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Gum cell changes linked to diabetes and periodontitis in new study

NCT ID NCT07375719

Knowledge-focused Sponsor: Çankırı Karatekin University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
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Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study examined 95 adults with diabetes and gum disease to see if blood sugar control and gum disease severity are linked to changes in gum cells. Researchers looked at cell samples under a microscope for signs of damage. The goal was to better understand how these conditions affect cells, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

95 people

The number who actually took part.

Started

Mar 2024

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with DM were stratified based on glycemic control, defined by HbA1c levels, and periodontal disease severity. Accordingly, patients with poor glycemic control (HbA1c ≥7%) were classified as having Stage I-II periodontitis (Group 1, n = 14) or Stage III-IV periodontitis (Group 2, n = 18), whereas patients with good glycemic control (HbA1c \<7%) were categorized as Stage I-II periodontitis (Group 3, n = 14) or Stage III-IV periodontitis (Group 4, n = 17). Systemically healthy individuals without diabetes served as controls and were further stratified according to periodontal disease severity, comprising Stage I-II periodontitis (Group 5, n = 16) and Stage III-IV periodontitis (Group 6, n = 16). This grouping strategy enabled assessment of both the independent and combined effects of periodontal disease severity and glycemic control on nuclear morphological alterations in gingival epithelial cells.

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 40 years * Diagnosis of periodontitis according to the 2018 periodontal classification * Absence of systemic diseases other than diabetes mellitus Exclusion Criteria: * Presence of oral mucosal lesions * History of malignancy * Receipt of periodontal therapy within the previous 6 months * Pregnancy or lactation * Current or former tobacco use * Alcohol consumption * Known anemia * Vitamin B12 deficiency * Folate deficiency * Presence of systemic diseases (other than diabetes mellitus) that could affect periodontal status or cellular morphology

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Conditions

The condition(s) this trial relates to.

diabetes mellitus periodontitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes (DM) Micronuclei count Periodontitis Periodontitis (stage 3)

Contacts and locations

Locations

  • Çankırı Karatekin Üniversitesi

    Çankırı, Turkey (Türkiye)

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