Diabetes mellitus

Researchers are testing an experimental oral drug called MBX-2982 in adults with type 2 diabetes. The trial compares three daily doses of MBX-2982 against a placebo and sitagliptin, a standard diabetes drug, over four weeks. Participants are treatment-naive or taking a single ora…

This study tests a mobile app that sends personalized reminders to help older adults with diabetes manage their blood sugar, diet, and medications. 184 participants will either use the app or receive standard nurse consultations. The goal is to see if the app can improve diabetes…

Researchers are testing a 12-week low-fat, plant-based diet program delivered in a doctor's office. The program encourages whole grains, vegetables, legumes, and fruits, with no animal products or added oils, and no calorie counting. The study measures changes in weight, blood pr…

This study tests whether a cookie made from Golden Rice and red betel leaf can improve cholesterol and triglyceride levels in adults with type 2 diabetes. Over 28 days, 102 participants will eat the cookies daily, and their blood fat levels will be measured before and after. The …

Researchers test whether a connected pillbox with pre-filled trays and automated text or phone reminders helps people with type 2 diabetes, high blood pressure, or high cholesterol take their medications as prescribed. The study enrolls about 50 adults who have struggled to stay …

This early-stage study tests an experimental drug called MK-1403 in people with type 2 diabetes. The main goals are to check if the drug is safe and tolerable, and to see how it behaves in the body. Researchers will also measure its effect on a marker of inflammation (hsCRP). Abo…

This study tests whether adding empagliflozin or semaglutide to insulin can improve blood sugar control in overweight or obese adults with type 1 diabetes. About 105 participants will take one of the two drugs or a placebo for 3 months. The goal is to see if these drugs help lowe…

This study tested an experimental drug called RZ402 in 94 people with diabetic macular edema, a condition that causes vision loss in people with diabetes. The goal was to see if the drug is safe and can reduce swelling in the retina and improve eyesight compared to a placebo. Par…

This study tests a telehealth program called REAL-T, designed to help young adults with type 1 diabetes fit diabetes care into their daily habits and routines. Participants receive about 12 hours of virtual coaching from an occupational therapist over six months. The study compar…

This study tests a new way to treat diabetic foot ulcers by using ultrasound to deliver tiny particles containing tadalafil (a drug similar to Viagra) directly to the wound. The goal is to see if this approach can help the ulcer heal faster and reduce pain. The trial involves one…

This study compares a new diabetes-specific nutritional formula to an existing one in 103 adults with type 1 diabetes, type 2 diabetes, or prediabetes who are at risk for malnutrition. The goal is to see if the new formula is as good as the current one at improving nutrition, mea…

This early-stage trial is testing whether a single topical application of FGF-1, a protein that helps cells grow, is safe for people with diabetic or venous stasis ulcers. The study enrolls a small group of adults with full-thickness leg ulcers that have lasted at least 8 weeks. …

This early-stage study tests an investigational drug called LY4086940 in healthy people and those with overweight, obesity, or type 2 diabetes. The main goal is to check the drug's safety and how the body processes it. About 216 participants will receive single or multiple doses …

This trial investigates whether a traditional herbal drug, NOSHIN SHAHD, can improve insulin resistance and reduce inflammation and oxidative stress in people with type 2 diabetes. Participants will take the herbal drug or a placebo for about six weeks, and researchers will measu…

This study compares two bowel cleansing solutions, Golytely and SUPREP, for colon cancer screening in people with diabetes. Researchers want to see which one cleans the colon better and is easier to tolerate. About 80 participants will be randomly assigned to one of the two preps…

This study looks at whether involving family members can help people with type 2 diabetes in rural Kentucky eat healthier and exercise more. Researchers will work with 75 participants and their families to create a personalized nutrition and physical activity plan for 6 months. T…

This trial tests whether a smart insulin pen called DIA:CONN P8 can help people with type 1, type 2, or pancreatogenic diabetes better control their blood sugar. Participants use the pen for 12 weeks, and the pen automatically calculates bolus insulin doses based on meal informat…

This trial tests whether a 'food as medicine' program can help people with diabetes better control their blood sugar. Participants receive weekly medically tailored meals, nutrition classes led by dietitians, and vouchers for fresh produce. The study will measure changes in HbA1c…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This trial tests whether using a continuous glucose monitor (CGM) before and after major surgery can reduce complications in adults with diabetes or impaired glucose tolerance. Participants wear the device for at least 6 hours before surgery and up to 7 days after, while a compar…

This study tests the safety of switching from the current drug metreleptin to a new experimental drug called mibavademab in people with generalized lipodystrophy, a rare condition where the body cannot properly store fat. Nine participants who have been stable on metreleptin will…

This trial tests whether adding supervised exercise to standard care can improve wound healing in people with diabetic foot ulcers. Participants are randomly assigned to aerobic exercise, a structured exercise protocol, or standard care alone for 12 weeks. Researchers track ulcer…

This study tests a culturally appropriate education program called Indigenous SIPin to help Native American men reduce their intake of sugary drinks like soda and juice. The program includes classes and text messages, and involves 48 men from Native American athletic communities.…

This study investigates whether continuous glucose monitor (CGM) data can pinpoint the time of day when a person with prediabetes experiences the largest blood sugar spikes after eating. Participants wear a CGM and activity tracker for 10 days to identify their personal 'vulnerab…

This pilot trial tests whether a single infusion of pegloticase, a drug that breaks down uric acid, can improve markers of heart and kidney health in young men aged 18–25 with youth-onset type 2 diabetes. High uric acid is common in this group and linked to later complications. T…

This trial investigates whether drinking fig leaf tea twice a day for 8 weeks, along with a low-glycemic diet, can help protect kidney function in adults with type 2 diabetes and stage 2 chronic kidney disease. Researchers will measure changes in blood sugar, cholesterol, and kid…

This study investigates whether reducing iron levels in the body through blood donation can improve insulin sensitivity and liver function in people with type 2 diabetes and non-alcoholic fatty liver disease. Participants will undergo phlebotomy until their iron stores are deplet…

This study tests whether a structured Diabetes Healthcare Program can help adults with type 2 diabetes improve their blood sugar control and feel more confident managing their condition. Participants attend six biweekly training sessions covering diet, exercise, medication, and s…

This study tests a support program for people with type 2 diabetes and chronic kidney failure who struggle to take their medications regularly. Participants receive an electronic pill bottle that tracks when they open it, plus short motivational interviews with a pharmacist. The …

This study tests whether taking date cider vinegar daily, alone or combined with 5:2 intermittent fasting, can improve cholesterol and other metabolic measures in adults with prediabetes and mild to moderate high cholesterol or blood pressure. Participants are randomly assigned t…

This study tests two approaches to help people with diabetic neuropathy improve their balance. One group uses textured insoles in their shoes, while the other group does a series of quick stretches and compressions called Rood's facilitatory technique. Both groups also receive co…

This phase 3 trial tests whether an experimental injectable drug called HRS9531 can help adults with type 2 diabetes achieve better blood sugar control when diet and exercise alone are not enough. Participants receive either HRS9531 or a placebo for 36 weeks. The main goal is to …

This study investigates whether adding foxtail millet muffins to the diet can help manage blood sugar and improve metabolic health in obese adults with type 2 diabetes. Over 10 weeks, participants eat either a wheat muffin or one or two foxtail millet muffins daily, alongside a l…

This trial investigates a surgical procedure for people with type 2 diabetes and mild obesity (grade 1). The surgery combines three steps: rerouting part of the small intestine, reducing the stomach size, and cutting certain abdominal nerves. The goal is to see if this approach c…

This study tests whether giving the antibiotic vancomycin directly into the bone (intraosseous) during diabetic foot amputation works better than the standard IV method to prevent surgical site infections. It includes 40 adults with diabetes who need a below-knee amputation. Rese…

This study tests whether community health workers (CHWs) who screen patients for social needs like food, housing, or transportation and connect them to resources can improve blood sugar and blood pressure control. About 3,120 adults with uncontrolled diabetes or hypertension from…

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This large phase 3 trial compares two injectable diabetes medications, tirzepatide and dulaglutide, to see which one better prevents major heart problems like heart attacks, strokes, or death from cardiovascular causes. The study includes over 13,000 adults aged 40 and older with…

This study tests whether combining two diabetes drugs—semaglutide and empagliflozin—can reverse liver damage from NASH (a severe form of fatty liver disease) in people with type 2 diabetes. Participants will receive either the combo, empagliflozin alone, or a placebo for 48 weeks…

This study tests whether a simple foot exercise called the soleus pushup can improve cholesterol, blood sugar, and hormone levels in people with thyroid problems, high blood pressure, or diabetes. Participants will perform the exercise, and researchers will measure changes in blo…

This study tests whether intensive dietary counseling from a dietitian can help women with gestational diabetes control blood sugar without needing insulin. 214 women will be randomly assigned to either intensive nutrition support or standard care. The main goal is to see if more…

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This trial investigates whether eating 100 grams of curd cheese daily as part of a personalized diet for 8 weeks can improve cholesterol levels, blood sugar, and body measurements in overweight adults aged 40 to 64. Participants are randomly assigned to either a curd cheese-suppl…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This study tests whether an artificial intelligence system can safely and effectively adjust insulin doses for people with type 2 diabetes while they are in the hospital. About 144 participants will be randomly assigned to have their insulin doses set either by the AI system or b…

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This study tested whether giving extra support to Black adults who don't lose weight early in a diabetes prevention program helps them lose more weight. Over 400 participants joined a 12-week program at churches or community centers. Those not losing weight early got extra phone …

This study tested whether a team of specialists—an endocrinologist, diabetes educator, and dietician—could help people with type 2 diabetes and heart disease control their blood sugar better than standard care. 169 patients were split into two groups: one received usual care from…

This study tested whether transplanting insulin-producing islet cells, along with immune-suppressing drugs, could safely prevent severe low blood sugar episodes in people with type 1 diabetes who don't feel warning signs. Ten participants received the transplant and were monitore…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This study tested a culturally tailored program called Together Overcoming Diabetes (TOD) for American Indian families in Ojibwe communities. Adult caregivers with type 2 diabetes and their youth (ages 10-16) worked with local health coaches to set health goals. The program inclu…

This study tested whether adding a smartphone app with short videos on mental health, diet, exercise, and insulin adjustment to standard care could improve blood sugar control and birth weight in pregnant women with diabetes. Over 600 women participated. The goal was to see if th…

This early-phase study tested whether a single infusion of donor stem cells could help repair damaged blood vessels in 26 adults with type 2 diabetes and symptomatic heart disease. Researchers measured blood vessel function and looked for signs of repair in the lab. The goal was …

This study tested whether a special vacuum dressing (negative pressure wound therapy) helps wounds heal better after major leg amputations. 158 adults who had a leg amputation (not due to injury) took part. The goal was to see if this dressing reduces problems like infection, reo…

This study tested two drugs—hydralazine-ISDN and metformin—in 1100 people with chronic heart failure and reduced heart function. Some participants also had diabetes or insulin resistance. The goal was to see if these drugs could lower the risk of death or hospital stays due to wo…

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study tested two anti-inflammatory drugs (etanercept and alpha-1 antitrypsin) in 43 adults with severe chronic pancreatitis who had their pancreas removed and their insulin-making cells (islets) transplanted into the liver. The goal was to see if these drugs could protect th…

This study tested whether regularly removing blood (like donating blood) can lower iron levels and improve diabetes control and fatty liver disease. 132 adults aged 40-75 with prediabetes or diabetes took part. The treatment group gave blood several times, while the control group…

This study followed 543 adults aged 18-60 who had bariatric surgery at four hospitals in Norway. Each hospital used a different surgical method, allowing researchers to compare how well each approach helped with weight loss and type 2 diabetes remission. The goal was to find whic…

This study tested a next-generation automated insulin delivery system in 48 adults with type 2 diabetes aged 16–70. The goal was to see if the smart algorithm could keep blood sugar in a safer range, reducing both low and high blood sugar events. Participants used a continuous gl…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This completed study tested an oral supplement made from generally recognized as safe (GRAS) ingredients in 8 people with end-stage kidney disease. Two participants had not produced urine for 16 and 22 years. The goal was to see if the supplement could restore even a small amount…

This study tested a device called VasQ that wraps around a surgically created blood vessel connection (fistula) used for dialysis in people with kidney failure. The device is designed to improve blood flow and reduce complications. 144 patients received the device and were follow…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This study looked at whether gastric bypass surgery or the best medical care is more effective for obese people with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, and costs. The go…

This study tested whether applying a probiotic (Lactobacillus reuteri) directly into gum pockets, alongside standard deep cleaning, improves gum health in people with type 2 diabetes. Fourteen adults with moderate to severe gum disease and controlled diabetes took part. Each pers…

This study tested whether a mobile app helps elderly people (70+) with diabetes better control their blood sugar, maintain physical function, and improve quality of life. Sixty participants were split into two groups: one used the app, the other did not. The app was designed to b…

This study tested a personalized approach using custom-made shoes and inserts to prevent foot ulcers from returning in people with diabetes. 126 adults with a history of foot ulcers were followed for 12 months. The goal was to see if this tailored approach could reduce ulcer recu…

This study looked at whether giving underserved patients with type 2 diabetes a continuous glucose monitor (CGM) plus monthly telehealth visits with a pharmacist helps them manage their blood sugar better. 46 adults with uncontrolled diabetes took part. Researchers compared those…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested whether GLP-1 receptor agonists, a type of diabetes drug, can improve heart function and reduce fat around the heart in 44 obese adults with type 2 diabetes. Participants received the drug BYETTA along with metformin. Researchers used MRI scans to measure heart …

This study looked at whether giving diabetes patients who are at risk for food insecurity money to buy fruits and vegetables, along with nutrition education, can improve their blood sugar control and reduce emergency room visits. Over 2,000 adults participated, with one group rec…

This study tested a visual injection site map to help people with diabetes rotate where they inject insulin. The goal was to reduce lipohypertrophy—lumpy fatty tissue caused by repeated shots in the same spot—and improve blood sugar control. 170 adults on insulin for at least six…

This study tested whether taking phytosterols (plant-based supplements) for 3 months can improve liver health, cholesterol, and insulin levels in people with nonalcoholic fatty liver disease (NAFLD). 27 participants took either phytosterol pills or a placebo. Researchers measured…

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This study tested a program to help teens and young adults (ages 16-25) with type 1 diabetes better manage their blood sugar. The program focused on supporting their independence and self-care. 113 participants took part to see if this approach could improve their long-term healt…

This study tested whether custom silicone toe orthoses (inserts) could reduce foot pressure and prevent pre-ulcerative lesions in people with diabetic neuropathy. Sixty participants with diabetes and foot deformities wore the orthoses for six months. The goal was to see if these …

This study tested whether a continuous glucose monitor (CGM) that alerts nurses to high or low blood sugar can help surgical patients with diabetes keep their glucose levels in a safe range. About 200 adults with diabetes who had surgery wore the Dexcom G7 device for up to 10 day…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested a new insulin (22011) to see if it works as well as an existing insulin (Ryzodeg) for people with type 2 diabetes. About 414 adults in China took part. The goal was to compare blood sugar control and safety. Results suggest the new insulin is a similar option fo…

This study looked at whether keeping blood sugar very low (under 130 mg/dL) is better than standard control (130-180 mg/dL) for non-critically ill patients with diabetes in the hospital. Researchers tracked 600 patients for complications like death, severe low blood sugar, infect…

This study looked at whether testosterone therapy can improve bone health in men who have both type 2 diabetes and low testosterone. About 92 male veterans aged 35 to 70 took part. Researchers measured bone strength using special scans and blood tests over 12 months to see if tes…

This early study tested whether transplanting insulin-making islet cells could help people with type 1 diabetes who already had a kidney transplant. Only 3 patients took part, and they stayed on anti-rejection drugs. The goal was to see if the procedure was safe and could reduce …

This study looked at 781 adults with moderate-to-severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Researchers wanted to see if adding a lifestyle intervention (diet and exercise) to the drug Secukinumab (Cosentyx) impr…

This study tested a virtual health program for African immigrants aged 25-75 who had at least two risk factors like diabetes, high blood pressure, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over 6 months. The program was deliv…

This study tested whether adding the antibiotic rifampin to standard treatment helps prevent amputations in diabetic patients with foot bone infections. Over 800 veterans participated, receiving either rifampin or a placebo for six weeks. The goal was to see if rifampin improves …

This completed trial tested whether providing free, healthy food boxes every two weeks for six months could improve blood sugar control and health behaviors in adults with type 2 diabetes living in a low-income community. 405 participants were randomly assigned to receive the foo…

This study tested whether a six-week empowerment-based health education program could improve self-management in 50 adults with type 2 diabetes. Participants learned about diabetes, diet, and physical activity through group activities and discussions. The goal was to see if this …

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…

This study tested whether a peer-led education program could help 100 diabetes patients in Ethiopia improve their blood sugar control and reduce costs. Participants received structured diabetes education from trained peers over several sessions. The main goal was to see if this a…

This study looked at whether high-intensity interval training (HIIT) can improve blood sugar control and insulin sensitivity in women with type 2 diabetes, comparing effects before and after menopause. Sixty women aged 40-65 completed an 8-week supervised HIIT program. Researcher…

This completed study tested whether a high-intensity medical weight loss program, supported by a digital platform and continuous glucose monitors, could help people with type 2 diabetes lose weight and achieve remission. 64 participants were enrolled and compared to a group recei…

This early study tested a new approach called Stem Cell Educator therapy in 13 adults with type 1 diabetes. The treatment involves taking a patient's own blood cells, processing them with stem cells, and returning them to the body. The main goal was to see if it is safe and feasi…

This study tested a special educational tool for parents of children under 6 with type 1 diabetes. The goal was to see if the tool could help parents better control their child's blood sugar and prevent serious events like low blood sugar or ketosis. The study enrolled 24 childre…

This study tested a fiber-enriched, low-sodium liquid formula as the sole nutrition for 32 tube-fed nursing home residents with diabetes. Over three months, researchers measured changes in blood sugar, blood pressure, and nutritional status. The goal was to see if this special fo…

This study tested a telenursing program that gave health education and lifestyle advice to 70 adults with type 2 diabetes in Bangladesh. Participants used their smartphones to get support from nurses on diet, exercise, and medication. The goal was to see if this approach could im…

This study tested a new oral drug called LY3549492 in 92 Japanese volunteers, some with type 2 diabetes and some healthy. The main goal was to check safety and how the body processes the drug. Participants took multiple doses over several weeks, and researchers monitored side eff…

This study tested a virtual culinary medicine program for 89 adults with type 2 diabetes and elevated body mass index. Participants attended five online cooking and nutrition sessions, learning basic skills and healthy eating habits. Researchers measured changes in blood sugar (H…

This study tested whether joining a peer support group helps people with diabetes better follow their medication plan, take care of themselves, and understand their condition. 120 adults with diabetes were split into two groups: one that joined a peer support group and one that c…

This pilot study tested whether combining financial navigation (help with costs) and peer support (connecting with others) can help adults with diabetes better manage their condition. 61 participants were randomly assigned to receive either financial navigation alone or financial…

This study looked at whether a special dietary supplement could help heal foot ulcers in people with diabetes and prevent the need for amputation. 35 adults with diabetes and foot ulcers were observed for 6 weeks while using the supplement at home. The main goals were to see how …

This study tested a culturally adapted diabetes self-management program for Filipino-Americans with type 2 diabetes. The program combined group classes taught in Tagalog with text message support. Researchers measured changes in diabetes knowledge, self-confidence, and blood suga…

This study tested whether levodopa, a drug used for Parkinson's disease, can help people with diabetes who have early signs of eye damage (diabetic retinopathy). The goal was to find the best dose and understand how it works to improve the retina's electrical signals. 230 adults …

This study looked at 100 liver transplant patients with diabetes to see if dapagliflozin or sitagliptin is better at reducing liver fat and improving body composition. Participants took one of the two drugs for 12 months. The goal was to find a safer and more effective way to man…

This study tested a web-based app called Mobile Diabetes Detective (MoDD) in 248 adults with type 2 diabetes. The app helps users identify problems with blood sugar control and suggests better behaviors. Researchers measured changes in blood sugar (HbA1c), problem-solving skills,…

This completed study tested whether painting metal roofs with a special heat-reflecting coating can lower indoor temperatures and improve health in Niue, a Pacific island nation facing record heat. Researchers enrolled 288 adults living in single-story homes with metal roofs. The…

This study tested whether using a computer model to adjust doses of two common drugs (sitagliptin for diabetes and duloxetine for nerve pain) works better in people with liver cirrhosis. 64 patients with cirrhosis, diabetes, and nerve pain were grouped by liver severity and given…

This study tested whether providing six months of diabetes-tailored meals and nutrition counseling can improve blood sugar control and reduce food insecurity in adults with type 2 diabetes. 281 participants received either the food support plus counseling or usual care. The main …

This study tested a lifestyle intervention designed for overweight or obese Hispanic women during pregnancy. The program included diet and physical activity guidance to control weight gain and improve metabolic health. 232 women participated, and researchers measured weight chang…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This study tested whether a once-weekly injection of exenatide (a diabetes drug) can protect the heart and kidneys in 57 adults with type 2 diabetes and mild kidney problems. Participants received either exenatide or a placebo for 38 weeks. Researchers measured blood and urine ma…

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This study tested a new insulin patch pump in 161 adults with type 1 or type 2 diabetes who needed intensive insulin therapy. Participants used either the new patch pump or a standard pump for 7 days in a hospital. Researchers measured changes in average blood sugar levels to see…

This completed study tested an AI-based system called X-Life that gives personalized lifestyle advice to adults with type 2 diabetes. The system uses glucose levels and wearable data to guide diet and activity. 124 participants were split into two groups: one using X-Life and the…

This study tested a program that helps pregnant women with gestational diabetes manage their condition with support from family members. 435 women in Vietnam took part. The goal was to see if this approach could improve health for both mothers and babies.

This pilot study tested whether using smart insulin pens together with continuous glucose monitors (CGMs) can improve blood sugar control in adults with type 2 diabetes. Thirty participants used these devices to track their glucose levels and insulin doses. The goal was to see if…

This study looked at how well the Xience Sierra drug-coated stent works in a broad group of heart disease patients, including those with diabetes or prediabetes. Over 1,700 participants received the stent during a routine procedure to open blocked arteries. Researchers tracked he…

This study looked at how well the drug Livalozet lowers bad cholesterol (LDL-C) in people with high cholesterol, comparing those with and without diabetes. Over 1,500 adults took part for 24 weeks. The main goal was to measure the change in LDL-C levels from the start of the stud…

This study tested whether a virtual weight control program combined with a continuous glucose monitor could help adults with type 2 diabetes lower their blood sugar levels. 152 overweight or obese adults with type 2 diabetes participated. The program used the WW (Weight Watchers)…

This study tested whether adding omega-3 fish oil and low-dose aspirin to standard deep-cleaning treatment helps smokers with severe gum disease. Forty-five smokers were split into three groups: one got omega-3 and aspirin, another got those plus the antibiotic doxycycline, and t…

This study tested a small, wearable sensor that sits just under the skin and measures blood sugar continuously for up to 5 days in adults with diabetes. 247 participants wore the sensor along with a standard monitor and took fingerstick tests to compare accuracy. The goal was to …

This study tested a special wound dressing called Symphony™ against standard care for people with diabetic foot ulcers that won't heal. 143 adults with mild to moderate ulcers took part. The goal was to see if Symphony™ helps more ulcers close completely within 12 weeks and how q…

This study tested a once-weekly injection called dulaglutide (a GLP-1 drug) against daily insulin in 80 children aged 10-18 with transfusion-dependent thalassemia and diabetes. The goal was to see if the weekly shot could control blood sugar just as well or better than insulin ov…

This pilot study tested a staged application of two wound dressings (Endoform and Symphony) on 44 adults with chronic diabetic foot ulcers. The goal was to see if the treatment could fully close the wound within 12 weeks. Researchers measured healing rates, wound size reduction, …

This study looked at whether a common diabetes medication (SGLT-2 inhibitor) can help people with type 2 diabetes lose weight. 360 participants took the pill daily for 3 months, and researchers measured changes in body mass index (BMI). The goal was to see if the drug could help …

This study tested the safety and effectiveness of the Omnipod 5 SmartAdjust 2.0 system, an automated insulin pump, in 48 people aged 2 to 70 with type 1 or type 2 diabetes. The system uses a continuous glucose monitor to automatically adjust insulin delivery. The main goals were …

This study tested a fully automated system that delivers both insulin and glucagon to manage blood sugar in adults with type 1 diabetes. Over 12 months, 243 participants used either the dual-hormone device or their usual care. The goal was to see if the system helps keep blood su…

This study looked at whether getting blood sugar under control for a short time before major abdominal surgery can lower the chance of problems or death. It included 53 adults with uncontrolled diabetes (HbA1c of 7.5% or higher) who were scheduled for surgery lasting over 2 hours…

This 16-week study tested whether a low-fat vegan diet can improve insulin sensitivity and blood sugar control in people with type 2 diabetes. Twenty-six adults with type 2 diabetes and a BMI between 26 and 40 participated. They received weekly nutrition classes and one-on-one di…

This study tested whether adding a community health worker to the diabetes care team helps children with type 1 diabetes. The health worker provided home visits, social support, and help with setting health goals. The study included 84 children and looked at blood sugar control, …

This study tested two ways to help food-insecure adults with heart risks eat more fruits and vegetables. One group got a $20 grocery credit every two weeks, the other got a box of produce delivered to their home. Researchers measured changes in diet and food security over time.

This study tested a program called Family Check-Up Heart, which adds heart-health coaching to regular home visits for new moms and their babies. About 150 mothers who had Medicaid and recently gave birth took part. The goal was to see if the program could help moms manage weight,…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study tested an experimental drug called TA-7284 in 61 adults with type 2 diabetes. Participants took different doses (25 to 400 mg) or a placebo once daily for 15 days. The main goal was to check safety and how the drug moves through the body, with a secondary look at its e…

This pilot study tested a 6-month program combining group classes, personal coaching, and a low-carb diet to help people with early type 2 diabetes lose weight and possibly reverse their condition. It involved 35 overweight adults in low-income Memphis neighborhoods. The goal was…

This study tested whether personalized, automatic coaching messages based on continuous glucose monitor readings and mood assessments could help people with insulin-treated type 2 diabetes improve their blood sugar control. 46 adults participated over 12 weeks. The goal was to se…

This study followed 50 adults with type 2 diabetes who were already prescribed oral semaglutide (Rybelsus) by their doctor. Researchers tracked changes in blood sugar (HbA1c) and body weight over about 8-10 months. Participants also filled out a questionnaire about how they took …

This early study tested a new medicine, NNC0519-0130, in 161 people to see if it is safe and how it works in the body. The medicine aims to lower blood sugar and reduce appetite, which could help people with type 2 diabetes and overweight. Participants received either the medicin…

This study looked at whether alerts from continuous glucose monitors (CGMs) help hospital patients with type 1 or 2 diabetes manage their blood sugar better. Over 500 adults who needed intensive insulin therapy took part. The main goal was to see if alerts increased the time bloo…

This early study tested a device that uses mild electric pulses to regenerate the lining of the upper small intestine in 20 adults with type 2 diabetes. The goal was to see if the procedure is safe and could help lower blood sugar. Participants were on 2-3 diabetes pills and had …

This study tested whether a Fitbit activity tracker combined with virtual health coaching could help people on weight loss medications (GLP-1/GIP) become more active. Fifteen participants wore a Fitbit and had up to six coaching sessions over 12 weeks. The main goal was to see if…

This study compared a new version of the Omnipod insulin pump (SmartAdjust 2.0) to the current Omnipod 5 in 132 people with type 1 or type 2 diabetes, ages 2 to 70. Participants used each system for about a month to see if the new one is safe and helps keep blood sugar in a healt…

This study looked at whether treating gum disease (periodontitis) can improve blood sugar control in people with diabetes. 91 patients were randomly assigned to receive either gum treatment or no treatment (with treatment offered later). The main measure was change in hemoglobin …

This early study tested whether a protein called apelin can improve how the body uses insulin in people with type 2 diabetes. Nine volunteers received both apelin and a placebo infusion to compare effects. The goal was to see if apelin increases the amount of sugar the body can p…

This study tested a 24-week lifestyle program for unemployed adults receiving employment services. The program included online classes and one-on-one coaching on topics like healthy eating, stress management, and exercise. Researchers measured changes in weight, blood pressure, a…

This early-phase study tested whether a new type of immune cell, called a tolerogenic dendritic cell, is safe for people with type 1 diabetes. The cells were made from each patient's own blood and designed to calm the immune system attack on the pancreas. 32 participants received…

This study tested an AI system called X Life that gives personalized diet and exercise tips to people with prediabetes or type 2 diabetes. Twenty participants used the system for 7 days via AR glasses or a smartphone. The goal was to see if people found it easy and helpful, not t…

This study tested whether a weekly injection of semaglutide (2.4 mg) can improve heart failure symptoms and reduce body weight in 617 people with obesity-related heart failure with preserved ejection fraction and type 2 diabetes. Participants received either semaglutide or a plac…

This completed study tested whether a diabetes-specific tube-feeding formula (Nutren Diabetes) can control blood sugar as well as another formula (Fresubin Diabetes) in diabetic patients who have trouble swallowing. 233 adults aged 18-90 took part, receiving tube feeding for up t…

This completed Phase 4 trial tested two different drug combinations in 200 adults with type 2 diabetes to see which helped reduce body weight more. Participants took either empagliflozin plus linagliptin or empagliflozin plus metformin for 12 weeks. Researchers measured changes i…

This study tested whether taking aspirin twice a day (200 mg total) works better than the standard once-daily dose (100 mg) to prevent another heart attack, stroke, or urgent heart procedure in diabetic patients who recently had a heart attack. About 2,500 participants were follo…

This study tested whether babies with a rare, permanent form of diabetes caused by specific gene changes could switch from daily insulin injections to an oral pill called glibenclamide. Nineteen infants took part. The goal was to see if the pill could control their blood sugar an…

This study looked at whether people with diabetes and a high risk of bleeding can safely stop taking two blood thinners (DAPT) just one month after getting a special stent, instead of the usual six months. Doctors used a special camera (OCT) to check if the artery had healed enou…

This study tested a surgery that combines two procedures to help people with obesity and type 2 diabetes lose weight and control their blood sugar. 18 adults aged 19-65 with a BMI between 35 and 50 took part. Researchers measured weight loss and metabolic changes over time.

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested a smartphone app called My Diabetes Care that uses simple graphics to help people with type 2 diabetes understand their health numbers (like blood sugar and cholesterol) and gives tips for self-care. 458 adults from two hospitals used the app or got usual care. …

This study tested a new daily pill, BMF-219, in healthy adults and people with type 2 diabetes. The goal was to see if it is safe and helps lower blood sugar levels over 26 weeks. About 443 participants took either the drug or a placebo to compare results.

This study tested a new way to deliver HIV and chronic disease care by bringing services into community microfinance groups in rural Kenya. About 1,200 adults with HIV took part, with some receiving care in the community and others at usual clinics. The goal was to see if combini…

This study tested whether lifestyle coaching delivered through a patient portal helps adults maintain weight loss. 269 participants who had already lost at least 5% of their body weight were randomly assigned to receive either coaching plus tracking tools or tracking tools alone …

This early-stage trial tested a new drug called CT-388 in 129 overweight or obese adults, including some with type 2 diabetes. The study aimed to check the drug's safety and how the body processes it, while also measuring weight loss and blood sugar changes. Participants received…

This study tested the safety of Lyumjev, a rapid-acting insulin, in 150 adults with type 2 diabetes in India. Participants used Lyumjev along with their usual long-acting insulin for 26 weeks. The main goal was to see how many people had low blood sugar episodes. The study is alr…

This study looked at whether adding vitamin B12 to the diabetes drug dapagliflozin improves blood sugar control in people with type 2 diabetes. Eighty volunteers took either dapagliflozin alone or dapagliflozin plus vitamin B12 for 12 months. Researchers measured HbA1c levels to …

This study tested two antibiotic gels (metronidazole and minocycline) in 380 adults with both diabetes and gum disease. Participants received deep cleaning alone or with one or both gels. Researchers checked gum pocket depth and gum color/texture at 7 and 15 days to see which tre…

This study tested whether colostrum (a supplement from cow's first milk) could improve physical performance and thinking skills in people with type 2 diabetes and healthy adults. About 80 participants took either colostrum or a placebo daily for 60 days. Researchers measured bloo…

This study tested a program to help South Asian adults with uncontrolled diabetes. It combined group health coaching sessions led by community health workers with electronic alerts for doctors. Over 850 participants took part. The goal was to see if this approach could lead to a …

This study tested a medication called tirzepatide in children and teenagers aged 10 to 17 with type 2 diabetes. Participants were already taking metformin or insulin but still had high blood sugar. The goal was to see if tirzepatide could safely lower blood sugar levels better th…

This completed study tested a comprehensive strategy to help manage high blood pressure and diabetes in primary care clinics in Brazil. Over 5,800 adult patients from resource-limited areas took part. The strategy included telehealth tools, education for healthcare workers, and s…

This pilot study tested whether high doses of omega-3 fatty acids (fish oil) and vitamin D are safe and can help preserve insulin production in people with type 1 diabetes. The trial included 27 participants, both children and adults, who had diabetes for up to 10 years. Research…

This study tested whether using Zoom for doctor visits (telecare) works as well as in-person visits for managing diabetes. 780 adults with diabetes in Hong Kong were assigned to either video consultations or usual face-to-face care. Researchers tracked blood sugar (HbA1c) and cho…

This study tested whether adding a mangosteen supplement to standard diabetes drugs (sitagliptin/metformin) improves blood sugar control in 47 adults with type 2 diabetes. Participants took either the standard drugs alone or with mangosteen for 12 weeks. Researchers measured chan…

This pilot study tested two computer algorithms designed to automatically control blood sugar levels in people with type 1 diabetes. Five adults who already use an insulin pump and continuous glucose monitor participated. The goal was to see if the systems could keep blood sugar …

This study tested a new way to help people aged 60 and older with type 2 diabetes manage their condition. Instead of traditional finger-prick blood tests, participants wore a non-invasive sensor on their wrist to track glucose levels. They also received personalized coaching via …

This completed study looked at whether the diabetes drug empagliflozin (Jardiance) can help repair heart damage in diabetic patients who had a major heart attack. 200 participants took either 10 mg or 25 mg of the drug daily for 6 months. Researchers measured changes in heart siz…

This Phase 3 trial tested whether adding a new drug called JW0201 to standard diabetes medications (metformin and another pill) helps lower blood sugar more effectively. The study included 196 adults with type 2 diabetes whose blood sugar was not well controlled on their current …

This study looked at whether a high dose of vitamin D (100,000 IU) is better than a low dose (12,000 IU) for kidney transplant recipients. The goal was to see if it could reduce new cases of diabetes, heart disease, cancer, or death. Over 500 patients took part for two years, but…

This large study tested whether the diabetes pill glyburide works as well as insulin shots for treating gestational diabetes in 914 pregnant women. The goal was to see if glyburide could prevent newborn complications like high birth weight, low blood sugar, and jaundice. If effec…

This completed Phase 2 trial tested whether colchicine, an anti-inflammatory drug, can improve insulin resistance in 152 adults and adolescents with obesity. Participants took either colchicine or a placebo daily for 12 weeks. The study measured changes in insulin resistance and …

Researchers are evaluating four blood glucose meters and four HbA1c point-of-care devices to see how accurately they measure blood sugar and long-term glucose control compared with standard lab methods. The study includes people with diabetes, both adults and teenagers, some of w…

This study tests whether a smartphone-based camera can accurately screen for eye diseases such as diabetic retinopathy, glaucoma, and age-related macular degeneration. About 550 patients will have photos taken with both the smartphone camera and standard equipment. Ophthalmologis…

This study explores whether a non-invasive imaging technique called spatial frequency domain imaging (SFDI) can measure changes in blood flow in the feet of people with diabetes who are undergoing angioplasty to treat peripheral arterial disease. Researchers will use SFDI to meas…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This study tested a new rapid blood test (LumiraDx HbA1c) to see how well it measures blood sugar control in people with diabetes. Researchers compared it to a standard lab method in 177 adults. The goal was to see if the quick test is accurate enough for routine diabetes monitor…

This completed study tested whether a special laser technique called surface-enhanced Raman spectroscopy (SERS) can diagnose diabetes from a blood sample. Researchers analyzed blood from 52 people (healthy and diabetic) to see if the laser could tell them apart. The goal is to de…

This study tested two simple bedside tools—the Neuropathy Disability Score and Neuropathy Symptom Score—to screen for diabetic nerve damage. Researchers compared them to standard nerve tests in 228 adults with diabetes. The goal was to see if these easy-to-use tools could help de…

This study tested a new, noninvasive technique called magnetogastrogram (MGG) to measure the stomach's electrical activity without radiation. Researchers studied 22 people, including those with diabetes, gastroparesis, and other stomach conditions, to see if the test can tell nor…

This study tested whether computer analysis of voice recordings can detect type 2 diabetes. Over 7,000 adults in the UK recorded themselves reading and answering questions online. A subset also provided blood samples to check accuracy. The goal is to see if voice biomarkers could…

This study tested a software called OPTDR01 that automatically checks retinal images for signs of diabetic retinopathy, a leading cause of vision loss. Researchers enrolled 300 adults with diabetes to see if the tool is easy to use and practical in a clinic setting. The goal is t…

This study looked at whether measuring ferritin (a marker of iron stores) in early pregnancy can help predict which women will later develop gestational diabetes. Researchers followed 556 pregnant women, measuring their ferritin and other blood markers early on. The goal was to s…

This study tested a new device called the Cmate blood glucose analyzer, which measures blood sugar without needing a finger prick. Researchers compared its readings to standard blood tests in 40 healthy, pre-diabetic, and diabetic adults. The goal is to see if this non-invasive m…

This completed study tested how accurately the LS-9 blood glucose monitor measures blood sugar in 219 people with diabetes. Participants had their blood sugar measured using the device and a standard lab method. The goal was to see if the LS-9 meets international accuracy standar…

This completed trial tested how accurately the True Vie I3 continuous glucose monitor measures blood sugar levels in 159 adults with type 1 or type 2 diabetes. Participants wore the device while researchers compared its readings to standard lab measurements. The goal was to see i…

This study tested a new continuous ketone monitoring (CKM) system in 16 adults with type 1 diabetes who use insulin pumps. Participants wore the CKM sensor for 14 days and followed special diets with a short insulin stop to see if the device accurately measures ketones compared t…

This study tested several simple bedside tests—like ankle and toe blood pressure measurements and handheld Dopplers—to see how well they detect poor leg circulation (peripheral arterial disease) in 604 people with diabetes. The results were compared to advanced imaging scans (CTA…

This pilot trial tests whether a multi-part program given to emergency department patients with metabolic syndrome can encourage more walking and healthier habits. Participants receive a Fitbit, watch a short educational video, get a written exercise prescription, receive text re…

This study tests whether screening women for type 2 diabetes while they are still in the hospital after giving birth can help catch the disease early and prevent it. About 116 women who had gestational diabetes will be randomly assigned to either early testing or usual care. The …

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This study tests two approaches to prevent obesity and type 2 diabetes in girls aged 7-10 who are at higher risk. One group receives a nutrition education program with newsletters and family events; the other takes part in after-school dance classes five days a week. Both program…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This study looked at whether giving low-dose blood pressure medication to people with high-normal blood pressure and other risk factors could prevent them from developing full-blown hypertension, diabetes, or heart problems. 690 participants aged 50-79 were given either telmisart…

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested a diabetes prevention program adapted for American Indian men living on the Colville reservation. Overweight and obese men without diabetes took part in a culturally informed program aimed at weight loss and reducing diabetes risk. The trial enrolled 113 men and…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested a group prenatal care program called TLC for obese women at high risk for gestational diabetes. Over 300 women joined small groups led by a healthcare provider and learned about nutrition, exercise, and healthy habits. The goal was to see if this approach could …

This study tested whether a structured educational program could help people with diabetes prevent foot ulcers. 42 adults with diabetes attended two specialist-led sessions or received standard care. The education group showed better foot care knowledge and habits, and no one dev…

This completed study tested whether switching from a Western diet to a plant-based diet for 5 weeks could improve insulin sensitivity in 9 adults with prediabetes. Participants received all meals and snacks, and researchers measured changes in insulin sensitivity and muscle inosi…

This study tested a program that gives healthy food incentives and coaching to adults at risk for diabetes. The goal was to help them stick with healthy habits and lower their chances of getting diabetes. 61 participants joined the program, and researchers tracked weight, blood s…

This study tested whether a non-invasive procedure called remote ischemic preconditioning (RIPC) can prevent kidney damage caused by contrast dye in diabetic patients undergoing coronary angiography. The procedure involves using a blood pressure cuff to briefly restrict blood flo…

This study compares two common anesthetics—propofol and sevoflurane—to see which one causes less confusion (delirium) after surgery in older diabetic patients. Researchers will enroll 450 people aged 60 and older undergoing non-cardiac surgery. The goal is to find the best anesth…

Doctors often withhold food from patients being treated for diabetic ketoacidosis in the intensive care unit, but no evidence supports this practice. Researchers are testing whether starting an oral diet early in treatment helps resolve the condition faster and shortens ICU and h…

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This trial tests whether a 14-week mindfulness-based cognitive behavioral program can improve quality of life and blood sugar control in adults with type 1 or type 2 diabetes. Participants will be randomly assigned to either the program or routine diabetes care. The study measure…

This study tests whether a gel made from a patient's own blood platelets can help diabetic individuals heal faster after tooth removal. Twelve adults with diabetes who need two similar-sized tooth extractions will receive the gel in one socket and standard care in the other. Rese…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This trial tests a set of conversation cards, called QBSafe, designed to help people with type 2 diabetes talk with their doctors about what matters most in their daily lives. The goal is to see if these conversations can reduce the burden of living with diabetes and improve well…

This trial tests whether a quick cold spray on the skin before a subcutaneous insulin injection can reduce pain compared to a placebo spray. Adults in the emergency department who need at least two insulin injections receive both sprays in random order, rating their pain after ea…

This study tested a program that sends text reminders and uses social support and game-like features to encourage people with chronic kidney disease, diabetes, and high blood pressure to check their blood pressure regularly. 70 adults from a University of Pennsylvania clinic part…

This study looks at whether people with diabetes experience more pain after a second root canal treatment compared to those without diabetes. About 50 adults with a single-rooted tooth needing retreatment will take part. Pain levels and painkiller use will be tracked for a week a…

This pilot study tested a word game-based workbook to help people with diabetes learn about managing their condition, focusing on diet and carbohydrate control. 25 participants used the workbook during clinic visits or at home, completing puzzles and goal-setting exercises. The s…

This study tested custom-made insoles for people with diabetic foot to see if they improve balance and walking. Twenty-five participants aged 40 to 65 with early-stage diabetic foot issues were included. The insoles were designed using pressure measurements to offload high-pressu…

This study tests whether inhaling medical cannabis three times a day can safely reduce pain in people with diabetic peripheral neuropathy. 122 adults will receive either a low, medium, or high dose of THC or a placebo using a special inhaler. The main goal is to see if pain score…

This study tested whether a 12-week Pilates program could improve erectile function in 60 men aged 40-60 with type 2 diabetes and erectile dysfunction. Participants did Pilates three times a week for 60 minutes each session. The study measured blood flow in the penis and used a q…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This study tested custom 3D printed insoles for people with diabetes who are at risk of foot ulcers. Thirty participants wore different types of insoles in a lab to see which ones best reduced pressure on the bottom of the feet. The goal was to improve foot health and mobility.

This study tested a program called T1DES designed to help Black young adults aged 18-30 with type 1 diabetes feel less stressed about their condition. Researchers wanted to see if the program was practical and could improve blood sugar levels and emotional well-being. The study i…

This study tested a culturally tailored education and support program called T1DES for Black young adults aged 18-30 with type 1 diabetes. The goal was to see if the program could reduce diabetes distress and improve blood sugar control. Forty-three participants received either s…

This study looked at whether exercising in the morning or evening helps control blood sugar better in pregnant women with gestational diabetes or glucose intolerance. 39 women walked or stepped for 30 minutes either after breakfast or after dinner. The researchers measured blood …

This study tested a new drug called naronapride in 328 adults with moderate to severe gastroparesis (stomach paralysis). Participants took either 10, 20, or 40 mg of the drug or a placebo daily for 12 weeks. The goal was to see if the drug could reduce symptoms like nausea, vomit…

This study tested four different ways of giving dilating eye drops to 84 diabetic patients who needed eye exams for diabetic retinopathy. The goal was to find which method works best to get the pupil large enough for a good exam. Researchers measured pupil size and watched for si…

This study tested a new method called inforatio to help heal diabetic foot ulcers. The technique involves making small cuts in the wound to trigger the body's natural healing response. 100 adults with diabetes and foot ulcers that had not healed for at least 6 weeks took part. Th…

This study tested whether Baduanjin, a traditional Chinese exercise that combines gentle movements with mindful breathing, can help people with type 2 diabetes. 42 adults aged 50-60 with diabetes for 5-10 years took part. Researchers measured changes in blood sugar, quality of li…

This study tested whether the diabetes drug acarbose, adjusted using continuous glucose monitoring (CGM), can reduce pain in adults with painful diabetic neuropathy. 170 participants with type 2 diabetes and high blood sugar swings were enrolled. The goal was to see if controllin…

This study tested whether a 12-session group therapy program for binge eating disorder could also improve blood sugar control in adults with type 2 diabetes. 34 participants received the therapy or were placed on a waitlist. Researchers measured changes in binge eating episodes a…

This study tested a program where community health workers helped young adults (ages 18-35) from underrepresented minority groups with type 1 diabetes start using devices like continuous glucose monitors and insulin pumps. Over 9 months, 119 participants were randomly assigned to…

This study looked at whether supervised exercise training is better than unsupervised exercise for improving balance and quality of life in people with diabetic nerve damage in their feet and legs. 32 adults aged 55-70 with type 2 diabetes for at least 10 years took part. The goa…

This study tested a mobile health program designed to support family caregivers of people with both dementia and diabetes. The program added weekly online support and resources to standard home visits. Researchers measured changes in caregiver burden and social support after 12 w…

This completed study tested whether online mindfulness group sessions could reduce stress, anxiety, and depression in adults with type 2 diabetes. 140 people were split into two groups: one did 30-minute mindfulness exercises online, the other did not. Researchers measured change…

This pilot study tested whether a structured foot-ankle exercise program could help adults with type 2 diabetes manage nerve pain, stress, and quality of life, compared to walking or standard care. Over 12 weeks, 108 participants either did foot-ankle exercises, walked regularly,…

This study tested whether foot-ankle exercises and walking exercises can reduce foot nerve pain, stress, and improve quality of life in people with type 2 diabetes. 375 adults with diabetes were split into three groups: foot-ankle exercises, walking exercises, or standard care. T…

This study tested whether a phone-based cognitive behavioral therapy program could help people with severe or morbid obesity reduce their food addiction. 154 participants received either 12 therapy sessions over 18 weeks or their usual care. The goal was to see if the therapy cou…

This study tested whether gargling with hawthorn vinegar, black mulberry syrup, or green tea could improve oral health and quality of life in 120 adults with diabetes who had mouth sores (mucositis). Participants used one of the three gargles three times a day for 14 days alongsi…

This completed pilot study tested a 12-week home-based exercise program for cancer survivors who also have diabetes or hypertension. The program used a wearable device and smartphone app to track activity and provide feedback, with options like walking, yoga, or strength exercise…

This early-phase trial tested a gene therapy called Engensis (VM202) in 12 people with painful diabetic peripheral neuropathy. Participants received injections into their calf muscles to see if it was safe and could reduce pain. The study focused on safety and pain scores over 12…

This study tested a phone-based coaching program for veterans with type 2 diabetes who feel stressed or overwhelmed by daily self-care tasks like checking blood sugar and taking insulin. The program gave personalized advice and support to help reduce that stress and improve blood…

This study tested a cream containing cannabidiol (CBD) and urea on 23 adults with diabetic foot neuropathy and dry skin. The goal was to see if it could reduce nerve pain and improve skin quality. While the treatment aims to ease symptoms, it does not cure the underlying diabetes…

This study tested whether playing a board game called 'Let's Learn Diabetes' could lower anxiety and help people with type 2 diabetes better follow their insulin treatment. 72 adults aged 40-65 who recently started insulin were randomly assigned to either four weekly game session…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

Researchers at Indonesia University are studying how diet, body measurements, genetic profiles, and blood biomarkers relate to glucose levels in healthy adults. The trial includes 181 participants split into three groups: one follows a balanced diet, one follows a low-carbohydrat…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This completed study looked at risk factors for diabetes and heart disease in 146 healthy African, African-American, and white women who were federal employees or contractors. Researchers compared things like triglyceride levels and insulin resistance to see if the best screening…

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This long-running study follows over 12,000 people from the Gila River Indian Community in Arizona to understand why type 2 diabetes develops and how it leads to complications. Participants receive regular check-ups every two years, including blood tests and physical exams. The g…

This observational study looks at records from Israel's National Insurance Institute to understand how often diabetes is linked to permanent disability. It will compare disability rates and severity across different regions and over time, from 2020 to 2025. No treatments or tests…

This study tests how well the adhesive parts of a future patch pump stick to the skin of children aged 7 to 17 who need insulin for diabetes. The device is a dummy—it has no electronics and just mimics the shape and weight of a real pump. Researchers will see if the patch stays a…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This study is investigating how often dangerous heart rhythm problems occur in people receiving hemodialysis for end-stage kidney disease. Researchers will implant a small device under the skin to continuously monitor heart rhythm for 18 months in 70 patients, half of whom have d…

This study used ultrasound to measure how much fluid remains in the stomach after standard preoperative fasting in 592 adults scheduled for elective surgery. Researchers compared diabetic and non-diabetic patients to see if diabetes affects stomach emptying. The goal is to help t…

This study looks at how false or misleading health information found online affects the way people with chronic illnesses like diabetes and high blood pressure take their medications and make treatment decisions. Researchers will survey 300 adults who use social media at least on…

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use …

This study tests whether nurses using an AI tool can plan care as well as doctors for common problems like high blood pressure, diabetes, fever, and shortness of breath. About 672 adults in rural and semi-urban India will see both a nurse with AI and a doctor, and their visits wi…

This study looks at how type 1 diabetes affects the heart, lungs, and overall fitness of children aged 6 to 17. It also measures their physical activity levels and quality of life. Researchers will compare these results with those of healthy children of the same age. The goal is …

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This study tested a clinical decision support tool that helps doctors identify social needs—like food, housing, or transportation—in African American patients with chronic diseases such as diabetes or heart failure. The tool uses a social risk score to flag patients who may need …

This study tests a two-year educational program for medical and physician assistant students in rural areas. The curriculum includes classroom sessions, simulations, and community rotations to improve teamwork skills. Researchers measure changes in knowledge, attitudes, and team …

This study tests different ways to invite adults with diabetes who struggle to take their medications as prescribed. Researchers will compare letters and phone call strategies to see which approach gets more people to schedule and attend a pharmacist appointment. The goal is to f…

This study tests how well a dummy patch pump (with no electronics or medicine) sticks to the skin of 175 adults with insulin-requiring diabetes. The goal is to see if the adhesive can stay on for 5 to 7 days in different body locations. The results will help design a future comme…

This study investigates whether type 2 diabetes changes the levels of key growth factors and inflammatory markers in Albumin Platelet-Rich Fibrin (Alb-PRF) membranes—a blood-derived material used to support wound healing and dental tissue repair. Researchers will compare Alb-PRF …

This study tested whether training healthcare providers to prescribe continuous glucose monitors (CGMs) increases their use among patients with type 2 diabetes. Researchers trained clinic staff at three community health centers serving a mostly Hispanic/Latino population. They th…

This study looked at how the heart fills and pumps blood when the body is tilted or exposed to lower body pressure. Researchers compared 30 people with type 1 diabetes and healthy volunteers. They used heart monitoring and ultrasound to measure changes, aiming to understand how d…

This observational study investigates whether a substance in the blood called nociceptin is linked to overactive nerves in people who have both type 2 diabetes and metabolic fatty liver disease. Researchers will compare 50 patients with both conditions to 50 healthy volunteers, m…

This completed study looked at how well Danish hospitals followed official guidelines for managing blood sugar in people with diabetes who had major, non-cardiac surgery. Researchers reviewed records from over 13,000 patients treated between 2017 and 2023. They focused on whether…

This study looked at over 30,000 adults admitted to hospitals in Maryland to understand why some patients wait in the emergency room even after being admitted (called boarding). Researchers wanted to find out what patient traits lead to longer waits, how boarding increases health…

This study tests whether pharmacists using a generative AI tool (ChatGPT) can provide more accurate and complete medication counseling compared to standard practice. The trial involves 136 adults with chronic conditions like diabetes, high blood pressure, or asthma who are pickin…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This completed study in India looked at 362 hospital patients to understand how common high blood sugar (hyperglycemia) is and how it affects their hospital stay. Researchers measured blood sugar levels, checked for diabetes, and looked at body composition and certain blood marke…

This study looked at how different ways of taking a blood sample from a finger affect blood sugar readings in people with diabetes. Researchers compared the first and second drops of blood, and also tested with and without squeezing the finger. The goal was to find the most accur…

This study checks if a program called COPE helps Navajo people with diabetes and related health problems. The program uses community health workers to support patients and connect them with doctors. Researchers compared nearly 29,000 people who took part in COPE with those who di…

This early-stage trial tested the safety and how the body processes a new drug called HR011408 in 62 healthy adults. Participants received two different versions of the drug to compare them. The goal was to check for side effects and measure drug levels in the blood, not to treat…

This study looked at how much blood sugar levels go up and down during the day in frail or disabled patients over 75 with diabetes who use basal insulin. Researchers used a continuous glucose monitor for 5 days to compare two types of insulin: human NPH and long-acting analogues.…

This completed study surveyed over 4,600 people living with type 2 diabetes and multiple health conditions, along with their family members, to identify their health literacy strengths and needs. Participants answered a 44-question questionnaire about how well they understand and…

This study looked at whether certain gene changes (in the TCF7L2 gene) make ICU patients with organ failure more likely to develop high blood sugar. Nearly 1,000 adults in the ICU were checked for these gene changes and their blood sugar levels. The goal was to understand the lin…

This study tested a new way to help women with heart risks like high blood pressure or diabetes get better care after giving birth. Researchers interviewed new moms to understand what makes it hard to attend follow-up visits, then designed a coordinated care system. They tested i…

This study looked at whether taking vitamin C (and vitamin E) supplements for 8 weeks can make red blood cells more flexible in people with type 2 diabetes. Stiff red blood cells can lead to tiny blood vessel damage. Researchers measured red blood cell flexibility before and afte…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This study tested a Turkish version of a questionnaire that helps people with diabetes take better care of their feet to prevent ulcers. Researchers interviewed 202 adults with diabetes to see if the tool was accurate and reliable. The tool covers daily foot care, checking for ea…

This study looked at how different levels of exercise change the bacteria in the gut of people with type 2 diabetes. Forty adults with type 2 diabetes did either moderate or high-intensity endurance and strength training for 16 weeks. Researchers compared changes in blood sugar a…

This study looked at over 4,000 ICU patients to find out how many have undiagnosed diabetes or prediabetes. Researchers used a blood test (HbA1c) to check blood sugar control and tracked whether these conditions led to more organ failure or death. The goal is to better understand…

This completed study looked at whether the Dexcom G7 continuous glucose monitor stays accurate in diabetes patients who have poor blood circulation during hospital stays. Researchers compared CGM readings to standard finger-stick blood tests in 60 adults undergoing surgery or in …

This study tested a new way to help young adults (ages 18-30) with type 1 or type 2 diabetes move from pediatric to adult diabetes care. Researchers compared a collaborative care model to usual care, looking at how many visits patients completed and changes in diabetes-related di…

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This study tested a computer tool that helps doctors classify the type of diabetes in adults diagnosed before age 50. Researchers interviewed 21 patients and staff to see if the tool was useful and acceptable. The goal is to gather initial data for a future, larger trial.

This study tested whether people with diabetes would use a special foot mat at home every day. The mat, called the Podimetrics SmartMat, measures foot temperature to spot early signs of foot ulcers. Twenty people who had a foot ulcer in the past used the mat for six months. The m…

This study looked at 142 people who had a sinus lift procedure using cow bone mineral before getting dental implants. Researchers measured how much bone was left around the implants years later, and checked if the original jawbone height, implant type, smoking, or diabetes played…

This pilot study tested a text-based platform that sends diabetes educational materials and resource referrals to emergency department patients with poorly controlled or new-onset diabetes. Researchers measured changes in diabetes knowledge, distress, and self-care among 50 Engli…

This study followed 99 people who had both an operable pancreatic tumor and diabetes for one year after surgery. Researchers tracked their fatigue, blood sugar control, diabetes self-care, and quality of life to understand how these factors change over time. The goal was to learn…

This completed study surveyed 166 adults with type 1 diabetes to understand what factors influence their choice of hybrid closed-loop (artificial pancreas) systems. Participants included those already using, waiting to start, or considering such technology. The goal was to learn …

This study looked at how two drugs, metformin and HRS-7535, behave in the bodies of 18 healthy men aged 18-50. The goal was to measure drug levels and safety, not to treat any disease. Results will help guide future diabetes research.

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This study looked at the gut bacteria of 200 heart attack patients, comparing those with high blood sugar to those with normal levels. Researchers collected stool samples before treatment and again at 6 and 12 months to see if changes in gut bacteria relate to survival. The goal …

This study looked at 150 people with coronary artery disease who had bypass surgery, comparing those with and without diabetes. Researchers measured the fat around the heart (epicardial fat) and checked how it relates to death and heart problems after surgery. They also tested if…

This study looked at whether taking short, regular walks during long periods of sitting can lower blood sugar and cholesterol after meals—key risk factors for Type 2 diabetes and heart disease. Researchers compared the effects in normal-weight and overweight/obese South Asian adu…

This pilot study tested whether continuous glucose monitors (CGMs) can help manage blood sugar in hospitalized adults with diabetes. Forty patients wore a Dexcom G6 device during their hospital stay to track glucose levels. The goal was to see if CGM could reduce dangerous low or…

This study examined how conditions like diabetes, smoking, heart disease, and osteoporosis affect the health of dental implants. Researchers looked at 93 people with 314 implants that had been in place for at least three years. They found that these systemic factors can influence…

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This study looked at how eating a high fat diet for just 5 days changes the way muscles handle sugar and fat. Researchers fed 11 healthy men a diet with 50-60% fat and measured muscle flexibility and gut health. The goal was to understand why muscles in people with diabetes becom…

This pilot study tested a new program to help prevent low blood sugar (hypoglycemia) in people with diabetes who take medications that can cause it. The program included a patient survey and a toolkit for doctors. The study involved 35 patients and their primary care providers at…

This study looked at whether giving metoclopramide, a drug that speeds up stomach emptying, helps diabetic patients have less stomach fluid before surgery. 60 adults having elective surgery were checked with ultrasound to measure stomach contents. The goal was to see if the drug …

This completed study looked for rare, single-gene causes of insulin-dependent diabetes in 127 participants. Researchers collected blood samples and performed metabolic tests to identify genetic defects. The goal was to better understand these genetic forms of diabetes and possibl…

This study tested several new cookie recipes to see how they affect blood sugar levels in healthy adults. Twelve participants ate different cookies and had their blood sugar measured over two hours. The goal was to find a tasty, low-sugar cookie that could be a friendlier option …

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This study tested whether replacing sitting with standing or walking during daily life could improve blood sugar levels in South Asian adults who are overweight or obese. Eighteen participants followed two regimens: one with more sitting and one with less sitting. The goal was to…

This study examined 200 adults who had surgery to remove plaque from their carotid arteries. Researchers identified bacteria living inside the plaques and tracked whether certain types were linked to later strokes, re-narrowing of the artery, or death. The goal was to learn which…

This study tested five different blood glucose meters in 501 adults with type 1 or type 2 diabetes who use insulin. Participants used multiple devices to see how accurate and reliable each meter is in real-world conditions. The goal was to help people with diabetes and their doct…

This study compared two types of gastric bypass surgery in 40 adults with obesity and type 2 diabetes. Researchers measured changes in gut hormones like GLP-1 to see which surgery better improves insulin resistance and diabetes. The goal was to understand how each surgery affects…

This study explored why some people with latent (inactive) tuberculosis (TB) are more likely to develop active TB. Researchers looked at 626 people in South India to see how malnutrition, diabetes, and worm infections might change the body's response to TB. Participants gave bloo…

This study tested whether a rapid DNA sequencing method (mNGS) could better identify bacteria in diabetic foot ulcers compared to standard lab cultures. 44 adults with diabetes and an infected foot ulcer had tissue samples analyzed using both methods. The goal was to see if this …

This study looked at what happens when active older adults (55+) reduce their physical activity for just 3 days. Researchers measured changes in blood sugar after meals and blood vessel function, comparing them to younger adults. The goal was to see how quickly inactivity can aff…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This completed study tested two strategies to improve diabetes care in older adults: giving doctors regular feedback on their patients' diabetes control, and assigning a diabetes resource nurse to coordinate care. About 1,891 people aged 65 and older with diabetes and Medicare to…

This study looked at how the experimental diabetes drug HRS-7535 behaves in people with mild or moderate liver impairment compared to those with normal liver function. Twenty-four adults completed the trial, which measured drug levels in the blood and checked for side effects. Th…

This study tested a special imaging method (SPECT/CT) to measure blood flow in the leg muscles of people with peripheral arterial disease (PAD) and diabetes. Researchers compared these images to those from healthy volunteers to see how treatment affects muscle blood flow. The goa…

This study measured three substances in the blood (endocan, alarin, and galanin-like peptide) in people with and without diabetic retinopathy, an eye complication of diabetes. Researchers compared these levels across different stages of the disease and looked at how they relate t…

This study looked at over 133,000 adults with newly diagnosed type 2 diabetes who were smokers. Researchers wanted to see if switching from regular cigarettes to e-cigarettes could lower the risk of heart problems and diabetes complications. The study used health records to compa…

This study tested whether taking acetaminophen (like Tylenol) interferes with a new continuous glucose monitor called Biolinq. Thirty-one adults with diabetes wore the Biolinq sensor and a standard CGM for three days. On day three, they took acetaminophen and researchers compared…

This study tested a program called ImPart-Multi, where a trained helper (lay navigator) coached Black patients with chronic kidney disease and their care partners on how to work together when making health decisions. 22 patients and their care partners joined, and patients comple…

This completed study looked at how physical activity, life satisfaction, and medication adherence are related in 82 older Turkish adults (65+) with chronic conditions like high blood pressure or diabetes. Researchers used surveys to measure each factor. The goal was to understand…

This study explored whether malnutrition makes it harder for foot sores to heal in people with diabetes. Researchers followed 75 patients with type 1 or 2 diabetes who had a foot sore for 1 to 24 months. They measured how many sores healed and checked for signs of malnutrition. T…

This study looked at a recently discovered hormone called 26RFa in 62 women who were obese, some with type 2 diabetes and some without. Researchers measured the hormone levels before and after weight-loss surgery (sleeve gastrectomy) and compared them to healthy-weight volunteers…

This study tested whether people with diabetes can use a smartphone game to monitor their vision at home, instead of always going to the clinic. 55 participants at high risk for diabetic retinopathy played vision games on their phones for 6 months. The goal was to see if people w…

This study looked at how often low blood sugar (hypoglycemia) occurs in elderly diabetic patients living in nursing homes. Researchers used a continuous glucose monitor worn on the skin for 14 days to track blood sugar levels. The goal was to better understand the frequency and c…

This study looked at 103 diabetic adults starting chemotherapy for cancer. Researchers used a continuous glucose monitor (Freestyle Libre) to track blood sugar changes. The goal was to see how often blood sugar went too low or too high during treatment, since chemotherapy and rel…

This study looked at whether COVID-19 lockdowns caused delays in treating diabetic foot ulcers, leading to more amputations. Researchers analyzed hospital records from millions of diabetic patients in France between 2017 and 2020. They compared amputation rates during and after l…

This study looked at how insulin use affects breathing and recovery after exercise in people with type 2 diabetes. 70 adults completed breathing tests and a 6-minute walk. The goal was to see if insulin users have different breathing strength or recovery patterns.

This study examined 95 adults with diabetes and gum disease to see if blood sugar control and gum disease severity are linked to changes in gum cells. Researchers looked at cell samples under a microscope for signs of damage. The goal was to better understand how these conditions…

This study followed 87 active adults with type 1 diabetes who use automated insulin pumps and exercise at least twice a week. Researchers tracked their blood sugar levels before, during, and after exercise to see how well the pumps handle physical activity. The goal was to learn …

This study tested a set of strategies to help community health centers routinely identify and act on social needs (like food or housing insecurity) for patients with or at risk for diabetes. Researchers used a tool built into electronic health records to collect this information.…

This study tested whether artificial intelligence (AI) can help doctors better predict how diabetic retinopathy (an eye disease from diabetes) will progress. Over 3,000 adults with diabetes were followed for about 2 years. The goal was to create a smarter system that uses eye ima…

This study looked at whether GLP-1 medications (used for diabetes and weight loss) increase the risk of having food or liquid in the stomach before surgery, even after the recommended fasting period. Researchers used a quick ultrasound to check stomach contents in 94 adults sched…

This study tested how well the GLUCUBE system measures blood sugar in 52 adults with type 2 diabetes. Participants used the device at home and compared its accuracy to a standard finger-stick monitor. The goal was to see if the system becomes more accurate with longer use.

This completed Phase 1 study from Columbia University enrolled 18 overweight or obese adults with insulin resistance and non-alcoholic fatty liver disease (NAFLD). Researchers used a technique called a pancreatic clamp to carefully control insulin levels and measure how blood sug…

This completed study looked at how blood sugar levels affect sleep in 30 adults with cystic fibrosis-related diabetes. Participants wore devices at home to track glucose and sleep for 10 days. The goal was to see if this kind of remote monitoring is practical and to gather early …

This study looked at how different diet compositions affect the number of calories people burn and their risk for chronic diseases like diabetes and heart disease after losing weight. Over 200 adults with overweight or obesity followed a weight-loss phase, then a weight-maintenan…

This study looked at how different shoe fit guidelines affect pressure inside the shoe for people with diabetes and nerve damage. Researchers measured foot pressure while 26 participants walked in standardized shoes with different toe gap sizes. The goal was to see which fit guid…

This study investigated whether people hospitalized with severe COVID-19 are more likely to develop diabetes later on. Researchers followed 23 participants who had no diabetes before their infection, measuring their blood sugar levels over time. The goal was to understand how COV…

This study looked at whether online referrals from doctors to the WIC food program help more pregnant women sign up. About 240 pregnant women on public insurance or uninsured took part. Some got usual care, others got a direct digital referral, and some also spoke with a dietitia…

This study looked at how a class of diabetes drugs called SGLT2 inhibitors changes kidney function in people with chronic kidney disease (CKD). Researchers compared 60 patients with and without diabetes to see if the drug affects their estimated glomerular filtration rate (eGFR) …

This study looked at whether viral infections and diabetes in pregnant women are linked to congenital heart defects in their babies. Researchers analyzed blood and stool samples from 114 women to detect viruses and immune responses. The goal was to gather knowledge for future lar…

This study looked at 186 pregnant women with type 1 or type 2 diabetes to understand how fats in the blood relate to baby birth weight. Researchers measured blood fats, diet, and placenta genes. The goal is to find new ways to prevent babies from being born too large, which can c…

This pilot study tested whether combining health information technology with practice facilitation could help clinics refer more people with diabetes to diabetes self-management education and support (DSMES). The study involved 22 clinics and their staff. Researchers measured ref…

This study tested whether regular meetings between different types of doctors could work well in a hospital to help people with diabetes and other chronic conditions. 55 patients joined, and researchers tracked how often the meetings happened, if doctors followed the recommendati…

This completed study looked at how muscle size and strength change in older adults with type 2 diabetes during bed rest and exercise. Researchers studied 95 participants to find targets for future treatments to prevent muscle loss and disability. The goal is to improve health and…

This study looked at whether the incremental shuttle walk test (a walking test that gets faster over time) is a valid and reliable way to measure exercise capacity in 120 people with type 2 diabetes. Participants did the test twice, one week apart, and also did a standard six-min…

This completed study followed 1,290 adults with type 1 or type 2 diabetes for two years. Researchers tracked mental health issues like depression, anxiety, and eating problems alongside daily blood sugar levels using smartphone surveys and continuous glucose monitors. The goal wa…

This study looked at 514 people with stable coronary artery disease to see if how their body processes fat after a meal (triglyceride tolerance) is linked to future heart attacks or death. Researchers also checked blood sugar tolerance. The goal was to find a better way to identi…

This completed study looked at 542 adults to see if having more leg fat is linked to a lower risk of type 2 diabetes, and whether belly fat plays a role in that link. Researchers used body scans and statistical models to explore these connections separately for men and women. The…

This completed study looked at how diet and exercise change blood sugar levels in 61 adults with diabetes. Researchers used advanced tests (genomics, proteomics, etc.) to understand the body's complex response. The goal is to build a tool that helps doctors personalize diabetes c…

This pilot study tested whether giving financial rewards for walking and healthy food could help low-income adults with obesity or diabetes. Eight participants were split into two groups: one received incentives, the other did not. The goal was to see if this approach could reduc…

This completed study looked at how long nerve blocks last in people with kidney failure or diabetes compared to those without these conditions. Researchers gave 120 patients a truncal block during hand or wrist surgery and measured when sensation returned. The goal was to see if …

This completed study looked at 58 adults with diabetes to find out which physical symptoms most affect their balance. Participants did a simple stepping test and answered questions about their daily activity. The goal was to understand the connection, not to test a treatment.

This study looked at 278 diabetic patients to see if the same staph bacteria found in their noses also appear in their foot ulcers. Researchers compared the genetic fingerprints of the bacteria to understand the link. The goal was to learn more about infection risks, not to test …

This completed study looked at medical records from over 740,000 older adults with diabetes to see if those taking semaglutide had a lower risk of developing dementia compared to those on other diabetes drugs (DPP4 inhibitors). The goal was to find out if semaglutide might help p…

This completed trial tested whether an on-screen electronic alert in the doctor's computer system could increase testing for chronic kidney disease (CKD) in people with type 2 diabetes. About 400 patients who hadn't had a key kidney test in the past year took part. The alert remi…

This study looked at how often older adults with diabetes in long-term care facilities experience low blood sugar (hypoglycemia). Researchers used a continuous glucose monitor (CGM) worn for 10 days to track blood sugar levels in 86 participants. The goal was to better understand…

This study looked at how people with below-knee amputations sense hot and cold on their skin and how their blood vessels react to temperature changes. Researchers tested 56 participants, including those with and without diabetes, to find the temperature thresholds where warmth or…

This study looked at health records from over 386,000 adults with type 2 diabetes and moderate heart disease risk. Researchers compared four common second-line diabetes drugs to see which ones were linked to fewer heart attacks, strokes, and other complications. They also asked p…

This study used national health survey data to estimate how many US adults with high cholesterol might be eligible for a new drug called inclisiran. Researchers also calculated how many heart attacks and strokes could be prevented over 10 years if these patients took the drug. Th…

This early study tests whether the antidepressant fluoxetine (Prozac) can improve the body's nervous system response during exercise in people with type 1 diabetes. Many with diabetes avoid exercise due to fear of low blood sugar. The study includes 64 adults—half with type 1 dia…

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This study looked at whether web-based childbirth education helps pregnant women bond with their baby and feel less fear about giving birth. 120 pregnant women in Turkey took part. The researchers measured attachment and fear levels using questionnaires. The goal was to see if on…

This study looked at 605 patients with esophageal cancer who had minimally invasive surgery to remove their esophagus. Researchers compared those with and without type 2 diabetes to see if diabetes affected short-term complications and long-term survival. The goal is to understan…

This completed observational study examined whether semaglutide, a drug used for diabetes and weight loss, improves blood flow in the coronary arteries. Researchers measured coronary flow reserve in 122 diabetic and non-diabetic patients before and after 3 months of treatment. Th…

This pilot study tested a quality improvement process called CUSP to help community mental health staff deliver better care for cardiovascular risk factors like high blood pressure, diabetes, and high cholesterol. The study included 85 staff and patients from psychiatric rehabili…

This study looked at 120 adults with type 2 diabetes and gum disease to see how well their blood sugar was controlled and how it related to the severity of gum problems and cavities. Researchers measured gum health, tooth decay, and HbA1c levels (a measure of blood sugar control)…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…

This completed study looked at gut bacteria in 90 adults with obesity, type 2 diabetes, or neither. Researchers collected samples from the small intestine and colon during routine endoscopies. They compared these to stool samples to see which bacteria are linked to metabolic heal…

This study looked at how pressure on the soles of the feet relates to balance in 32 adults with diabetic foot. Participants stood on special pressure mats and balance boards under different conditions. The goal was to find patterns that could help prevent foot ulcers and falls.

This completed study surveyed 179 adults with diabetes in England to understand how environmental factors like job type, lifestyle, and other health conditions affect the risk, severity, and return of diabetic foot ulcers. Participants filled out a 10-15 minute questionnaire, wit…

This completed study looked at whether the amount of energy people burn through daily activity is linked to body weight and diabetes risk. Researchers measured activity levels in 2500 Black adults from Ghana, South Africa, Seychelles, Jamaica, and the US. They tracked weight chan…

This study looks at 55 adults with diabetes who are either allergic to insulin or not, to better understand and diagnose insulin allergy. Researchers will test a step-by-step diagnostic approach and study the immune system's role. The goal is to make it easier to identify the exa…

This study looked at 362 adults who had a heart attack to understand why they waited before going to the hospital. Researchers collected information on symptoms, travel time, and other barriers. The goal is to find patterns that can help doctors and communities reduce delays and …

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…

This completed study in Cameroon followed 406 adults with and without type 2 diabetes for one year. Researchers tested blood and stool samples at four time points to see if diabetes increases the risk of malaria and other parasitic infections. The goal is to understand how non-co…

This completed study looked at whether people with type 2 diabetes who show signs of premature aging (like shortened telomeres) are more likely to develop heart muscle disease. Researchers used heart scans and blood tests in 150 adults aged 40-55 with diabetes but no heart sympto…