Fish oil and aspirin may boost gum treatment for smokers
NCT ID NCT07385300
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding omega-3 fish oil and low-dose aspirin to standard deep-cleaning treatment helps smokers with severe gum disease. Forty-five smokers were split into three groups: one got omega-3 and aspirin, another got those plus the antibiotic doxycycline, and the third got only deep cleaning. The goal was to see if the supplements improve gum pocket depth and attachment levels better than cleaning alone.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Omega-3 fatty acids (fish oil), aspirin, and doxycycline
- What this could lead to
- If it works, this could point toward a better way to treat gum disease in smokers, who often respond poorly to standard treatment.
- What could go wrong
- This is a small, completed trial with only 45 participants, so results may not apply to everyone. The benefits seen may be modest and need confirmation in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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45 people
The number who actually took part.
- Started
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Aug 2023
- Finished
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Aug 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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35 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Smoker patients who smoke ≥ 10 cigarettes per day. * Stages III, Grades C periodontitis with at least one site with PD≥6 and CAL ≥5 mm. Exclusion Criteria: * Scaling and root planning in the previous 6 months(that may confound the effect of treatment) * Antimicrobial therapy in the previous 6 months(that may confound the effect of treatment) * Chronic systemic diseases that may have an impact on periodontitis progression (diabetes mellitus). * Systemic diseases that may contraindicate aspirin or doxycycline taking (kidney and liver diseases) * Allergy to doxycycline * Long-term usage of medications that may impair periodontal health * Allergy to fish/seafood
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Outpatient Clinic of Oral medicine Department, Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Egypt
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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