CARDIOMYOPATHIES

This study tests a special pacing method called high intensity his bundle pacing in 34 heart failure patients with narrow QRS (a heart rhythm pattern). The goal is to see if this pacing can improve the heart's pumping ability and quality of life. Participants already have an impl…

This early-stage study tests a gene therapy called AAVrh.10hFXN for heart problems caused by Friedreich's ataxia, a rare genetic disorder. The therapy delivers a working gene to help heart cells function better. About 25 people aged 12 to 50 with mild to moderate heart disease wi…

This study tests whether destroying abnormal heart tissue (ablation) during LVAD surgery can reduce dangerous heart rhythms after the procedure. About 100 adults with advanced heart failure who are getting an LVAD will be included. The goal is to see if this extra step lowers the…

This study tests a heart-lung support device (Cardiohelp) in 50 children with severe heart failure to see if it is safe and effective for up to 30 days. It also compares two blood thinners (heparin vs. bivalirudin) to find which causes fewer bleeding or clotting problems. The goa…

This study tests whether a non-invasive radiation treatment (SBRT) can reduce dangerous heart rhythms as effectively as the standard catheter ablation procedure in 60 people with advanced heart disease. Participants will be randomly assigned to receive either radiation or cathete…

This study tests an experimental drug called acoramidis in 587 adults aged 18–75 who carry a faulty gene that causes transthyretin amyloidosis (ATTR) but have no symptoms yet. The drug aims to stabilize a key protein and prevent or delay the buildup of harmful plaques in the hear…

This study is testing whether a special smartwatch can detect heart problems by analyzing pulse signals. Researchers will compare the watch's readings with standard heart tests in 500 adults. If successful, this could lead to easier, non-invasive heart disease screening.

This study creates an online registry for 10,000 adults with cardiomyopathy or myocarditis (heart muscle diseases). Researchers will track participants over time to learn about serious outcomes like heart failure, dangerous heart rhythms, and death. The goal is to better understa…

This study follows people aged 12 and older who have a genetic heart condition called PKP2-ACM. Researchers will monitor heart rhythms, biomarkers, and quality of life over time to better understand how the disease naturally progresses. No new treatments are given; participants c…

This study aims to find genetic heart problems that might explain why some people with epilepsy die suddenly. Researchers will test 600 adults aged 18-50 with epilepsy, seizures, or related events, plus their blood relatives. They use advanced gene sequencing to look for known he…

This study follows 1,500 people with heart failure who already have an implantable defibrillator (ICD). The goal is to learn which patients are at highest risk of sudden cardiac death by looking at heart structure, electrical signals, genetics, and blood markers. This information…

This study is testing a cloud-based artificial intelligence program called Willem that reads electrocardiograms (ECGs) to detect heart rhythm problems and other abnormal patterns. Researchers will compare the AI's performance to that of board-certified cardiologists using data fr…

This study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns for different heart conditions, like cardiomyopathy and heart transplant recovery. The goal is to improve how doctors diagn…