Ischemic stroke

This phase 3 trial tests whether adding a clot-busting drug (alteplase) directly into the brain artery during mechanical clot removal improves recovery for people with severe stroke. About 440 participants with large vessel blockages will be randomly assigned to receive the drug …

This study tests two different medicines given before a procedure to remove a blood clot from the brain in people having a major stroke. The goal is to see which medicine helps more people recover with little or no disability. About 800 adults who arrive at the hospital within 24…

This early-stage trial tests whether exosomes from stem cells can help people recover from a recent stroke. 29 participants will receive either the exosome treatment or a placebo, and researchers will check for safety and any signs of improved function. The study is small and exp…

This trial tests a virtual reality system called RGS that guides stroke survivors through reaching, grasping, and placing virtual objects to aid motor and cognitive recovery. The study enrolls adults who have had a first stroke with mild to moderate arm weakness. Participants use…

This trial tests whether pairing vagus nerve stimulation (VNS) with rehabilitation can improve arm function in people who have had an ischemic stroke. Participants receive an implanted VNS device and undergo weeks of therapy, with some receiving active stimulation and others a sh…

This trial tests whether a four-week course of electroacupuncture changes tongue appearance in people recovering from an ischemic stroke. Researchers will use an automated tongue imaging system to capture and analyze tongue color, shape, and coating before and after treatment. Th…

This trial tests whether a specific acupuncture technique, called Xingnao Kaiqiao (or 'Brain Awakening'), can improve arm movement in people recovering from a stroke. It compares this method to standard electroacupuncture. The study involves 66 adults aged 40-80 who had a stroke …

This study tests whether intensive visual retraining at home can help people who have lost part of their vision due to damage to the brain's visual cortex, often from a stroke. Participants will use a computer program to practice detecting motion and orientation of visual stimuli…

This trial explores whether combining hyperbaric oxygen therapy with moderate-intensity aerobic exercise can improve working memory in older adults who have mild cognitive impairment after a stroke. Participants, aged 65-85, will be randomly assigned to receive either this combin…

This study tests whether a very low blood pressure target (below 120 mmHg) can prevent major heart problems in people who have had a stroke or mini-stroke. About 4,300 participants are randomly assigned to either intensive or standard blood pressure control and followed for about…

This trial tests a device called Tigertriever 13 to treat distal ischemic strokes, where a blood clot blocks a small artery deep in the brain. About 168 patients with disabling symptoms will receive either the device or standard medical care within 24 hours of stroke onset. The g…

This trial tests whether giving the clot-busting drug alteplase directly into the brain artery, right after a mechanical thrombectomy has reopened a blocked vessel, can improve recovery from acute ischemic stroke. The study enrolls adults with large-vessel blockages in the front …

This trial tests whether a motor rehabilitation program using mixed reality games can improve postural stability (balance) in children and adults with neurological impairments, such as cerebral palsy, Parkinson's disease, multiple sclerosis, or stroke. Participants will be random…

This trial tests whether low-intensity focused ultrasound (LIFU) can safely stimulate the brain to help people recover arm and hand function after a stroke. Researchers will try different intensities and frequencies of ultrasound in stroke survivors to find the best settings that…

This trial tests whether giving a clot-busting drug called tenecteplase directly into the brain artery, right after a standard procedure to remove a clot, can help people who have had a severe ischemic stroke. The study includes adults aged 18-85 with a blocked artery in the fron…

This phase 3 trial investigates whether N-acetyl cysteine (NAC), an antioxidant supplement, can improve recovery in people hospitalized with an acute ischemic stroke. Participants receive either NAC or a placebo (saline) shortly after admission, and researchers track their neurol…

This study compared two medications, edaravone and sodium ozagrel, for treating acute ischemic stroke. Researchers wanted to see which drug helped more people recover with little or no disability three months after treatment. The study included 401 adults who started treatment wi…

This study tests a new biologic drug called redasemtide in 680 adults who have had an acute ischemic stroke. Participants receive either the drug or a placebo within 25 hours of their stroke. The goal is to see if redasemtide improves recovery and reduces disability at 90 days. T…

This trial investigates whether breathing high-dose oxygen (normobaric hyperoxia) for four hours, given together with standard clot-busting medication, can improve recovery in people having an acute ischemic stroke. The study enrolls adults who arrive at the hospital within 4.5 h…

This trial investigates whether the antibiotic minocycline can reduce brain injury in people with acute ischemic stroke who undergo mechanical thrombectomy (clot removal). Minocycline may protect the blood-brain barrier and limit damage from restored blood flow. The study enrolls…

This trial tests whether combining robotic gloves with task-oriented mirror therapy can improve hand motor function in people recovering from a stroke. Thirty sub-acute stroke patients will receive either the combined therapy or mirror therapy alone, alongside standard rehabilita…

This study compares two ways to perform carotid artery stenting—a procedure that opens narrowed neck arteries to prevent stroke. The standard method uses an artery in the groin, while the experimental method uses an artery in the wrist. Researchers will enroll 3000 adults with si…

This study tests whether a procedure to reopen a major blocked artery in the brain can help people who had a severe stroke 24 to 72 hours earlier. About 224 participants will either get the procedure plus standard care or standard care alone. The goal is to see if the procedure i…

This study tests whether combining two types of electrical stimulation can improve hand and arm movement in people who recently had a stroke. One stimulation is applied to the brain (tDCS) and the other to a nerve in the wrist. Participants receive five daily sessions, and their …

This study tested a drug called Edaravone (MCI-186) in 36 people who had an acute ischemic stroke. The goal was to check the drug's safety and how the body processes it. Participants received either Edaravone or a placebo through an IV over 72 hours. The trial was completed, but …

After a stroke, patients are at high risk of having another one, especially in the first 21 days. This study tests whether adding clopidogrel to the standard aspirin treatment is safe and feasible for preventing a second stroke. About 200 patients who had a mild to moderate strok…

This study tests whether a robotic hand device can improve grip strength and fine motor skills in people who had a stroke at least six months ago. Participants use the HWARD exoskeleton, which assists hand opening and closing, during 45-minute sessions three times a week for 12 w…

This study tested a new device called the Millipede System in 246 stroke patients with large blood clots in the brain. The device is designed to remove clots and restore blood flow. Researchers measured how often blood flow was successfully restored and tracked any side effects. …

This clinical trial tests whether adding the drug glenzocimab to standard endovascular therapy (a procedure to remove blood clots) improves recovery in people with acute ischemic stroke. The study includes adults aged 18 and older who are eligible for clot removal within 24 hours…

This trial tests whether an experimental drug called Y-3, given as an injection for 10 days, helps people recover better after an acute ischemic stroke. The study includes Chinese adults who had a stroke within the past 48 hours and have moderate to severe symptoms. Participants …

This study tests whether infusing cold saline directly into the brain during emergency clot removal can improve recovery after a severe stroke. About 258 adults aged 18 to 80 with a large-vessel blockage in the front part of the brain will be randomly assigned to receive either s…

This study tests whether adding a traditional Chinese herbal decoction (Buyang Huanwu Decoction combined with Wuling Powder) to standard stroke care helps people recover better after an acute ischemic stroke. Participants receive either standard care alone or standard care plus t…

This study tests a device called the Penumbra System with Thunderbolt Aspiration Tubing to remove blood clots in people having a severe stroke caused by a blockage in a large brain artery. The goal is to see if the device can safely and effectively restore blood flow within 8 hou…

This study tests whether a smart bracelet system can help hospitals treat stroke patients faster. The bracelets track where patients are in the emergency room and send alerts if treatment is delayed. The goal is to shorten the time between arrival and life-saving clot-busting the…

This phase 2 trial tested a new gel called OTR4132 in 60 people who had a stroke and received a clot-removal procedure. The gel is designed to help repair damaged brain tissue. Researchers measured neurological function at 24 hours and disability at 3 months to see if the gel imp…

This study looked at how well a mechanical device works to remove blood clots from the brain during a stroke. Researchers followed 230 adults who had a stroke within the previous 8 hours and received the procedure. The goal was to see if the treatment helps patients recover and r…

This study tested whether Mongolian medicine ZhenBao Pills help people recover arm function after an ischemic stroke. 216 adults who had a stroke within the past 30 days took either the pills or a placebo twice daily for 90 days. The main goal was to see if arm movement improved …

This study tests whether using a blood test to guide antiplatelet medication can reduce the risk of a second stroke. People who have had a non-cardioembolic ischemic stroke and are already taking aspirin will be assigned to either continue standard aspirin or switch to a differen…

This study tested a soft robotic sock called VACOM in 19 stroke patients who had trouble moving their ankle. The sock gently moves the ankle to prevent stiffness and improve blood flow, aiming to reduce the risk of blood clots and contractures. The trial is complete, but results …

This study tested whether giving a powerful cholesterol-lowering drug (evolocumab) along with standard statins within 48 hours of a stroke could prevent early neurological decline. It included 429 adults with moderate to severe narrowing of brain arteries. The goal was to see if …

This study looked at whether a therapeutic education program, added to standard medical care, helps people who have had a heart attack or stroke better control their risk factors over one year. About 202 adults aged 18-75 took part. The goal was to see if the program improves phy…

This study tested whether the drug rivaroxaban works as well as warfarin to prevent further brain damage in people who have had a stroke due to antiphospholipid syndrome (APS), a condition that causes abnormal blood clotting. About 40 participants took either rivaroxaban or warfa…

This completed study tested a new device called the Supernova stent retriever in 55 people with severe stroke caused by a large blood clot in the brain. The device is threaded through blood vessels to grab and remove the clot, restoring blood flow. Researchers measured how often …

This study tested a new way of caring for stroke patients that brings together doctors, nurses, and family members using technology and teamwork. About 1,200 adults who had a stroke took part. The goal was to see if this coordinated care helps people recover better and have a hig…

This study looked at whether a procedure to remove a blood clot from the brain (endovascular therapy) works better than medication alone for people with mild stroke symptoms and a visible clot. About 4,800 adults with mild stroke were included. The goal was to see which approach …

This study tested whether adding dornase alfa (a drug used for cystic fibrosis) to standard clot-busting treatment could improve blood flow before a clot removal procedure in people having a major stroke. 330 adults with acute ischemic stroke and a large vessel blockage were enro…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested whether a 40-hour, 8-week cognitive telerehabilitation program could reduce the risk of memory and thinking problems after a stroke. 86 adults who recently had a stroke were randomly assigned to either the home-based brain training or standard care. The program …

This pilot study tested whether low-frequency magnetic stimulation (rTMS) applied to the brain within 48 hours of an acute ischemic stroke could reduce the growth of damaged tissue and lower disability. Sixty adults aged 18–80 with moderate to severe strokes were enrolled. The tr…

This study tested whether low-frequency magnetic brain stimulation (rTMS) can improve recovery in 60 people who had a severe stroke and received emergency treatment to reopen blocked arteries. Participants received either real or sham stimulation for 3 days after their procedure.…

This study tested two blood thinners—tirofiban and aspirin—in 240 stroke patients who also had a severe blockage in the neck artery. The goal was to see which drug better prevents the artery from reclosing after emergency surgery, while also checking for bleeding risks. Results w…

This study tested a new medical wire, called the Tarvos Microguidewire, used during surgery on blood vessels in the brain. The wire helps doctors guide other tools to the right spot. Researchers looked back at records of 121 patients who had this wire used in their surgery for co…

This study tested whether giving heparin (a blood thinner) during brain angiography can prevent the radial artery in the wrist from becoming blocked afterward. The trial involved 440 acute stroke patients and compared heparin to a placebo. The goal was to see if heparin reduces a…

This study tested whether adding sodium sivelestat, a drug that reduces inflammation, to standard mechanical thrombectomy could improve outcomes in 20 stroke patients with large vessel occlusion. The drug aims to prevent 'futile recanalization,' where blood flow is restored but p…

This early study tested a new device that cools the brain in 8 people who had a stroke caused by a large blood clot. After doctors removed the clot, the device cooled the brain for 30 minutes to try to protect it from further damage. The main goal was to see if the cooling was sa…

This study tested whether using a special tongue brush (Orabrush) can lower the chance of aspiration pneumonia and improve swallowing in people who had a stroke. Researchers enrolled 252 stroke patients and compared those who used the brush to those who did not. The goal was to s…

This study tested whether using a balloon-guided catheter helps doctors remove blood clots more effectively in people having a stroke. 110 adults with acute ischemic stroke were randomly assigned to receive clot removal with either a balloon-guided or standard catheter. The main …

This study tested whether giving the blood-thinning drug tirofiban after mechanical clot removal improves outcomes for people with severe stroke. Over 1,300 participants were randomly assigned to receive tirofiban or a placebo. The goal was to see if more patients could live inde…

This completed trial tested a new stent (SINOMED SR) for removing blood clots in 218 people with acute ischemic stroke. The stent was used within 24 hours of symptom onset. The main goal was to see if the stent could successfully reopen blocked brain arteries. Researchers also tr…

This study tested an experimental drug called SCP776 in 120 adults having emergency surgery to remove a blood clot after a severe stroke. The goal was to see if the drug is safe and helps protect the brain from further damage. Participants received either the drug or a placebo, a…

This study tested whether giving N-Acetylcysteine (NAC) intravenously soon after an acute ischemic stroke could improve outcomes. Only 4 adults with moderate to severe stroke were enrolled. Researchers measured stroke severity and disability at 30 and 90 days. The trial is comple…

This early-stage study tested whether a single intravenous infusion of stem cells from human umbilical cord tissue is safe for people who had an ischemic stroke 3 to 6 months earlier. 18 participants were monitored for side effects and any improvement in daily function. The goal …

This phase 3 trial tested whether giving a clot-dissolving drug called tenecteplase directly into the brain artery can improve blood flow in stroke patients who still have blockages after standard mechanical clot removal. 156 adults with acute ischemic stroke were randomly assign…

This study tested a brain-computer interface (BCI) combined with functional electrical stimulation (FES) to help stroke survivors with foot weakness walk better. 62 adults who had a stroke at least 6 months prior and had trouble walking participated. The therapy used brain signal…

This study tested a program to help people with heart disease, stroke, or heart failure in India. The program used non-physician health workers, text messages about healthy living, and a computer tool to help doctors make decisions. 410 adults took part to see if the program impr…

This Phase IIa trial tested a single dose of LT3001, a new drug, in 24 people who had an acute ischemic stroke within the past 24 hours. The main goal was to see if the drug causes dangerous bleeding in the brain compared to a placebo. Researchers also looked for early signs that…

This study compares two ways to remove large blood clots from the brain during a stroke: direct aspiration (ADAPT) and using a stent retriever. About 381 adults with stroke caused by a blocked artery in the front part of the brain took part. The goal is to see which method clears…

This study tested whether giving two blood thinners (ticagrelor and aspirin) early, along with standard clot-busting treatment, helps people recover better after a stroke. Over 1,300 patients with mild to moderate stroke were treated within 6 hours of symptoms. The goal was to se…

This study tested whether a drug called dornase alfa (Pulmozyme) can help restore full blood flow to the brain after a stroke. The trial included 39 people who had a stroke and were already receiving standard clot-busting medication and a mechanical clot removal procedure. The go…

This study tested whether using a bronchoscope (a thin tube with a camera) to clean the lungs could help people who develop pneumonia and swallowing problems after a stroke. 50 patients were split into two groups: one received standard care, and the other also got 1-2 bronchoscop…

This Phase 2 trial tested the safety of an experimental drug called RNS60 in 83 people having a severe stroke caused by a large blood clot. Participants received either RNS60 or a placebo as a 48-hour infusion, starting within 30 minutes of consent. The main goal was to check for…

This study tested a clot-dissolving medicine called alteplase in 58 people who had a stroke caused by a blocked artery. The goal was to see how well it reopened blocked brain arteries and improved patients' ability to function three months later. The results were compared to exis…

This study tested a lower dose (0.6 mg/kg) of the clot-busting drug alteplase in 103 Japanese patients who had a stroke within the previous 3 hours. The goal was to see if this dose was both safe and effective for this population. Results focused on how many patients had little t…

This study tested whether adding Mexidol to standard stroke care helps people recover better after a first ischemic stroke. 304 adults who had a stroke within 48 hours were given either Mexidol or a placebo for about 10 weeks. Researchers measured disability, neurological symptom…

This Phase 2 trial tested a drug called LT3001 in 89 people who had an acute ischemic stroke. Participants received either the drug or a placebo within 24 hours of their stroke. The study found no serious drug-related side effects, suggesting LT3001 is safe. Researchers are now l…

This Phase 2 trial tested an experimental drug called elezanumab in 121 people who had an acute ischemic stroke. The goal was to see if it could safely improve neurological function and reduce disability compared to a placebo. Participants received the drug or placebo by IV withi…

This study tested a technique called ischemic postconditioning in 60 stroke patients who already had a procedure to remove a clot. After the clot was removed, doctors briefly stopped and restarted blood flow in the affected artery four times. The goal was to see if this extra ste…

This study tested a new medicine called MLC1501 to help people recover after a stroke. 303 adults who had a stroke within the past 2 to 10 days took either a high dose, low dose, or a placebo pill twice a day for 24 weeks. The main goal was to see if MLC1501 improves motor functi…

This study tested whether Enhanced External Counterpulsation (EECP) therapy, a non-invasive treatment using leg cuffs to boost blood flow, can improve brain circulation in people with severe narrowing of key brain arteries. The 130 participants had recently experienced a stroke o…

This study tested a clot-dissolving drug called non-immunogenic staphylokinase in over 23,000 adults who had an acute ischemic stroke within the last 4.5 hours. The goal was to see how safe and effective the drug is in everyday hospital practice. Researchers measured how many pat…

This study tested whether a clot-busting drug called rhTNK-tPA can help people having a stroke when given 4.5 to 24 hours after symptoms begin. It included 570 adults with a stroke that did not involve a large blocked artery. The goal was to see if the drug leads to better recove…

This study looked at 260 people having emergency stroke treatment to remove a clot. Some were given sedation (awake but relaxed) and others were put under general anesthesia (completely asleep). The goal was to see which approach leads to better recovery and fewer complications a…

This phase 3 trial tested a drug called tenecteplase in 452 people with a severe type of stroke caused by a blockage in the basilar artery at the back of the brain. Participants received either tenecteplase or the current best treatment (which could include another clot-buster or…

This study tested a procedure called rapid local ischemic postconditioning in 25 people who had a stroke and successful clot removal. Right after reopening the blocked artery, doctors briefly inflated and deflated a balloon in the neck to temporarily stop blood flow, aiming to he…

This study looked at 391 people with a type of stroke caused by a blockage in a major brain artery, treated 4.5 to 24 hours after symptoms started. Half got a clot-busting drug called tenecteplase followed by a mechanical clot removal procedure, while the other half had the proce…

This study looked at 345 people with a severe stroke caused by a blockage in the basilar artery, a major blood vessel in the brain. It compared two treatments: giving a clot-busting drug followed by a procedure to remove the clot, versus doing the procedure alone. The goal was to…

This study looked at whether a medication called Renexin CR can help people who have had a certain type of stroke (non-cardioembolic ischemic stroke) within the last 72 hours. The goal was to see if it reduces the chance of getting worse in the hospital or having another stroke w…

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below …

This study tested whether lying in a head-down position (10 degrees) after successful stroke treatment improves recovery. 90 adults with large-vessel stroke were randomly assigned to head-down or standard care. Researchers measured changes in stroke severity and functional outcom…

This early-stage study tested a drug called PP-007 in 24 people having an acute ischemic stroke. The drug is designed to carry oxygen to the brain. Researchers checked if adding it to standard treatments like clot-busting drugs or clot removal was safe. The goal was to see how th…

This study tested a new drug called SHPL-49 in 270 people who had an acute ischemic stroke. Participants received either the drug or a placebo as an IV infusion twice daily for 7 days. The goal was to see if the drug helps improve recovery and is safe to use.

This study tested a new medicine called HRS-7450 in 64 adults who had a stroke within the past 4.5 to 24 hours. The goal was to check if the drug is safe and might help restore blood flow to the brain. Researchers monitored for bleeding and other side effects to see if the treatm…

This completed study tested a new device designed to remove blood clots from the brain in people having a severe stroke. Eight patients were treated within 8 hours of symptoms starting. Researchers measured how well the device restored blood flow and tracked any serious side effe…

This study tested whether trimetazidine, a drug usually used for heart conditions, can improve outcomes in people who had an acute ischemic stroke. 60 adults were enrolled within 6-12 hours of their stroke. Researchers measured inflammation levels, stroke severity, and disability…

Researchers are testing whether a bedside ultrasound of the eye can help emergency doctors tell ischemic stroke (caused by a clot) from hemorrhagic stroke (caused by bleeding). The team measures the optic nerve sheath diameter, a marker linked to pressure inside the skull, in adu…

This study tests whether smartwatches can detect atrial fibrillation (AF) in people who recently had a stroke. Participants already have an implanted heart monitor (the gold standard) and will also wear a smartwatch for 12 weeks. The goal is to see how well the smartwatch catches…

This trial evaluates the safety and feasibility of a portable, low-field MRI device called Axana for imaging the brain in people with suspected stroke. Researchers will compare scans from the Axana device with standard hospital MRI scans in 60 adults, including healthy volunteers…

This trial tests whether a wearable patch called MEMO Patch V2 can detect heart rhythm disorders (arrhythmias) more effectively than the standard 24-hour Holter monitor. Adults with symptoms like palpitations or dizziness, or those who have had a stroke of unknown cause, will wea…

This study tested a new imaging method to detect inflammation in fatty plaques that cause strokes. It involved 3 men who had a recent stroke and were scheduled for surgery to remove a plaque in their neck artery. The goal was to see if a special PET scan tracer could highlight in…

This study looked at whether measuring two proteins in the blood (GST-π and PRDX1) can accurately determine if a stroke occurred within the last 4.5 hours. That time window is critical because it determines if patients can receive clot-busting medication. Researchers enrolled 935…

This pilot study tested whether a quick, 20-second ultrasound of the brain's blood vessels could help paramedics identify patients with a severe stroke caused by a large blocked artery. The study included 60 participants: healthy volunteers and suspected stroke patients. Research…

This study tested whether a special CT scan done in the procedure room can accurately detect bleeding in the brain of stroke patients. The goal is to speed up diagnosis and treatment by avoiding extra trips to the regular CT scanner. 252 adults with stroke symptoms were enrolled …

This study looked at whether a special type of CT scan (dual-energy CT) can more accurately tell the difference between bleeding and harmless contrast dye in the brains of stroke patients after treatment. About 189 adults who had a stroke and received clot-busting drugs or a clot…

This study tested a device called NIRSITX that uses light to measure oxygen levels in the brain. Researchers compared oxygen readings from the injured side of the brain to the healthy side in 35 adults who had a stroke within the past week. The goal was to see if the device could…

This study combined data from nearly 4,000 stroke patients to see how often a heart CT scan finds blood clots that standard ultrasound might miss. Researchers looked at how well this quick scan, done during the initial stroke workup, detects clot sources in the heart. The goal is…

This study looked at whether a panel of blood biomarkers can quickly identify stroke patients who have a large vessel occlusion (a major blockage) and would benefit from a specialized clot-removal procedure. Researchers enrolled nearly 3,900 adults with stroke symptoms and tested…

This study tested a drug called conestat alfa in 141 people undergoing a minimally invasive heart valve replacement (TAVI) for severe aortic stenosis. The goal was to see if the drug could reduce the risk of small strokes and kidney damage that can happen after the procedure. Par…

This study tested a new daily pill called asundexian in over 12,000 people who recently had a stroke or mini-stroke caused by a blood clot from outside the heart. The goal was to see if adding asundexian to standard antiplatelet therapy could prevent another stroke without increa…

Researchers in Finland are testing a web-based neuropsychological rehabilitation program for adults who have recently had an acquired brain injury from causes such as stroke, encephalitis, or trauma. The program, called the iRENE Digital Pathway, uses online sessions and question…

Researchers are testing an experimental oral drug called XY03-EA in adults who have just had an acute ischemic stroke. The trial compares several doses of the drug with a placebo to see whether it improves recovery and reduces disability. About 360 participants receive treatment …

This study tests whether pairing a mild electrical stimulation to the ear with arm exercises can improve motor recovery in people who had a stroke at least six months ago. Participants will do task-specific training at home three times a week for two weeks, with the ear stimulati…

This study will test if a low-intensity leg workout using blood flow restriction cuffs can improve strength and balance in stroke survivors as well as traditional high-intensity exercises. Eighty people who had an ischemic stroke 3 to 12 months ago will take part. The goal is to …

This study tests whether applying vibration to a specific muscle or the whole arm can reduce spasticity (stiffness) and improve arm control in people who had a stroke 3 to 6 months ago. Fifty-four participants will receive either focal muscle vibration or whole upper limb vibrati…

This study tests whether health education videos redesigned using semiotics—the science of signs and symbols—can help stroke survivors improve daily activities, sleep, anxiety, and depression. Two hundred stroke patients will be randomly assigned to watch either these optimized v…

This study tests whether balance exercises that challenge the senses (like closing eyes or standing on uneven surfaces) can improve balance and reduce fall risk in people who had a stroke over 6 months ago. 46 participants will be split into two groups: one doing these special ex…

This study tested whether fast arm movement training helps people who had a stroke regain arm function better than standard accuracy training. 44 chronic stroke survivors with mild to moderate arm weakness participated. The training focused on moving quickly, and researchers meas…

This pilot study tests a home-based rehabilitation program called TASSRET for stroke survivors who have limited access to physiotherapy. Fifty participants will use either a video or a manual guide to practice specific tasks aimed at improving arm and leg function, balance, and q…

This study tested whether adding augmented cues—like visual and auditory feedback from a sensor-based glove—to standard physical therapy could improve hand function in people recovering from a stroke. Fifty patients with subacute ischemic stroke were randomly assigned to receive …

This study tested a treatment that shines a laser light inside a vein to help people recover after an ischemic stroke. 22 adults with mild to moderate stroke symptoms received the laser therapy. Researchers measured their disability and stroke symptoms before treatment, and again…

This study looked at whether giving a sour liquid early on can improve swallowing function in people who have trouble swallowing after a stroke. Researchers worked with 95 patients who had an acute ischemic stroke and developed dysphagia. They measured swallowing ability at the s…

This study tested whether task-oriented gait training combined with core stabilization exercises can improve mobility, balance, and walking in people who had a stroke. Fifty-four adults aged 45-75 with left-side weakness took part in an 8-week program. The goal was to see if thes…

This study tested whether a 24-session program of functional electrical stimulation (FES) on the tibial nerve could improve walking in people who had a stroke more than a year ago. Fifteen participants with chronic stroke and leg weakness were enrolled. The main goal was to see i…

This study looked at whether electroacupuncture (a type of acupuncture with mild electric pulses) can lower inflammation and help people recover after a stroke. 17 adults who had their first ischemic stroke took part. Researchers measured changes in symptoms and blood markers to …

This study tested whether a chin tuck against resistance (CTAR) exercise can improve swallowing in stroke patients with dysphagia. 112 participants did the exercise daily for two weeks alongside standard rehab. Researchers measured swallowing ability with a water test and a quali…

This completed trial looked at how two different feeding tubes affect the mental health of 156 stroke patients with swallowing problems. One group used a standard nasogastric tube, the other an intermittent oro-esophageal tube. Researchers measured anxiety, depression, and feelin…

This study tested whether chewing real food (like candies and dumplings) before meals can improve swallowing and quality of life in stroke patients who have trouble swallowing. 120 patients were split into two groups: both got standard rehab and tube feeding, but one group also c…

This study tested a simple, non-invasive procedure called ischemic conditioning in 132 chronic stroke survivors. The procedure involves inflating a blood pressure cuff on the affected leg to briefly stop blood flow, then releasing it, repeated several times. Researchers measured …

This study tested whether vibration training can help people who recently had a stroke improve leg muscle strength, daily function, and mood. 148 patients took part. The approach uses whole-body vibration to stimulate muscles, aiming to speed recovery after a stroke.

This study tested a new program called CATCHES for people who had a stroke and are afraid of falling. The program combines physical therapy at home with coaching to reduce fear. 30 adults who had a mild to moderate stroke took part. The goal was to see if the program is practical…

This study tested two methods to help people regain arm movement after a stroke: looking at a mirror to trick the brain, or using a robotic hand glove that mimics the healthy arm. Thirty adults who had a stroke within the past year took part. Both groups also received standard ph…

This study tested whether adding a drug called Cytoflavin to standard physical rehab helps stroke survivors recover better. Cytoflavin is an antioxidant that may protect brain cells and improve learning of new skills. The trial involved 240 adults aged 40-80 who had a stroke 2 we…

This study tested a non-invasive brain stimulation technique called continuous theta-burst stimulation (cTBS) in 60 people who had a stroke within the past two weeks and had moderate to severe arm weakness. The stimulation was guided by brain scans to target areas involved in mov…

This study looked at whether starting more frequent or intense physical therapy within the first day after a stroke helps patients regain movement and balance. 102 adults with acute stroke were split into groups receiving standard care, more sessions, harder exercises, or both. R…

This study looked at whether listening to self-chosen Italian music during and after a stroke hospital stay can improve mood, reduce anxiety and depression, and boost overall well-being. 150 stroke patients were randomly assigned to either regular music listening or standard care…

This study tested whether combining a drug called galantamine with a specific cognitive training program could improve thinking skills in adults aged 35-70 who had a first stroke 3 months earlier. 47 participants received either the drug or a placebo, plus brain training, and wer…

This study tested whether a gentle electrical current applied to the scalp (tES) can improve movement and thinking in people who had a stroke. Sixty adults who had a stroke between 2 weeks and 2 years ago received real or fake stimulation while doing physical therapy. Researchers…

This study tested whether adding vibration therapy to standard rehabilitation could improve leg muscle strength, daily function, and emotional well-being in people who recently had a stroke. 115 hospitalized patients were randomly assigned to receive either standard care alone, s…

This study tested whether adding art therapy to standard speech rehab could help people who recently had a stroke and now have trouble speaking (aphasia). Fifteen participants received 12 art therapy sessions alongside their usual therapy. Researchers used brain scans to see if a…

This study tested a therapy called cognitive multi-sensory rehabilitation (CMR) in 40 people who had a stroke 6 to 18 months earlier. The therapy uses movement awareness and discrimination exercises to help the brain and arm work together. Participants received 12 sessions over f…

This study tested whether playing special rehabilitative games (SmartPose) could help stroke survivors recover arm and hand function. 34 people who had an ischemic stroke took part. One group did standard therapy plus SmartPose games, while the other did only standard therapy. Th…

This study tested whether adding mirror therapy to Botox injections can better reduce arm spasticity in stroke survivors. Thirty patients who had a stroke at least three months earlier received Botox injections and then either mirror therapy or a sham treatment. Researchers measu…

This study tested whether training one leg at a time on a treadmill improves walking and balance in stroke survivors more than standard two-legged training. 63 people who had an ischemic stroke at least 3 months prior took part. They did either unilateral step training, rhythmic …

This study tested whether kinesio taping (a special elastic tape placed on the skin) can improve arm and hand function, reduce pain, and boost mood in people who recently had a stroke. 26 adults with arm weakness were randomly assigned to get either real kinesio taping or a fake …

This study tested whether a robotic device called Luna EMG, which uses muscle signals to assist movement, can improve walking and balance in people recovering from a stroke. 62 older adults with leg weakness after a stroke were randomly assigned to get either robotic training plu…

This study looked at 34 adults with acute ischemic stroke and very high blood pressure. Researchers compared two drugs, nicardipine and labetalol, to see which one lowered blood pressure faster before stroke treatment. The goal was to find the best way to quickly and safely get b…

This study tested whether giving a very high dose of lovastatin (a common cholesterol drug) for 3 days after a stroke is safe. 162 stroke patients received either the high-dose drug or a placebo within 24 hours of symptoms. The main goal was to check for liver or muscle damage, w…

This study looked at whether giving the drug butylphthalide earlier (within 3 hours of a stroke) helps patients recover better than giving it later (3-6 hours). The trial involved 204 adults with acute ischemic stroke. Researchers measured recovery using standard disability and n…

This study looked at whether starting gentle exercise soon after a stroke helps patients regain daily living skills, feel less anxious or depressed, and improve their quality of life. 102 adults with acute stroke took part. The results suggest early mobilization may support both …

This study tested whether adding a gentle brain stimulation technique (tDCS) to physical therapy could improve walking, balance, and leg strength in people who had a stroke. 34 adults with sub-acute or chronic stroke participated. The goal was to see if this combination helps the…

This study tested whether a brain-computer interface (BCI) system could help stroke survivors recover arm function. 84 participants with arm weakness after a stroke used the BCI to control muscle stimulation with their brain signals. The study measured improvements in arm movemen…

This study looked at ways to help people who had a stroke use a CPAP machine for sleep apnea during their rehab stay. Sleep apnea is common after stroke and can slow recovery. The researchers tested different approaches to improve how often patients used the CPAP machine over thr…

This study tested whether a non-invasive brain stimulation technique called tDCS, combined with balance and walking exercises, could help stroke survivors improve their mobility and thinking. Thirty adults who had a stroke participated. The results suggest tDCS may enhance rehabi…

Some people develop an irregular heartbeat called atrial fibrillation after a stroke or mini-stroke. Researchers want to understand what causes this by comparing nerve function, inflammation, and heart rate patterns in three groups: patients with this post-stroke irregular heartb…

This study tests two leg devices—the geko® nerve stimulator and an intermittent pneumatic compression (IPC) sleeve—to see if they increase blood flow to the brain in people who recently had an ischemic stroke. Eighty adults within 36 hours of stroke onset will use one of the devi…

This study is observing tiny energy-producing parts of cells, called mitochondria, in the spinal fluid of people who have had a stroke or have Alzheimer's disease. Researchers want to see if these markers relate to how well patients recover after a stroke. The study does not give…

This study follows 140 working-age stroke survivors in France to find out what factors help or hinder their return to work. Researchers will look at medical details, personal beliefs, and job-related issues. The goal is to create better support plans for people recovering from a …

This study looked at how fast treadmill walking, with or without a small electrical stimulation to the ankle muscles, helps people who have had a stroke walk better. Fifty-five participants who were at least six months past their stroke took part. The goal was to understand the b…

Researchers are studying blood samples from people who have had a stroke to understand how blood clotting and inflammation affect recovery. They will take samples at several time points during the first week and measure markers of coagulation and inflammation. The goal is to see …

This trial is testing whether an artificial intelligence (AI) tool can accurately predict how patients with acute ischemic stroke will recover. The AI analyzes patient data in real time to forecast outcomes, such as functional disability, which is then compared with the actual ou…

This study tests whether a specialized training program called off-script diagnosis and differential diagnosis (D&D) training can improve neurology residents' ability to diagnose and manage acute ischemic stroke. The training focuses on structured analysis of stroke causes, mimic…

This study aims to understand if COVID-19 vaccines have any impact on brain health in healthy people. Researchers will use MRI scans to look for changes in the brain's blood vessels and structure. The study will follow 500 adults from Hong Kong who have already had a baseline bra…

This study investigates whether inflammation and stress compounds in the blood are linked to depression after a stroke. Researchers measure inflammatory markers and stress hormones in blood samples from 25 adults who have had an acute ischemic stroke. Participants also complete d…

This observational study investigates fear of falling in adults who have had a stroke. Researchers will assess motor, cognitive, and psychological factors to understand what contributes to this fear. The goal is to help clinicians design better, more personalized rehabilitation s…

This study looks at how certain immune cells (neutrophils) behave in people having a severe stroke. Researchers want to find the best time and target for treatments that block these cells. 440 adults having emergency stroke treatment will give blood samples and have their recover…

This study tests a tablet- and smartphone-based system designed to help ICU staff decide when and how to safely start moving patients with severe brain injuries. The system checks safety factors and suggests mobility levels, from simple stretches to walking. Researchers will see …

This study tested whether a video call between paramedics and a stroke specialist can help decide the right treatment—like clot-busting drugs or clot removal—before the patient arrives at the hospital. About 215 adults with suspected stroke took part. The goal was to see if remot…

This completed study looked at 140 stroke patients to understand what affects how long they stay in the hospital for rehabilitation. Researchers measured things like functional independence, balance, mental state, and depression in both patients and caregivers. The goal is to hel…

This study tested a new, powerful MRI scan on 56 stroke patients to see if it could detect subtle brain damage not visible on standard scans. The goal was to better understand how much brain tissue is truly saved after treatment. The findings could help doctors predict recovery m…

This study tested whether daily mood check-ins via a mobile app could help predict and prevent depression in people who recently had a stroke. Over 400 participants used the app for three months while researchers tracked their emotional symptoms. The goal was to see if this kind …

This study tested a 4-hour head ultrasound (transcranial-holter) to detect tiny blood clots in people who recently had a stroke. The goal was to see if this test could help doctors find the exact cause of the stroke, which is important for choosing the right treatment to prevent …

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This completed study looked at 192 adults with acute ischemic stroke to see if large swings in blood sugar (glycemic variability) are linked to worse outcomes, including death and disability. Participants wore a continuous glucose monitor for 96 hours. The goal was to understand …

This study tested a tool called the TriAGE+ score to see how well it predicts stroke risk in 818 emergency room patients with dizziness. Dizziness can be a sign of a stroke, but it is often missed. The goal was to check if the score is safe and reliable for use in busy ERs to hel…

This study looked at 38 people who had a first stroke in the cerebellum, a brain area involved in mood. Researchers used interviews and smartphone tracking to measure depression, anxiety, and apathy in daily life. The goal was to better understand how these mood problems develop …

This completed study followed 550 people who had a stroke within the last 48 hours. Researchers wanted to understand why some patients recover better than others by looking at their medical history, lifestyle, and blood markers. The goal is to find out what factors protect the br…

This pilot study tested a web-based tool designed to improve communication and decision-making between doctors and families of patients with severe acute brain injuries, such as stroke or traumatic brain injury. The tool helps prepare families for their role as decision-makers an…

This study adapted several questionnaires that measure arm and hand function after a stroke into Polish, and checked how reliable and accurate they are. One hundred people who had an ischemic stroke at least six months ago took part. The goal was to give Polish-speaking patients …

This early-stage study tested the safety and tolerability of a new drug called HRS-8829 in 83 healthy adults aged 18 to 55. The drug is being developed for acute ischemic stroke. Participants received either the drug or a placebo, and researchers monitored side effects and how th…

This study tested a new ultrasound technique called ultrasound localization microscopy (ULM) to see very small arteries in the brain. Researchers used it on 24 people who had a stroke or Moya Moya disease. The goal was to see if ULM could find more tiny arteries than standard MRI…

This study looked at 481 stroke patients who had a procedure to remove a blood clot from their brain. Researchers compared those who received general anesthesia (fully asleep) versus sedation (awake but relaxed). They tracked death rates and recovery to see if one method was bett…

This study looked at 455 stroke patients to see if a continuous finger blood pressure monitor (Clearsight) or standard arm cuff measurements better predict brain bleeding after clot removal. Each patient had both methods used within 24 hours after treatment. The goal was to see w…

This early study tested whether breathing short bursts of low oxygen (like being on a tall mountain) is safe for people who had a stroke. The idea is that this might trigger the brain to release proteins that help it recover. 16 stroke survivors took part, and the main goal was t…

This study tested whether a special type of MRI, called high-resolution vessel wall imaging, can help predict if a stroke will happen again in people with a narrowed brain artery. Researchers followed 74 patients who had a stroke or mini-stroke and received artery-opening treatme…

This study tested whether a special MRI scan called IVIM can predict how well people recover three months after an acute ischemic stroke. Researchers added a two-minute scan to the standard MRI for 274 adults admitted with stroke. They then compared the scan results to the patien…

This study looked at 174 adults who had a stroke and were treated under general anesthesia. Researchers compared removing the breathing tube early versus later to see which approach leads to better functional recovery after 90 days. The goal is to find the best time to take patie…

This study tested whether raising the legs (elevated leg positioning) is safe and practical for people who have had a moderate ischemic stroke. Fifty adults with moderate stroke symptoms were enrolled within 24 hours of symptom onset. The goal was to see if this simple, non-drug …

This study observed how breathing machines (mechanical ventilation) are used in 2,299 brain-injured patients in intensive care units worldwide. Researchers collected data on different ventilation strategies and their link to patient recovery. No new treatments were tested; the go…

This study tested whether telephone interviews after a stroke can help patients better understand and follow their medication plans. 54 adults who had an ischemic stroke and were returning home received a pharmaceutical interview before discharge, followed by phone calls at one w…

This study measured levels of a brain protein called BDNF in 50 stroke patients who received a clot-busting drug. Researchers wanted to see if BDNF levels rise after treatment and if they could help predict recovery of movement, thinking, and mood three months later. The goal is …

This study looked at 1499 people who had an acute ischemic stroke and got a chest CT within 24 hours. Researchers wanted to see if combining CT findings with clinical signs and inflammation markers could better predict who would develop pneumonia within a week. They built and tes…

This small pilot study explored whether advanced heart imaging can detect hidden strokes in people who have never had atrial fibrillation but are at high risk due to conditions like diabetes or heart failure. Researchers used brain MRIs to find silent, symptom-free strokes and li…

This Phase 1 trial tested the safety of LT3001, a potential clot-busting drug for acute ischemic stroke, in 65 healthy adults. Participants received multiple doses of LT3001 alone or with common stroke medications like aspirin and clopidogrel. The goal was to check for side effec…

This study tested whether intensive treadmill training with a harness to support body weight can improve walking and balance in people who recently had a stroke. Forty participants in the subacute phase (2-6 weeks after stroke) completed a 3-week program. Researchers also measure…

This first-in-human study tested a new smart guidewire (Clotild®) in 45 stroke patients undergoing emergency clot removal. The wire helps guide the removal tool and also measures the clot's electrical properties to determine its composition. The main goal was to check safety, suc…

This study looked at over 2,400 stroke patients who received clot-busting drugs (alteplase or tenecteplase) within 4.5 hours of symptoms. Researchers wanted to see if adding Shuxuetong injection, a traditional Chinese medicine, could improve recovery and reduce disability. The go…

This study looked at how small blood vessels in the brain change after a stroke caused by small vessel disease. Researchers used a special 3D X-ray technique to take detailed pictures of these vessels. The goal was to learn more about the disease process, which could help doctors…

This study looked at 91 Chinese patients with atrial fibrillation who had a stroke while taking blood thinners (NOACs). The goal was to understand why these strokes happen and whether not taking the medication as prescribed played a role. Researchers hope this knowledge will help…

This study evaluated how aware caregivers are of secondary complications after a stroke, such as muscle stiffness, swallowing problems, and depression. Researchers surveyed 80 caregivers of stroke patients to see if education during rehabilitation improves their knowledge. The go…

This study looked at 120 people who had an acute ischemic stroke to see if the types of bacteria in their gut were linked to how well they recovered. Researchers analyzed stool samples and brain scans, and tracked disability over 6 months. The goal was to understand the role of g…

This study measured the amount of common blood thinners (dabigatran, apixaban, and rivaroxaban) in the blood of 308 Chinese adults with atrial fibrillation who had been taking the medication for at least 3 months. The goal was to establish normal reference ranges for these drugs …

This completed study looked at 213 people with acute ischemic stroke to see if combining brain scans with blood tests could better predict complications like brain swelling or bleeding. Researchers also used a mouse model to study how brain cells change after stroke. The goal is …

This study used artificial intelligence to learn the patterns of reduced blood flow to the brain during planned surgeries. 60 patients having carotid artery surgery or stroke clot removal were monitored with non-invasive devices. The goal was to teach AI to recognize these patter…

This completed study tested a program to help stroke survivors in rural Kentucky take their blood pressure medications as prescribed. Four participants received one-on-one education and tailored sessions from a pharmacy technician and community health worker. The goal was to see …

This pilot study tested a wearable robotic exoskeleton called EksoNR in 5 people with stroke, spinal cord injury, cerebellar ataxia, or spastic paraplegia. The goal was to see if using the device for gait training in an outpatient setting is safe, tolerable, and feasible. Researc…

This study looked at how different types of exercise (interval vs. continuous) and intensity levels (moderate vs. high) affect aerobic fitness and blood vessel health in people who have had a stroke. 59 participants used a seated stepper that moves both arms and legs. The goal wa…

This study tested whether emergency physicians can accurately predict stroke by interviewing witnesses who saw the symptoms start. Researchers asked 235 witnesses to describe what they observed, then compared the doctors' scores to brain scans. The goal was to see if this method …

This study looked at how well the ReVive™ SE device works to restore blood flow in the brain during a stroke. Only one patient took part, and the goal was to see if the device is useful in standard care. The main measure was how much blood flow returned after using the device.

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This study tested two types of non-invasive brain stimulation (called paired associative stimulation) to see if they could help improve hand movement in people who had a stroke. 81 participants (60 stroke survivors and 24 healthy volunteers) took part. The main goal was to unders…

This study tested a wearable sensor system (IMAS) to measure arm movement in 30 people who recently had a stroke. The goal was to see if the sensors could accurately predict how well arm function would recover. Researchers used motion data to build a model and compared it to stan…

This study tested whether an artificial intelligence (AI) tool called qER 2.0 EU helps doctors and other health professionals read head CT scans more accurately and quickly. Thirty-three readers, including radiologists, emergency doctors, and radiographers, reviewed 150 scans wit…

This completed study followed 633 stroke or TIA survivors in France to understand why some stop taking their secondary prevention medications. Researchers looked at factors like age, beliefs about medicine, and healthcare access. The goal is to improve long-term adherence and pre…

This study reviewed medical records of 70 children under 18 who received clot-busting drugs or mechanical clot removal for a stroke. Researchers measured how quickly treatment was given and looked for side effects like bleeding. The goal is to better understand the safety and tim…

This study tested whether an artificial intelligence system that gives doctors feedback could improve the quality of emergency stroke treatment. Over 1,200 stroke patients were involved. The AI system aimed to help doctors make better decisions during a procedure to remove blood …

This completed pilot study tested whether giving a daily multi-nutrient drink to people who recently had an ischemic stroke is practical and acceptable. Twenty-four adults were split into two groups: one received the drink plus standard care, the other standard care alone. The ma…

This study created a database of information from 105 stroke patients who had a procedure to remove a large blood clot from the brain. Doctors used a special wire to help guide a tube to the clot. The goal was to see if the wire alone could get the tube to the right spot. This wa…

This study tested whether a mild electrical pulse on the ear (vagus nerve stimulation) can reduce inflammation after a stroke. Forty adults with a recent stroke received either standard care or standard care plus the ear stimulation. Researchers measured changes in blood markers …

This study followed 364 adults with severe stroke who needed a breathing machine in the ICU. Researchers measured their recovery and disability levels at 3 months and 1 year after ICU admission. The goal was to better understand what happens to these patients over time, not to te…

This study looked at how often people have vision problems after a stroke. Researchers followed 127 stroke patients for 3 months, testing their eyesight and comparing results with brain scans. The goal was to find out how common these issues are and whether a simple vision screen…

This study looked at whether measuring the optic nerve sheath with ultrasound can help identify which side of the brain is affected in suspected stroke patients. Researchers measured the nerve sheath in 19 adults in the emergency department and compared it to their physical exam …

This study gathered brain monitoring data from 162 patients with serious brain injuries, such as traumatic brain injury or stroke. Using a noninvasive ultrasound device, researchers recorded blood flow signals to build a database. The goal is to develop algorithms that could one …

This study looked at 55 stroke survivors to see if arm function in the first days after stroke can predict trunk (core) recovery weeks later. Researchers measured trunk impairment and arm skills using standard tests. The goal is to find simple early clues that help therapists pla…

This study tested whether a special MRI contrast agent called ferumoxytol can detect inflammation in brain arteries of people who recently had a stroke. Researchers compared it to standard gadolinium contrast in 30 participants with narrowed brain arteries. The goal was to see if…

This completed study in 600 stroke patients in the Middle East looked at what factors might predict different types of brain bleeding after treatment with the clot-busting drug alteplase. Researchers analyzed patient characteristics, how quickly the drug was given, and stroke ris…

This study looked at 400 stroke patients who had a clot-removal procedure (thrombectomy) within 24 hours of symptoms. Researchers wanted to find out which factors helped patients recover well, such as being able to walk independently. The goal is to better predict who benefits fr…

This study used advanced MRI scans to look at how water and brain chemicals move in the brain after a stroke. Researchers scanned 24 stroke patients and 24 healthy volunteers to track changes over three months. The goal was to learn more about how brain cells are affected, which …

This completed study looked at how the brain adapts eye movements and how that relates to visual perception and attention. Researchers studied 24 people, including healthy adults and those with cerebellar disease. Participants performed specific eye movement tasks while researche…