New combo therapy could boost stroke recovery

NCT ID NCT05797792

Ongoing Disease control Sponsor: Hospital Clinic of Barcelona Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This phase 3 trial tests whether adding a clot-busting drug (alteplase) directly into the brain artery during mechanical clot removal improves recovery for people with severe stroke. About 440 participants with large vessel blockages will be randomly assigned to receive the drug or not. The main goal is to see if more patients are disability-free 90 days later.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: alteplase (a clot-busting drug given directly into the brain artery)
What this could lead to: If it works, this could become a standard add-on treatment to improve outcomes for people having a major stroke, potentially reducing long-term disability.
What could go wrong: This is an early-stage trial with 440 participants, so results may not apply to all stroke patients. Adding a clot-buster carries a risk of bleeding in the brain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

ischemic stroke large artery stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STROKE, ACUTE STROKE, ACUTE ISCHEMIC

Contacts and locations

Locations

Hospital Clinic Barcelona

Barcelona, Spain, 08014, Spain
Hospital Germans Trías i Pujol

Badalona, Spain, Spain
Hospital Josep Trueta

Girona, Spain, Spain
Hospital Universitario Central de Asturias

Oviedo, Spain, Spain
Hospital Universitario Dr. Balmis

Alicante, Spain, Spain
Hospital Universitario Son Espases

Palma de Mallorca, Spain, Spain
Hospital Universitario Virgen de la Arrixaca

Murcia, Spain, Spain
Hospital Universitario de A Coruña

A Coruña, Spain, Spain
Hospital Universitario de Cruces

Bilbao, Spain, Spain
Hospital Universitario de Donostia

San Sebastián, Spain, Spain
Hospital Universitario de Navarra

Pamplona, Spain, Spain
Hospital Universitario de Valladolid

Valladolid, Spain, Spain
Hospital Univesitario y Politénico La Fe

Valencia, Spain, Spain
Hospital de la Santa Creu i Sant Pau

Barcelona, Spain, Spain

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