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New pain combo may help kids recover faster after chest surgery

NCT ID NCT07290582

Knowledge-focused Sponsor: Papa Giovanni XXIII Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 16, 2026 · Updated 3 times

Summary

This study looks at two ways to manage pain in children having the Nuss procedure for pectus excavatum (a sunken chest). One group received standard nerve freezing (cryoanalgesia) alone, while the other also had a nerve block near the diaphragm. Researchers will compare pain scores, opioid use, and how quickly children get back to walking, eating, and using the bathroom. The goal is to see if the combined approach offers better pain control and faster recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
phrenic nerve infiltration as cryoanalgesia adjuvant
What this could lead to
If successful, this could point toward a better pain management strategy for children undergoing pectus excavatum surgery, potentially reducing opioid use and speeding recovery.
What could go wrong
This is a small observational study (50 participants) that looks back at existing medical records, so it cannot prove cause and effect. The results may not apply to other hospitals or patient groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

50 people

The number who actually took part.

Started

Sep 2023

Finished

Sep 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adolescents and young adults with pectus excavatum undergoing the Nuss procedure for its correction

Ages

14 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients who undergo minimally invasive repair at the pediatric surgery department of our referral tertiary center Exclusion Criteria: * patients who refuse OR whose parents refuse to participate in the study

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Conditions

The condition(s) this trial relates to.

pectus excavatum respiratory paralysis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cryo analgesia Pectus excavatum Phrenic nerve-related diaphragmatic impairment

Contacts and locations

Locations

  • Sc Ricerca Clinica, Sviluppo E Innovazione

    Bergamo, BG, 24100, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.