Can Oxygen-Rich therapy and exercise reboot memory after stroke?

NCT ID NCT07772947

Completed Disease control Sponsor: Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University Source: ClinicalTrials.gov ↗

The trial has finished. Results may not be published yet.

First seen Aug 19, 2026 · Last updated Aug 21, 2026 · Updated 2 times

Summary

This trial explores whether combining hyperbaric oxygen therapy with moderate-intensity aerobic exercise can improve working memory in older adults who have mild cognitive impairment after a stroke. Participants, aged 65-85, will be randomly assigned to receive either this combined treatment or standard rehabilitation alone for two weeks. Researchers will measure memory performance and brain activity in the prefrontal cortex to see if the combined approach offers greater cognitive benefits.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Combined hyperbaric oxygen therapy and moderate-intensity aerobic exercise
What this could lead to: If effective, this combined therapy could offer a new way to improve memory and cognitive function in stroke survivors, potentially enhancing their quality of life.
What could go wrong: This is a small, early-stage trial, so results may not be conclusive or widely applicable. Hyperbaric oxygen therapy carries risks like ear pressure issues, and the exercise may be challenging for some stroke patients.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

50 people

The number who actually took part.

Started

Dec 2024

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

65 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * First-ever ischemic stroke confirmed by cranial MRI/CT; * Age 65-85 years old; * MoCA score 18-26 points (mild cognitive impairment after stroke); * Right-handed, able to complete 2-back cognitive task and fNIRS detection; * Signed written informed consent voluntarily. Exclusion Criteria: * History of dementia, traumatic brain injury or other central nervous system diseases; * Severe visual/auditory impairment unable to finish cognitive assessment; * Contraindications for hyperbaric oxygen therapy (untreated pneumothorax, severe emphysema etc.); * Severe cardiac insufficiency or unstable vital signs; * Taking cognitive improvement drugs within 1 month before enrollment; * Dropping out voluntarily during the 14-day intervention.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COGNITIVE IMPAIRMENT STROKE

Contacts and locations

Locations

Wuhan Sixth Hospital

Wuhan, Hubei, 430070, China

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