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Dark chocolate compound may rescue muscle energy from statins

NCT ID NCT02490527

Disease control Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 31, 2026 · Last updated Jul 31, 2026

Summary

This trial tests whether epicatechin, a compound naturally found in dark chocolate, can counteract the muscle-related side effects caused by statins, a common cholesterol-lowering medication. Participants with statin intolerance will receive epicatechin or a placebo, and researchers will measure changes in exercise capacity and muscle energy production. The goal is to see if epicatechin can improve mitochondrial function and reduce the fatigue and weakness that some people experience with statins.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pure epicatechin capsules (50mg), a compound found in dark chocolate
What this could lead to
If epicatechin helps, it could offer a way to ease muscle-related side effects of statins, potentially helping people stick with cholesterol-lowering treatment.
What could go wrong
This is a small early-stage trial, so results may not apply broadly. Epicatechin might not reverse statin-induced muscle issues, and its long-term safety is not yet established.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

19 people

The number who actually took part.

Start date

Jun 2015

Finished

Jul 2021

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

30 to 75 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Patient Inclusion Criteria: * Must be between 30-75 years of age * LDL\>100mg/dL (or on drug treatment) * VO2 max greater than 25 ml/kg/min Patient Exclusion Criteria: * Liver or kidney disease * Currently taking drugs that interfere with statin metabolism * Currently taking blood thinners * Acute or chronic infectious disease; autoimmune/inflammatory disease, cancer, COPD, anemia, psychiatric illness, insulin-dependent diabetes * smokers or illicit drug users * adverse cardiovascular event (ex: heart attack) * history of knee surgery or active history of knee pain

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Conditions

The condition(s) this trial relates to.

Fatigue muscle tissue disorder Muscle Weakness Spasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Statin intolerance

Contacts and locations

Locations

  • University of California, San Diego

    La Jolla, California, 92093, United States