all of the following criteria: * (e)glomerular filtration rate (GFR) \<45 ml/min/1.73m2 * Age: 18 - 80 y * Able to provide written informed consent 2. In order to be eligible to participate in this study, a healthy subject must meet all of the following criteria: * (e)GFR \>60 ml/min/1.73m2 without albuminuria * Age: 18 - 80 y * Able to provide written informed consent 1\. A potential subject with CKD who meets any of the following criteria will be excluded from participation in this study: * Insulin-dependent diabetes mellitus or two or more oral glucose lowering medications * Active inflammatory disease / malignancies * Uncontrolled hypertension (\>160/100mm Hg), unstable angina pectoris, or arrhythmia * Pulmonary disease restricting exercise performance (e.g. COPD) * A history of neuromuscular problems * Cognitive Impairment * Diagnosed GI tract diseases / dysphagia * Allergies to milk proteins / Lactose intolerance * Pregnancy * Hospitalization \<1 months prior to study period * Participation in any structured exercise program * Any medications known to affect protein metabolism (i.e. corticosteroids or prescription strength acne medications). * Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants. * Dialysis treatment or previous kidney transplantation 2\. A potential healthy subject who meets any of the following criteria will be excluded from participation in this study: * Insulin-dependent diabetes mellitus or two or more oral glucose lowering medications * Active inflammatory disease / malignancies * Uncontrolled hypertension (\>160/100mm Hg), unstable angina pectoris, or arrhythmia * Pulmonary disease restricting exercise performance (e.g. COPD) * A history of neuromuscular problems * Cognitive Impairment * Diagnosed GI tract diseases / dysphagia * Allergies to milk proteins / Lactose intolerance * Pregnancy * Hospitalization \<1 months prior to study period * Participation in any structured exercise program * Any medications known to affect protein metabolism (i.e. corticosteroids or prescription strength acne medications). * Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants.