New study tests if adding a Clot-Buster before mechanical stroke treatment boosts recovery

NCT ID NCT06221371

Completed Disease control Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 391 people with a type of stroke caused by a blockage in a major brain artery, treated 4.5 to 24 hours after symptoms started. Half got a clot-busting drug called tenecteplase followed by a mechanical clot removal procedure, while the other half had the procedure alone. The goal was to see if adding the drug leads to better recovery and less disability at 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tenecteplase (a clot-busting drug given intravenously)
What this could lead to: If successful, this could show that adding tenecteplase before a mechanical clot removal procedure improves recovery for people with late-window stroke.
What could go wrong: This is a completed Phase 3 trial, but results are not yet published. The benefit of adding tenecteplase may be small or outweighed by bleeding risks, and findings may not apply to all stroke patients.

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Conditions

The condition(s) this trial relates to.

ischemic stroke middle cerebral artery infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ENDOVASCULAR TREATMENT ISCHEMIC STROKE, ACUTE THROMBOLYSIS

Contacts and locations

Locations

Beijing Daxing District People's Hospital

Beijing, Beijing Municipality, China
Beijing Tiantan Hospital, Capital Medical University

Beijing, Beijing Municipality, 100070, China
Dalian Municipal Central Hospital

Dalian, Liaoning, China
First Affiliated Hospital of Wannan Medical College

Wuhu, Anhui, China
First Affiliated Hospital of Xi 'an Jiaotong University

Xi'an, Shaanxi, 710061, China
First People's Hospital of Chenzhou

Chenzhou, Hunan, 423000, China
Heze Municipal Hospital

Heze, Shandong, 274400, China
Jining NO.1 People's Hospital

Jining, Shandong, China
Liaocheng Third People's Hospital

Liaocheng, Shandong, 252006, China
Linyi Central Hospital

Linyi, Shandong, China
Linyi People's Hospital

Linyi, Shandong, 276003, China
People's Hospital of Queshan

Zhumadian, Henan, China
Puyang Oilfield General Hospital

Puyang, Henan, China
Qingdao Central Hospital

Qingdao, Shandong, 266000, China
Rizhao People's Hospital

Rizhao, Shandong, 276800, China
Rizhao Traditional Chinese Medicine Hospital

Rizhao, Shandong, 276800, China
The 2nd affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China
The First Affiliated Hospital of USTC

Hefei, Anhui, China
Weifang People's Hospital

Weifang, Shandong, China
Zaozhuang Municipal Hospital

Zaozhuang, Shandong, China
Zhejiang Provincial People's Hospital

Hangzhou, Zhejiang, China

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