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Jaw pain breakthrough? three injections tested after TMJ procedure

NCT ID NCT07479693

Symptom relief Sponsor: Ondokuz Mayıs University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding an injection of hyaluronic acid, platelet-rich fibrin, or dextrose to a standard jaw washout procedure (arthrocentesis) improves pain and jaw function more than the washout alone. Thirty-six adults with TMJ disorders who hadn't improved with other treatments took part. The goal was to see which, if any, of these add-on injections provides better relief.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Hyaluronic acid, injectable platelet-rich fibrin (i-PRF), and dextrose prolotherapy
What this could lead to
If one of these injections proves superior, it could offer a more effective, longer-lasting option for easing TMJ pain and improving jaw movement after a standard washout procedure.
What could go wrong
This is a small, completed trial with only 36 participants, so results may not apply to everyone. The study compared several treatments, and none may be clearly better than the standard procedure alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

36 people

The number who actually took part.

Started

Jan 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients presenting with temporomandibular joint (TMJ) pain, limited mouth opening, and/or unilateral joint pain * Patients diagnosed with internal derangement of the temporomandibular joint classified as DC/TMD * Patients who did not respond adequately to conservative treatment modalities * Patients who underwent temporomandibular joint magnetic resonance imaging (MRI) evaluation * Individuals aged 18-65 years Exclusion Criteria: * Individuals who did not provide informed consent or were unwilling to participate in the study * Patients whose primary source of pain was myofascial pain dysfunction or cervical-origin pain * Pregnant or breastfeeding patients * Patients with a known allergy to any of the injected solutions used in the study * Patients with systemic joint diseases such as rheumatoid arthritis * Patients with acute infection in the temporomandibular joint region * Patients with hematological disorders * Patients with a history of previous temporomandibular joint surgery * Patients with tumors or malignant neoplasms involving the temporomandibular joint * Patients with a history of oral or maxillofacial trauma affecting the temporomandibular joint * Patients who were unable to cooperate with clinical examination or follow-up procedures

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Conditions

The condition(s) this trial relates to.

temporomandibular joint disorder temporomandibular joint dysfunction syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthrocentesis Temporomandibular joint pain

Contacts and locations

Locations

  • Ondokuz Mayis University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery

    Samsun, Atakum, Turkey (Türkiye)

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Other studies related to the condition(s) this trial covers.