A gentle current to the brain: a new hope for stroke arm recovery?

NCT ID NCT07778342

Registered, but not yet taking participants.

First seen Aug 21, 2026 ยท Last updated Aug 21, 2026

Summary

This pilot trial tests whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve arm movement in people who had a stroke at least nine months ago. Participants receive either real or sham stimulation three times a week for about a month, while researchers monitor brain activity. The study measures arm function, muscle stiffness, and grip strength before treatment, right after, and one month later to see if tACS helps the brain control muscles better.

What this could mean

Our plain-language read of the trial. This is informational only โ€” not medical advice or a prediction.

Active substance
transcranial alternating current stimulation (tACS) delivered via a cap with electrodes
What this could lead to
If effective, tACS could become a non-invasive add-on therapy to improve arm function in people living with long-term stroke effects.
What could go wrong
This is a small pilot study, so results may not be conclusive. The stimulation is mild but may cause discomfort, and benefits might not last beyond the treatment period.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 34 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Dec 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 21-80 years old; 2. First ever stroke, at least 9 months after stroke onset; 3. Evidence of corticomotor excitability as manifested by a recordable Motor Evoked Potential from the ipsilesional Motor Cortex (M1) by TMS measurement. 4. Objectively documented motor weakness of the upper extremity as manifested by an Upper Extremity-Fugl-Meyer Assessment score \<=55 Exclusion Criteria: 1. Patients with implants: cardiac, neural or medication implants; any electrically, magnetically or mechanically activated implant; brain medical devices; vascular clips or any other electrically sensitive support system in the brain; other metal implants inside the body that are contraindications of MRI scan; 2. Pregnancy; 3. Patients with a history of seizures; Patients with unexplained episodes of loss of consciousness, since such condition could be related with brain alterations or epilepsy; 4. Patients with serious brain injury; 5. Patients showing damage of skin at sites of stimulation; 6. Patients with unstable or non-controlled neuropsychiatric illness; 7. Patients suffering from severe or frequent headaches; 8. Patients with any serious life-threatening disease such as congestive heart failure, pulmonary obstructive chronic disease or active neoplasia; 9. Sensorimotor disturbance due to other causes other than stroke;

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Alexandra Hospital

    Singapore, Singapore

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