Muscle tissue disorder

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

This phase 2 trial tested vamorolone, a drug similar to steroids, against a placebo in 46 males with Becker muscular dystrophy. The goal was to check safety and tolerability over 24 weeks, while also looking for early signs of benefit. The study is complete, but results are not y…

This phase 3 trial tests an oral drug called brepocitinib in 241 adults with dermatomyositis, a rare disease causing muscle weakness and skin rash. Participants receive either the drug or a placebo for 52 weeks to see if it improves symptoms. The study is active but no longer rec…

NUTRIREA-3 compares two feeding strategies for adults on ventilators with shock. One group receives low-calorie low-protein feeding for the first week, while the other receives standard-calorie standard-protein feeding. Researchers track survival and time to leave the ICU to see …

Researchers are testing a combination of the experimental antibody MEDI5752 and stereotactic body radiotherapy in people with metastatic soft tissue sarcoma that has spread to the lungs. MEDI5752 targets two immune checkpoints, PD-1 and CTLA-4, and the radiation is aimed at one l…

This study looks at whether the drug eplontersen can reduce abnormal protein buildup in the heart for people with a condition called ATTR-CM. About 150 participants from a larger trial will get heart scans after 140 weeks of treatment. The goal is to see if the drug helps clear t…

This study is a follow-up to an earlier trial, testing the long-term safety and effects of a drug called AOC 1001 in adults with myotonic dystrophy type 1 (DM1), a genetic muscle disease. 37 participants who completed the first study received multiple doses of AOC 1001 by IV infu…

This trial tests two treatments for a jaw joint condition called TMJ disc displacement with reduction, where the disc that cushions the joint slips out of place but returns to normal when the mouth opens. Researchers will compare injecting hyaluronic acid, a natural lubricant, ag…

This early-phase trial tests a new drug called IMM01-STEM, made from stem cell secretions, in 28 people with muscle wasting due to knee osteoarthritis. The main goal is to check safety and find the right dose. Participants receive injections and are monitored for side effects ove…

This phase 2 study tests a combination of two nucleoside drugs, doxecitine and doxribtimine, in 47 people with thymidine kinase 2 (TK2) deficiency, a rare genetic disorder that weakens muscles. Participants already receiving nucleoside therapy continue treatment to see if the dru…

This trial evaluates the long-term safety and effectiveness of mexiletine in children aged 6 to 18 with myotonic disorders, conditions where muscles have trouble relaxing after contraction. Participants, who previously completed a study of mexiletine, receive the drug for about 8…

This trial is testing an experimental drug called eplontersen in people with transthyretin-mediated amyloid cardiomyopathy (ATTR CM), a condition where abnormal protein builds up in the heart and leads to heart failure. The study aims to see if the drug, given as a regular inject…

This Phase 3b study is testing whether the drug benralizumab (Fasenra) can allow people with severe eosinophilic asthma to safely reduce their daily maintenance medications. About 504 participants aged 12-75 in China will try to step down from drugs like inhaled steroids or long-…

This phase 3 trial tests an experimental drug called AOC 1001 in 159 adults with myotonic dystrophy type 1, a genetic condition that causes muscle weakness and stiffness. Participants receive either the drug or a placebo by intravenous infusion. The main goal is to see if the dru…

This trial tests whether injecting platelet-rich fibrin (a substance made from the patient's own blood) into the jaw joint, along with botulinum toxin (Botox) into a nearby muscle, improves symptoms of anterior disc displacement, a common TMJ disorder. The study includes 39 peopl…

This trial tests whether metformin, a drug that improves insulin sensitivity, can help overweight children with neurological or neuromuscular conditions. These children often face mobility challenges that lead to a sedentary lifestyle and weight gain. The study compares six month…

This study is monitoring 110 adults in Korea who are taking Vyndamax (tafamidis) for a rare heart condition called ATTR-CM. The goal is to track side effects and see how well the drug works over 10 years in everyday medical practice. Researchers will check heart function and symp…

This trial tests whether injecting platelet-rich fibrin (PRF), made from a patient's own blood, into the jaw joint can improve symptoms of temporomandibular joint (TMJ) internal derangement. Adults aged 18 to 55 with a displaced jaw disc who have not improved with standard care w…

This study looks at whether dupilumab, an injectable medication, can improve lung function and reduce symptoms in adults with COPD who have a specific type of inflammation. The researchers are reviewing medical records from patients who received dupilumab as part of routine care,…

This study tested an experimental drug called daxdilimab in 12 adults with dermatomyositis or anti-synthetase myositis that wasn't well controlled by standard treatments. The goal was to see if the drug could reduce disease activity and skin symptoms, and help lower steroid use o…

This trial tests an experimental drug called HRS-1893 in people with non-obstructive hypertrophic cardiomyopathy, a condition where the heart muscle thickens and makes it harder for the heart to pump blood. The study will see if the drug is safe and whether it can improve exercis…

This trial asks whether whole-body vibration or gravity-force stimulation can better improve postural stability in children with Duchenne muscular dystrophy (DMD). It will include 60 children aged 6 to 10 who can walk independently. The study compares two exercise-based approache…

This trial tests whether adding structured telemonitoring—weekly text messages and video calls—to standard conservative care helps people with temporomandibular disorder (TMD)-related jaw pain. Participants receive behavioral counseling, habit reversal training, and home exercise…

This trial tests whether kinesio taping, TENS therapy, or home exercises work best for people with cervical myofascial pain syndrome—a condition causing pain and weakness from tight muscle bands in the neck and upper back. About 45 adults aged 18–65 will be randomly assigned to o…

This Phase 3 trial tests whether TAS-205, an oral drug, can improve movement and safety in people with Duchenne muscular dystrophy. It includes 104 participants, both those who can walk and those who cannot. The study compares TAS-205 to a placebo over 52 weeks.

This trial tests three different injection combinations for people with a painful jaw joint condition called TMJ internal derangement. Participants receive one injection of hyaluronic acid mixed with either platelet-rich plasma, tenoxicam, or a corticosteroid. The study measures …

This pilot trial is asking whether injecting magnesium sulfate into the jaw joint after a standard washout procedure (arthrocentesis) can reduce pain and improve jaw function better than the usual treatments. It compares magnesium sulfate against hyaluronic acid (a common injecti…

This phase 2 study tested a drug called belantamab mafodotin in 35 people with AL amyloidosis, a rare disease where abnormal proteins build up in organs. Participants had already tried other treatments without success. The goal was to see if the drug could reduce or eliminate tho…

This trial tests whether epicatechin, a compound naturally found in dark chocolate, can counteract the muscle-related side effects caused by statins, a common cholesterol-lowering medication. Participants with statin intolerance will receive epicatechin or a placebo, and research…

This trial tests whether efgartigimod, an injected drug that blocks certain immune antibodies, can improve muscle strength and function in adults with active idiopathic inflammatory myopathy — a group of rare autoimmune diseases that cause muscle inflammation and weakness. About …

This trial investigates whether a single injection of platelet-rich plasma (PRP), made from a person's own blood, can reduce pain and improve function in chronic patellar tendinopathy (knee tendon pain). The study includes 29 adults aged 18–65 who have had tendon pain for over th…

This study investigates whether high- or low-intensity inspiratory muscle training (IMT) better improves diaphragm function in patients who have been on mechanical ventilation for over 21 days. Using ultrasound, researchers will measure changes in diaphragm movement and thickness…

This study tested a new medicine called AOC 1020 in 90 adults with facioscapulohumeral muscular dystrophy (FSHD), a genetic condition that causes muscle weakness. The goal was to check if the drug is safe and how the body processes it. Participants received either the drug or a p…

This phase 2 trial tests whether the drug abatacept can safely and effectively treat severe heart inflammation (myocarditis) caused by immune checkpoint inhibitors, a type of cancer immunotherapy. The study enrolls adults with any cancer who develop this rare but often fatal hear…

This study tests a new, less invasive procedure called PIMSRA for children with obstructive hypertrophic cardiomyopathy, a condition where the heart muscle is too thick and blocks blood flow. The procedure uses a needle guided by ultrasound to deliver radiofrequency energy to the…

This study compares two surgical approaches for laparoscopic hysterectomy in women with benign or premalignant uterine conditions. One method uses a single incision through the belly button, while the other uses three to four small abdominal cuts. The goal is to see which techniq…

This study tests a new pacing lead (Solia CSP S) placed deep in the heart to treat slow heart rhythms. About 192 people with heart block or sinus node problems will get the lead. The main goals are to check safety (no serious device issues in 3 months) and how often the lead is p…

This trial evaluates the safety and performance of three types of suture anchors (REGENESORB, Knotless REGENESORB, and Knotless PEEK) used to reattach soft tissue to bone in the shoulder or hip. About 300 people needing repair for labral tears, shoulder instability, or rotator cu…

This study tests whether low-load arm exercises combined with inflatable cuffs that briefly restrict blood flow can improve muscle size and small blood vessel health in older adults. Participants aged 50 and older are randomly assigned to exercise with the cuffs, exercise without…

This study tests whether adding platelet-rich plasma (PRP) — a concentrated solution made from a patient's own blood — to standard rotator cuff repair surgery improves healing. About 51 adults with confirmed rotator cuff tears who have not improved with physical therapy will rece…

This study tested whether using a heart MRI to find scar tissue can help decide which people with mild-to-moderate heart failure should get a defibrillator (ICD) to prevent sudden cardiac death. About 449 adults with a weakened heart pump (ejection fraction 36-50%) and scar tissu…

This trial investigates whether tranexamic acid, a drug that reduces bleeding, improves visual clarity during arthroscopic rotator cuff repair. Patients with full-thickness rotator cuff tears receive the drug either through an IV or directly into the joint, and surgeons rate how …

This Phase 2b trial tests an oral drug called zagociguat in 43 adults with MELAS syndrome, a rare genetic disorder that causes fatigue, muscle weakness, and stroke-like episodes. Participants take either 15 mg, 30 mg, or a placebo daily for 12 weeks. The study measures changes in…

This study tested the drug mepolizumab in 16 children aged 6 to 17 with hypereosinophilic syndrome (HES), a rare condition causing too many eosinophils (a type of white blood cell). The goal was to see if mepolizumab could reduce disease flares and lower the need for steroids ove…

This study looked at 100 people with hypertrophic cardiomyopathy, a condition where the heart muscle thickens and blocks blood flow. Researchers compared different surgical techniques—removing part of the thickened heart muscle alone or combined with repairing the mitral valve—to…

This study looked at whether tocilizumab, a drug already used for arthritis, can help people with a rare autoimmune lung condition called anti-synthetase syndrome-associated interstitial lung disease (ASyS-ILD) that hasn't responded to standard treatments. Researchers reviewed me…

This study tested whether atorvastatin, a cholesterol-lowering drug, can protect the heart in breast cancer patients receiving doxorubicin-based chemotherapy. 44 women with newly diagnosed breast cancer took atorvastatin daily for 3 months alongside their chemo. Researchers measu…

This study tested whether giving protein-rich formula in short bursts (intermittent feeding) is better than the standard continuous drip for preventing muscle loss in critically ill patients. 113 ICU adults expected to stay at least 5 days were randomly assigned to one of the two…

This trial tests whether CardiolRx, a pharmaceutical cannabidiol, can improve heart recovery in adults with acute myocarditis (heart muscle inflammation). Participants receive either CardiolRx or a placebo for 12 weeks. The study uses heart MRI scans to measure changes in heart t…

This study tested the safety and effectiveness of eliglustat, an oral medication, in 57 children aged 2 to 17 with Gaucher disease types 1 and 3. Some children also received the standard enzyme therapy imiglucerase. Researchers measured how the drug moves through the body, side e…

This study tested whether dapagliflozin (Farxiga), a drug used for diabetes and heart failure, can prevent heart damage caused by anthracycline chemotherapy. 94 adults with cancer took either dapagliflozin or a placebo daily for four months alongside their chemo. Researchers meas…

This study looked at whether using a blood test (NTproBNP) to guide heart-protecting medications can safely prevent heart damage in people with breast cancer or lymphoma receiving anthracycline chemotherapy. About 108 adults participated, and researchers measured how many joined,…

This study tested whether taking anlotinib pills after initial chemotherapy can help keep advanced soft tissue sarcoma from growing. 49 adults with certain types of sarcoma took anlotinib daily. The goal was to see how long the cancer stayed stable and to check safety. Anlotinib …

This study tested whether adding an immunotherapy drug called APX005M to standard chemotherapy (doxorubicin) could help shrink tumors in people with advanced soft tissue sarcoma. 27 adults with certain sarcoma types took part. The goal was to see if the combination was safe and w…

This study tested a drug called SB-UF, which combines hormones and a plant extract, to see if it can shrink uterine fibroids in pregnant women. 66 women took the drug or a placebo throughout their pregnancy. The goal was to reduce fibroid size and help them disappear, which could…

This study tested a new drug called aficamten against the standard medicine metoprolol in 175 adults with a heart condition that makes the heart muscle thick and blocks blood flow. The goal was to see which drug better improves exercise ability and symptoms like shortness of brea…

This study investigates whether adding a contract-relax physical therapy technique to standard respiratory care can improve diaphragm function in patients who develop diaphragmatic paresis after cardiac surgery. The trial enrolls adults who have undergone heart surgery with a hea…

This pilot study tested a procedure called FETO, where a tiny balloon is placed in the windpipe of an unborn baby with severe congenital diaphragmatic hernia (CDH). The goal was to see if the balloon could be safely placed and removed to help the lungs grow. Four pregnant women p…

This study tested giving chemotherapy before surgery to children with Wilms tumor, a rare kidney cancer. The goal was to shrink tumors so surgeons could remove less kidney tissue, helping preserve kidney function. 249 children took part, and the approach aimed to reduce the need …

This early-stage trial tested a new gene therapy called FLT201 in 10 adults with Gaucher disease type 1. The therapy uses a harmless virus to deliver a working copy of the gene that produces a missing enzyme. The main goal was to check safety and see if the treatment can boost en…

This pilot study tested whether giving critically ill children on breathing machines extra protein along with a personalized exercise program could help preserve muscle mass and improve recovery. The trial enrolled 18 children in the ICU and measured how feasible and safe the app…

This study tested a new type of pacemaker that doesn't use wires (leads) to help both the upper and lower chambers of the heart beat in sync. It involved 464 people with slow heart rhythms who needed a pacemaker. The main goals were to see if the device was safe and worked well a…

This study looked at how safe and effective Vyndaqel is for people with a rare heart condition called transthyretin amyloid cardiomyopathy. Over 1,200 patients in Japan were followed while taking the drug in regular medical practice. The main goal was to track side effects and su…

This study tested two different methods of pacing the left side of the heart in people with severe heart failure. The goal was to see if pacing from inside the heart (endocardial) works better than the usual method from outside (epicardial). Only 6 adults took part, and the main …

This study tested whether a daily combination pill (relugolix, estradiol, and norethindrone acetate) can prevent pregnancy in women aged 18 to 50 who have uterine fibroids or endometriosis. Over 1,100 women took the pill for up to a year, and researchers counted how many became p…

This study tested a new way to help heart failure patients with weak hearts get the right medications. Over 2,400 people with a heart device took part. A nurse used a simple checklist to guide doctors in prescribing better treatments, aiming to reduce hospital visits and improve …

This study tested an oral drug called GLPG3667 (Cadefrecitinib) in 40 adults with dermatomyositis, a rare disease causing muscle weakness and skin rash. Participants took the drug or a placebo daily for 24 weeks to see if it improves symptoms. The trial is complete, and results w…

This study tested whether sacubitril/valsartan (Entresto) works better than enalapril for people with heart failure caused by chronic Chagas disease. Over 900 adults with reduced heart function took part. The goal was to see if the drug could reduce heart-related deaths, hospital…

This study tested whether adding the drug berzosertib to standard chemotherapy (gemcitabine) can help control a rare soft-tissue cancer called leiomyosarcoma. 58 adults with advanced or spreading disease took part. The goal was to see if the combination could stop or shrink tumor…

This study tested the drug spironolactone in 15 adults with chronic right-sided heart failure. The goal was to see if it is safe and can improve heart function and reduce stress on the heart. Participants took either the drug or a placebo to compare effects.

This study tested whether adding a nanofiber scaffold during rotator cuff surgery helps the tendon heal better in people over 55. 91 patients were randomly assigned to get either standard repair or repair with the scaffold. The main goal was to see if the scaffold reduces the cha…

This study tested a wearable defibrillator called the Jewel P-WCD in 322 adults at high risk for sudden cardiac arrest. The device is designed to automatically deliver a shock to restore normal heart rhythm if a dangerous heart rhythm occurs. The main goals were to see how often …

This study tested whether a drug called mepolizumab, given after a severe COPD flare-up that required hospital care, could prevent future hospital stays or death. It involved 238 adults with eosinophilic COPD (a type with high levels of certain white blood cells). Participants re…

This study looked at whether a high-fat diet changes how children with mitochondrial disease burn energy. 36 children aged 5 to 21 were randomly assigned to eat either a normal or high-fat diet for a month, then switched. Researchers measured their resting energy use and body com…

This study tested the drug baricitinib, given with steroids, in 16 children aged 3-18 with newly diagnosed juvenile dermatomyositis, a rare disease causing muscle weakness and skin rashes. The goal was to see if baricitinib works better than the standard treatment (methotrexate p…

This study looked at 222 adults with obstructive hypertrophic cardiomyopathy, a condition where the heart muscle thickens and blocks blood flow. Researchers compared those who took mavacamten (Camzyos) with those on standard therapy, measuring changes in heart function and sympto…

This study looked at how safe and effective a new medical device called the HEALICOIL Knotless Suture Anchor is for repairing torn rotator cuff tendons in the shoulder. A total of 138 people who needed this type of surgery took part. The main goal was to see how many patients nee…

This study followed 152 adults in Greece with severe eosinophilic asthma who were starting benralizumab, a medication that helps control severe asthma. Researchers measured not only standard asthma control but also quality of life, sleep, mood, and physical activity using wearabl…

This Phase 3 trial tested a gene therapy called GS010 in 98 people with Leber hereditary optic neuropathy (LHON), a genetic condition that leads to rapid vision loss. Participants received injections of the therapy or a placebo into both eyes. The study measured changes in vision…

This study compared surgery to physical therapy for people with rotator cuff tears (a common cause of shoulder pain). 187 adults aged 40-84 with MRI-confirmed tears were randomly assigned to either arthroscopic surgery or physical therapy. The goal was to see which treatment bett…

This study tested an oral drug called ifetroban in 46 males aged 7 and older with Duchenne muscular dystrophy (DMD). The goal was to see if the drug is safe and can help prevent or treat heart problems, which are a leading cause of death in DMD. Participants received either ifetr…

This study tested a new drug called AOC 1001 in 39 adults with myotonic dystrophy type 1, a genetic muscle disorder. Participants received either the drug or a placebo by IV infusion. The goal was to check safety and how the drug moves through the body. Results will help decide i…

This study looked at how well benralizumab (Fasenra) works for people with severe eosinophilic asthma in real-world clinics across the Gulf, Latin America, and India. Researchers tracked 291 patients to see if their asthma control improved over time using a standard questionnaire…

This study tested a drug called ataluren in 360 boys with Duchenne muscular dystrophy caused by a specific genetic mistake (nonsense mutation). The main goal was to see if ataluren could help them walk farther over 72 weeks compared to a placebo. All participants were also taking…

This study tested whether eating tuna-based nuggets for three months could improve health in 120 people with heart disease and related conditions like obesity and diabetes. The nuggets were given as a source of selenium. Results showed improvements in some markers of inflammation…

This study tested the long-term safety of a combination therapy (ATB200 and AT2221) in 119 adults with late-onset Pompe disease who had completed a prior study. Participants received the drugs for an extended period, and researchers tracked side effects, walking distance, and lun…

This pilot study tested a combined bone marrow and kidney transplant from a partially matched family donor in 10 people with both a blood disorder and chronic kidney disease. The goal was to treat both conditions at once and possibly reduce the need for lifelong anti-rejection dr…

This study followed 62 people with Leber Hereditary Optic Neuropathy (LHON), a rare inherited eye disease that causes vision loss, for up to 5 years after they received a single gene therapy treatment called GS010. The goal was to see if the treatment remained safe and if any vis…

This phase 3 trial tested a single injection of GS010 gene therapy in 39 people with Leber Hereditary Optic Neuropathy (LHON) who had vision loss for 6 months or less. The treatment aims to improve vision by delivering a working copy of the ND4 gene to the eye. Results measured c…

This study tested a one-time gene therapy injection, GS010, in 37 adults with Leber Hereditary Optic Neuropathy (LHON), a genetic condition that causes rapid vision loss. Participants had vision loss for 6 to 12 months before treatment. The goal was to see if the therapy could im…

This Phase 3 trial tested a daily pill called aficamten in 282 adults with a type of thickened heart muscle that blocks blood flow and causes symptoms like shortness of breath and chest pain. Participants received either aficamten or a placebo for 24 weeks. The main goal was to s…

This study tested a new daily pill called CK-3773274 (aficamten) in 96 adults with symptomatic hypertrophic cardiomyopathy, a condition where the heart muscle is abnormally thick. The goal was to find the right dose and check safety, including effects on heart pumping strength. P…

This study tested whether adding nintedanib (OFEV) to standard immunosuppressant therapy can improve symptoms in people with myositis-associated interstitial lung disease, a condition where lung tissue becomes scarred and stiff. 49 adults in the U.S. participated, receiving eithe…

This study looked at the long-term safety of the drug mavacamten in adults with hypertrophic cardiomyopathy, a condition where the heart muscle thickens. About 314 people who had already finished earlier studies took part. The goal was to track side effects over time, not to cure…

This study compared a newer pacing method, called HIS or left bundle branch (LBB) pacing, to the standard biventricular pacing in 150 heart failure patients with a specific heart electrical problem (left bundle branch block). The goal was to see if the new method could improve he…

This early-stage trial tested a single dose of the drug PGN-EDODM1 in 24 adults with myotonic dystrophy type 1, a genetic muscle disorder. The main goal was to check safety and how the body handles the drug. The study is complete, but results are not yet available.

This early-phase study tested whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (gemcitabine) is safe for people with two rare types of soft tissue sarcoma (leiomyosarcoma and undifferentiated pleomorphic sarcoma). Twenty-five adults with advanced or in…

This study tested a small device that delivers gentle electrical currents to the heart in 70 people with severe heart failure. Participants received either the device plus standard medications or medications alone. The main goal was to see if the device improved the heart's pumpi…

This study tested a new computer simulation, called a 'virtual heart,' to help doctors find the best spots to burn heart tissue (ablation) in patients with ventricular tachycardia (VT) caused by prior heart attacks. Ten adults with VT and scarred heart muscle were enrolled. The a…

This study tested a drug called mavacamten in 38 Japanese adults with a condition where the heart muscle is too thick, making it hard for the heart to pump blood. The goal was to see if the drug could improve heart function and symptoms over 30 weeks. Participants took the drug a…

This study tested a new drug called OMT-28 in 28 people with primary mitochondrial disease, a condition that affects how cells produce energy. Participants took the drug once daily for 6 months, and researchers measured safety, blood markers of inflammation, and symptoms like fat…

This Phase 3 trial tested apitegromab, a drug that blocks a muscle-limiting protein, in 188 nonambulatory children and young adults with later-onset spinal muscular atrophy (SMA types 2 and 3). All participants were already taking standard SMA therapies (nusinersen or risdiplam).…

This study tested a one-time gene therapy called OAV101 (Zolgensma) in 27 children aged 2 to 18 with spinal muscular atrophy (SMA) who had previously stopped taking other SMA medications (Spinraza or Evrysdi). The goal was to see if the treatment is safe and can help maintain or …

This study tested a one-time gene therapy called OAV101 in 126 children aged 2 to 18 with type 2 spinal muscular atrophy (SMA) who had never received other SMA treatments. The therapy was given as a spinal injection and compared to a sham procedure. The goal was to see if it coul…

This study looked at whether dupilumab, a drug that blocks certain immune signals, can reduce signs of autoimmunity in the airways of people with severe asthma. 30 patients were followed for 4 months. The goal was to see if this approach could help those who don't get better with…

This study tested whether adding a small balloon-like spacer (InSpace) during rotator cuff repair surgery helps prevent the tendon from tearing again. Thirty adults with a first-time rotator cuff tear were split into two groups: one got standard repair, the other got repair plus …

This study tested whether using computer-guided surgery is better than the standard approach for fixing a jaw that keeps dislocating. Seven adults with the condition took part. The main goal was to see if the jaw stayed in place after surgery, and the study also measured how wide…

This study tested whether using cardiac MRI to guide ablation (a procedure that destroys small areas of heart tissue) can improve outcomes for people with ventricular tachycardia, a dangerous fast heart rhythm. 104 adults with structural heart disease were randomly assigned to on…

This study tested a combination of two drugs—pembrolizumab (an immunotherapy) and cyclophosphamide (a chemotherapy)—in 129 people with advanced sarcomas that had spread or could not be removed by surgery. The goal was to see if the combination could shrink tumors or stop them fro…

This study tested a combination of two drugs, lenvatinib and eribulin, in 30 people with advanced soft tissue sarcomas (liposarcoma or leiomyosarcoma) that could not be removed by surgery or had spread. The goal was to see if the combo could shrink tumors or slow their growth. Th…

This study looked at 115 Canadian adults with obstructive hypertrophic cardiomyopathy (oHCM) who started taking mavacamten as part of routine care. Researchers reviewed patient charts to see if the drug improved heart function and symptoms. The goal was to understand how mavacamt…

This completed Phase 3 trial tested whether dobutamine, a heart-strengthening drug, can reduce organ failure in 136 ICU patients with septic cardiomyopathy and low blood flow. Patients received either dobutamine or a placebo alongside standard care. The study measured changes in …

This study compared two treatments for symptomatic uterine fibroids—surgery (myomectomy) and a minimally invasive procedure (uterine artery embolization)—to see which one better helps women get pregnant and have a live birth. It included 9 women aged 18 to 43 with fibroids larger…

This study tested a new device (Smart-TO) that places a small balloon in the windpipe of unborn babies with congenital diaphragmatic hernia, a condition where the diaphragm has a hole and the lungs don't grow properly. The balloon is later removed using a special MRI technique. T…

This study tested the long-term safety and effectiveness of a drug called KZR-616 in 18 adults with active polymyositis or dermatomyositis, rare diseases that cause muscle inflammation and weakness. Participants who completed an earlier study received weekly injections of KZR-616…

This study tested two drugs, casimersen and golodirsen, in 228 boys with Duchenne muscular dystrophy who have specific genetic mutations. The goal was to see if these drugs could slow muscle decline, measured by how fast they could climb four steps. Participants received either t…

This Phase 2 trial tested a drug called KZR-616 (zetomipzomib) in 25 adults with active polymyositis or dermatomyositis, two rare diseases that cause muscle inflammation and weakness. Participants received either the drug or a placebo for 16 weeks, then switched to the other trea…

This study tested a procedure called FETO (fetal endotracheal occlusion) in 20 pregnant women whose babies had a severe form of congenital diaphragmatic hernia (CDH). In CDH, a hole in the diaphragm allows abdominal organs to move into the chest, preventing the lungs from growing…

This Phase 3 trial tested a daily injection called elamipretide in 102 adults with primary mitochondrial myopathy, a genetic condition that causes muscle weakness and fatigue. Participants received either the drug or a placebo for 48 weeks. The main goal was to see if the drug co…

This early-phase study tested whether the heart medication carvedilol could safely protect breast cancer patients from heart damage caused by chemotherapy drugs like doxorubicin and trastuzumab. 68 women with early-stage breast cancer were assigned to either receive carvedilol or…

This study tested whether the drug trientine can reduce heart muscle thickening and improve exercise ability in people with hypertrophic cardiomyopathy (HCM), a condition where the heart muscle becomes abnormally thick. 154 adults with HCM took either trientine or a placebo for 1…

This study tested whether MitoQ, a drug that targets cell energy centers, can improve heart function in 53 people with dilated cardiomyopathy. Participants took MitoQ or a placebo for several months while researchers measured heart energy levels and pumping ability using MRI scan…

This study tested a computer program called REDvent that helps doctors set ventilators to match a child's natural breathing effort. The goal was to prevent the diaphragm from weakening while on a breathing machine. Researchers enrolled 248 children with lung disease who needed ve…

This completed Phase 2 trial tested whether enobosarm, an experimental oral drug, can prevent muscle loss in older adults (aged 60+) who are taking GLP-1 receptor agonists like Wegovy for chronic weight management. The study enrolled 168 participants and measured changes in lean …

Nearly 60% of children with cancer become malnourished, which can lead to infections and worse outcomes. This pilot study tested three nutrition approaches—oral supplements, appetite-stimulating drugs, and tube feeding—in 19 children to see which best improved body composition an…

This phase 3 trial tested a new treatment for adults with late-onset Pompe disease, a rare genetic disorder that weakens muscles and breathing. Participants received either the experimental combo (cipaglucosidase alfa plus miglustat) or the current standard therapy (alglucosidase…

This study followed over 1,500 women with moderate to severe uterine fibroids who were taking Esmya (ulipristal acetate) long-term. Researchers tracked side effects, especially those affecting the uterus, and how doctors prescribed the drug in everyday practice. The goal was to b…

This study tested whether using a special bag during laparoscopic fibroid removal (myomectomy or hysterectomy) can prevent the spread of cells that might be cancerous. Forty-eight women were randomly assigned to have the procedure with or without the bag. Researchers then checked…

This study tested whether rapamycin, a drug used in organ transplants, can help people with Inclusion Body Myositis (IBM), a rare muscle disease that causes progressive weakness and has no approved treatment. Forty-four adults with IBM received either rapamycin or a placebo for o…

This study aims to develop new imaging methods to better detect and understand myofascial pain, a common muscle pain condition. Researchers will compare 52 participants—some with myofascial pain and some healthy—using MRI, muscle electrical activity, and fiber-optic imaging. The …

This study is testing a new device that uses near-infrared light to measure pelvic floor muscle fitness in women with myofascial pelvic pain, a condition that affects up to 26% of women. The goal is to create a simple, non-invasive diagnostic tool that could replace the need for …

This study tests whether a special PET/CT scan can measure changes in amyloid deposits in organs of people with systemic amyloidosis. Participants receive an injection of a radiolabeled peptide that binds to amyloid, then undergo imaging at different times. Researchers compare th…

This study investigates whether advanced heart imaging and blood tests can detect early signs of heart damage in adults who received anthracycline chemotherapy as children. Anthracyclines are effective cancer treatments but can increase the risk of cardiomyopathy years later. Cur…

This completed Phase 3 study tested whether a radioactive tracer called [18F]Florbetaben, used in PET scans, can accurately diagnose cardiac AL amyloidosis—a condition where abnormal proteins build up in the heart. 244 adults with suspected cardiac amyloidosis received a single P…

This trial evaluates a new high-sensitivity blood test (Mindray hs-cTnI) for diagnosing heart attacks in people arriving at the emergency room with symptoms like chest pain. Researchers will compare the test's accuracy against an existing approved test, using blood samples taken …

This study explores whether a cardiac MRI can safely and effectively gather the same heart pressure and flow measurements normally obtained through right heart catheterization, a more invasive procedure. Researchers will attempt to perform the catheterization inside the MRI machi…

This study explores whether ultrafast ultrasound can accurately assess diaphragm function in adults with known or suspected diaphragm dysfunction. Researchers will compare ultrasound measurements with standard tests like pressure measurements and electrical signals from the diaph…

This study tested whether a special heart scan (SPECT) can predict how well patients with ischemic cardiomyopathy will recover after heart surgery. 120 patients underwent imaging at rest and during stress to measure heart function and blood flow. The goal was to find patterns tha…

This study tested whether a special PET scan using 68Ga-DOTATOC can detect inflammation in the heart muscle of people with myocarditis. 33 adults with suspected acute myocarditis and normal angiograms received the scan. The goal was to see if this method is as good as or better t…

This study looked at 15 patients with a rare heart condition called wild-type transthyretin amyloid cardiomyopathy (ATTRwt) who also had signs of aortic stenosis. Researchers used dobutamine stress echocardiography—a test that uses a drug to make the heart pump harder while imagi…

This completed pilot study tested whether a computer algorithm could diagnose facioscapulohumeral muscular dystrophy (FSHMD) by analyzing video recordings of people's faces. Researchers recorded 17 participants, including patients with FSHMD, other muscle diseases, and healthy co…

This study tested a new MRI technique that lets patients breathe normally during heart scans, instead of holding their breath. Researchers used special software (GRICS) to remove motion artifacts. They compared the free-breathing images to standard breath-hold images in 30 adults…

This study examined whether the level of neutrophils, a type of white blood cell, in the blood can help predict how severe antisynthetase syndrome (ASyS) will be. ASyS is a rare autoimmune disease that can cause muscle inflammation, lung disease, and other symptoms. Researchers l…

This study compared two contrast agents (Dotarem and Gadovist) used in cardiac MRI to see which provides clearer images of heart muscle damage. 120 adults with coronary artery disease or cardiomyopathy received one of the two dyes during their scan. Researchers rated image qualit…

This study looked at whether whole body MRI can accurately diagnose inflammatory myopathies—a group of muscle diseases causing weakness and damage. Researchers compared MRI results with muscle biopsies in 139 people suspected of having these conditions. If MRI proves reliable, it…

This study screened 646 elderly Black and Hispanic patients with heart failure to find out how many have cardiac amyloidosis, a condition where abnormal proteins build up in the heart. Researchers used a special heart scan and blood tests to detect the disease. The goal was to le…

This study aimed to develop a non-invasive prenatal test using fetal cells from a mother's blood to detect triplet repeat diseases like Huntington's disease, Fragile X syndrome, and certain types of muscular dystrophy and ataxia. Researchers enrolled 60 pregnant women at risk and…

This study tested a device called SUDOSCAN, which measures sweat function in just two minutes, to see if it can detect small fiber nerve damage in people with autoimmune diseases (like lupus or rheumatoid arthritis) or unexplained pain. Researchers enrolled 139 adults and compare…

This study tested whether a new device called EndoFLIP can better diagnose anismus, a condition where the anal muscles don't relax properly during bowel movements, causing severe constipation. Researchers measured anal stretchiness in 61 patients with chronic constipation and com…

This phase 2 trial tested a radioactive tracer called 124I-AT-01 to see how well it can measure amyloid buildup in organs like the heart, kidneys, liver, and spleen using PET/CT scans. 33 adults with systemic amyloidosis received the tracer twice, six weeks apart. The goal was to…

This trial tests whether oxytocin nasal spray can prevent postoperative delirium—a state of confusion that can occur after surgery—in older adults undergoing orthopedic procedures. Participants aged 65 and older will receive the spray before the end of anesthesia and twice daily …

This study tested whether a single infusion of zoledronic acid can prevent bone and muscle loss in adults aged 35 and older who are undergoing bariatric surgery. Fifty-nine participants were randomly assigned to receive either the drug or a placebo. The main goal was to measure c…

This pilot study tested a virtual program designed to help older men at high risk for fractures reduce their risk of falls and broken bones. The program included personalized exercise plans delivered through a smartphone app and virtual nutrition counseling. Researchers enrolled …

This study tested whether nebivolol, a beta-blocker heart drug, could prevent heart failure in 51 boys aged 10-15 with Duchenne muscular dystrophy. Participants had normal heart function at the start and were randomly given either nebivolol or a placebo. The trial found that nebi…

Parents of children with complex medical conditions often feel unsure about managing their child's symptoms at home. This trial tests whether a mobile app with nurse support can help. Ninety-six parents receive either the app, which offers health checks, monitoring, education, an…

This study tests whether adding an injection called Tropho Tend to standard physical therapy helps reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Sixty adults with shoulder pain lasting at least six weeks will be randomly assigned to receive e…

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This study tested whether adding virtual reality exercises to standard physical therapy helps people with partial shoulder tendon tears. 49 adults with shoulder pain did either regular rehab or rehab plus VR. Researchers measured pain, movement, and quality of life to see if VR m…

Researchers at the University of Porto studied 30 adults with myofascial temporomandibular disorder who still had jaw muscle pain after using a stabilization splint for at least five years. All participants kept using their splints and received four weekly 30-minute acupuncture s…

Calcific tendinitis of the rotator cuff causes long-lasting shoulder pain when calcium builds up in the tendon. Standard treatment flushes the deposit with fluid, but the calcium often dissolves slowly. Researchers are testing whether injecting sodium thiosulfate, a chemical that…

Calcific tendinitis of the rotator cuff causes long-lasting shoulder pain when calcium builds up in a tendon. A common treatment is ultrasound-guided needling and lavage to break up and flush out the deposit, often followed by a corticosteroid injection to prevent a pain flare. R…

Researchers compare two treatments for long head of the biceps brachii tendinopathy, a common cause of shoulder pain. One group receives a single ultrasound-guided injection of triamcinolone acetonide and lidocaine around the tendon. The other group receives transcutaneous electr…

Bariatric surgery helps people with severe obesity lose weight, but it also strips away muscle and bone. Many men who have the surgery also have low testosterone, which worsens muscle loss. This trial tests whether testosterone replacement, combined with exercise and diet counsel…

Researchers are testing whether a hybrid cardiac rehabilitation programme can help adults recover after heart surgery. Participants start with two weeks of supervised exercise at the hospital, then continue training at home for six weeks using heart-rate monitors, a cloud care pl…

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This phase 2 trial tests whether pitolisant, a wake-promoting drug, can reduce excessive daytime sleepiness in adults aged 18 to 65 with myotonic dystrophy type 1. Participants receive either pitolisant or a placebo for a period, and researchers measure changes in sleepiness, fat…

This study compares two hands-on treatments—Integrated Neuromuscular Inhibition and Active Release Technique—for people with neck pain caused by trigger points in the upper trapezius muscle. About 64 adults with active trigger points and forward head posture will receive one of t…

This study tests a special fabric shoulder brace designed to mimic muscle support for people with neuromuscular disorders like muscular dystrophy, SMA, and ALS. About 30 participants will wear the brace and perform arm tasks to see if it improves movement, strength, and daily fun…

This study tests whether a 5-minute educational video about uterine fibroids and their treatments can help patients feel less conflicted when deciding on a treatment plan. About 154 women with fibroids will be randomly assigned to watch the video before their appointment or recei…

This trial tests whether brief mindfulness-based audio recordings can ease pain and improve jaw function in university students with painful temporomandibular disorders (TMD), a common cause of chronic jaw pain. Participants listen to the recordings three times a week for three m…

This study tests whether adding shock wave therapy to a standard exercise program can reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Fifty adults aged 30 to 55 with chronic shoulder pain will receive either exercises alone or exercises plus sh…

This study tests whether a special laser (LightForce) can reduce shoulder pain caused by inflammation from conditions like impingement or rotator cuff tendinitis. About 130 adults with pain lasting over 3 months will get either real laser or a sham laser, plus standard physiother…

This trial compares two non-drug treatments for myofascial pelvic pain syndrome in women: precise AI-controlled radiofrequency therapy versus biofeedback combined with electrical stimulation. Researchers will randomly assign 70 women to one of the two treatments and measure chang…

This study compares two non-surgical treatments for rotator cuff syndrome, a common cause of shoulder pain. Researchers will test if video game-based exercises or body awareness therapy better reduce pain and improve movement. 66 adults with partial rotator cuff tears will partic…

This study tests if a biceps tendon cutting procedure (tenotomy) done in the doctor's office with a tiny camera and local anesthesia works as well as the same surgery in an operating room. 14 adults with shoulder pain from biceps or rotator cuff problems will be enrolled. The mai…

This study tests a hands-on technique called Integrated Neuromuscular Inhibition (INIMT) for people with painful muscle knots in the upper neck. 60 adults with trigger points will receive either INIMT plus standard therapy or standard therapy alone for four weeks. Researchers wil…

This trial investigates whether ultrasound-guided nerve blocks, targeting the suprascapular and axillary nerves, can reduce pain after arthroscopic rotator cuff repair. Participants receive either a local anesthetic (ropivacaine) or a saline placebo before surgery, alongside stan…

This trial asks whether adding a mild electrical current to dry needling improves outcomes for people with neck pain caused by muscle knots, known as myofascial trigger points. Adults aged 18 to 60 with neck pain lasting at least three weeks will receive either standard dry needl…

This study looks at whether adding kinesio taping to standard rehab after rotator cuff surgery helps reduce pain and improve shoulder function. Fifty adults aged 18 to 70 who had surgery for a torn rotator cuff are randomly assigned to get either standard rehab alone or standard …

This study tests whether a new high-intensity exercise program is feasible and can improve dynamic balance and physical activity in adolescents with cerebral palsy or spina bifida. Participants will perform a series of exercises twice a week, with researchers measuring walking sp…

This study compares task-oriented occupational therapy to standard rehab for people recovering from rotator cuff surgery. Thirty participants will be randomly assigned to one of two groups, attending 40-minute sessions twice a week for 10 weeks. The goal is to see if focusing on …

This study asks whether the physical and social environment where shoulder treatment happens can influence pain, function, and satisfaction. Adults with rotator cuff-related shoulder pain will follow the same exercise program but in different therapeutic settings. Researchers wil…

This trial tests whether different kinesio taping methods can reduce pain and stiffness in people with myofascial pain syndrome, a condition where sensitive spots in muscles cause pain. Participants will be divided into groups receiving either a muscle-inhibition tape, a special …

This trial tests whether giving trigger point injections—small amounts of numbing medication into tender neck muscles—shortly after anterior cervical surgery can reduce pain and the need for opioid painkillers. Patients undergoing elective anterior neck surgery are randomly assig…

This study looks at how two common treatments for myofascial jaw pain—a mouth splint and lidocaine injections—affect the muscles of the jaw and neck. Researchers use ultrasound to see changes in muscle structure, like how well the muscle fibers reflect sound waves. The goal is to…

This study tests whether a gamified physical therapy software, called Yoomi, can help older hospital patients exercise safely in their beds. The goal is to see if this fun, interactive approach can preserve muscle strength and function during a hospital stay, reducing the need fo…

This study tested two physical therapy techniques—myofascial release and positional release—in 30 young adults with neck pain from a condition called unilateral trapezitis. Both treatments reduced pain, improved neck movement, and eased disability when added to standard exercises…

This study tests whether MRI scans can predict how much people with jaw joint problems improve after a single injection of hyaluronic acid combined with platelet-rich plasma (PRP) made from their own blood. Adults aged 18–45 with TMJ internal derangement who haven't improved with…

This trial tests whether a 12-week ketogenic diet program, delivered entirely online, is practical and acceptable for adults with Long COVID who also have ME/CFS and dysautonomia. Participants follow a low-carb, high-fat diet with vitamin B1 and electrolyte support, plus weekly v…

This trial tests whether a wearable suit called EXOPULSE Mollii, which sends gentle electrical pulses to muscles, can help children with cerebral palsy. The study focuses on kids aged 5 to 12 who have spasticity and some walking ability. Researchers will measure changes in balanc…

This trial tests three ultrasound-guided treatments for myofascial pain syndrome in the upper neck muscle: dry needling, lidocaine injection, and oxygen-ozone injection. About 76 adults with neck pain lasting at least three months will receive one of these treatments weekly for t…

This study tested three ways to treat jaw pain caused by teeth grinding (bruxism): a custom mouthguard (occlusal splint), Botox injections, or both together. Sixty adults completed the 3-month trial. Researchers measured pain and jaw function changes to see which approach worked …

This trial compares Botox injections with ibuprofen pills to see which better eases jaw muscle pain and improves quality of life in people with sleep bruxism (teeth grinding). Forty adults with jaw pain are randomly assigned to receive either Botox injections into the masseter an…

This trial tests whether shining red and infrared LED light on the jaw and neck muscles can reduce pain and improve movement in people with temporomandibular joint (TMJ) disorders. About 32 adults with TMJ pain will receive either real LED therapy or a placebo treatment over six …

This trial investigates whether eccentric isokinetic exercise — a type of controlled, lengthening muscle contraction performed on a special machine — can reduce pain and improve shoulder function in people with rotator cuff tendinopathy. Fifty adults aged 20 to 50 with confirmed …

This study compared two procedures for treating painful calcium buildup in the shoulder: barbotage (a needle-guided washout) and shock wave therapy. Sixty-three adults aged 30–60 with chronic shoulder pain were randomly assigned to one treatment. Researchers tracked pain levels a…

This trial compares two ultrasound-guided nerve blocks—interscalene and supraclavicular—for controlling pain after outpatient arthroscopic rotator cuff repair. About 108 adults undergoing surgery will receive one of the two blocks, and researchers will measure how much opioid pai…

This trial investigates whether a manual therapy called the Jones Technique, a combination of ultrasound and TENS, or both together can reduce neck pain caused by muscle knots in the upper back. The study includes women aged 18 to 40 with active trigger points and neck pain lasti…

This study tests whether injecting dextrose (sugar water) into painful muscle knots, called myofascial trigger points, can reduce pain. Adults with trigger point pain in the upper back and neck are randomly assigned to receive an injection of normal saline, 5% dextrose, or 15% de…

This study compares two common therapies—dry needling and cupping—for people with myofascial pain syndrome, a condition causing persistent muscle knots and pain. Participants receive either dry needling or cupping, and researchers measure changes in pain intensity, number of trig…

This study tested whether an injection of platelet-rich plasma (PRP) made from a patient's own blood can reduce pain and clicking in the jaw joint (TMJ) and improve mouth opening. Thirty adults with a slipped jaw disc were randomly assigned to receive PRP, a steroid with anesthet…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This trial investigates whether jaw exercises (Rocabado programme) work better when guided by a physiotherapist through online video sessions versus doing them at home with written instructions alone. Adults aged 18-60 with jaw-joint pain and teeth grinding are randomly assigned …

This study tests whether virtual reality training can help children aged 6 to 16 with the childhood form of myotonic dystrophy type 1 (DM1) improve their ability to understand others' thoughts and emotions. Participants engage in social scenarios in a virtual environment, guided …

This study tested two different strengths of ozone gas injections into the jaw joint for people with TMJ disorders. Twenty adults who had clicking, popping, or limited mouth opening that didn't improve with other treatments received the injections. Researchers measured pain and j…

This study tested whether injecting botulinum toxin (Botox) into jaw muscles can reduce pain and improve mouth opening in people with temporomandibular joint (TMJ) myofascial pain. 118 adults with at least moderate pain for over a month received injections in their masseter and t…

This study followed 53 adults with non-dystrophic myotonic disorders who were taking Namuscla (mexiletine) to manage muscle stiffness. Researchers monitored side effects and how often patients needed to reduce their dose or stop treatment over up to 36 months. The goal was to see…

This study tests two short behavioral therapies delivered over video calls for adults with chronic orofacial (jaw or face) muscle pain and insomnia. One therapy focuses on sleep habits and routines; the other uses jaw relaxation and breathing exercises. The goal is to see which a…

This study tested two treatments for neck pain caused by forward head posture and trigger points: dry needling (thin needles inserted into tight muscle knots) and phonophoresis (ultrasound with anti-inflammatory gel). Forty adults with chronic neck pain and trigger points were sp…

This study tested whether using a smaller amount of a weaker numbing medicine (ropivacaine) during a shoulder nerve block could reduce the risk of temporary diaphragm paralysis. 60 adults having shoulder surgery took part. The goal was to see if the low-dose approach could still …

This study looked at three different ways to manage pain after abdominal wall repair surgery: an epidural, a nerve block, and local injections. 160 adults who had this surgery were randomly assigned to one of the three methods. The goal was to see which approach provides the best…

This study looked at whether mesotherapy — injecting anti-inflammatory medicine into the skin near the jaw — can help people with chronic jaw muscle pain. Twenty-two adults with myofascial pain syndrome received treatment over 4 weeks. Researchers measured pain levels and how wid…

This study tested whether wearing a virtual reality headset during heart device implantation (like pacemakers) could reduce patients' anxiety and pain. 111 adults were randomly assigned to use VR or standard care. The goal was to see if distraction through VR lowers stress and di…

This completed study tested a laser device (BTL-043) on 31 adults with temporomandibular joint (TMJ) pain. Participants received four 20-minute laser sessions over a few weeks. Researchers measured pain levels, jaw movement, and daily function at 1 and 3 months after treatment to…

This study tested whether a single session of radial shock wave therapy combined with either stretching or isometric contraction could immediately reduce muscle tightness and stiffness in the upper neck. Thirty healthy adults with no recent neck pain participated. Researchers mea…

This study tested if a dual-frequency laser can reduce pain and improve neck movement in people with myofascial trigger points (muscle knots) in the upper neck. 48 adults with chronic neck pain received either a single-wavelength laser or a dual-frequency laser, plus standard exe…

This study tested two ways to manage pain in 70 children undergoing chest surgery. One method, the erector spinae plane block, was compared to the standard epidural block. The goal was to see which provides better pain relief and keeps the heart rate and blood pressure more stabl…

This study compared two non-invasive treatments for neck muscle pain in 50 adults. One group received shockwave therapy, the other low-level laser therapy, both once a week for three weeks. Laser therapy led to greater pain reduction and improved neck movement at the three-week m…

This study tested two different therapies for rotator cuff tendinopathy, a common cause of shoulder pain. Thirty-four patients received either blood flow restriction therapy or gua sha scraping, both combined with exercises, twice a week for six weeks. The goal was to see which a…

This study tested whether adding a manual therapy called Graston technique to standard McKenzie back exercises helps people with chronic lower back myofascial pain. 70 adults were split into two groups: one did McKenzie exercises alone, the other added Graston. Researchers measur…

This study tested two treatments for shoulder pain caused by subacromial impingement syndrome. 94 adults received either high-intensity laser therapy or a combination of physical therapy treatments, plus exercises. Researchers measured pain, function, and quality of life right af…

This phase 2 trial tested a drug called BX1514M in 38 people with hypertrophic cardiomyopathy, a genetic heart condition that can cause shortness of breath, chest pain, and dizziness. The drug aims to improve blood flow by tightening veins, which may reduce blockages in the heart…

This completed study tested whether a nerve block (erector spinae plane block) works better than standard trigger point injections for easing myofascial back pain. 60 adults with myofascial pain syndrome received one of the two procedures. Researchers measured pain levels using a…

This study tested a 3-month treatment with a combination of vitamin D, green tea extract (EGCG), vitamin B6, and D-Chiro-inositol in 108 women with uterine fibroids who were planning surgery. The goal was to see if the supplement could ease symptoms and possibly help some women a…

This study tested two different hands-on treatments for neck pain caused by trigger points (knots in the muscle). 34 adults with at least one trigger point received either a gentle hold-and-release technique or a scraping tool technique. Researchers measured pain, neck disability…

This study looked at whether adding robot-assisted walking training to stationary cycling helps people who recently had a stroke and are losing muscle. 53 participants did either cycling alone or cycling plus robot walking for 4 weeks. The goal was to see if the combination impro…

This study tested a new injection treatment called PIT (using a sugar-water solution) against TENS (a mild electrical stimulation device) for people with shoulder pain. Thirty-two adults with ongoing shoulder pain received either PIT or TENS, plus exercises, over two weeks. The g…

This study looked at 120 women having open surgery for uterine fibroids to see which method best reduces bleeding. Doctors compared using a tourniquet, clamping the uterine artery, or no compression at all. The goal is to find the safest way to control blood loss and improve reco…

This study looked at whether adding aerobic or strength exercises to standard physical therapy can better reduce pain and sensitivity in people with chronic jaw disorders. 51 adults with jaw pain and nociplastic pain (widespread sensitivity) participated. The goal was to see if t…

This study looked at whether taking creatine and coenzyme Q10 supplements, along with exercise, could help children with juvenile myositis (a disease that causes muscle weakness and fatigue). Fifteen children aged 7 to 18 took part. The goal was to see if these supplements could …

This study tested the drug dapagliflozin (a diabetes medicine) in 50 adults with heart failure due to amyloid cardiomyopathy, a rare condition where abnormal proteins stiffen the heart. Researchers measured changes in quality of life, walking distance, and heart stress markers ov…

This study tested whether virtual reality (using Xbox Kinect) or biofeedback training could improve motor function and balance in 24 children with neuromuscular diseases like Duchenne muscular dystrophy and spinal muscular atrophy. Participants were split into three groups: VR tr…

This study looked at 80 people with painful calcium deposits in the shoulder tendon that didn't get better with standard care. All received a needle procedure to remove the deposits, and half also got an injection of their own platelet-rich plasma (PRP). The goal was to see if ad…

This small study looked at 17 adults with bruxism (teeth grinding) who received Botox injections into their jaw muscle. Researchers used ultrasound to measure muscle thickness and texture before treatment, at 14 days, and at 90 days. They also tracked pain levels. The goal was to…

This study tested whether an interactive virtual reality (VR) system could help children aged 5–10 with Duchenne muscular dystrophy (DMD) stick to their physiotherapy exercises at home. Fourteen children used the VR system for 8 weeks, and researchers measured how often and how l…

This study tested a powered leg exoskeleton (Keeogo) in 50 people with various muscle disorders to see if it is safe and helps them walk better. Participants performed walking tests with and without the device. The goal was to see if the device could improve walking distance and …

This study compared two types of minimally invasive hysterectomy: vNOTES (done through the vagina) and conventional laparoscopic hysterectomy (done through small belly cuts). About 90 women having hysterectomy for non-cancer reasons took part. The goal was to see which method cau…

This study tested a wearable robotic suit called MyoSuit that assists knee and hip movement in people with various muscle disorders. 32 participants used the device to perform walking tests, and researchers checked for safety and any immediate improvements in walking ability. The…

This study tested whether a gentle, light-touch therapy (therapeutic touch) could help advanced cancer patients in palliative care sleep better and feel less tired. Sixty-one patients were randomly assigned to receive either 5 days of 10-15 minute touch sessions or standard care.…

This completed Phase 3 trial tested whether two widely available drugs—fluvoxamine (an antidepressant) and metformin (a diabetes drug)—can reduce fatigue and other symptoms in people with long COVID. 399 adults with confirmed prior COVID-19 infection and persistent symptoms took …

This study tested two common treatments for painful knots in the upper back muscles: dry needling (inserting thin needles) and manual trigger point release (applying pressure and stretching). Forty-eight adults with at least four weeks of moderate to severe pain took part. Resear…

This study looked at whether adding a technique called tissue flossing (wrapping an elastic band around the lower leg and doing exercises) to standard heel-drop exercises can reduce pain and improve movement in people with Achilles tendinopathy. Thirty adults aged 20-45 with long…

This study tested two different exercise programs in 28 children and teens with rheumatic diseases like juvenile arthritis and familial Mediterranean fever. One program used external focus (thinking about the movement's effect), the other used internal focus (thinking about the b…

This study tested whether drinking a set amount of water each day (30-35 ml per kg of body weight) for one week could improve how older adults in nursing homes build muscle protein. Seventeen people aged 65 and older took part. The goal was to see if better hydration could help w…

This small pilot study looked at whether acupuncture given twice before surgery could help stabilize blood pressure in women having their uterus removed (total laparoscopic hysterectomy) for fibroids. Thirty-five adult patients received acupuncture before the operation, and resea…

This study tested whether a personalized exercise program, guided by an Apple Watch, can improve fitness and well-being in people with dilated cardiomyopathy, a condition that weakens the heart. 300 adults aged 18-65 with the condition took part over 13 months. The main goal was …

This study tested if dry needling (inserting thin needles into muscle knots) can reduce jaw pain in people with temporomandibular disorder (TMD). 40 adults with jaw pain for at least 3 months were randomly assigned to receive either dry needling or standard physical therapy. The …

This study looked at whether using a cold compression device after arthroscopic rotator cuff repair surgery can help patients use fewer opioid painkillers. Fifty adults having shoulder surgery were randomly assigned to either standard care or standard care plus cold compression t…

This completed study tested whether adding dry needling to standard treatment (medication and physiotherapy) improves pain and function in people with myofascial low back pain. 156 adults with at least 3 months of pain took part. The researchers measured pain intensity, pressure …

This completed study tested whether the MIND diet—a mix of Mediterranean and DASH diets—could improve fatigue, quality of life, and brain fog in 62 adults with multiple sclerosis. Participants followed either the MIND diet or a traditional healthy diet for 3 months, with weekly o…

This study tested whether a nerve block (stellate ganglion block) combined with standard anesthesia could help women with uterine fibroids sleep better and feel less anxious after laparoscopic surgery. 233 women aged 35-55 took part. Results aim to show if this approach reduces s…

This study tested a traditional Chinese medicine patch made from herbs like ginger and Artemisia on 21 dialysis patients who had pain from their fistula. The patch was placed on specific acupoints during dialysis sessions for 4 weeks. Researchers measured pain, depression, and qu…

This study tested a device called the Human Regenerator Jet, which emits cold atmospheric plasma, to see if it can improve quality of life in adults with chronic stress, fatigue, pain, or Long COVID. Forty participants received 10 sessions of either the plasma or plain air, and r…

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study tested whether a technique called intratissue percutaneous electrolysis (IPE) works better than dry needling for a tight foot muscle caused by myofascial pain syndrome. Forty adults with foot pain received three treatments over 12 weeks. Researchers measured pressure o…

This study tested whether combining two physical therapies—extracorporeal shockwave therapy and cryoflow (cold) therapy—can reduce shoulder pain and spasticity in stroke survivors with rotator cuff tendonitis. Thirty participants received either one therapy alone or both together…

This study tested whether giving an anti-inflammatory steroid directly into the uterine arteries during a non-surgical fibroid treatment can lessen pain, nausea, vomiting, and tiredness afterward. Forty-two women with symptomatic fibroids took part. The goal was to see if this si…

This study tested whether injecting the numbing drug ropivacaine into the belly and around a nerve cluster before surgery can lower pain after laparoscopic fibroid removal. 207 women having fibroid surgery were randomly assigned to get either ropivacaine or a placebo. The main go…

This study tested whether a supervised resistance training program could help lymphoma patients maintain muscle mass and physical function while undergoing chemotherapy. Forty-two adults with newly diagnosed lymphoma were randomly assigned to either the exercise program or usual …

This study tested whether using ultrasound to guide hyaluronic acid injections into the jaw joint works better than the usual method for people with a displaced jaw disc. Forty adults who had not improved with other treatments received either ultrasound-guided or standard injecti…

This pilot study tested whether taking a combination of EGCG (from green tea), vitamin D, and D-chiro-inositol for three months before hysteroscopic myomectomy improves surgical outcomes. 90 women with uterine fibroids were divided into two groups: one received the supplements be…

This study looked at whether adding Traditional Chinese Medicine (TCM) to a self-care program helps people with jaw pain (TMD). 135 adults with moderate to severe pain were given different levels of care based on how they responded. The goal was to see if TCM could improve pain a…

This study tested two different low-level laser wavelengths (635nm and 980nm) to see if they could reduce pain and improve jaw function in people with myofascial pain syndrome of the jaw. Thirty participants received laser treatment twice a week for five weeks. The main goal was …

This study tested whether doing physical therapy at home via video calls (telerehabilitation) works as well as going to a clinic after rotator cuff surgery. Thirty people who had surgery at least six weeks earlier took part. Both groups did the same exercises for eight weeks, and…

Researchers at Hacettepe University are studying people who had surgery for a massive rotator cuff tear. They want to see how the brain's signals to shoulder muscles, shoulder function, and psychological resilience relate to each other. Participants complete shoulder and mood que…

This study followed 293 people with autoimmune diseases and healthy volunteers to see how COVID-19 infection or vaccination affects their immune system, inflammation, and blood vessels. Participants were grouped based on their COVID-19 history and had up to 5 visits over 12-18 mo…

This study investigated whether environmental exposures during military service increase the risk of developing myositis, a rare autoimmune disease that attacks muscles. Researchers compared 37 military personnel with and without myositis using questionnaires and blood samples. N…

This study follows up to 5,000 people with autoinflammatory diseases (like NOMID, CANDLE, and juvenile dermatomyositis) and their healthy relatives. Researchers will collect medical history, blood samples, and imaging over 2-5 day visits to learn how these diseases work and find …

This study followed 78 people with GNE myopathy, a rare genetic disease that causes progressive muscle weakness starting in young adulthood. Researchers collected medical history, blood samples, and muscle function tests over up to two years to understand how the disease progress…

This study looks at two ways to manage pain in children having the Nuss procedure for pectus excavatum (a sunken chest). One group received standard nerve freezing (cryoanalgesia) alone, while the other also had a nerve block near the diaphragm. Researchers will compare pain scor…

Researchers at the University of Malaya are studying how COVID-19 affects muscle loss and strength in critically ill patients. They will compare quadricep muscle thickness and cross-sectional area, along with handgrip and knee extension strength, between COVID-19 and non-COVID-19…

This study looked at whether using low tidal volume (gentle) ventilation during heart-lung bypass surgery helps preserve diaphragm movement and reduce lung problems after surgery. Sixty adults having elective coronary artery bypass surgery were randomly assigned to receive either…

This study uses MRI scans to measure amyloid protein buildup in the hearts of up to 150 people with transthyretin-mediated amyloid cardiomyopathy (ATTR-CM). Participants are already enrolled in a larger treatment trial. The goal is to see how amyloid levels change over time, not …

This study asks over 1,600 African American women aged 23-35 about their experiences during the COVID-19 pandemic. Participants fill out a short online or paper survey covering infection, vaccination, childcare, job loss, and emotional stress. The goal is to understand how the pa…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study looks at how well a bio-inductive implant helps heal torn rotator cuff tendons in the shoulder. Researchers will use MRI scans at 3 and 6 months after surgery to check if the repair is holding and if there are any problems. About 20 people with partial or full tears wi…

This study looks at whether antioxidant supplements can prevent muscle loss and blood vessel problems in older adults (ages 65-85) during five days of bed rest. Participants take either a placebo or two antioxidants (MITO-AO and PB-125) while researchers measure changes in blood …

This study tests a new imaging method called MR Elastography to measure how muscles and their surrounding tissues move in people with myofascial pain syndrome. Researchers will compare results from 106 participants, including those with chronic pain and healthy volunteers. The go…

This study looks at children and adolescents aged 6 to 16 with inherited arrhythmias, such as long QT syndrome, to see if a controlled exercise test on a treadmill reflects their actual heart rate and activity levels during daily life. Participants will complete a routine exercis…

This study looked at 719 people, including patients with autoimmune connective tissue diseases like myositis, their blood relatives, and healthy volunteers. Researchers collected blood samples and medical histories to find genetic and environmental factors that may trigger these …

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This study looks at what influences treatment expectations in adults with myofascial pain syndrome (MPS), a common cause of muscle pain. Researchers measure pain intensity, pain duration, quality of life, and fatigue to see which factors best predict how much benefit patients exp…

This study measured calf muscle thickness and length in 26 children with Duchenne muscular dystrophy (ages 6-12) who could still walk. Researchers used ultrasound and motion analysis to see how muscle structure relates to walking and other movements. The goal was to better unders…

This observational study will measure how well the upper neck moves and how that relates to jaw motion in 50 adults with temporomandibular disorders (TMD). Participants will have their neck and jaw movements measured with simple tools. The goal is to understand if limited neck mo…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study is testing whether a special ultrasound technique called shear-wave elastography can measure the quality and elasticity of tendons after arthroscopic rotator cuff repair surgery. Researchers will compare the operated shoulder to the healthy one in 75 people who had sur…

This study uses MRI scans to check how well the subscapular tendon—a key shoulder tendon—heals years after surgical repair. Researchers want to see if a new arthroscopic classification of tendon tears predicts better healing and less fatty buildup in the muscle. Adults who had th…

This study looks at whether natural substances in the blood, called cardiac biomarkers, can help doctors manage children with cardiomyopathy—a disease of the heart muscle. The goal is to see if these blood tests could be a less invasive alternative to echocardiograms or MRIs for …

This study follows adults having arthroscopic rotator cuff repair to see how their depression symptoms change over two years and whether those changes relate to shoulder pain and function. Participants are grouped by pre-surgery depression scores, then tracked at regular interval…

This study is building an international registry of people with GNE myopathy, an ultra-rare muscle disease that causes progressive weakness and often leads to wheelchair use. Participants will complete online questionnaires about their symptoms, medical history, quality of life, …

This study looks at how often women develop intrauterine adhesions (scar tissue inside the uterus) after having fibroids removed through laparoscopic or open surgery. Researchers will check for adhesions using a small camera inserted into the uterus three months after surgery. Th…

This study explores whether a single bout of exercise can protect against muscle damage from a later session—a phenomenon called the repeated bout effect—in people with neuromuscular diseases. Unlike healthy individuals, patients with these conditions may experience muscle damage…

This study looks at whether it is safe and possible to do a special exercise test (MRI combined with a bike workout) in 20 people who already have a specific type of pacemaker. The goal is to see how different pacemaker settings affect the heart's pumping ability during light exe…

This trial asks whether the barbell back squat or the barbell hip thrust is better for building glute muscle and strength. About 39 young, untrained adults will train twice a week for nine weeks with one of the two exercises. Researchers will measure muscle size with MRI and stre…

This study looks at how scar tissue (fibrosis) forms in the heart in conditions like aortic stenosis, heart damage from chemotherapy, and carcinoid syndrome. Researchers will use special PET scans to see active scarring early. About 180 adults will take part to help improve detec…

This study investigates whether chronic neck pain changes how the neck works in people with temporomandibular disorders (TMD), and whether those neck changes relate to jaw function, mouth opening, and jaw pain. Researchers will compare 67 adults with TMD—some with chronic neck pa…

This study explores how weight-loss surgery changes the body's protein needs and whether fast-absorbing milk proteins can help preserve muscle mass and strength. Researchers will measure nitrogen balance and muscle function in 25 adults with severe obesity before and after gastri…

This observational study looks at how people's beliefs about pain—whether they see it as psychological or organic—relate to fear of movement, pain catastrophizing, pain knowledge, and disability in individuals with chronic shoulder pain. Researchers will assess 109 adults aged 18…

This study follows boys with Duchenne muscular dystrophy who have small mutations in their genes, a group that is less understood than others. Over one year, researchers will use muscle MRI, genetic tests, and motor and respiratory assessments to see how the disease progresses. T…

This project creates a central repository of medical records, genetic test results, and patient-reported information from people with Duchenne or Becker muscular dystrophy, as well as carriers. Anyone aged 4 weeks or older with a confirmed diagnosis can join. The goal is to provi…

This study uses ultrasound to measure diaphragm movement and breathing in 15 adults receiving a stellate ganglion block — a nerve injection for certain pain conditions. The goal is to see how often the block temporarily paralyzes one side of the diaphragm. Researchers also check …

This study tested whether a special MRI scan of the wrist can detect amyloid deposits in people with systemic amyloidosis, a condition where abnormal proteins build up in organs. Researchers enrolled 128 adults, including patients with cardiac amyloidosis and healthy volunteers. …

This study looks at two ways to examine the uterine cavity after women have had hysteroscopic surgery for conditions like polyps, fibroids, or a uterine septum. One method is a non-invasive 3D ultrasound; the other is an office hysteroscopy, which involves inserting a small camer…

This study looks at how mepolizumab (Nucala), a treatment for severe eosinophilic asthma, impacts emotions and mental well-being in patients and their partners. Researchers will track changes in feelings like anxiety, depression, and stress using questionnaires and interviews. Th…

This study looks at how much protein adults with facioscapulohumeral muscular dystrophy (FSHD) need each day to support muscle health. Researchers will test different amino acid intakes in 10 participants using a non-invasive technique. The goal is to improve dietary recommendati…

This trial tests different doses of a fluorescent dye called IC-Green in people having arthroscopic rotator cuff repair. The dye binds to blood proteins and makes blood vessels visible under a special camera. The goal is to find the best dose for seeing blood flow in the torn ten…

This study investigates whether people with late-onset Pompe disease have a higher risk of severe blood vessel problems in the brain and aorta. Researchers will collect medical and genetic data from adults with Pompe disease and from those who have had a brain aneurysm or bleedin…

This study looks at people with chronic constipation to see if a specific muscle problem called puborectalis syndrome can be better identified using three different tests: defecography, high-resolution anorectal manometry, and pelvic floor ultrasound. Researchers will compare res…

This observational study looks at how anthracycline chemotherapy affects inflammation, oxidative stress, and heart function in adult women who had breast cancer. Researchers measure blood markers and use echocardiograms to assess heart changes about 10 years after treatment. The …

This study looks at whether people with dyssynergic defecation—a condition where the pelvic muscles don't relax properly during bowel movements—are more likely to have psychiatric disorders like anxiety or depression. Researchers will compare 148 patients to healthy volunteers us…

This study uses advanced heart imaging to understand how blood flows inside the heart in people with cardiac amyloidosis, a condition where abnormal proteins build up in heart tissue. Researchers will compare these images with those from healthy volunteers to find unique patterns…

This completed study looked at 260 patients with ischemic cardiomyopathy (a weak heart due to blocked arteries) who had heart surgery. The goal was to develop a personalized approach to choose the best type of surgery and predict risks and outcomes. Researchers used imaging, bloo…

This study tested a decision algorithm to help doctors diagnose the cause of eosinophilia (high levels of a type of white blood cell). The algorithm guides which tests to do and in what order. Researchers enrolled 53 patients and measured how many followed the algorithm correctly…

This study used ultrasound to measure how much the diaphragm thickens during a sniff in 60 healthy adults. The goal was to define a normal range for this measurement, which could help doctors spot diaphragm problems in the future. Participants were grouped by age and gender to se…

This study looks at how getting too little sleep and not putting weight on one leg affects muscle strength and balance. Healthy adults who exercise regularly will walk on one leg and sleep either 5 or 9 hours for three days. Researchers will measure muscle size, strength, and how…

This study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…

This completed study examined muscle cells from 8 children with obstetrical brachial plexus palsy, a birth injury that affects arm nerves. Researchers took small muscle samples during planned shoulder surgery to see if the cells can repair themselves. The goal was to understand w…

This study compared 80 women with and without fibromyalgia to measure muscle strength, muscle thickness, vitamin D levels, and sleep quality. Researchers used advanced tools like isokinetic dynamometers and ultrasound to find differences between the groups. The goal was to better…

This completed study surveyed 566 adolescents aged 14 to 16 to understand how jaw pain (temporomandibular disorders) relates to other painful conditions like headaches, neck pain, and back pain. Researchers used anonymous questionnaires to identify common co-occurring health issu…

This study looked at whether ECMO, a machine that does the work of the heart and lungs, helps people with severe COVID-19 who have lung failure or heart failure. Researchers tracked 761 patients across France to see how many survived and how quickly they recovered. The goal was t…

This study observed 61 adults having shoulder surgery to see how a specific combination of nerve blocks affects the diaphragm, the main muscle for breathing. Researchers used ultrasound to measure diaphragm movement before and after the block. The goal was to find out if this tec…

This study reviewed information from 683 adults with obstructive hypertrophic cardiomyopathy who took mavacamten through a support program in Canada. Researchers looked at patient characteristics and how long they stayed on the medication. The goal was to understand real-world us…

This study tested whether giving general practitioners a simple, evidence-based guideline improves care for people with shoulder pain. 160 adults with shoulder pain took part in Norwegian GP clinics. Researchers measured pain, disability, and quality of life to see if the guideli…

This study looked at how blood vessel function relates to heart blockage in people with a genetic heart condition called hypertrophic cardiomyopathy. Researchers measured blood flow and vessel flexibility in 40 adults. The goal was to understand the connection, not to test a trea…

This study looked at whether DNA can be taken from heart muscle cells to help diagnose arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare heart condition. Researchers collected cells from 34 people during a routine heart procedure. The goal was to see if the DNA from …

This study checked how often nerve damage (neuropathy) occurs in people with a rare heart condition called wild-type TTR cardiac amyloidosis. Researchers examined 65 patients using interviews, physical exams, and nerve tests (electromyograms). The goal was to find out if nerve pr…

This study looked at whether measuring the stiffness of uterine fibroids can help predict how well they respond to a non-invasive treatment called MR-HIFU. Forty women with symptomatic fibroids were enrolled. The goal was to improve patient selection so that only those likely to …

This study looked at the extra costs that families of people with Duchenne muscular dystrophy (DMD) in France have to pay out of their own pockets. It included 28 patients of any age who had been diagnosed for at least six months. The researchers measured things like uninsured me…

This study tested a new way to predict dangerous heart rhythm problems after a common heart valve procedure called TAVR. Researchers combined ECG results with CT scan measurements and implant depth to see if they could safely identify low-risk patients. The study looked back at 2…

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looked at whether adding extra carbohydrates to a daily protein supplement helps resistance-trained men build more muscle and strength. Twenty-five men took either a protein-only or a protein-plus-carb supplement for 8 weeks each. The results showed no significant diff…

This study collected information from over 15,000 people hospitalized with cardiomyopathy, a heart muscle disease. Researchers looked at how much these hospital stays cost and what the money was spent on. The goal was to understand the real-world financial impact and help manage …

This study tested whether a telehealth system could help people with motor neurone disease (MND) receive specialist care from home, avoiding long trips to the clinic. It involved 40 patients and their caregivers, with half using the system for up to 18 months. The goal was to see…

This study tested whether doctors can accurately assess physical function and quality of life in children with Duchenne muscular dystrophy (DMD) through video calls. Twenty ambulatory patients aged 5-18 completed timed tests and questionnaires remotely. The goal was to see if tel…

This completed study involved 250 adults with AL amyloidosis, a rare disease where abnormal proteins damage organs. Researchers analyzed patient samples and data to find biological markers that predict how well someone will respond to initial treatments. The goal is to help docto…

This study looked at different types of immune cells (eosinophils) in the blood of people with asthma, chronic sinusitis with nasal polyps, or both, compared to healthy volunteers. The goal was to find patterns that could help doctors choose the best targeted therapy for each pat…

This study looked at 40 women with symptomatic uterine fibroids to understand why MR-guided focused ultrasound (HIFU) works better for some than others. Researchers used MRI and contrast-enhanced ultrasound to measure fibroid blood flow, stiffness, and other features before treat…

This study tested whether a special MRI scan (31P-MRS) can detect early signs of damage to heart and muscle cells caused by chemotherapy drugs like doxorubicin. Twelve cancer patients scheduled for chemo underwent three scans over time. The goal was to see if the scan could measu…

This study looked at how eating more or fewer calories affects muscle protein production and muscle size in healthy middle-aged adults during a short period of leg immobilization. Twenty-three participants were monitored under different energy intake conditions. The goal is to un…

This completed study looked at 262 people with dilated cardiomyopathy, a condition where the heart muscle is weakened and enlarged. Researchers used a special MRI technique (T1 mapping) to measure scarring (fibrosis) in the heart. They wanted to see if the amount of scarring coul…

This study tested whether doing light arm exercises with a blood pressure cuff on the upper arm (blood flow restriction) can build biceps muscle as well as lifting heavy weights. Thirty-three healthy young men who had never done arm training before followed an 8-week program. Res…

This study looked at 60 women aged 35 to 60 who had a hysterectomy (removal of the uterus) through small cuts in the belly (laparoscopy). The goal was to compare two different methods of tying off the uterine arteries to see which one led to less blood loss during surgery. The re…

This study checked how accurately a practitioner can locate a rib by touch (palpation) compared to using ultrasound. 44 healthy adults took part. The goal was to see if palpation alone is reliable enough for dry needling of deep shoulder muscles. Results help guide safer practice…

This study looked at how dental students hold their bodies while doing root canal work. Ten students were recorded on video for 5 minutes, and their posture and muscle fatigue were analyzed. The goal was to understand how their working positions might lead to pain or injury. This…

This completed study looked at how muscle oxygen levels change during exercise in people with various neuromuscular diseases compared to healthy volunteers. Seventeen participants did a knee-extension exercise while a device measured muscle oxygen. The goal was to understand diff…

This study looked at how critically ill patients on breathing machines process protein. Researchers gave 8 patients two different protein amounts (1.3 vs 2.0 grams per kilogram per day) and measured protein breakdown using a special breath test. The goal was to learn more about m…

This study looked at 22 people with severe aortic stenosis who were scheduled for valve replacement. Before surgery, they had an ultrasound of the heart, and during surgery a tiny sample of heart muscle was taken to check for scarring (fibrosis). The goal was to see if ultrasound…

This study watched 60 adults with ME/CFS (a condition causing severe fatigue) after they received hyperbaric oxygen therapy (HBOT) in a high-pressure chamber. Participants filled out health questionnaires to track changes in physical function and fatigue. The goal was not to prov…

This study looked at 30 people newly diagnosed with cardiac AL amyloidosis, a rare disease where abnormal proteins damage the heart. Researchers used advanced MRI, echocardiogram, and PET scans to see if these images could predict survival and show how well chemotherapy works. Th…

This study looked at 66 people with Takotsubo syndrome, also known as broken heart syndrome, to understand how their bodies react to emotional stress. Participants recalled a stressful event while researchers measured stress hormones and heart rate. The goal was to learn more abo…

This study tracked 157 heart surgery patients to see how many still have a weak diaphragm 7 days after their operation. Using ultrasound, researchers measured diaphragm movement during breathing and sniffing. The goal is to understand how common persistent diaphragm problems are …

This study looked back at 46 women who had a procedure called uterine artery embolization to treat fibroids. The goal was to see how often women later had a baby and what pregnancy complications occurred. The researchers reviewed medical records from one hospital in France to gat…

This completed study looked at 60 heart failure patients with reduced pumping function and dangerous heart rhythms. Researchers compared metabolic profiles between those with ischemic (blocked arteries) and non-ischemic (other causes) heart disease. By analyzing blood samples, th…

This pilot study examined whether inflammation, measured by cytokines in the blood, plays a role in type 1 facioscapulohumeral muscular dystrophy (FSHD1). Researchers compared 20 FSHD1 patients with healthy controls to see if certain inflammatory markers are higher in the disease…

This study looked at 70 family caregivers of stroke patients who also have bladder issues. Researchers measured how much burden, fatigue, poor sleep, and depression caregivers experience. The goal was to understand the challenges these caregivers face, not to test a new treatment…

This study looked at 86 people with severe aortic valve stenosis who had valve replacement surgery. Researchers used special MRI scans to measure scarring in the heart muscle before and one year after surgery. The goal was to see if the scarring improves and whether MRI could hel…

This study compared two types of exercise training for people who had a heart attack: continuous moderate exercise and intermittent high-intensity exercise. One hundred participants completed an 8-week program, and researchers used ultrasound to measure changes in heart function.…

This study followed 37 people with a genetic risk for hereditary ATTR amyloidosis over five years. Researchers measured levels of misfolded proteins in the blood to see if they could detect the earliest signs of the disease. The goal is to develop a way to catch the condition bef…

This completed study enrolled 150 people with Duchenne muscular dystrophy to create a video database of their movement abilities. Caregivers recorded children doing specific tasks at home using a secure app. The goal was to help validate a new tool called the Duchenne Video Asses…

This study looked at 44 people with a rare inherited eye condition called Leber Hereditary Optic Neuropathy (LHON) that causes vision loss. Researchers reviewed medical records and asked participants about their vision, health, and quality of life. The goal was to better understa…

This study involved 116 people with Limb Girdle Muscular Dystrophy (LGMD), a group of rare muscle-weakening disorders. Researchers measured how well participants could walk, move their arms, and breathe, and asked about their daily activities and overall health. The goal was to i…

This study looked at children aged 6 to 18 who had heart surgery before they were 3 months old. Researchers asked parents to fill out a questionnaire about their child's emotions, behavior, and social skills. The goal was to see if these children face any developmental challenges…

This pilot study enrolled 5 people with hypertrophic cardiomyopathy who needed an implantable cardioverter defibrillator (ICD) but did not require pacing. Participants were randomly assigned to receive either a subcutaneous ICD (placed under the skin) or a transvenous ICD (with l…

This study tested whether a mobile app (myFSHD) can help doctors monitor patients with facioscapulohumeral muscular dystrophy (FSHD) remotely. 70 adults with FSHD used the app at home for 12 months, completing questionnaires and video-recorded exercises. The goal was to see if pa…

This study tested whether coaching sessions are practical for young people with rheumatic diseases moving from pediatric to adult care. 26 participants received up to 8 coaching sessions covering self-advocacy, medication management, and future planning. The main goal was to see …

This study tested whether advanced MRI and ultrasound techniques can better measure muscle changes in people with rotator cuff tears. Three adults with a tear on one side and a healthy shoulder on the other took part. The goal was to see if these imaging tools could provide clear…

This study compared two ultrasound-guided nerve block techniques for hand, wrist, or forearm surgery to see which one causes less temporary diaphragm paralysis. 91 adults were randomly assigned to receive either a costoclavicular or lateral sagittal infraclavicular block. The goa…

This study followed 30 adults with myotonic dystrophy type 1 (Steinert disease) and 30 healthy volunteers over three years to see how muscle strength and function change naturally over time. Researchers measured things like muscle power, walking ability, and nerve responses to fi…

This completed study looked at 110 people with cardiac amyloidosis, a condition where protein deposits build up in the heart. Researchers implanted a small device under the skin to continuously monitor heart rhythms for up to several years. The goal was to learn more about when a…

This study looked at whether a tailored program of protein supplements and exercise can increase muscle protein production in people with advanced chronic kidney disease (CKD) who are not yet on dialysis. Researchers compared these patients to healthy adults to see how their bodi…

This study looked at whether ultrasound measurements of the diaphragm, the main breathing muscle, can help predict if ICU patients on ventilators will successfully breathe on their own. Researchers measured diaphragm thickness and movement in 60 patients before removing the breat…

This study tested whether ultrasound can detect early facial muscle changes in people with facioscapulohumeral muscular dystrophy (FSHD), a rare muscle disease. Researchers compared 20 FSHD patients with 19 healthy adults, measuring muscle thickness and echo intensity in key faci…

This study looked for new biological markers to help diagnose hypereosinophilic syndrome (HES), a rare condition where too many eosinophils (a type of white blood cell) cause damage. Researchers compared blood samples from 41 people with HES, those with other causes of high eosin…

This study used advanced MRI scans to look at the hearts of 276 people with chronic kidney disease, including those on dialysis. The goal was to identify different types of heart damage and link them to patient outcomes. No new treatment was tested; instead, researchers aimed to …

This study looked at whether MRI scans can reliably find a torn disc in the jaw joint (temporomandibular joint). Researchers reviewed MRI images and medical records from 282 people to see how often disc tears occur and how they relate to pain, disc shape, and bone changes. The go…

This study looked at whether daily protein supplements (from plants or milk) can help healthy older adults build and maintain muscle, especially when combined with exercise. Fifty-one participants aged 60-80 received either a plant protein blend, milk protein, or a placebo, along…

This completed study looked at how children (ages 9-13) and adults (ages 18-50) respond to 12 weeks of resistance exercise using either flywheel or traditional weight stack machines. 91 healthy participants were randomly assigned to one of three groups: flywheel training, weight …

This study looked at how children with Noonan syndrome process energy and sugar. Researchers measured insulin sensitivity in 20 children with the condition to see if they have unique metabolic traits. The goal was to better understand the disease, not to test a new treatment.

This study looked at 183 women with menstrual pain to understand why it happens and how naproxen (a common painkiller) relieves it. Using MRI scans, researchers measured uterine activity, blood flow, and oxygen levels before and after taking naproxen or a placebo. The goal is to …

This study followed 113 adults with myotonic dystrophy (Steinert's disease) for 5 years to find out what factors lead to low breathing (hypoventilation). Researchers measured lung function, sleepiness, fatigue, and thinking skills. The goal is to better understand which patients …

This study tested whether PET scans can detect early response to chemotherapy in people with retroperitoneal sarcoma, a rare cancer in the abdomen. 18 participants received extra PET scans before and after their first chemo cycle. The goal was to see if PET could predict tumor sh…

This study looked at whether briefly pressing on the phrenic nerve during lung surgery could help reduce complications like air leaks. Researchers compared 55 patients who had this temporary nerve compression with those who did not. They measured diaphragm activity, lung function…

This study looked at the DNA of 73 children with a rare birth defect called isolated congenital diaphragmatic hernia (CDH), where a hole in the diaphragm allows organs to move into the chest. Researchers wanted to find new genetic changes that might cause the condition. They used…

This study looked at 80 people with muscle pain to see if genetics can predict which treatment works best. Participants received laser, ultrasound, or sugar-water injections. Researchers analyzed blood and urine to find markers that could guide personalized pain care in the futur…

This early-phase trial tested a single oral dose of HRS-1893 in 20 healthy white male volunteers to see how the body processes the drug and whether it is safe. The study is a first step toward potentially treating hypertrophic cardiomyopathy, a condition where the heart muscle th…

This completed study followed 6,000 adults who had COVID-19 symptoms and were tested for the virus. Participants completed online surveys every 3 months for 18 months to track long-term health issues like fatigue, brain fog, and heart problems. The goal was to better understand t…

This study looked for Fabry disease, a rare genetic disorder, in 409 Portuguese adults with unexplained heart muscle diseases. Researchers tested patients with different types of cardiomyopathy to see how many actually had Fabry disease. The goal was to better understand how comm…

This study looked at 18 heart failure patients with a specific heart block to find the best spots for pacing the heart's natural electrical system. Doctors used a 3D mapping system during device implant to see where pacing corrects the heart's rhythm. The goal was to gather infor…

This study looked at how the location of uterine fibroids affects blood flow in the uterine artery. Researchers used ultrasound to measure blood flow in 185 women with fibroids and compared results based on fibroid location. They found that fibroids located within the uterine mus…

This study tests whether doing heavy resistance exercise before a period of leg immobilization can prevent muscle loss. 48 healthy adults (young and older) will have one knee immobilized for 7-10 days, then undergo 4 weeks of retraining. Half will also exercise for 4 weeks before…

This study tested a mixed reality system called HOLOBLUEPRINT that helps surgeons see 3D plans during shoulder replacement surgery. 44 adults having shoulder surgery used the tool. Researchers checked if the implant was placed accurately by comparing CT scans before and after sur…

This completed study looked at 258 people with different types of cardiomyopathy (a disease of the heart muscle) to see if special imaging could predict stroke risk. Researchers used echocardiograms and MRI scans to measure blood flow in the heart and check for silent brain infar…

This study looked back at 20 children under 18 who were in intensive care with heart inflammation (myocarditis) and a possible COVID-19 infection. The goal was to describe their symptoms, lab results, and heart function, and to figure out whether the virus directly damages the he…

This completed Phase 1 study looked at how HRS-1893 tablets are processed in people with mild or moderate kidney impairment compared to healthy subjects. The goal was to understand dosing needs for patients with hypertrophic cardiomyopathy who also have kidney issues. Twenty-four…

This completed study tested whether augmented reality (AR) can help surgeons during laparoscopic surgery for uterine fibroids or adenomyosis. AR overlays images from pre-surgery scans onto the live video feed, potentially making it easier to see and remove benign tumors. Forty pa…

This study looked at 44 people with shoulder pain from rotator cuff tears to see if a condition called central sensitization (where the nervous system is extra sensitive to pain) changes how well a steroid injection works. Participants got a shot of betamethasone and prilocaine i…

This study investigates why people with myotonic dystrophy type 1 are 10 times more likely to develop dangerous blood clots in the legs or lungs. Researchers will compare blood samples from 130 participants—including patients with the disease, those with a history of clots, and h…

This completed registry study collected real-world data on 99 patients receiving HydroPearl microspheres to block blood flow to conditions like uterine fibroids, arteriovenous malformations, hypervascular tumors, and benign prostatic hyperplasia. The procedure was done through th…

This study tested new MRI methods to detect bleeding inside the heart muscle after a heart attack. Researchers studied 14 patients to see if these scans could better identify damage that raises the risk of heart failure. The goal was to improve imaging, not to test a treatment.

This pilot study looked at 8 newborns with congenital diaphragmatic hernia (a hole in the diaphragm) after surgery. Researchers compared two types of breathing machines: standard ventilation and a newer method called NAVA, which senses the baby's own breathing signals to provide …