Ozone and PRP combo shows promise for jaw pain relief
NCT ID NCT07452289
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a procedure called arthrocentesis (joint washing) using ozonated water, with or without a platelet-rich plasma (PRP) injection, for people with a displaced jaw disc. The goal was to see if adding PRP improves mouth opening, reduces pain, and lowers inflammation. Twenty patients who had not responded to other treatments took part.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- ozonated water and platelet-rich plasma (PRP) injection
- What this could lead to
- If this works, it could offer a more effective treatment for TMJ pain and limited mouth opening, improving quality of life.
- What could go wrong
- This is a very small, early-stage trial with only 20 participants, so results may not apply to everyone. The treatment is not a cure and only aims to ease symptoms.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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20 people
The number who actually took part.
- Started
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Jul 2024
- Finished
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May 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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16 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Pain located in the affected TMJ, especially during opening. * Joint noises. * Limited mouth opening (less than 35 mm). * Impeded lateral movement toward the unaffected side. * Deflection toward the affected side in opening in cases of unilateral affection. * Patient who did not respond to conservative management. Exclusion Criteria: * Patients receiving anticoagulation treatment or non-steroidal anti-inflammatory drugs within 48 hours preoperatively, corticosteroid injection at the treatment site within 1 month, or systemic use of corticosteroids within 2 weeks. * Patients suffering from any systemic inflammatory (degenerative) joint disease, and bleeding disorders such as coagulation disorders, platelet disorders, vascular disorders, and fibrinolytic defects. * Patients with overlying infection or cellulitis in preauricular region. * Patients with condylar pathology (hypoplasia, hyperplasia or tumor). * Patients with previous open TMJ surgery or previous joint fracture. * Patients with normal disc positions as seen by the MRI and the limitation is due to another extraarticular cause such as zygomatic arch fracture or elongated coronoid process.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Outpatient Clinic of Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Alexandria University, Egypt
Alexandria, Azarita, 00203, Egypt
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