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Could a single workout shield damaged muscles? a new trial investigates

NCT ID NCT05599568

Knowledge-focused Sponsor: Mads Peter Godtfeldt Stemmerik Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time

Summary

This study explores whether a single bout of exercise can protect against muscle damage from a later session—a phenomenon called the repeated bout effect—in people with neuromuscular diseases. Unlike healthy individuals, patients with these conditions may experience muscle damage even with concentric exercise, so the trial tests both concentric and eccentric exercise. Researchers will measure changes in creatine kinase levels after two exercise sessions to see if the protective effect occurs. The findings could help design safer, more effective exercise programs for people with myopathy.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exercise (concentric or eccentric)
What this could lead to
If the repeated bout effect occurs in neuromuscular diseases, it could inform safer exercise programs that reduce muscle damage and improve training benefits for patients.
What could go wrong
This is a small, early study (27 participants) and the effect may not appear in all patients or translate to real-world exercise. Exercise itself carries a risk of muscle damage in this population.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

27 people

The number who actually took part.

Started

May 2022

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \> 18 years * The ability to complete the exercise challenge * No concurrent medical condition that could interfere with interpretation of the results * Molecular diagnosis of the specific condition in specified patient groups or healthy control * No active muscle injury on the test day (caused by recent exercise, seizures, trauma, etc.) Exclusion Criteria: * Cardiac or pulmonary disease contraindicating peak exercise testing or strenuous exercise defined as NYHA-class III-IV * Veins that are too difficult to puncture for blood sampling, evaluated by the investigator * Severe muscle weakness, that prevents the subject completing the exercise test, evaluated by the investigator

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Conditions

The condition(s) this trial relates to.

muscle tissue disorder myopathy neuromuscular disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Myopathy

Contacts and locations

Locations

  • Neuromuscular Research Unit, 3342

    Copenhagen, DK-2100, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.