Blood cell count may reveal who faces worst outcomes in rare autoimmune disease
NCT ID NCT05989399
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study examined whether the level of neutrophils, a type of white blood cell, in the blood can help predict how severe antisynthetase syndrome (ASyS) will be. ASyS is a rare autoimmune disease that can cause muscle inflammation, lung disease, and other symptoms. Researchers looked at data from 89 patients to see if a high neutrophil count at diagnosis was linked to more severe disease. The goal is to find a simple, widely available test to identify high-risk patients early.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to a simple blood test to identify which patients with antisynthetase syndrome are at risk for severe disease, helping doctors intervene earlier.
- What could go wrong
- This is a small, retrospective study that only looks back at existing data. The findings may not apply to all patients and need to be confirmed in larger, prospective trials.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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89 people
The number who actually took part.
- Started
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Jan 2024
- Finished
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Jan 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients with ASyS diagnosis between January 2010 and December 2022
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients with ASyS diagnosis according to Connors criteria Exclusion Criteria: * Active infection at ASyS diagnosis * Evolutive cancer at ASyS diagnosis * Corticosteroid therapy initiation before circulating neutrophils evaluation
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
CHU Nancy
Nancy, France
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Other studies related to the condition(s) this trial covers.
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