Tiny cuts may speed healing of diabetic foot ulcers

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

INCLUSION CRITERIA * Age ≥ 18 years * Diabetes mellitus * Non-surgical ulcer located distal to the malleoli * Wound diameter \>4 millimeters * Patient-reported wound duration ≥ 6 weeks Only one ulcer will be included from each participant. If a patient has more than one eligible ulcer, the largest ulcer is included. In case of equally sized ulcers, the ulcer with the most recent onset is included. EXCLUSION CRITERIA * Dementia or other reasons that cause inability to give informed consent * Malignant disease * Current treatment with systemic immunosuppressive drugs. Exclusion criteria related to the index extremity: * Diagnosed with or awaiting evaluation of suspected acute phase Charcot arthropathy or osteomyelitis * Non-palpable pulse in both arteria dorsalis pedis and arteria tibialis posterior accompanied by systolic toe pressure \<30 mmHg in the index foot. * Amputation at midfoot level or proximal to midfoot level * Revascularization procedure awaits or has been undertaken within the last 8 weeks or the patient awaits a vascular surgeons' decision on revascularization * Gangrene Exclusion criteria related to the index ulcer * Infection of the ulcer defined according to IWGDF/IDSA (International Working Group on the Diabetic Foot/ Infectious Diseases Society of America system) classification as presence of at least 2 of the following; 1) local swelling or induration; 2) erythema \>0.5 to ≤2 cm around the ulcer; 3) local tenderness or pain; 4) local warmth; or 5) purulent discharge. Current antibiotic treatment due to infection of the index ulcer will also be considered as an ongoing infection regardless of presence of clinical signs of infection. * Positive probe-to-bone test * Exposed joint or tendon * The soft tissue layer covering bone or joint is evaluated to be too thin to allow for inforatio technique anywhere in the wound bed. * Interdigital ulcer location