New Clot-Buster shows promise for Tough-to-Treat strokes

NCT ID NCT06196320

Completed Disease control Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tested a drug called tenecteplase in 452 people with a severe type of stroke caused by a blockage in the basilar artery at the back of the brain. Participants received either tenecteplase or the current best treatment (which could include another clot-buster or standard care) within 24 hours of symptoms. The main goal was to see if tenecteplase helps more people recover with little or no disability after 3 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tenecteplase (a clot-busting drug given intravenously)
What this could lead to: If successful, this could provide a more effective and convenient treatment for severe strokes in the back of the brain, potentially reducing long-term disability.
What could go wrong: This is a completed phase 3 trial, but results are not yet published. The drug may not prove superior to current best practice, and there is a risk of bleeding, a known side effect of clot-busting drugs.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

basilar artery occlusion ischemic stroke

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ISCHEMIC STROKE, ACUTE

Contacts and locations

Locations

Affiliated Hospital of Hebei University

Baoding, Hebei, China
Beijing Daxing District People's Hospital

Beijing, China
Beijing Tian Tan Hospital, Capital Medical University

Beijing, Beijing Municipality, 100070, China
Chenzhou First People's Hospital

Chenzhou, Hunan, China
First People's Hospital of Tianshui

Tianshui, Gansu, China
Gaomi People's Hospital

Gaomi, Shandong, China
Guangdong Second Provincial General Hospital

Guangzhou, Guangdong, China
Guangshan County People's Hospital

Xinyang, Henan, China
Haikou People's Hospital

Haikou, Hainan, China
Hengyang Central Hospital

Hengyang, Hunan, China
Heyuan People's Hospital

Heyuan, Guangdong, China
Hongxinglong Hospital of Beidahuang Group

Shuangyashan, Heilongjiang, China
Huaxian People's Hospital of Henan

Anyang, Henan, China
Huazhou People's Hospital

Huazhou, Guangdong, China
Jiaozuo Coal Industry Central Hospital

Jiaozuo, Henan, China
Jilin Electric Power Hospital

Changchun, Jilin, China
Jiujiang First People's Hospital

Jiujiang, Jiangxi, China
Keshketeng Banner Chinese-Mongolian Hospital

Keshketeng Banner, Inner Mongolia, China
Laizhou City People's Hospital

Laizhou, Shandong, China
Linfen Central Hospital

Linfen, Shanxi, China
Linyi People's Hospital

Linyi, Shandong, China
Liuhe County People's Hospital

Tonghua, Jilin, China
Liuyang Jili Hospital

Liuyang, Henan, China
Lixin County People's Hospital

Haozhou, Anhui, China
Nanle County People's Hospital

Puyang, Henan, China
Nanle Zhongxing Hospital

Puyang, Henan, China
Nanshi Hospital of Nanyang

Nanyang, Henan, China
Ningbo Beilun District People's Hospital

Ningbo, Zhejiang, China
People's Hospital of Queshan

Zhumadian, Henan, China
Puyang Oilfield General Hospital

Puyang, Henan, China
Qiandongnanzhou People's Hospital

Qiandongnan, Guizhou, China
Qingdao Municipal Hospital

Qingdao, Shandong, China
Qinghe County People's Hospital

Xingtai, Hebei, China
Qiu County People's Hospital

Handan, Hebei, China
Shaoguan Qujiang District People's Hospital

Shaoguan, Guangdong, China
Siping City Central People's Hospital

Siping, Jilin, China
Taihe County Traditional Chinese Medicine Hospital

Fuyang, Anhui, China
Taikang Xian People's Hospital

Zhoukou, Henan, China
Tangshan Guye Traditional Chinese Medicine Hospital

Tangshan, Hebei, China
The 2nd Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China
The Affiliated Hospital of Shandong Second Medical University

Weifang, Shandong, China
The First Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, China
The First Affiliated Hospital of Jinzhou Medical University

Jinzhou, Liaoning, China
The First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China
The First People Hospital of Lingbao

Lingbao, Henan, China
The Fourth People's Hospital of Chenzhou

Chenzhou, Hunan, China
The People's Hospital of Liaoning Province

Shenyang, Liaoning, China
The Second Affiliated Hospital of Guizhou Medical University

Guiyang, Guizhou, China
The Second Affiliated Hospital of Shandong First Medical University

Taian, Shandong, China
The Second Hospital of Qinhuangdao

Qinhuangdao, Hebei, China
The Second People's Hospital of Dongying

Dongying, Shandong, China
The Second People's Hospital of Guiyang

Guiyang, Guizhou, China
Tongliao People's Hospital

Tongliao, Inner Mongolia, China
Weifang People's Hospital

Weifang, Shandong, China
Weihai Central Hospital

Weihai, Shandong, China
Xi County People's Hospital

Xinyang, Henan, China
Yantai Taochun Central Hospital

Yantai, Shandong, China
Zaozhuang Municipal Hospital

Zaozhuang, Shandong, China
Zhumadian Traditional Chinese Medicine Hospital

Zhumadian, Henan, China

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