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Could ozone gas ease your jaw pain? new study tests it

NCT ID NCT07523451

Symptom relief Sponsor: Alexandria University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two different strengths of ozone gas injections into the jaw joint for people with TMJ disorders. Twenty adults who had clicking, popping, or limited mouth opening that didn't improve with other treatments received the injections. Researchers measured pain and jaw function using a standard scale and mouth opening ability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ozone gas
What this could lead to
If it works, this could provide a simple, low-cost injection to ease jaw pain and improve mouth opening for people with TMJ disorders.
What could go wrong
This was a very small, completed trial with only 20 participants. Ozone injections are not yet standard treatment, and results may not apply to everyone with TMJ issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Feb 2025

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adult patients above 18 years old. 2. Patients suffering from sounds during condylar movements (clicking or popping). 3. Patients suffering from limited mouth opening and impaired joint movements. 4. Patients who did not respond to conservative treatment as a first line of treatment. Exclusion Criteria: 1. Patients with history of condylar fracture. 2. Patients with degenerative joint disease. 3. Coagulopathy blood disorders. 4. Presence of infection at the site of injection.

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TMJ disc disorder

Contacts and locations

Locations

  • Faculty of Dentistry, Alexandria University

    Alexandria, Alexandria Governorate, 21523, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.