MUSCLE WEAKNESS

This early-phase study tests a new treatment called anitocabtagene autoleucel (anito-cel) for people with generalized myasthenia gravis, a condition that causes muscle weakness. Anito-cel is a type of CAR-T cell therapy that targets BCMA, a protein on certain immune cells. The st…

This study looks at whether taking creatine supplements helps breast cancer survivors get stronger and have more energy from exercise. About 60 women who finished chemotherapy in the last 6 months will do virtual exercise sessions. Some will take creatine, some won't, and researc…

This study looks at 40 adults having back surgery for a herniated disc that causes leg weakness. Researchers want to find out which factors before surgery (like age, weight, or how long the weakness lasted) affect how well strength returns. The goal is to better predict recovery,…

This study follows 209 adults who survived a stay in the intensive care unit (ICU) to understand why some never fully regain muscle strength. Researchers will measure physical function and look at muscle cells to find clues. The goal is to identify who is at risk for long-term di…

This study looks at why survivors of childhood acute lymphoblastic leukemia (ALL) often have weak muscles. Researchers will use MRI scans, ultrasound, and small muscle samples to compare survivors with healthy volunteers. The goal is to learn how cancer and its treatment affect m…

This study looks at how well a new robotic leg brace (exoskeleton) helps children and young adults with muscle weakness from conditions like cerebral palsy, muscular dystrophy, spina bifida, or spinal cord injury. Researchers will test the device during different activities like …

This study tests a new way to prescribe flywheel exercises for astronauts to prevent muscle loss and weakness during spaceflight. Researchers will monitor 16 healthy, active adults as they perform specific exercises, measuring muscle strength, size, and nerve function. The goal i…

This study looks at how losing weight affects the fat stored inside your muscles, called IMAT. Researchers want to see if this fat sends out signals that make your muscles less responsive to insulin, and if weight loss can quiet those signals. About 70 adults with obesity will fo…

This study looks at why some patients become very weak after being in the intensive care unit (ICU). Researchers will take blood and small muscle samples from 20 high-risk surgical patients to find chemical markers linked to this weakness. The goal is to better understand the pro…