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Heart shield for chemo: carvedilol may protect breast cancer Patients' hearts

NCT ID NCT04023110

First seen Nov 01, 2025 · Last updated Jun 14, 2026 · Updated 34 times

Summary

This early-phase study tested whether the heart medication carvedilol could safely protect breast cancer patients from heart damage caused by chemotherapy drugs like doxorubicin and trastuzumab. 68 women with early-stage breast cancer were assigned to either receive carvedilol or standard care based on their personal heart risk. The main goals were to see if the approach was safe, tolerable, and practical, not to prove it prevents heart failure.

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Contacts and locations

Locations

  • Abramson Cancer Center of the University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

Conditions

The condition(s) this trial relates to.

breast neoplasm cardiomyopathy Cardiotoxicity chemotherapy-induced toxicity heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.