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Good bacteria vs. gum disease: could probiotics help diabetics?

NCT ID NCT07598656

Disease control Sponsor: Mahsa University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether applying a probiotic (Lactobacillus reuteri) directly into gum pockets, alongside standard deep cleaning, improves gum health in people with type 2 diabetes. Fourteen adults with moderate to severe gum disease and controlled diabetes took part. Each person received both the probiotic and a placebo (distilled water) on different sides of the mouth, and gum measurements were tracked for 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lactobacillus reuteri probiotic
What this could lead to
If it works, this could point toward a simple, natural add-on treatment to improve gum health in people with diabetes.
What could go wrong
This is a very small, early study with only 14 participants. The probiotic may not provide extra benefit over standard care, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

14 people

The number who actually took part.

Started

Jul 2024

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged between 18 and 65 years; * Diagnosed with controlled type 2 diabetes mellitus (HbA1c \< 7%); * Presence of a minimum of 20 natural teeth; * Untreated stage II, III, or IV periodontitis (Tonetti et al., 2018), with radiographic evidence of generalized alveolar bone loss; * At least one periodontal pocket per quadrant with a probing pocket depth of 5 mm and bleeding on probing. Exclusion Criteria: * Participation in another clinical trial; * Pregnancy or lactation; * Smoker; * Individuals with autoimmune diseases; * Individuals with compromized medical conditions requiring prophylactic antibiotic therapy (e.g., patients with valvular prosthesis, patients with history of infective endocarditis, heart transplant recipients, etc.); * Individuals currently receiving ongoing drug therapy (corticosteroid, bisphosphonates, nonsteroidal anti-inflammatory drugs, etc.); * Use of systemic antibiotics within the 3 months prior to the study; * Use of probiotic products within the 3 months prior to the study; * History of subgingival instrumentation within the previous 6 months; * Presence of acute periodontal lesions and/or endo-periodontal lesions (Herrera et al., 2018); * Physical limitations that may interfere proper oral hygiene practices.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus periodontitis type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes Periodontitis

Contacts and locations

Locations

  • Mahsa University

    Hulu Langat, Selangor, 42610, Malaysia

More trials for these conditions

Other studies related to the condition(s) this trial covers.