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Supplements before fibroid surgery show promise in small study

NCT ID NCT06768086

Symptom relief Sponsor: Centro di Ricerca Clinica Salentino Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tested whether taking a combination of EGCG (from green tea), vitamin D, and D-chiro-inositol for three months before hysteroscopic myomectomy improves surgical outcomes. 90 women with uterine fibroids were divided into two groups: one received the supplements before surgery, the other did not. Researchers compared surgery time, fluid use, and how completely fibroids were removed.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Epigallocatechin gallate (EGCG), vitamin D, and D-chiro-inositol
What this could lead to
If it works, this could make hysteroscopic myomectomy faster and more complete for women with uterine fibroids.
What could go wrong
This is a small pilot study (90 participants) with no blinding or placebo, so results may not be reliable or generalizable. The supplements may not meaningfully improve surgery outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

90 people

The number who actually took part.

Started

Feb 2025

Finished

Nov 2025

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Women of reproductive age, in good health, without pathologies compromising general anesthesia and willing to participate in the study, on a voluntary basis. The decision about whether to pretreat patients medically or not, was twice: 1. patient' preference design. 2. if the patients were undecided, at the discretion of the staff physician, as was the choice of therapy.

Ages

30 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Clinical diagnosis of FIGO type 0 to 2 fibroids, with a diameter of 20 - 35 mm. Must be able to swallow tablets. Exclusion Criteria: Clinical diagnosis of polyps associated to FIGO type 0 to 2 fibroids. Non-hysteroscopic surgical procedures. The presence of more than 2 FIGO type 0 to 2 fibroids.

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Conditions

The condition(s) this trial relates to.

leiomyoma myofibroma Patient Compliance uterine corpus leiomyoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hysteroscopic myomectomy Patient compliance Treatment compliance Treatment complication Uterine fibroids

Contacts and locations

Locations

  • Ospedale Veris delli Ponti

    Scorrano, Lecce, 73020, Italy

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