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Tight blood sugar control in hospital: help or harm?

NCT ID NCT03510078

Disease control Sponsor: Rabin Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether keeping blood sugar very low (under 130 mg/dL) is better than standard control (130-180 mg/dL) for non-critically ill patients with diabetes in the hospital. Researchers tracked 600 patients for complications like death, severe low blood sugar, infections, and heart issues within 30 days. The goal is to find the safest glucose target for hospitalized patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Insulin
What this could lead to
If it works, this could help doctors choose the best blood sugar target for hospitalized patients to reduce complications like infections or heart events.
What could go wrong
This trial is completed but results may not apply to all patients. Intensive control could increase the risk of dangerously low blood sugar.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

600 people

The number who actually took part.

Started

Apr 2018

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 120 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age older than 18 years old. * History of type 2 diabetes mellitus for at least three months or a blood glucose level of 200 mg per deciliter or higher in two different consecutive measurements. * A minimum of three days of hospitalization. Exclusion Criteria: * Diabetic ketoacidosis or hyperosmolar non-ketotic state. * Patients expected to require intensive care unit admission or immediate surgical intervention. * History of current drug or alcohol abuse. * History of current mental illness. * Child-bearing potential or a positive urine pregnancy test.

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Conditions

The condition(s) this trial relates to.

diabetes mellitus type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus Non-critically ill patients

Contacts and locations

Locations

  • Rabin Medical Center

    Petah Tikva, Israel, Israel

  • Rambam Medical Center

    Haifa, Israel

  • Shamir Medical Center

    Ẕerifin, Israel

  • Soroka University Medical Center

    Beersheba, Israel

  • Unit of Geriatric Medicine University of Modena and Reggio Emilia, University Hospital of Baggiovara

    Modena, Italy

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