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Pumping iron against cancer: exercise may protect muscle during chemo

NCT ID NCT05556239

Symptom relief Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether a supervised resistance training program could help lymphoma patients maintain muscle mass and physical function while undergoing chemotherapy. Forty-two adults with newly diagnosed lymphoma were randomly assigned to either the exercise program or usual care for 4 months. The main goal was to see if the training helped preserve lean body mass, with additional measures of walking speed, stair climbing, and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
supervised resistance exercise training
What this could lead to
If effective, this training program could become a standard part of care to help lymphoma patients preserve muscle and physical function during chemotherapy.
What could go wrong
This is a small, single-center trial with only 42 participants, so results may not apply broadly. The intervention requires significant commitment and may not be feasible for all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

42 people

The number who actually took part.

Started

Oct 2022

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants must: * Be newly diagnosed with diffuse large B-cell lymphoma and Hodgkin Lymphoma * Be expected to receive treatment with an anthracycline-containing combination chemotherapy at the Department of Hematology, Rigshospitalet * Be ≥ 18 years of age at the time of signing the informed consent form. * Be residing in Denmark * Have an Eastern Cooperative Oncology Group (ECOG) performance status score ≤ 2 * Be able to speak and read Danish, and to provide a signed informed consent form. Exclusion Criteria: * Patients with: * Clinically significant cardiovascular disease, including, but not limited to: Heart failure NYHA (New York Heart Association) class III-IV, uncontrolled hypertension, and symptomatic cardiac arrhythmias. * Psychiatric, neurological, or geographical conditions that could influence protocol adherence. * Disorders that cause an inability to perform exercise training for one hour. * Any other known malignancy requiring active treatment.

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Conditions

The condition(s) this trial relates to.

B-cell neoplasm diffuse large B-cell lymphoma Hodgkins lymphoma Motor Activity Sarcopenia skeletal muscle disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Body composition Exercise Lymphoma, B-cell Lymphoma, Hodgkin Muscle, skeletal Patient reported outcome measures Physical functional performance Quality of life Sarcopenia

Contacts and locations

Locations

  • Rigshospitalet

    Copenhagen, Denmark

More trials for these conditions

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