Glucose metabolism disease

This study tested a new once-weekly injection called UBT251 in 211 adults with type 2 diabetes. Participants received either UBT251, a placebo, or the existing drug semaglutide for 24 weeks. The main goal was to see how well UBT251 lowers blood sugar (HbA1c) and to find the right…

This large study compares two diabetes drugs—oral semaglutide and sitagliptin—in over 25,000 people with type 2 diabetes and heart failure. Researchers want to see which drug better prevents heart failure worsening or death. The study uses existing medical records to mimic a clin…

This study tests an experimental tablet called ASC30 in 100 adults with type 2 diabetes. The goal is to see if it safely lowers blood sugar and helps with weight over 13 weeks compared to a placebo. Participants must have stable weight and a BMI of 23 or higher.

This study tested a new medicine called NNC0519-0130 in 299 adults with type 2 diabetes. The goal was to see if a once-weekly injection can lower blood sugar and body weight. Participants received up to 7 different doses for about 40 weeks. The results will help find the best dos…

Researchers are testing an experimental oral drug called MBX-2982 in adults with type 2 diabetes. The trial compares three daily doses of MBX-2982 against a placebo and sitagliptin, a standard diabetes drug, over four weeks. Participants are treatment-naive or taking a single ora…

This study tested a smart cap that attaches to insulin pens to help people with type 1 diabetes track their injections and glucose data. 42 adults used the device or a blinded version for comparison. The goal was to see if it reduces time spent with high blood sugar and improves …

Researchers are testing whether a 24-month weight-loss program delivered by trained health coaches through an electronic medical record patient portal can help Black adults with obesity and type 2 diabetes or prediabetes. The study enrolls 352 people aged 40 to 70 in Louisiana pr…

Researchers test whether adding doxycycline to sitagliptin helps control blood sugar and heart health in adults over 40 with newly diagnosed type 2 diabetes. Participants receive both drugs, and the team tracks changes in fasting blood sugar and HbA1c. The trial also measures hea…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study tests a mobile app that sends personalized reminders to help older adults with diabetes manage their blood sugar, diet, and medications. 184 participants will either use the app or receive standard nurse consultations. The goal is to see if the app can improve diabetes…

Researchers are testing a 12-week low-fat, plant-based diet program delivered in a doctor's office. The program encourages whole grains, vegetables, legumes, and fruits, with no animal products or added oils, and no calorie counting. The study measures changes in weight, blood pr…

Researchers are testing whether continuous glucose monitoring, alone or combined with a family behavioral program, helps children under 8 with type 1 diabetes keep their blood sugar in a healthy range. The trial compares these approaches to standard home blood glucose monitoring.…

This study tests whether a cookie made from Golden Rice and red betel leaf can improve cholesterol and triglyceride levels in adults with type 2 diabetes. Over 28 days, 102 participants will eat the cookies daily, and their blood fat levels will be measured before and after. The …

This study looked at whether delivering healthy food to the homes of rural adults with type 2 diabetes and food insecurity could improve their blood sugar control and diet. Over 400 participants either received standard care alone or standard care plus free healthy food deliverie…

Researchers test whether a connected pillbox with pre-filled trays and automated text or phone reminders helps people with type 2 diabetes, high blood pressure, or high cholesterol take their medications as prescribed. The study enrolls about 50 adults who have struggled to stay …

This pilot study tests whether having a pharmacist oversee continuous glucose monitoring (using a FreeStyle Libre device) can improve blood sugar control and health behaviors in people with type 2 diabetes. Forty participants will use the monitor for 12 weeks, and their results w…

This early-stage study tests an experimental drug called MK-1403 in people with type 2 diabetes. The main goals are to check if the drug is safe and tolerable, and to see how it behaves in the body. Researchers will also measure its effect on a marker of inflammation (hsCRP). Abo…

This pilot trial tests whether a social media platform can provide continuous dietary and lifestyle support for women with gestational diabetes. Forty pregnant women diagnosed with gestational diabetes receive either usual care from a diabetes nurse and dietitian, or usual care p…

This study looks at how different exercise programs (moderate or high-intensity) and a diet plan affect appetite, blood sugar, and body fat in people with type 2 diabetes. About 146 adults will take part in a 12-week program. The goal is to find the best combination to improve he…

This phase 3 study tested a new once-daily pill called orforglipron against an existing oral semaglutide in nearly 1,700 adults with type 2 diabetes whose blood sugar was not well controlled on metformin. The main goal was to see how well orforglipron lowers blood sugar levels ov…

This study tests an experimental drug called NT-0796 in 176 obese adults, some with type 2 diabetes. Participants take the drug or a placebo alongside a reduced-calorie diet and increased physical activity for 6 months. The goal is to see if the drug helps with weight loss and re…

Researchers compare three weekly GLP-1 receptor agonists, dulaglutide, semaglutide, and tirzepatide, in 159 obese adults, 84 with diabetes and 75 without. Participants receive one of the drugs for 24 weeks. The trial measures changes in body weight, BMI, blood sugar, cholesterol,…

Researchers test whether continuous glucose monitors (CGM) can help hospitalized adults with type 2 diabetes reach a tighter average blood sugar target of 90 to 130 mg/dL without causing dangerous low blood sugar. Participants are randomly assigned to standard care (target 140 to…

This study tests whether combining a shared decision-making checklist during doctor visits with mobile text reminders helps people with type 2 diabetes take their medications as prescribed. About 378 patients from community health centers in Michigan are taking part. The goal is …

Researchers at Nantes University Hospital are testing a computer model that describes how glucose and insulin interact in people with type 1 diabetes. The model aims to help doctors choose insulin pump settings, including basal rate, insulin sensitivity, and carbohydrate ratios. …

This early study is testing a new magnetic device that creates a shortcut in the digestive system to help people with obesity and type 2 diabetes lose weight and control blood sugar. Ten adults aged 18-65 with a BMI between 30 and 35 will have the device placed using a scope, wit…

This study tests a new magnetic system (MagDI) that creates a connection between two parts of the small intestine to help with weight loss and blood sugar control. It involves 25 adults with obesity and type 2 diabetes. The goal is to see if the device is safe, works as intended,…

This Phase 2 trial tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve kidney health in 140 people with obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat and b…

This completed Phase 1 study tested a new fast-acting insulin called NNC0471-0119 in 43 adults with type 1 diabetes who use an insulin pump. The goal was to see how quickly the insulin enters the bloodstream, how long it works, and how safe it is compared to a standard insulin (i…

Researchers are testing whether adding an SGLT2 inhibitor to the usual treatment for type 2 diabetes improves blood sugar control and other metabolic measures. The trial enrolls about 482 adults with type 2 diabetes who are not already taking these drugs. Participants will be com…

This study tests whether giving doctors a reminder and providing patients with a one-page handout can help women who had gestational diabetes or high blood pressure during pregnancy get a primary care visit within six months of delivery. The goal is to prevent future diabetes and…

This study tested whether a supplement called nicotinamide mononucleotide (NMN) can improve how the body handles sugar in people with prediabetes. Researchers gave NMN to 56 adults with higher-than-normal blood sugar and measured changes in insulin sensitivity and glucose toleran…

This Phase 2 trial tests a once-weekly injection called petrelintide in 221 people with overweight or obesity and type 2 diabetes. Participants receive either petrelintide or a placebo for several weeks. The main goal is to see how much weight they lose and whether blood sugar im…

This study tested a new investigational medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide) in one weekly injection. It was given to 274 adults with type 2 diabetes who were already taking daily insulin, with or without metformin. The goal was to se…

This study tests a new investigational medicine called CagriSema against an approved drug, tirzepatide, in people with type 2 diabetes whose blood sugar is not well controlled by current pills. About 1,023 adults will receive either CagriSema or tirzepatide once a week for up to …

Researchers are testing whether lanifibranor, a drug for fatty liver disease, can improve blood sugar control in adults with NASH and type 2 diabetes. They are also studying whether combining lanifibranor with empagliflozin, a diabetes medication, works better than lanifibranor a…

Researchers test whether shared decision making helps adults with type 2 diabetes who have poor blood sugar control. Participants are randomly assigned to receive either shared decision making sessions or routine health education. The trial measures changes in self-efficacy, heal…

This completed trial tested whether a faster-acting insulin (Lyumjev) used with a special conversion factor in an automated insulin pump (Control-IQ) could improve blood sugar control in 11 adolescents with type 1 diabetes. Participants were randomly assigned to use Lyumjev with …

This study tested whether a short period of intensive insulin therapy, followed by a combination of basal insulin, metformin, and vildagliptin, could help people with poorly controlled type 2 diabetes simplify their long-term treatment. The goal was to see if more participants co…

This phase 3 study tested an experimental once-daily pill called orforglipron (LY3502970) against a placebo in 1613 adults who are overweight or have obesity and type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants…

This study tested a new investigational drug called CagriSema against a currently available medicine, tirzepatide, in over 1,000 adults with type 2 diabetes. The goal was to see which works better at lowering blood sugar and body weight. Participants received weekly injections of…

This phase 2 trial tests whether a low dose of everolimus, a drug used in cancer, can safely improve signs of aging in 106 adults aged 55-80 who have insulin resistance or prediabetes. Participants take the drug daily or weekly for 24 weeks, and researchers measure changes in met…

This study tests whether choosing diabetes medications based on a person's genetic profile helps control blood sugar better than standard treatment. About 500 adults with type 2 diabetes that is not well controlled will be randomly assigned to either gene-guided or standard care.…

This early-stage trial tests an investigational drug called MWN105, given as an injection under the skin, in healthy Chinese volunteers aged 18 to 45. The study aims to check the drug's safety, how the body processes it, and whether it triggers an immune response. Researchers wil…

This trial tests an oral medication called MWN109 in Chinese adults with type 2 diabetes, overweight, or obesity. Researchers want to see if the amount of water taken with the pill and the timing of the next meal change how much drug enters the blood. The study also checks safety…

This study tested a once-daily pill called orforglipron in 559 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The pill was compared to a placebo (a dummy pill) over about 54 weeks to see if it safely lowers blood sugar levels. Th…

This study looks at whether the amount of effort you put into strength training can improve blood sugar control and mental health in people with type 2 diabetes. About 48 adults with type 2 diabetes will do resistance exercises at different effort levels. Researchers will track b…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes by reducing depression and insulin resistance. 120 teens aged 12-17 with overweight, a family history of diabetes, and elevated depression symptoms took part. They were randomly as…

This early trial tests montbretin A, a compound extracted from crocosmia plant bulbs, in people with type 2 diabetes and in healthy volunteers. The main goal is to find a safe dose and see if it causes fewer stomach side effects than standard diabetes medications. Participants ta…

This study tests whether adding empagliflozin or semaglutide to insulin can improve blood sugar control in overweight or obese adults with type 1 diabetes. About 105 participants will take one of the two drugs or a placebo for 3 months. The goal is to see if these drugs help lowe…

This study tested whether providing medically tailored meals (10 ready-to-eat meals per week for 6 months) plus phone-based lifestyle coaching could improve blood sugar control in adults with type 2 diabetes who also face food insecurity. 215 participants were randomly assigned t…

This study tested an experimental drug called RZ402 in 94 people with diabetic macular edema, a condition that causes vision loss in people with diabetes. The goal was to see if the drug is safe and can reduce swelling in the retina and improve eyesight compared to a placebo. Par…

This study tested a 4-month online program that encourages a very low-carbohydrate breakfast for adults with poorly controlled type 2 diabetes. Researchers measured how satisfied participants were, how well they stuck to the diet, and changes in blood sugar, weight, and medicatio…

This study tests whether giving probiotics to pregnant women with diabetes can improve their babies' brain development. Researchers will give 60 mothers a probiotic supplement and then measure their infants' brain responses to sounds and sights at 1 and 6 months old. The goal is …

This study tests whether adding culturally tailored heart-health education to medically tailored meal programs helps people with type 2 diabetes and high blood pressure eat better and improve their blood sugar and blood pressure. About 176 adults from low-income New York City nei…

This study is checking how safe and effective an updated insulin pump system (Control-IQ 1.5) is for children ages 2 to 6 with type 1 diabetes. About 144 kids will use the pump for a year while researchers track dangerous low blood sugar events and diabetic ketoacidosis. The goal…

This pilot study tests a 12-week text message program called AYUDA for younger Latinx adults recently diagnosed with type 2 diabetes who are also caring for a child. Participants receive twice-weekly texts with diabetes education and self-management resources. Researchers compare…

This trial asks whether eating tinned mackerel twice a week can improve blood sugar control in South Asian adults with type 2 diabetes. Participants with diabetes will either keep their usual diet or replace some red meat or poultry with mackerel for 16 weeks. Researchers will me…

Researchers at the University of Aberdeen are testing whether a buckwheat beverage can reduce blood sugar spikes after meals. The study includes healthy adults and people with type 2 diabetes whose condition is managed by diet or metformin. Participants drink the beverage and hav…

This study tests a new insulin infusion set designed to last up to 7 days for people with type 1 diabetes. Twenty adults currently using a Tandem insulin pump and Dexcom CGM will try the SteadiSet at home. The goal is to see if the set can survive a full week without causing high…

This trial tests whether personalized education, guided by a risk assessment for six major diabetes complications, can improve blood sugar control in adults with type 2 diabetes. Participants receive education focused on their highest predicted risk, such as kidney disease or str…

This trial tests a multimodal program for adults aged 65 and older with type 2 diabetes who are frail or prefrail. The program combines a 16-week exercise routine, educational sessions on diabetes self-care, and adjusted blood sugar and blood pressure goals. Researchers compare t…

This trial tests whether eating freeze-dried strawberry powder daily for four weeks can lower chronic inflammation and improve blood vessel function and insulin sensitivity in adults with prediabetes. Participants will be randomly assigned to receive either a low dose, a high dos…

Many adults with type 1 diabetes don't get enough sleep, which can make blood sugar harder to control. This trial tests a 12-week program called Sleep-Opt that uses wearable sleep trackers, phone coaching, and educational materials to improve sleep habits. Researchers will measur…

This trial tests whether a daily 10-gram dose of sea buckthorn extract, taken for 12 weeks, can improve blood sugar control and immune cell balance in adults with type 1 diabetes. Type 1 diabetes is an autoimmune condition where the body attacks insulin-producing cells. The study…

This trial investigates whether high-intensity interval training (HIIT) can improve how the body uses insulin in obese adults with glucose intolerance. Participants will be assigned to either HIIT (short bursts of intense exercise) or moderate-intensity continuous training (MICT,…

This study tests a telehealth program called REAL-T, designed to help young adults with type 1 diabetes fit diabetes care into their daily habits and routines. Participants receive about 12 hours of virtual coaching from an occupational therapist over six months. The study compar…

This Phase 3 trial is testing whether a once-daily 50 mg semaglutide tablet can help East Asian adults with overweight or obesity lose weight. Participants will take either the active tablet or a placebo for 68 weeks, alongside lifestyle counseling on diet and physical activity. …

This study looked at whether aspirin or a diabetes drug called an SGLT2 inhibitor (like dapagliflozin) can improve liver health in people with type 2 diabetes and non-alcoholic fatty liver disease. Researchers measured liver enzymes, cholesterol, and liver stiffness (using FibroS…

This trial tests an experimental oral drug called HTD1801 in adults with nonalcoholic steatohepatitis (NASH), a serious liver condition, along with liver fibrosis and type 2 diabetes or prediabetes. Participants receive either HTD1801 or a placebo to see if the drug can improve l…

This trial tests a smart insulin pump algorithm designed to automatically adjust insulin delivery during the night to keep blood sugar levels in a safe range. The algorithm predicts when blood sugar might drop too low and pauses insulin, and when it might rise too high, it gives …

This trial investigates whether a traditional herbal drug, NOSHIN SHAHD, can improve insulin resistance and reduce inflammation and oxidative stress in people with type 2 diabetes. Participants will take the herbal drug or a placebo for about six weeks, and researchers will measu…

This trial tests whether a 12-week calorie-restricted diet, combined with the weight-management drug Contrave, can help people with type 2 diabetes and obesity achieve remission. Remission means blood sugar levels drop below the diabetes threshold without needing glucose-lowering…

This study tests a new procedure called ReCET that uses gentle electrical pulses to regenerate the lining of the small intestine. Combined with a diabetes drug (semaglutide), the goal is to help people with type 2 diabetes stop using insulin. The study involves 32 adults and comp…

This trial asks whether cooking with refined high-oleic palm oil can improve cholesterol and blood sugar levels as effectively as olive oil. Healthy adults will be randomly assigned to use one of the two oils in their daily cooking for four months. Researchers will measure change…

This trial tests whether a smartphone app called Kiplin, which uses games, telecoaching, and social support, can increase daily physical activity in people with obesity or type 2 diabetes. It compares the app to a standard three-month face-to-face exercise program. The main goal …

This trial tests whether a specially designed mealtime insulin, HDV-insulin lispro, can reduce nighttime low blood sugar (hypoglycemia) in adults with type 1 diabetes. Participants will use continuous glucose monitors and work with doctors to adjust doses. One group receives the …

This trial tests whether time-restricted eating (TRE) — limiting all food intake to an 8-10 hour daily window — can improve blood sugar control and metabolic health in people with metabolic syndrome or prediabetes. Participants are randomly assigned to either standard nutritional…

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apn…

This study investigates whether continuous glucose monitor (CGM) data can pinpoint the time of day when a person with prediabetes experiences the largest blood sugar spikes after eating. Participants wear a CGM and activity tracker for 10 days to identify their personal 'vulnerab…

This pilot trial tests whether a single infusion of pegloticase, a drug that breaks down uric acid, can improve markers of heart and kidney health in young men aged 18–25 with youth-onset type 2 diabetes. High uric acid is common in this group and linked to later complications. T…

This trial tests whether a mobile health system that sends real-time text messages—prompting users to take a walk or stand up after sitting too long—can increase physical activity in people with prediabetes or type 2 diabetes. Participants receive a Fitbit tracker and brief advic…

This study looks at whether offering financial rewards, along with nurse coaching and home monitoring, helps adults with type 2 diabetes improve their blood sugar control. About 450 participants will be randomly assigned to receive either nurse coaching and home monitoring alone,…

This study tests whether a connected smartphone app called Health2Sync helps adults with type 2 diabetes who use basal insulin achieve better blood sugar control. The app syncs blood glucose readings and shares them with doctors, who can then adjust insulin doses. Researchers com…

This study tests how different amounts of dietary carbohydrates affect insulin needs and blood sugar control in adults with type 1 diabetes. Participants are randomly assigned to one of three diets: a traditional diet with 50-60% of calories from carbs, a moderately low-carb diet…

This study investigates whether a 12-week program combining aerobic and resistance exercise can improve blood sugar control and cognitive function in adults aged 65-79 with type 2 diabetes and mild memory issues. Participants follow a supervised exercise routine that gradually in…

This study tests whether a peer coaching program delivered by phone and text can help adolescents and young adults (ages 16–22) with chronic conditions like sickle cell disease, diabetes, or cystic fibrosis improve their self-management skills. Participants are paired with a trai…

This study tests a support program for people with type 2 diabetes and chronic kidney failure who struggle to take their medications regularly. Participants receive an electronic pill bottle that tracks when they open it, plus short motivational interviews with a pharmacist. The …

This study tests two approaches to help people with diabetic neuropathy improve their balance. One group uses textured insoles in their shoes, while the other group does a series of quick stretches and compressions called Rood's facilitatory technique. Both groups also receive co…

This study investigates whether taking two medications—finerenone and empagliflozin—together can better slow kidney function decline in people with chronic kidney disease and type 2 diabetes compared to taking either drug alone. Participants are randomly assigned to receive the c…

This study tests whether a low-carbohydrate diet (under 75 grams per day) can help adults with type 1 diabetes preserve their remaining insulin production. The idea is that the diet might calm the immune attack on insulin-making cells. Participants will follow the diet for a peri…

This study tests a four-week virtual program designed to help teens aged 12-21 with type 1 diabetes use technology like insulin pumps and continuous glucose monitors. Participants complete surveys and interviews about their diabetes management and technology use. The goal is to u…

This study tracks the long-term safety of dorzagliatin, a drug for type 2 diabetes, in over 2,000 patients over 52 weeks. Researchers monitor side effects and how well the drug controls blood sugar. The goal is to ensure the drug remains safe for everyday use.

This study tests a program called 'Disfrutando' designed to help people with type 2 diabetes, especially those in high-burden communities, better manage their condition. The program focuses on practical self-management skills and addressing social factors that make diabetes harde…

This study tests whether walking with a wearable hip exoskeleton can improve blood sugar control after meals in people with type 2 diabetes. Participants walk for 30 minutes after a meal, either without assistance or wearing the exoskeleton in two different support modes. The goa…

This study tests whether using a continuous glucose monitor (CGM) — a small sensor that tracks blood sugar levels in real time — helps teens and young adults (ages 14 to under 25) with type 1 diabetes improve their blood sugar control compared to standard fingerstick testing. Par…

This large study looks at real-world data from 60,000 people with type 2 diabetes and obesity to compare four diabetes drugs—dulaglutide, semaglutide, tirzepatide, and sitagliptin—in preventing heart attacks, strokes, and death. Researchers are analyzing insurance claims to see w…

This study tests two strategies in low-income seniors with chronic conditions like heart disease, diabetes, or kidney disease. One group gets free preventive medications (no copayment), and another receives personalized education on medication use and lifestyle. The goal is to se…

This study tests whether a 3-month community program combining nutrition education, cooking classes, and exercise can improve health outcomes for people with Cardiovascular Kidney Metabolic (CKM) syndrome—a cluster of conditions including diabetes, high blood pressure, high chole…

This completed trial tested whether laser acupuncture could improve body shape index (ABSI) in 50 women aged 40-50 with uncontrolled type 2 diabetes and obesity. Participants received either real or sham laser acupuncture twice a week for 12 weeks, plus a low-glycemic diet. The s…

This large phase 3 trial compares two injectable diabetes medications, tirzepatide and dulaglutide, to see which one better prevents major heart problems like heart attacks, strokes, or death from cardiovascular causes. The study includes over 13,000 adults aged 40 and older with…

This study investigates whether giving endocrinologists (diabetes specialists) a one-week intensive training program helps them manage type 2 diabetes more effectively. The training includes a hospital stay experience and hands-on patient management. Researchers will compare bloo…

This study tests whether combining two diabetes drugs—semaglutide and empagliflozin—can reverse liver damage from NASH (a severe form of fatty liver disease) in people with type 2 diabetes. Participants will receive either the combo, empagliflozin alone, or a placebo for 48 weeks…

This study tests a software upgrade for an automated insulin pump system (Control-IQ) in adults with type 1 diabetes. The upgrade adds an adaptive biobehavioral control module that learns from the user's patterns to improve blood sugar management. Participants use the standard sy…

This trial compares continuous glucose monitoring (CGM) with standard fingerstick testing in 400 critically ill ICU patients with high blood sugar. CGM uses a small sensor under the skin to measure glucose every 5 minutes and alerts staff when levels are too high or low. The goal…

This study investigates whether a passive stretching program can reduce muscle and tendon stiffness in people with type 2 diabetes. Diabetes can cause muscles and tendons to become stiffer, making walking harder and increasing energy use. The trial compares stiffness in people wi…

This study tests the long-term safety of an experimental oral drug called orforglipron in adults with type 2 diabetes whose blood sugar is not well controlled by diet, exercise, or other diabetes pills. Participants take the drug once daily for about a year, and researchers monit…

This trial tests a package of services called TASKPEN, which combines HIV care with screening and treatment for high blood pressure, diabetes, and tobacco use. It involves over 5,700 adults living with HIV in Lusaka, Zambia. The goal is to see if this integrated approach helps mo…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This completed study tested whether a customizable texting program could help veterans with type 2 diabetes improve their blood sugar control. 366 veterans were randomly assigned to receive either standard daily diabetes texts or a more interactive version with check-ins, medicat…

This study tested a 6-week diabetes self-management program for ethnic minority elderly (aged 60+) in rural Thailand. The program included weekly group sessions on diet, exercise, medication, and emotional coping, plus two home visits. Researchers measured changes in blood sugar …

This study tested an electronic glucose management system (eGMS) designed to help doctors decide insulin doses for hospitalized patients with type 2 diabetes. The trial compared the eGMS to the usual insulin ordering protocol in 140 patients. The goal was to see if the eGMS could…

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This study tested whether adding mindful eating training to a low-carb diet education helps people with type 2 diabetes follow the diet better. About 125 adults were randomly assigned to get either diet education alone or diet education plus mindful eating sessions. The main goal…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This completed study tested whether resveratrol, a natural compound found in grapes and berries, can improve blood vessel health and blood sugar control in people with type 2 diabetes. 48 adults took either a resveratrol pill or a placebo daily for 12 weeks. Researchers measured …

This study tested a culturally tailored program called Together Overcoming Diabetes (TOD) for American Indian families in Ojibwe communities. Adult caregivers with type 2 diabetes and their youth (ages 10-16) worked with local health coaches to set health goals. The program inclu…

This study tested whether making U.S. dietary guidelines more culturally relevant for African Americans could improve diet quality and reduce type 2 diabetes risk. 63 overweight or obese African American adults with at least three diabetes risk factors attended weekly classes for…

This study tested a new insulin called icodec, taken just once a week, against a standard daily insulin (degludec) in 588 adults with type 2 diabetes who had never used insulin before. Participants received either weekly icodec plus a daily placebo, or daily degludec plus a weekl…

This study tested a new once-a-week injection called IcoSema, which combines insulin and semaglutide, against semaglutide alone in 683 adults with type 2 diabetes. The goal was to see if IcoSema improves blood sugar levels more effectively. Participants received weekly shots for …

This study looked at 100 people with severe leg artery disease (including some with diabetes) who needed bypass surgery above the knee. Doctors compared using a man-made tube (Dacron or PTFE) versus the patient's own leg vein to reroute blood flow. The goal was to see which metho…

This study tested whether dapagliflozin, a drug used for type 2 diabetes, can lower blood pressure in people who have received a kidney transplant. Fifty-two participants took either the drug or a placebo for 12 weeks. The goal was to see if the drug helps control blood pressure …

This study tested an oral medication called APX3330 in 103 adults with moderate to severe diabetic retinopathy, a leading cause of vision loss. The pill aims to reduce inflammation and low-oxygen stress in the eye. Researchers measured whether the drug could improve the severity …

This study followed 543 adults aged 18-60 who had bariatric surgery at four hospitals in Norway. Each hospital used a different surgical method, allowing researchers to compare how well each approach helped with weight loss and type 2 diabetes remission. The goal was to find whic…

This study tested whether a lifestyle guide called GEM (Glycemic Excursion Minimization), combined with a continuous glucose monitor (Freestyle Libre 2) and a Fitbit activity tracker, could help people with prediabetes better manage their blood sugar. Sixty-one adults aged 25-70 …

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program included four video therapy sessions to reduce drinking, a coaching call to plan heart-healthy steps, and daily text messages for a month. The …

This study tested whether adding a smart, AI-powered insulin boost before meals could improve blood sugar control in adults with type 1 diabetes. Nineteen participants used either a standard automated insulin system or the same system with the AI boost during hotel stays and at h…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This study looked at whether gastric bypass surgery or the best medical care is more effective for obese people with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, and costs. The go…

This completed phase 3 trial tested three doses of the oral drug HRS-7535 against a placebo in 284 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The main goal was to see if HRS-7535 could lower HbA1c (a measure of average blood …

This study tested whether using activity trackers, text reminders, and short exercise videos could help people with type 2 diabetes reduce the time they spend sitting at work. Forty-six adults with type 2 diabetes who had mostly desk jobs took part. The goal was to see if these m…

This study tested whether a daily postbiotic capsule (a substance that helps good gut bacteria) could improve blood sugar control in adults with type 2 diabetes. 106 participants took either the postbiotic or a placebo for 12 weeks. Researchers also analyzed genetics and gut bact…

This study tested whether verapamil, a drug usually used for high blood pressure, can help preserve insulin-making cells in adults newly diagnosed with type 1 diabetes. 136 participants received either verapamil or a placebo for 12 months. The main goal was to see if verapamil co…

This study tested whether taking a melatonin supplement (3 mg each night for 6 months) could improve sleep, thinking skills, and blood sugar control in 70 adolescents with type 1 diabetes. Half received melatonin and half received a placebo. The researchers measured changes in bl…

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with overweight or obesity lose weight. About 242 people took part, comparing the drug to a placebo over roughly one year. The main goal was to see how much weight they lost and how many lost at least 5% …

This study tested whether a mobile app helps elderly people (70+) with diabetes better control their blood sugar, maintain physical function, and improve quality of life. Sixty participants were split into two groups: one used the app, the other did not. The app was designed to b…

This study looked at whether a DASH-style diet (modified for diabetes) combined with lower salt intake can lower blood pressure in adults with type 2 diabetes and high blood pressure. 105 participants ate specially prepared meals for 5-week periods. The goal was to find a practic…

This study tested whether an enhanced continuous glucose monitor (eCGM) linked to a decision-support system can help older adults (65+) with type 1 diabetes manage their blood sugar. The system automatically uploads glucose, insulin, and activity data to give personalized insulin…

This study looked at how the diabetes drugs glyburide and metformin work in pregnant women with gestational diabetes. 177 women between 20 and 32 weeks pregnant took part. The goal was to find the right dose and understand how these drugs control blood sugar and improve insulin f…

This study looked at whether a seaweed supplement or a Mediterranean-style diet could help people with pre-diabetes control their blood sugar and strengthen their immune system against infections. Researchers studied 45 adults with pre-diabetes, measuring changes in blood glucose…

This pilot study tested a mobile app and wearable devices to give personalized diet and activity advice to 27 adults with type 2 diabetes or prediabetes. The goal was to see if the app could help them improve their blood sugar levels and make healthier food choices. The study als…

This small pilot study tested whether a remote digital care program (TELEDUC-DIAB) could help 10 teens aged 12-17 with poorly controlled type 1 diabetes. Participants used a monitoring platform and educational app alongside their usual care. The main goal was to see if their bloo…

This study looked at whether dapagliflozin, a diabetes medication, can improve how the heart uses sugar and blood flow in people with type 2 diabetes and stable coronary artery disease. 25 adults took either the drug or a placebo for 4 weeks. The goal was to see if the drug helps…

This study looked at how well adults with obesity or complicated overweight could stick to different very low-calorie ketogenic diets (VLCKD) in a real-world clinic. Participants chose one of four diet plans, ranging from all-natural foods to all meal replacements, and followed a…

This study tested whether a dietary supplement called phosphatidylserine can improve blood flow in people with type 2 diabetes. 36 adults took either the supplement or a placebo for 4 weeks. Researchers measured blood flow in the leg and arm to see if the supplement helped blood …

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This pilot study tested a 12-week phone program for 60 African American women aged 40-64 with type 2 diabetes and multiple caregiving responsibilities. Half received extra support for their caregiving stress plus diabetes education, while the other half got standard diabetes educ…

This study tested whether a form of vitamin B6 called pyridoxamine can improve the health of small blood vessels in people with type 2 diabetes. The researchers gave 40 participants either pyridoxamine or a placebo for a period, then switched treatments to compare effects. They m…

This study looked at how well the TouchCare Nano automated insulin delivery system works for children and teens with type 1 diabetes in everyday life. Researchers tracked 76 kids aged 6 to 18 over six months to see if the system helped them spend more time with healthy blood suga…

This study looked at 781 adults with moderate-to-severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Researchers wanted to see if adding a lifestyle intervention (diet and exercise) to the drug Secukinumab (Cosentyx) impr…

This study tested whether empagliflozin, a diabetes medication, lowers blood pressure more than other diabetes pills in adults with type 2 diabetes and high blood pressure. 300 participants took either empagliflozin or another diabetes drug for 12 weeks. Researchers measured bloo…

This study looked at whether a 3-month supervised exercise program can improve blood sugar, body fat, and fitness in sedentary men aged 35-65 with type 2 diabetes, prediabetes, or overweight. Participants exercised at a fitness center under supervision. The goal was to see how di…

This study tested a program designed to help women with type 2 diabetes become more physically active. 86 women aged 30-65 took part. The program included a video, a pamphlet, and regular check-ins to encourage exercise. The goal was to see if this approach could increase daily a…

This study tested whether the Omnipod 5, a tubeless automated insulin pump, works better than multiple daily insulin injections for managing type 1 diabetes. 189 children and adults participated. The main goal was to see if the pump improved blood sugar control (HbA1c) over 13 we…

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. About 61 participants were assigned to either the program or standard care. The goal was to see if the…

This study tested whether a peer-led education program could help 100 diabetes patients in Ethiopia improve their blood sugar control and reduce costs. Participants received structured diabetes education from trained peers over several sessions. The main goal was to see if this a…

This study tested whether a nurse-led mobile app could improve diabetes management in 112 adults with type 2 diabetes. The intervention group received structured education and reminders via the app for 6 months, while the control group got standard care. The main goal was to see …

This study followed 30 adults with type 1 diabetes who used the Smartguard system, a partially automated insulin pump that can pause insulin delivery when it predicts a low blood sugar. The goal was to see how well the system works in everyday life, focusing on time spent in the …

This study tested a special educational tool for parents of children under 6 with type 1 diabetes. The goal was to see if the tool could help parents better control their child's blood sugar and prevent serious events like low blood sugar or ketosis. The study enrolled 24 childre…

This study tested whether wearing a continuous glucose monitor (CGM) and watching AI-generated health education videos could help 30 adults with prediabetes control their blood sugar. Participants wore a CGM that tracked glucose levels without showing them the readings during the…

This study tested a fiber-enriched, low-sodium liquid formula as the sole nutrition for 32 tube-fed nursing home residents with diabetes. Over three months, researchers measured changes in blood sugar, blood pressure, and nutritional status. The goal was to see if this special fo…

This study tested whether a serious computer game called DIVE helps children aged 10-17 with newly diagnosed type 1 diabetes learn about their disease. 78 kids played the game twice a week for at least an hour, covering topics like diet and treatment. Researchers measured their k…

This study tested a mobile app that teaches teenagers with type 1 diabetes how to better manage their condition. 96 teens aged 12-18 were split into two groups: one used the app, the other received standard care. Researchers measured changes in diabetes knowledge, self-confidence…

This study tested whether sending supportive text messages to teenagers with poorly controlled type 1 diabetes could help lower their blood sugar levels. 92 teens aged 12-21 with high HbA1c levels participated. The approach used mobile phone reminders to encourage better diabetes…

This study tested whether taking low-dose aspirin (150 mg) daily, starting in the first trimester, could reduce pregnancy complications in women with type 1 or type 2 diabetes. The trial included 137 women and looked at outcomes like preeclampsia, early preterm birth, low birth w…

This study tested a nutrition checklist and educational module (M-FIGO) designed for Malaysian women with gestational diabetes. 206 pregnant women were randomly assigned to receive either the checklist plus standard care or standard care alone. The goal was to see if the tool hel…

This pilot study tested a web-based version of the DECIDE program, called eDECIDE, which teaches problem-solving skills to help African Americans manage type 2 diabetes. The study involved 36 participants and compared the online program to the traditional in-person group sessions…

This study tested whether adding pioglitazone or dapagliflozin to standard diabetes pills (alogliptin and metformin) helps control blood sugar better in adults with type 2 diabetes. A total of 133 participants took one of the two extra drugs for 26 weeks. The main goal was to see…

This completed study looked at how two common diabetes drugs, dapagliflozin and empagliflozin, affect weight, cholesterol, and inflammation in 260 obese adults newly diagnosed with type 2 diabetes. Over six months, researchers measured changes in body weight, blood fats, and mark…

This study tested whether using a very tight glucose target (80-99 mg/dL) in an advanced hybrid closed-loop insulin pump (CamAPS FX) improves blood sugar control in adults with type 1 diabetes who had poor control. Forty participants who previously used multiple daily injections …

This study tested a personalized dietary program for 30 adults with type 2 diabetes. The program was designed to help participants better manage their blood sugar and potentially achieve remission. Researchers measured changes in HbA1c and other health markers to see if the diet …

This study looked at whether giving vitamin D supplements to adults with type 2 diabetes who also have low vitamin D levels can improve their blood sugar control. 119 participants took a high dose of vitamin D once a month for three months. Researchers measured blood sugar and ot…

This pilot study tested DiaBuddy, a mobile app designed to help children with type 1 diabetes and their families make better decisions about insulin dosing and managing sick days. Twenty-five children aged 5 to 18 used the app for three months. The study found that the app's reco…

This study tested whether a daily supplement of overripe banana powder can improve blood sugar control in adults with type 2 diabetes. Sixty participants took either the banana supplement or a standard formula for 12 weeks. Researchers measured changes in fasting blood sugar, HbA…

This study tested whether a structured nursing guideline could improve outcomes for children aged 6-16 with diabetic ketoacidosis (DKA), a serious diabetes complication. Sixty children were split into two groups: one received standard care, the other care guided by the new nursin…

This study followed 410 people with type 1 diabetes who use closed-loop insulin pumps—devices that automatically adjust insulin delivery. Researchers measured how well these pumps control blood sugar over time using HbA1c levels. The goal was to see if the pumps work effectively …

This study tested whether eating tuna-based nuggets for three months could improve health in 120 people with heart disease and related conditions like obesity and diabetes. The nuggets were given as a source of selenium. Results showed improvements in some markers of inflammation…

This pilot study tested whether combining financial navigation (help with costs) and peer support (connecting with others) can help adults with diabetes better manage their condition. 61 participants were randomly assigned to receive either financial navigation alone or financial…

This small pilot study tested whether transplanting pancreatic islets together with parathyroid glands into the muscle could help people with type 1 diabetes stop using insulin. The 4 participants already had a functioning kidney or liver transplant and were on lifelong immunosup…

This study tested whether a program that combines technology (like a monitoring system) with diabetes education and skills training can help African American adults with poorly controlled type 2 diabetes. About 200 participants used the system for 12 months, and researchers measu…

People with spinal cord injury (SCI) face higher risks of heart disease and diabetes, partly due to chronic inflammation and poor blood vessel function. Exercise helps but is often not possible. This small study tested whether repeated passive heating (using a water-perfused suit…

This pilot study tested a new computer algorithm that uses continuous glucose monitor (CGM) readings to automatically suggest the right dose of long-acting insulin for people with type 2 diabetes. Thirty adults already using basal insulin were followed for 18 weeks to see if the …

This study compared two common diabetes drugs—dapagliflozin and metformin—in over 2,000 people with early type 2 diabetes (diagnosed less than 4 years). The goal was to see which drug better prevents serious complications like death, heart attack, stroke, heart failure, kidney di…

This study looked at 100 liver transplant patients with diabetes to see if dapagliflozin or sitagliptin is better at reducing liver fat and improving body composition. Participants took one of the two drugs for 12 months. The goal was to find a safer and more effective way to man…

This study tested whether a longer intestinal bypass during stomach cancer surgery improves diabetes control better than the standard method. It included 94 adults with early-stage gastric cancer and type 2 diabetes. Researchers measured blood sugar and hormone levels one year af…

This pilot study tested two approaches to improve metabolic health in Black adults with stage 1 obesity and conditions like high blood pressure or prediabetes. Participants received either weight-focused or weight-neutral health coaching for 7 weeks. The goal was to see if a larg…

This completed study tested whether painting metal roofs with a special heat-reflecting coating can lower indoor temperatures and improve health in Niue, a Pacific island nation facing record heat. Researchers enrolled 288 adults living in single-story homes with metal roofs. The…

This study tested a home-based behavioral program called Home DM-BAT for low-income seniors with type 2 diabetes. Two hundred Black or Hispanic seniors aged 65 and older took part. The program involved 8 weekly in-home sessions and monthly booster calls to help improve blood suga…

This completed study tested a health system intervention called ENHANCE in 1,837 adults aged 40+ with at least two chronic conditions (HIV, high blood pressure, diabetes, asthma, or depression). The intervention included a clinical decision support tool for clinicians, health edu…

This pilot study tested whether giving a mix of glucose, insulin, and potassium (GIK) during abdominal surgery can reduce serious complications in patients who do not have diabetes. About 106 adults took part to see if the treatment is practical and safe. The goal is to plan a la…

This study tested whether the drug dapagliflozin (Forxiga) works better than standard treatments for people with type 2 diabetes whose blood sugar is not well controlled on metformin alone. Over 600 adults took either dapagliflozin plus metformin or usual care (like sulfonylureas…

This study tested whether a faster-acting insulin (Lyumjev) works better than standard insulin (Humalog) in a dual-hormone artificial pancreas for people with type 1 diabetes. Twelve adults who already used the artificial pancreas took part. Each person used both insulins for 30 …

This study tested whether people with type 2 diabetes and kidney damage can safely participate in a clinical trial from home. Twelve participants took the drug empagliflozin, and depending on their response, some added or switched to finerenone. The goal was to see if remote data…

This study looked at whether community health workers (CHWs) can help low-income, mostly minority adults better manage chronic diseases like diabetes, high blood pressure, and obesity. Over 10 months, 202 participants either received CHW support plus standard care or just standar…

This early-stage study tested a new treatment called IBC with MAS-1 in 21 adults recently diagnosed with type 1 diabetes. The goal was to see if it is safe and can retrain the immune system to stop attacking the pancreas, potentially helping the body control blood sugar naturally…

This study looked at whether replacing breakfast with a low glycemic index shake helps overweight and obese adults manage their blood sugar. 46 non-diabetic adults aged 25-65 with a BMI between 25 and 40 took part. For two weeks, they either drank the shake or ate oat cereal for …

This study tested a program that helps pregnant women with gestational diabetes manage their condition with support from family members. 435 women in Vietnam took part. The goal was to see if this approach could improve health for both mothers and babies.

This study compared several common diabetes medications when added to metformin in 7,850 adults with type 2 diabetes. The goal was to see which combination best kept blood sugar under control over time. Results help doctors and patients choose the most effective treatment plan.

This study tested whether a 12-week Ayurveda-inspired program combining a special diet, yoga, and breathing exercises was practical for adults with type 2 diabetes. Seventeen people started, and twelve completed the program. Participants followed the plan at least five days a wee…

This study looked at 83 people with diabetes and early-stage eye disease. It compared having laser treatment in one session versus four sessions to see which approach better controls the disease and reduces the risk of swelling in the center of the eye. The main goal was to measu…

This study tested whether a continuous glucose monitor (CGM) could help nurses manage blood sugar in ICU patients receiving IV insulin. Researchers enrolled 201 adults with high blood sugar or on insulin at Ohio State University. The goal was to see if using the CGM alongside sta…

This study looked at how well the drug Livalozet lowers bad cholesterol (LDL-C) in people with high cholesterol, comparing those with and without diabetes. Over 1,500 adults took part for 24 weeks. The main goal was to measure the change in LDL-C levels from the start of the stud…

This completed phase 4 trial compared two common diabetes drugs, dapagliflozin and empagliflozin, added to metformin in 108 adults with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD). Participants took one of the two drugs daily for six months. Researchers used live…

This completed study looked at over 28,000 people with type 2 diabetes and a type of heart failure called HFpEF. Researchers compared two drugs, tirzepatide and semaglutide, to see which one better reduces the risk of death or hospitalization for heart failure. The study used rea…

This completed study tested whether a health behavior program designed with input from immigrant communities can improve diabetes management in first-generation immigrants with type 2 diabetes. Researchers compared the culture-sensitive program to standard care in 202 participant…

This study tested a new drug called OMT-28 in 28 people with primary mitochondrial disease, a condition that affects how cells produce energy. Participants took the drug once daily for 6 months, and researchers measured safety, blood markers of inflammation, and symptoms like fat…

This study tested a new device, DyaMX, that uses an endoscope to regenerate the lining of the upper small intestine in people with type 2 diabetes. The goal was to see if the procedure is safe and can help improve blood sugar control. 65 adults with diabetes took part. The main f…

This study tested a fully automated system that delivers both insulin and glucagon to manage blood sugar in adults with type 1 diabetes. Over 12 months, 243 participants used either the dual-hormone device or their usual care. The goal was to see if the system helps keep blood su…

This study tested whether a daily semaglutide tablet helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the drug or a placebo for 44 weeks, along with guidance on diet and exercise. The main goals were to measure the percentage of weig…

This study tested two ways to help food-insecure adults with heart risks eat more fruits and vegetables. One group got a $20 grocery credit every two weeks, the other got a box of produce delivered to their home. Researchers measured changes in diet and food security over time.

This study tested whether eating one avocado and one cup of mango daily for 8 weeks could improve blood vessel health and thinking in 82 adults with pre-diabetes. Participants were randomly assigned to either a diet including these fruits or a matched control diet. Researchers me…

This study tested whether adding social gaming (earning points and supporting each other) to a weight loss app helps adults with overweight or obesity and at least 3 risk factors for type 2 diabetes lose more weight over 12 months. About 240 adults used a mobile app to track food…

This study tested whether a sleep coaching program could help young adults (ages 18-26) with type 1 diabetes sleep longer and improve their blood sugar levels. Participants received personalized sleep advice and weekly check-ins over several weeks. The goal was to see if better s…

This early-phase study tested a special form of cannabidiol (CBD) called DehydraTECH, alone or combined with GLP-1 drugs (like Ozempic), in 148 overweight or obese adults with prediabetes or type 2 diabetes. The main goal was to check safety and how the body processes the drugs, …

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

People with cystic fibrosis often develop prediabetes and then diabetes, but doctors lack a good way to predict who will progress. This pilot study at Indiana University tests whether a continuous glucose monitor worn for up to 10 days, combined with a mathematical model called t…

Researchers are evaluating four blood glucose meters and four HbA1c point-of-care devices to see how accurately they measure blood sugar and long-term glucose control compared with standard lab methods. The study includes people with diabetes, both adults and teenagers, some of w…

Researchers are testing a device called Glyconics-DS that shines near-infrared light on a fingernail to measure glycated keratin, a marker linked to blood sugar. The trial enrolls about 486 adults who do not know their diabetes status and compares the scan result with a standard …

This pilot study explores whether three different home sleep apnea testing devices—NightOwl, SleepImage, and Nox T3—are practical and user-friendly for adults with type 2 diabetes. Participants will wear each device at home for three nights and answer questionnaires about their e…

Researchers at Assiut University are investigating whether the ratio of two blood proteins, fibrinogen and albumin, is linked to diabetic kidney disease in people with type 2 diabetes. The study compares 50 patients who have both type 2 diabetes and kidney disease with 50 patient…

This study investigates whether hearing problems are an under-recognized complication of diabetes. Researchers will screen 172 adults with type 1 or type 2 diabetes using hearing tests and a questionnaire. If a hearing issue is found, a more detailed assessment will be done to de…

This study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…

This study tested a new rapid blood test (LumiraDx HbA1c) to see how well it measures blood sugar control in people with diabetes. Researchers compared it to a standard lab method in 177 adults. The goal was to see if the quick test is accurate enough for routine diabetes monitor…

This study looked at new markers in blood and urine to detect and predict the severity of drug-associated acute pancreatitis in adults. Researchers compared these markers in 175 patients with drug-induced pancreatitis, other pancreatic diseases, and healthy volunteers. The goal i…

Researchers are testing whether a very-low-carbohydrate diet can help adults with prediabetes and obesity lose weight, reduce body fat, and improve insulin sensitivity. The trial enrolls adults aged 30 to 65 with obesity and newly diagnosed prediabetes. Participants are randomly …

Women with class III obesity who gain too much weight during pregnancy face higher risks of diabetes, high blood pressure, cesarean delivery, and larger babies. Standard prenatal care often does not include nutrition counseling based on weight. This trial tests whether adding gro…

Researchers at Stanford University are testing whether the Diabetes Body Project, a six-session group program, can reduce eating disorder symptoms and improve blood sugar control in young women with type 1 diabetes. The study enrolls 55 female-identifying participants aged 15 to …

This study tested whether adding a special 'pre-session'—which includes education about diabetes risks, motivational interviewing, and help solving barriers—could encourage more people to attend a national diabetes prevention program. The trial involved 483 adults at risk for dia…

This pilot trial tests whether a multi-part program given to emergency department patients with metabolic syndrome can encourage more walking and healthier habits. Participants receive a Fitbit, watch a short educational video, get a written exercise prescription, receive text re…

This study tested a program to prevent type 2 diabetes in Chinese immigrants with prediabetes. Participants received weekly videos on diabetes prevention and fresh, culturally appropriate produce. The goal was to see if this approach could help people lose weight and build health…

This study follows people at high risk for diabetes who previously took part in a program testing intensive lifestyle changes or the drug metformin. The goal is to see if these approaches can prevent or delay diabetes and reduce long-term health problems like heart disease and ca…

This study analyzes health records from over 2 million adults across five continents to see if GLP-1 receptor agonists (like semaglutide and liraglutide) can lower the risk of developing Alzheimer's disease. It focuses on people aged 40 and older with type 2 diabetes or obesity, …

This completed study tested a 24-month program that combined face-to-face counseling with digital tools to help families prevent and manage type 2 diabetes and high blood pressure. Over 1,200 adults and their children from Albania, Bulgaria, Greece, and Spain took part. The progr…

This study tested a diabetes prevention program adapted for American Indian men living on the Colville reservation. Overweight and obese men without diabetes took part in a culturally informed program aimed at weight loss and reducing diabetes risk. The trial enrolled 113 men and…

This study tested a six-month home-based exercise program using elastic bands to prevent frailty in 120 adults aged 50-85 with type 2 diabetes and chronic kidney disease. The program aimed to improve muscle strength and daily functioning. Researchers measured changes in frailty s…

This study tested whether giving a daily mix of two types of friendly bacteria (Lactobacilli) to children at genetic risk could prevent or slow down autoimmune diseases like celiac disease, type 1 diabetes, and thyroid problems. The researchers enrolled 202 children who already h…

This study tested a special version of the Diabetes Prevention Program designed specifically for men. 301 men with pre-diabetes or high risk took part to see if the program helped them lose weight and prevent type 2 diabetes. The program focused on lifestyle changes and was deliv…

This completed study tested a 6-month program that taught nutrition and exercise to mothers and their children (ages 7-12) in the Yaqui Valley, Mexico. The goal was to improve lifestyle habits and prevent food insecurity, malnutrition, and related health problems like heart disea…

This study tested a new way to prevent type 2 diabetes in people with pre-diabetes. Participants wore a continuous glucose monitor (CGM) on their arm and received AI-generated educational videos on their smartphone. The goal was to see if this combination could help lower average…

People with type 2 diabetes often need daily insulin injections and blood sugar checks, which can cause pain and fear. Researchers are testing whether viewing a nature image on a screen for a few minutes before these procedures reduces pain and fear. The trial enrolls 64 adults w…

This study tested whether watching calming VR videos or squeezing a stress ball could reduce pain, anxiety, and improve satisfaction during insulin injections in older adults (65+) with type 2 diabetes. 90 participants were split into three groups: VR, stress ball, or usual care.…

This study tested a video-based telemedicine program called REDCHiP for parents of young children (ages 2-6) with type 1 diabetes. The program uses education, behavior training, and therapy to reduce parents' fear of hypoglycemia (low blood sugar). 396 families participated, comp…

This study tests whether a 6-week program of non-weight bearing exercise can help diabetic foot ulcers heal faster than standard wound care alone. Forty adults with type 2 diabetes and a foot ulcer will be randomly assigned to exercise plus standard care or standard care only. Re…

This study compares two common anesthetics—propofol and sevoflurane—to see which one causes less confusion (delirium) after surgery in older diabetic patients. Researchers will enroll 450 people aged 60 and older undergoing non-cardiac surgery. The goal is to find the best anesth…

Researchers are testing whether a two-week course of functional magnetic stimulation applied to the sole of the foot can improve feeling, foot strength, balance, and walking in adults with type 2 diabetes and diabetic peripheral neuropathy. Participants are randomly assigned to r…

Doctors often withhold food from patients being treated for diabetic ketoacidosis in the intensive care unit, but no evidence supports this practice. Researchers are testing whether starting an oral diet early in treatment helps resolve the condition faster and shortens ICU and h…

Researchers are testing whether cognitive behavioral therapy for insomnia (CBT-I) can improve blood sugar control in older Chinese adults with type 2 diabetes and insomnia. The trial compares CBT-I to usual care in 214 participants aged 60 and older. They will measure changes in …

People with type 2 diabetes often face higher rates of anxiety and depression than the general public. Researchers at Dasman Diabetes Institute are testing whether six weeks of guided breath awareness, practiced inside a pyramid-shaped structure, can reduce those symptoms. The pi…

This study tests whether a new medicine called CagriSema can reduce nerve pain in people with type 2 diabetes. About 142 adults with painful diabetic neuropathy will receive either CagriSema or a placebo for around 10 months. The main goal is to see if the drug lowers weekly pain…

This small study in Uganda looks at how meals made with local fruits and vegetables affect blood sugar and fat levels in people with type 2 diabetes. Eight participants will eat five different test meals over five weeks, with blood samples taken over three hours after each meal. …

This study looked at whether quercetin, a natural substance found in foods like apples and onions, can change how the body absorbs sugar. Researchers gave 24 obese adults (some with type 2 diabetes) either quercetin or a placebo during a sugar-drink test. They measured blood suga…

This study asks whether using a continuous glucose monitor (CGM) — a small sensor worn under the skin that tracks blood sugar levels in real time — can improve quality of life for adults with type 2 diabetes. Participants will use the device for 12 months and complete questionnai…

This study tests whether a walking program that uses FitBit tracking and personalized coaching can help people who recently had a leg amputation due to diabetes or peripheral artery disease become more physically active. Participants will use a FitBit to monitor their steps and r…

This study tested a smartphone app called SNAQ that estimates the carbohydrate content of a meal from a single photo. The goal was to see if using the app helps people with type 1 diabetes keep their blood sugar in a healthy range. 44 adults who already use an automated insulin p…

This study tested a non-invasive ear-clip device that gently stimulates the vagus nerve to see if it can reduce pain in people with diabetic peripheral neuropathy. 185 adults with type 2 diabetes and chronic nerve pain used the device or a sham version twice daily for 12 weeks. T…

This study tested custom 3D printed insoles for people with diabetes who are at risk of foot ulcers. Thirty participants wore different types of insoles in a lab to see which ones best reduced pressure on the bottom of the feet. The goal was to improve foot health and mobility.

This study tested whether a single dose of TRPTI (oleoylethanolamide), a dietary supplement, could improve how the body handles sugar in 19 healthy adults. Participants received either 150 mg, 300 mg, or a placebo in random order, then had their blood sugar and insulin levels mea…

This study looked at whether exercising in the morning or evening helps control blood sugar better in pregnant women with gestational diabetes or glucose intolerance. 39 women walked or stepped for 30 minutes either after breakfast or after dinner. The researchers measured blood …

This study tested whether personalized text messages could help young adults with type 1 diabetes feel more confident managing their condition as they moved from pediatric to adult care. 234 participants received either usual care or usual care plus a text messaging program. The …

This study tested a new drug called naronapride in 328 adults with moderate to severe gastroparesis (stomach paralysis). Participants took either 10, 20, or 40 mg of the drug or a placebo daily for 12 weeks. The goal was to see if the drug could reduce symptoms like nausea, vomit…

This study tested whether using electrical stimulation on the thigh muscles could improve how the body uses insulin in people with type 2 diabetes. Eighteen adults with type 2 diabetes who were overweight and on oral medication received a single session and then six days of daily…

This small phase 2 trial tested whether taking abscisic acid (ABA), a natural plant hormone, can improve how the body handles sugar in people with prediabetes. Five adults with elevated fasting glucose or HbA1c took ABA and had their insulin sensitivity measured using a precise c…

This small study tested whether gummy candies made with maqui berry could help overweight adults control their blood sugar after eating a carb-rich meal. Ten participants ate white bread alone, or with maqui berry gummies, and had their blood sugar and antioxidant levels measured…

This study tested whether adding spiritual care to standard diabetes care helps adults with type 2 diabetes. 80 participants received either usual care or usual care plus a structured spiritual program. Researchers measured changes in psychological resilience, distress, and blood…

Researchers collect small samples of abdominal fat during planned surgery to study how fat tissue releases chemical messengers called endocannabinoids. They compare samples from people with obesity, with or without type 2 diabetes, to samples from people without these conditions.…

This pilot study adapted a behavioral intervention called BECOME to help people with dementia or mild cognitive impairment and their caregivers manage non-communicable diseases (like diabetes and high blood pressure) and common mental health conditions (like depression and anxiet…

This observational study investigates the role of hormonal and metabolic disorders in the development of gestational diabetes mellitus (GDM). Researchers are analyzing data from over 600 pregnant women to identify risk factors and markers that could predict adverse outcomes for b…

This completed study looked at insurance claims data from 70,000 people with type 2 diabetes and established heart disease to compare the heart-related risks of three diabetes drugs: tirzepatide, dulaglutide, and semaglutide. The goal was to see if any of these drugs was linked t…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

This study looks at whether a continuous glucose monitor (CGM) can provide better insight into blood sugar patterns in pregnant women at risk for gestational diabetes than the usual oral glucose tolerance test (OGTT). Researchers will give 400 high-risk pregnant women a CGM senso…

This study looks at how the menstrual cycle changes blood sugar and energy use in women with type 1 diabetes. About 40 women will use a closed-loop insulin pump and continuous glucose monitor to track these changes. The goal is to understand how hormone shifts affect insulin need…

This study looked at how different types of aerobic exercise (moderate continuous training vs. high-intensity interval training) and diet counseling affect cell health in people with type 2 diabetes. Researchers measured changes in mitochondria (the cell's power plants) and oxida…

Researchers at KK Women's and Children's Hospital are studying whether the timing of meals and snacks during pregnancy relates to blood sugar levels. About 300 pregnant women in Singapore, between 18 and 21 weeks gestation, will keep food diaries and use a food record app. The te…

This completed study looked at 1759 adults aged 18-55 to uncover why some people develop type 2 diabetes. Researchers measured how the body handles sugar, uses energy, and stores fat, and also collected genetic samples. The goal was to find genetic and lifestyle factors that lead…

Researchers are examining the medical records of 12,000 people with type 2 diabetes who visited a large diabetes care center in Southern India during 2022 and 2023. The study aims to estimate how many of these patients have kidney insufficiency, a complication that past estimates…

Researchers at the University at Buffalo are studying whether insulin can reduce inflammation by suppressing toll-like receptors, which are part of the body's immune alarm system. The trial compares insulin infusion with dextrose and saline infusions in three groups: lean healthy…

This study uses computer simulations to compare two treatment strategies for people with chronic kidney disease and type 2 diabetes. Researchers will model whether adding empagliflozin to finerenone reduces heart failure, hospitalizations, and cardiovascular death more than finer…

This completed study in Kazakhstan looked at 240 adults recently diagnosed with diabetes. Researchers measured blood sugar, insulin resistance, and immune markers to understand how different forms of diabetes develop. The goal is to help doctors diagnose and treat adult-onset dia…

This study is testing whether following a Mediterranean-style diet based on U.S. dietary guidelines improves heart health more when combined with weight loss. Researchers will provide all meals for 70 adults with obesity or excess body fat for eight weeks. Participants will be sp…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looks at American Indians with type 2 diabetes who had early kidney disease and took a drug called losartan years ago. Researchers want to see if the benefits of that treatment still help protect their kidneys today. About 141 people who were in the earlier study or th…

Researchers in Belgium are studying adults with type 2 diabetes to understand how often they develop non-alcoholic fatty liver disease (NAFLD) and what that condition looks like. Participants will undergo a liver scan, provide blood samples, and answer questionnaires about their …

This trial tests whether a single dose of the antipsychotic drugs olanzapine or ziprasidone changes how the body responds to insulin, compared with a placebo. The study enrolls healthy young men who are overweight or have early signs of insulin resistance, but who have never take…

This study compares two diets in people with overweight and early signs of blood sugar problems: a low-carbohydrate diet and a Mediterranean diet, both designed to produce similar weight loss. Each participant follows both diets for four weeks, in random order, with a break in be…

Researchers are using ultrasound to measure the thickness of ankle cartilage in people with type 2 diabetes who have nerve damage, and comparing it with healthy adults. Diabetic polyneuropathy may change how the lower limbs move, which could affect the ankle joint. The study incl…

Researchers at Indonesia University are studying how diet, body measurements, genetic profiles, and blood biomarkers relate to glucose levels in healthy adults. The trial includes 181 participants split into three groups: one follows a balanced diet, one follows a low-carbohydrat…

This study looked at the genes and lifestyle of over 7,400 people in Nigeria to understand why some develop type 2 diabetes. Researchers compared people with and without diabetes to find genetic differences. The goal is to learn more about diabetes causes in African populations a…

This completed study looked at risk factors for diabetes and heart disease in 146 healthy African, African-American, and white women who were federal employees or contractors. Researchers compared things like triglyceride levels and insulin resistance to see if the best screening…

This study looks at how body weight influences physical activity, balance, and quality of life in 50 adults with type 2 diabetes. Researchers will measure body composition, muscle strength, walking ability, and balance using simple tests and questionnaires. The goal is to better …

This completed Phase 1 study looked at how vitamin E is absorbed and used in the bodies of normal-weight and obese women, and whether vitamin C helps. Fifty women aged 18 to 40 took part, including some with type 2 diabetes. Researchers gave different doses of vitamin E (by mouth…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study tests whether a non-invasive device called Gastric Alimetry can detect changes in stomach muscle activity caused by semaglutide (Ozempic). Researchers will measure stomach electrical signals and symptoms in people with and without diabetes before and after taking the w…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

Researchers at Texas A&M University are studying whether small molecules in blood and skin fluid can predict how the body handles carbohydrates, protein, and fat from meals. The study involves 30 adults aged 50 to 75 who will eat different test meals and have their blood and skin…

This observational study looks at records from Israel's National Insurance Institute to understand how often diabetes is linked to permanent disability. It will compare disability rates and severity across different regions and over time, from 2020 to 2025. No treatments or tests…

This pilot study tests whether eating a low-carbohydrate, high-unsaturated-fat diet for three days can alter the liver's fat composition and the activity of genes linked to fat metabolism, inflammation, and scarring in people with pre-diabetes. Participants will follow either thi…

This study follows adolescents with youth-onset type 2 diabetes, along with obese and lean peers, into young adulthood to see how their kidneys change over time. Using advanced imaging and kidney function tests, researchers aim to understand early signs of diabetic kidney disease…

This study is looking at whether peripheral artery disease (PAD) is linked to lower levels of regenerative cells in the blood. Researchers will compare blood samples from adults with PAD to those without the condition, measuring the number of certain progenitor cells and markers …

This study looks at whether a substance in the blood called neurofilament light chain (NfL) is linked to how severe nerve damage is, how well people balance, and their risk of falling. Researchers will measure NfL levels in 80 adults with type 2 diabetes, some with and some witho…

This study is investigating how often dangerous heart rhythm problems occur in people receiving hemodialysis for end-stage kidney disease. Researchers will implant a small device under the skin to continuously monitor heart rhythm for 18 months in 70 patients, half of whom have d…

This study looks at whether adrenaline, the body's stress hormone, triggers an immune reaction during low blood sugar (hypoglycemia) in people with and without type 1 diabetes. Researchers will lower participants' blood sugar and then give drugs that block adrenaline's effects to…

This trial investigates how replacing animal proteins with plant proteins in the diet influences metabolism. Adults with early signs of metabolic syndrome (like high triglycerides or slightly elevated blood pressure) will follow a controlled diet for four weeks, either predominan…

This study explores whether compounds in cannabis, like THC and CBD, can reduce inflammation and improve how the body responds to insulin. Researchers will measure blood markers of inflammation and insulin sensitivity in people across the weight spectrum, both after a single use …

This study looks at how type 1 diabetes affects the heart, lungs, and overall fitness of children aged 6 to 17. It also measures their physical activity levels and quality of life. Researchers will compare these results with those of healthy children of the same age. The goal is …

This study tests a two-year educational program for medical and physician assistant students in rural areas. The curriculum includes classroom sessions, simulations, and community rotations to improve teamwork skills. Researchers measure changes in knowledge, attitudes, and team …

This study looks at whether drinking a beverage with artificial sweeteners (erythritol or xylitol) changes how blood platelets clump together, which could affect heart attack or stroke risk. Researchers will measure platelet activity and blood levels of these sweeteners in 50 hea…

This study investigates how women with type 1 diabetes manually adjust their automated insulin delivery (AID) systems to manage blood sugar changes during their menstrual cycle. Researchers will interview 69 women to catalog strategies like entering fake carbohydrates or changing…

This study tests different ways to invite adults with diabetes who struggle to take their medications as prescribed. Researchers will compare letters and phone call strategies to see which approach gets more people to schedule and attend a pharmacist appointment. The goal is to f…

This study investigates how the liver processes nutrients after a meal in healthy individuals and in patients with fatty liver disease or cirrhosis. Researchers will take blood samples and liver biopsies after fasting or eating a standardized meal, and after a glucagon injection.…

This study investigates why athletes with type 1 diabetes often experience higher blood sugar during competitions compared to regular training. Researchers will monitor 12 athletes with type 1 diabetes and 12 healthy athletes during a 5K race and a 5K training session, measuring …

This study tested whether training healthcare providers to prescribe continuous glucose monitors (CGMs) increases their use among patients with type 2 diabetes. Researchers trained clinic staff at three community health centers serving a mostly Hispanic/Latino population. They th…

This study tests French versions of three questionnaires that measure fear of low blood sugar (hypoglycemia) in children with type 1 diabetes and their parents. The goal is to ensure these tools are reliable for French-speaking families. About 194 children aged 2 to 18 and their …

This study looked at how the heart fills and pumps blood when the body is tilted or exposed to lower body pressure. Researchers compared 30 people with type 1 diabetes and healthy volunteers. They used heart monitoring and ultrasound to measure changes, aiming to understand how d…

This study looked at 347 children and teens with type 1 diabetes who use the Medtronic MiniMed 780G insulin pump. Researchers tracked how much carbohydrate they ate each day and measured their blood sugar control over time. The goal was to understand the link between daily carb i…

This study analyzed health records from over 450,000 adults with obesity and type 2 diabetes to see if adding a GLP-1 or SGLT2 drug early improves survival and kidney health. Researchers compared those who added the other drug class within 90 days to those who added a different d…

This study investigates whether stress hormone activity is linked to depression and brain changes in children with type 1 diabetes. Researchers will measure cortisol levels and use brain scans in children aged 6–12 who have had diabetes for at least a year, comparing them to thei…

This study aimed to create a detailed map of the cells in the human appendix and understand their genetic activity. Researchers analyzed appendix tissue from 5 patients undergoing colon cancer surgery. The goal was to learn more about the appendix's role in the immune system and …

This completed study took small tissue samples from the colons of 40 people during routine colonoscopies. Using advanced genetic techniques, researchers created a detailed map of the different cell types and their gene activity. The goal is to better understand how colon diseases…

This completed study in India looked at 362 hospital patients to understand how common high blood sugar (hyperglycemia) is and how it affects their hospital stay. Researchers measured blood sugar levels, checked for diabetes, and looked at body composition and certain blood marke…

This study looked at how gut bacteria affect the development of type 2 diabetes and help personalize treatment. Researchers followed 100 adults newly diagnosed with type 2 diabetes who had not taken diabetes medication before. They analyzed stool samples and blood tests, then ass…

This study tested whether a special heart ultrasound (speckle tracking strain echocardiography) can detect early heart muscle changes in 61 adults with type 1 diabetes, before symptoms appear. Researchers looked for links between these changes and small blood vessel damage (micro…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study looked at how quickly bringing high blood sugar under control, combined with moderate treadmill walking, affects certain proteins linked to bone health in people with type 2 diabetes. The goal was to understand why some patients develop a rare but serious joint conditi…

This study looked at the genes of 40 adults with type 2 diabetes to find DNA differences that might explain why some develop Charcot foot, a serious joint problem. Half of the participants had Charcot foot, and half did not. Researchers compared their exomes (the part of DNA that…

This study looked at how the COVID-19 lockdown changed blood sugar control and self-care in 77 young people aged 13 to 25 with type 1 diabetes. Researchers used data from a glucose monitoring platform to compare blood sugar levels before, during, and after the two-month lockdown …

This study looked at whether people with severe, long-term uncontrolled type 1 diabetes would accept and benefit from a closed-loop insulin delivery system (an 'artificial pancreas'). Researchers followed 66 adults with very high blood sugar levels over several years. The goal wa…

This study looked at how much blood sugar levels go up and down during the day in frail or disabled patients over 75 with diabetes who use basal insulin. Researchers used a continuous glucose monitor for 5 days to compare two types of insulin: human NPH and long-acting analogues.…

This study looked at 100 pregnant women with gestational diabetes to see if they were taking the recommended amount of iodine. Iodine is important for both mother and baby, and health authorities suggest supplements during pregnancy. The goal was simply to find out if these women…

This completed study tested a new biosensor designed to measure blood glucose every 10 minutes in people with type 1 diabetes who use an insulin pump. The sensor uses microdialysis to sample interstitial fluid and was compared to standard continuous glucose monitors (CGM) during …

This completed study looked at 192 adults with acute ischemic stroke to see if large swings in blood sugar (glycemic variability) are linked to worse outcomes, including death and disability. Participants wore a continuous glucose monitor for 96 hours. The goal was to understand …

This completed study looked at 126 people with different fat distribution patterns—including those with lipodystrophy (abnormal fat loss or distribution), obesity, and normal weight—to understand how fat tissue relates to insulin resistance and immune signals. Researchers measure…

This study looked at whether getting an islet transplant after a kidney transplant helps people with type 1 diabetes avoid kidney failure or death. Researchers reviewed data from 327 people in France who had a kidney transplant between 2000 and 2017. They compared those who also …

This study looked at how type 1 diabetes and long-term blood sugar control (HbA1c) affect the body's ability to deliver and use oxygen during exercise. Researchers compared 79 people with and without diabetes to understand why fitness levels may be lower in those with high blood …

This study looked at whether certain gene changes (in the TCF7L2 gene) make ICU patients with organ failure more likely to develop high blood sugar. Nearly 1,000 adults in the ICU were checked for these gene changes and their blood sugar levels. The goal was to understand the lin…

This study looked back at medical records of 2,740 adults with type 2 diabetes who were admitted to the ICU for septic shock, a life-threatening infection. Researchers wanted to see if those who were already taking metformin (a standard diabetes pill) before getting sick had a lo…

This study looked at whether women with different types of gestational diabetes respond differently to meals with varying amounts of carbs, protein, and fat. Nineteen women with gestational diabetes wore a continuous glucose monitor and ate two test meals. The goal was to see if …

This study looked at 42 infants who had surgery for a rare birth defect called esophageal atresia type III. Researchers gave the babies a sugary drink to see how often they developed dumping syndrome, a condition causing rapid blood sugar changes. The goal was to find out how com…

This completed study looked at how sleep apnea and other health problems like diabetes and high blood pressure affect pain after root canal treatment. 78 adults were divided into three groups: those with sleep apnea, those with diabetes or high blood pressure, and healthy people.…

This completed study looked at 172 people with and without HIV to understand why those with HIV have a higher risk of diabetes. Researchers examined fat tissue and immune cells to see if chronic immune activation in fat contributes to insulin resistance. The goal was to learn how…

This study looked at how different levels of exercise change the bacteria in the gut of people with type 2 diabetes. Forty adults with type 2 diabetes did either moderate or high-intensity endurance and strength training for 16 weeks. Researchers compared changes in blood sugar a…

This study tested whether a family history app can help doctors collect and use information about patients' family health risks. Over 600 adults aged 30-69 took part. The goal was to see if the app leads to better screening and genetic referrals for conditions like cancer, heart …

This study looked at how inherited gene variants influence the body's response to two common type 2 diabetes medications, metformin and glipizide. Over 1,000 participants took each drug and had their glucose and insulin levels measured. The goal was to understand why some people …

This study tested a new computer algorithm that uses data from wearable sensors and food diaries to predict a person's real-time risk of developing prediabetes. 77 overweight or obese adults wore glucose monitors and fitness trackers for 4 months. The goal was to collect data to …

This study analyzed data from over 16,500 adults with chronic heart failure who were part of a remote monitoring program in France. Researchers looked at how having diabetes, other health conditions, and short-term weight changes were linked to survival. The goal was to better un…

This completed trial tested whether electronic alerts in the emergency room can improve care for people with type 2 diabetes. The alerts prompted doctors to order an A1c test when blood sugar was very high, and to consider admitting the patient for better diabetes management. Res…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This completed study from Denmark looked at 101 people to see if nerve damage from type 2 diabetes is linked to memory and thinking problems. Researchers compared people with and without diabetes using tests of thinking skills, nerve function, and brain scans. The goal was to und…

This completed study looked at why people with type 1 diabetes lose their natural defense against low blood sugar—the hormone glucagon. Researchers tested whether blocking a hormone called GLP-1 with a drug (exendin(9-39)amide) could restore glucagon release during low blood suga…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study looked at how blood sugar levels change in hospitalized babies with intestinal failure when their intravenous nutrition is given in cycles instead of continuously. Nine infants wore a small sensor on their thigh that measured glucose every 5 minutes for up to 30 days. …

This study tested a tool called HealtheRx, which gives African American patients in rural North Carolina a personalized list of local resources for food, housing, transportation, and more. The goal was to see if this information helps patients feel more confident finding and usin…

This pilot study tested whether taking metformin 30 or 60 minutes before a meal affects carbohydrate absorption in people with obesity and prediabetes or type 2 diabetes. One participant completed three oral glucose tolerance tests—one without metformin, one with metformin taken …

This completed early-phase study tested different doses of fatty acids (Intralipid) in 9 healthy volunteers to find the dose that causes mild insulin resistance. The goal was to create a reliable model for future diabetes research. Participants received low or medium doses of fat…

This study looked at how eating disorders, like anorexia or bulimia, impact blood sugar levels in women with type 1 diabetes. Researchers compared glucose control between those with and without eating disorders. The goal was to better understand these risks and improve screening …

This study followed over 2,000 pregnant women to measure their blood sugar levels throughout pregnancy. The goal was to see how glucose patterns relate to gestational diabetes and whether the baby is born larger than normal. Researchers used continuous glucose monitors and standa…

This study looked at how the amount of salt in the diet changes the effects of the diabetes drug ertugliflozin on blood pressure and kidney function. Overweight adults with type 2 diabetes followed either a low-salt or high-salt diet while taking the drug or a placebo. The goal w…

This study looked at data from 348 people with type 2 diabetes in Germany who use the myTherapy app. Researchers wanted to see how many had high levels of a protein called albumin in their urine, which is a sign of kidney damage. They also tracked how these levels changed over a …

This completed study looked for rare, single-gene causes of insulin-dependent diabetes in 127 participants. Researchers collected blood samples and performed metabolic tests to identify genetic defects. The goal was to better understand these genetic forms of diabetes and possibl…

This study combines data from four earlier trials to track 262 adults with type 2 diabetes and obesity for up to 13 years. Researchers want to see if bariatric surgery keeps blood sugar under control longer than medical or lifestyle changes. Participants were originally in random…

This study tested a smartphone-based tool called PEPPER that gives personalized insulin dose advice to people with type 1 diabetes. The tool uses artificial intelligence to learn from each person's past data and includes safety features like low-glucose alarms. Eight adults used …

This study tested whether home automation and remote monitoring can help elderly people (65+) with multiple chronic conditions live safely at home. Over 500 participants had their homes equipped with sensors that tracked health signs and sent alerts to doctors. The main goal was …

This small pilot study looked at whether aprepitant, a drug used for nausea, can reduce aldosterone (a hormone that raises blood pressure) in people with type 2 diabetes and low-renin hypertension. Five participants took either aprepitant or a placebo for two weeks, then switched…

This completed study looked at how the hormone GIP changes blood flow in the gut after a sugary drink in 10 people with type 2 diabetes. Researchers used a GIP-blocking drug to see what happens when GIP is stopped. The goal was to better understand GIP's role in digestion and met…

This completed study looked at 189 adults with type 1 diabetes who used one of three advanced hybrid closed-loop insulin pump systems: Medtronic Minimed 780G, Tandem T Slim X2, or CamAPS Fx. The goal was to see which system helped patients keep their blood sugar in a very tight r…

This completed study looked at 115 young people aged 10 to 25 with type 1 diabetes in Spain. Participants filled out an online survey about their mental health, eating habits, and how well they manage their diabetes. The goal was to see if these factors differ by age and sex, and…

This study tested a personalized medicine approach in 239 people with type 2 diabetes who use multiple daily insulin injections. Researchers used blood tests (C-peptide and GAD antibodies) to see if some patients could safely stop their mealtime insulin and switch to other diabet…

This study looked at whether giving a carbohydrate drink (yogurt with honey) before elective abdominal surgery is safe and helpful for people with type 2 diabetes. 120 patients were split into three groups: non-diabetic controls, non-diabetic with the drink, and diabetic with the…

This study looked at whether giving oral glucose at a slightly higher blood sugar threshold can prevent mild-to-moderate hypoglycemia in people with type 1 diabetes. Thirty adults with type 1 diabetes were given 16g of oral carbohydrates when their blood glucose reached a target …

This pilot study tested two automated insulin delivery systems (Medtronic 780G and Tandem t:slim X2) in 20 adolescents with type 1 diabetes. Participants ate breakfasts without telling the device how many carbs they were eating. The goal was to see how well each system controlled…

This study looked at how automated insulin delivery (AID) systems, including homemade DIY versions, perform in physically active adults with type 1 diabetes. Over six weeks, 76 participants wore their own AID systems and a fitness tracker while sharing glucose and insulin data. T…

This study looks at why dapagliflozin, a diabetes drug, can raise 'bad' cholesterol levels. Researchers will track how the body makes and clears cholesterol in 28 adults with type 2 diabetes over 6 months. Half the participants will get dapagliflozin, the other half a placebo. Th…

This study looked at 1500 people with obesity (BMI 25 or higher) to find out what helps diabetes go away and other health issues improve after weight-loss surgery. Researchers collected health data before and after surgery, including weight, blood sugar, and quality of life. The …

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This completed study looked at how people change their eating habits after starting GLP-1 drugs like Ozempic or Mounjaro for weight or diabetes. Researchers tracked 37 adults using dietary records and questionnaires to see if it's feasible to study diet changes this way. The goal…

This study looked at over 133,000 adults with newly diagnosed type 2 diabetes who were smokers. Researchers wanted to see if switching from regular cigarettes to e-cigarettes could lower the risk of heart problems and diabetes complications. The study used health records to compa…

This study looked at how brown adipose tissue (brown fat) works in people with type 2 diabetes. Researchers used special PET scans with a fat-based tracer to measure brown fat activity more accurately than before. The study included 6 participants and aimed to better understand h…

This study tested a program called ImPart-Multi, where a trained helper (lay navigator) coached Black patients with chronic kidney disease and their care partners on how to work together when making health decisions. 22 patients and their care partners joined, and patients comple…

This study looked at how diabetes changes the way certain fats (arachidonic acid) are processed in fatty plaques that build up in the carotid artery. Researchers compared plaque samples from 204 diabetic and non-diabetic patients undergoing surgery for carotid stenosis. The goal …

This study looked at how semaglutide, a diabetes medicine, affects the kidneys in people with type 2 diabetes and chronic kidney disease. 106 participants received either semaglutide or a placebo injection once a week for about a year. Researchers used MRI scans, blood and urine …

This study looked at whether improving blood sugar control can restore a protein called apoC1, which helps reduce bad cholesterol. Researchers compared 160 type-1 diabetes patients with poor blood sugar control to 80 healthy controls. They took blood samples to measure how well a…

This study looked at a recently discovered hormone called 26RFa in 62 women who were obese, some with type 2 diabetes and some without. Researchers measured the hormone levels before and after weight-loss surgery (sleeve gastrectomy) and compared them to healthy-weight volunteers…

This study explored whether personality type (A or B) and stress levels differ between people with type 2 diabetes who have foot wounds and those who do not. Researchers used questionnaires to measure personality, stress, depression, and quality of life in 66 participants. The go…

This study looked at whether a special education program could help people with diabetic foot (a serious complication of type 2 diabetes) become more prepared for disasters like earthquakes or floods. 68 patients took part, with some receiving the education and others getting usu…

This study looked at how often low blood sugar (hypoglycemia) occurs in elderly diabetic patients living in nursing homes. Researchers used a continuous glucose monitor worn on the skin for 14 days to track blood sugar levels. The goal was to better understand the frequency and c…

This study tested whether simulation (a kind of role-play) can help adults with insulin-dependent diabetes learn to use the Freestyle Libre glucose monitor. Twenty-seven patients who had already completed a standard education program took part. The goal was to see if simulation i…

This study looked at whether GLP-1 agonists, a class of diabetes drugs, can reduce fat buildup in the heart muscle of people with type 2 diabetes. Researchers used MRI scans to measure heart fat before and after 6 months of treatment in 42 adults over 50. The goal was to understa…

This study looked at 103 diabetic adults starting chemotherapy for cancer. Researchers used a continuous glucose monitor (Freestyle Libre) to track blood sugar changes. The goal was to see how often blood sugar went too low or too high during treatment, since chemotherapy and rel…

This completed study looked at healthcare claims data from over 58,000 people to see if it could reproduce the results of the STEP-HFpEF DM trial, which tested semaglutide for heart failure with preserved ejection fraction in people with type 2 diabetes. Researchers compared new …

This study looked at whether COVID-19 lockdowns caused delays in treating diabetic foot ulcers, leading to more amputations. Researchers analyzed hospital records from millions of diabetic patients in France between 2017 and 2020. They compared amputation rates during and after l…

This completed study looked at whether information from healthcare claims (like insurance records) can be used to get similar results as a real clinical trial. Researchers compared people with type 2 diabetes and heart failure who started taking tirzepatide to those who started t…

This study tested whether continuous glucose monitors (CGMs) can reliably track blood sugar levels in newborns at risk of low blood sugar (hypoglycemia) during their first 72 hours. Researchers enrolled 25 babies born large for gestational age or to mothers with diabetes. The goa…

This study followed 87 active adults with type 1 diabetes who use automated insulin pumps and exercise at least twice a week. Researchers tracked their blood sugar levels before, during, and after exercise to see how well the pumps handle physical activity. The goal was to learn …

This study looked at how different types of exercise—short bursts of intense cycling versus steady moderate cycling—affect blood sugar levels in adults with type 1 diabetes. It also compared exercising after a meal versus on an empty stomach. Twenty-one physically active adults c…

This study looked at how well 60 adults with type 2 diabetes could follow a Mediterranean diet for 12 months. Researchers wanted to see what makes it hard or easy to stick with this healthy eating plan. The goal is to find ways to help more people with diabetes adopt this diet.

This study tested a set of strategies to help community health centers routinely identify and act on social needs (like food or housing insecurity) for patients with or at risk for diabetes. Researchers used a tool built into electronic health records to collect this information.…

This study looked at whether measuring pancreatic polypeptide levels after a meal can help doctors tell the difference between type 1 diabetes and type 3c diabetes (caused by pancreas damage). Thirty-six adults with either type 1 or type 3c diabetes gave blood and stool samples. …

This study looked at whether GLP-1 medications (used for diabetes and weight loss) increase the risk of having food or liquid in the stomach before surgery, even after the recommended fasting period. Researchers used a quick ultrasound to check stomach contents in 94 adults sched…

This study examined whether type 2 diabetes influences how well a dental procedure called pulpotomy works in adults. Researchers compared 70 diabetic and non-diabetic patients who had a molar treated for irreversible pulpitis. They checked the tooth's health, symptoms, and X-ray …

This study looked at how different diet compositions affect the number of calories people burn and their risk for chronic diseases like diabetes and heart disease after losing weight. Over 200 adults with overweight or obesity followed a weight-loss phase, then a weight-maintenan…