Jaw pain study: which simple therapy works best?
NCT ID NCT05989217
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested five different non-surgical treatments for jaw joint (TMJ) pain in 160 adults. Treatments included a mouthguard, low-level laser therapy, laser acupuncture, or combinations of these. The goal was to see which approach best reduced pain and improved mouth opening over four weeks.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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160 people
The number who actually took part.
- Started
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Mar 2023
- Finished
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Jan 2025
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Adults of legal age * Both sexes * Regardless of race or social class * With the main complaint of pain in the temporomandibular joint or orofacial region * With or without limitation of mouth opening, diagnosed through the DC/TMD axis1, with pain in the masticatory mm and muscular TMD * Participants must have complete permanent dentition and normal occlusion. Exclusion Criteria: * Congenital problems affecting the TMJ and/or orofacial and cervical region of the skull; * Neoplastic conditions; * History of recent trauma to the orofacial/cervical region of the skull; * Previous use of any type of TMD treatment plate; * Current use of functional orthopedic appliances or fixed and/or removable orthodontic appliances; * Cleft lip and/or palate syndromes; * Psychiatric disorders; * Severe cardiac problems; * A severely poor dental condition such as periodontitis and/or indication for endodontic treatment; * Those using topical or systemic photosensitizing drugs; * Pregnant women; * Dermatological diseases in the region where irradiation will be performed; * Patients with impaired cognitive ability; * History of head trauma related to the etiology of orofacial pain; * Migraine or intracranial disorders; * Who used medications in the last 3 months that may interfere with the effect of therapies, such as relaxants, anticonvulsants and who used medications to treat TMD or muscular pain; * Who had other causes of orofacial pain, such as caries, neuropathies and fibromyalgia; * Who had phobia about needles or bleeding disorders; * Patients who are unable to attend the clinic during the prescribed treatment period; * Patient who insists on a specific treatment (e.g. occlusal adjustments, medication); * Presence of removable full or partial dentures with distal extension.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Universidade Federal de Alfenas
Alfenas, Minas Gerais, 37130001, Brazil
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Other studies related to the condition(s) this trial covers.
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