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Which anesthetic is safer for elderly diabetics? new trial aims to find out

NCT ID NCT06788743

Symptom relief Sponsor: Xijing Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 16, 2026 · Updated 3 times

Summary

This study compares two common anesthetics—propofol and sevoflurane—to see which one causes less confusion (delirium) after surgery in older diabetic patients. Researchers will enroll 450 people aged 60 and older undergoing non-cardiac surgery. The goal is to find the best anesthesia approach to protect brain function in this vulnerable group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
propofol and sevoflurane (anesthetic drugs)
What this could lead to
If propofol works better, it could offer a safer anesthesia choice for elderly diabetic patients, reducing confusion after surgery.
What could go wrong
This is a mid-stage trial with 450 participants, so results may not apply to all patients. The difference between drugs might be small or absent.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

450 people

The number who actually took part.

Started

Jun 2025

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥60 years * Elective surgery (with an expected duration of 2 hours or more) * ASA grade Ⅰ-Ⅲ * Voluntary participation and informed consent obtained * Diabetes mellitus Exclusion Criteria: * Pre-operative BMI≥35 kg/m² (Class II obesity or above) * Severe hepatic dysfunction (Child-Pugh class C) or pre-operative dialysis-dependent renal dysfunction * Known neurological or psychiatric diseases (Parkinson's disease, depression, schizophrenia), or cognitive impairment (dementia) * Severe visual or auditory impairments, language barriers, or patients who cannot cooperate * Long-term use of sedatives, antipsychotic drugs, or long-term alcohol abuse * Neurosurgical patients * Patients with a known allergy to the drugs used in this study or those suspected of having propofol infusion syndrome

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Conditions

The condition(s) this trial relates to.

diabetes mellitus Emergence Delirium

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes Postoperative delirium (POD)

Contacts and locations

Locations

  • The First Affiliated Hospital of Air Force Medical University

    Xi’an, Shanxi, 710032, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.