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Friendly bacteria may help fight gum disease in diabetics

NCT ID NCT07652255

Disease control Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into gum pockets after cleaning. The trial measures changes in gum bleeding, pocket depth, and HbA1c over three months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lactobacillus reuteri (probiotic)
What this could lead to
If effective, this probiotic could become a simple, low-cost addition to standard gum disease treatment for people with diabetes, potentially improving both oral health and blood sugar control.
What could go wrong
This is a very small, early-stage trial with only 5 participants, so results may not apply to everyone. The probiotic may offer no extra benefit over standard care, and individual responses can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

5 people

The number who actually took part.

Started

Nov 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥18 years. * Diagnosed with diabetes mellitus according to WHO criteria. * Stage III Grade B periodontitis or higher according to the 2017 AAP/EFP classification. * At least 15 remaining teeth. * Periodontal pockets ≥5 mm with bleeding on probing. * Clinical attachment loss ≥5 mm. Exclusion Criteria: * Current smokers. * Pregnant or lactating women. * Use of antibiotics or anti-inflammatory medications within 1 month before enrollment. * Periodontal therapy within the previous 3 months. * Undergoing orthodontic treatment. * Presence of pulpal lesions or severe occlusal trauma.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus Periodontitis

Contacts and locations

Locations

  • Faculty of Dentistry, University of Medicine and Pharmacy at Ho Chi Minh City

    Ho Chi Minh City, Ho Chi Minh City, 700000, Vietnam

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