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Lack of sleep and not using a leg may weaken muscles and wobble balance

NCT ID NCT05956964

Knowledge-focused Sponsor: Lance Bollinger Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how getting too little sleep and not putting weight on one leg affects muscle strength and balance. Healthy adults who exercise regularly will walk on one leg and sleep either 5 or 9 hours for three days. Researchers will measure muscle size, strength, and how well participants can stand on one leg.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could help explain why muscle weakness and balance problems occur after bed rest or poor sleep, pointing toward better recovery strategies.
What could go wrong
This is a small, early-stage study in healthy volunteers, not patients. Results may not apply to older adults or people with medical conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Aug 2023

Finished

Mar 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 18 and 50 years * Regularly engaging in aerobic exercise (\> 150min/wk) and resistance exercise (\>1 time per week) for the past 12 months * Regularly sleep at least 7 hours per night Exclusion Criteria: * Age \< 18 or \> 50 years * Height between \<150 (F) or \<170 (M) and \> 190 cm (both sexes) * Waist circumference \< 55cm or \> 90cm (F) and \< 75cm or \> 100cm (M) * Body mass index \< 18.5 or \> 27.5 * Do not regularly sleep between 7 and 9 hours each night * Have a known sleep disorder * Not regularly engaging in exercise for previous 12 months * Blood clotting disorder * Heart arrhythmia * Implanted device which could negatively be affected by electrical impulse or strong magnetic field such as pacemaker, internal defibrillator, or cochlear implant * Diagnosed cardiovascular, pulmonary, renal, or metabolic disease * Pregnancy (within previous 6 months) * Oral contraceptive use (within previous three months) * High resting blood pressure (\>140 systolic and/or \> 90 diastolic) * Currently or previously undergone gender-affirming therapy (hormone therapy or sexual reassignment surgery) * Low back or leg injury in previous 6 months * Currently taking medication to assist with sleep * Muscle, bone, or joint injury that limits physical activity within previous 6 months * Neurological disorder which affects balance (such as multiple sclerosis or Parkinson's disease)

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Conditions

The condition(s) this trial relates to.

Muscle Weakness muscular atrophy Parasomnias sleep disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Muscle weakness Quadriceps muscle atrophy Sleep disturbance

Contacts and locations

Locations

  • University of Kentucky

    Lexington, Kentucky, 40506, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.