Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New daily pill could help control blood sugar in type 2 diabetes

NCT ID NCT05971940

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 04, 2026 · Updated 2 times

Summary

This study tested a once-daily pill called orforglipron in 559 adults with type 2 diabetes whose blood sugar was not well controlled by diet and exercise alone. The pill was compared to a placebo (a dummy pill) over about 54 weeks to see if it safely lowers blood sugar levels. The goal is to offer a new, convenient treatment option for managing diabetes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

559 people

The number who actually took part.

Started

Aug 2023

Finished

Apr 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have Type 2 Diabetes * Have HbA1c ≥7.0% (53 mmol/mol) to ≤9.5% (80 mmol/mol) despite diet and exercise treatment, as determined by the central laboratory at screening. * Are naïve to insulin therapy except for gestational diabetes or ≤14 days use for acute treatment and have not used any oral or injectable antihyperglycemic medications during the 90 days preceding screening or between screening and randomization. * Are of stable weight (±5%) for at least 90 days prior to screening and agree to not initiate an intensive diet or exercise program during the study with the intent of reducing body weight other than the lifestyle and/or dietary measures for diabetes treatment. * Have a body mass index (BMI) ≥23.0 kilogram/square meter (kg/m²) at screening. Exclusion Criteria: * Have Type 1 Diabetes * Have a history of ketoacidosis or hyperosmolar state or coma within the last 6 months prior to screening, or between screening and randomization. * Currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema * Have New York Heart Association functional classification IV congestive heart failure. * Have acute or chronic pancreatitis

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Type 2 diabetes are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Type 2 diabetes

Contacts and locations

Locations

  • Abe Clinic

    Ōita, 870-0039, Japan

  • Advance Medical Research Center

    San Juan, 00926, Puerto Rico

  • Affiliated Hospital of Jiangsu University

    Zhenjiang, Jiangsu, 212000, China

  • All India Institute of Medical Sciences (AIIMS) - Nagpur

    Nagpur, Maharashtra, 441108, India

  • Alliance for Multispecialty Research, LLC

    New Orleans, Louisiana, 70119, United States

  • Alliance for Multispecialty Research, LLC

    Norman, Oklahoma, 73069, United States

  • American Health Network of Indiana, LLC - Muncie

    Muncie, Indiana, 47304, United States

  • Amir A Hassan, MD, PA

    Houston, Texas, 77089, United States

  • Ark Clinical Research

    Long Beach, California, 90815, United States

  • BSES MG Hospital

    Mumbai, Maharashtra, 400058, India

  • Beijing Hospital

    Beijing, Beijing Municipality, 100730, China

  • Beijing Pinggu District Hospital

    Beijing, Beijing Municipality, 101200, China

  • Billings Clinic

    Billings, Montana, 59101, United States

  • Burke Internal Medicine and Research

    Burke, Virginia, 22015, United States

  • Central New York Clinical Research

    Manlius, New York, 13104, United States

  • Centricity Research Dublin Multispecialty

    Dublin, Ohio, 43016, United States

  • Centro de Investigacion Medica Integral

    Guadalajara, Jalisco, 44160, Mexico

  • Centro de Investigacion Medica de Occidente, S.C.

    Zapopan, Jalisco, 44260, Mexico

  • Clinical Research Atlanta

    Stockbridge, Georgia, 30281, United States

  • Connecticut Clinical Research - Cromwell

    Cromwell, Connecticut, 06416, United States

  • Ellipsis Research Group - Brooklyn - 7th Street

    Brooklyn, New York, 11215, United States

  • Endocrine Ips, Pllc

    Houston, Texas, 77079, United States

  • Epic Medical Research - Surprise

    Surprise, Arizona, 85378, United States

  • FAICIC S. de R.L. de C.V.

    Veracruz, 91900, Mexico

  • Family First Medical Center

    Idaho Falls, Idaho, 83404, United States

  • Fukuwa Clinic

    Chuo-ku, Tokyo, 104-0031, Japan

  • GMERS Medical College and General Hospital

    Vadodara, Gujarat, 390021, India

  • Global Health Research Center, Inc.

    Miami Lakes, Florida, 33016, United States

  • Grant Medical Foundation - Ruby Hall Clinic

    Pune, Maharashtra, 411001, India

  • Hasegawa Medical Clinic

    Chitose, Hokkaido, 066-0032, Japan

  • Hayashi Diabetes Internal Medicine Clinic

    Chigasaki, Kanagawa, 253-0044, Japan

  • Heishinkai Medical Group ToCROM Clinic

    Shinjuku-ku, Tokyo, 160-0008, Japan

  • Hillcrest Medical Research

    DeLand, Florida, 32720, United States

  • Huizhou Municipal Central Hospital

    Huizhou, Guangdong, 516001, China

  • Infinity Clinical Research - Norco

    Norco, California, 92860, United States

  • Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital

    Kolkata, West Bengal, 700020, India

  • Instituto Veracruzano en Investigación Clínica S.C.

    Veracruz, 91851, Mexico

  • Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos

    Chihuahua City, 31110, Mexico

  • Invictus Clinical Research Group

    Coconut Creek, Florida, 33073, United States

  • Iwamoto Clinic

    Zentsujichó, Kagawa-ken, 765-0071, Japan

  • Jinan Central Hospital

    Jinan, Shandong, 250013, China

  • Juno Research

    Houston, Texas, 77040, United States

  • K2 Medical Research

    Maitland, Florida, 32751, United States

  • Kumudini Devi Diabetes Research Center

    Hyderabad, Telangana, 500072, India

  • Lucas Research - New Bern

    New Bern, North Carolina, 28562, United States

  • Luhe Hospital

    Beijing, Beijing Municipality, 100000, China

  • M S Ramaiah Medical College and Hospitals

    Bangalore, Karnataka, 560054, India

  • MDFirst Research, LLC

    Lancaster, South Carolina, 29720, United States

  • Madras Diabetes Research Foundation

    Chennai, Tamil Nadu, 600086, India

  • Medical Corporation Heishinkai OCROM Clinic

    Suita-shi, Osaka, 565-0853, Japan

  • Medical Corporation Yuga Tsuruma Kaneshiro Diabetes Clinic

    Yamato-shi, Kanagawa, 242-0004, Japan

  • Medstar Speciality Hospital

    Bangalore, Karnataka, 560092, India

  • MinamiAkatsukaClinic

    Mito, Ibaraki, 311-4153, Japan

  • Monroe Biomedical Research

    Monroe, North Carolina, 28112, United States

  • Morinaga Ueno Clinic

    Kumamoto, 860-0863, Japan

  • Nanjing First Hospital

    Nanjing, Jiangsu, 210006, China

  • Nanyang First People's Hospital

    Nanyang, Henan, 473001, China

  • Neighborhood Healthcare Institute of Health

    Escondido, California, 92025, United States

  • Norcal Endocrinology & Internal Medicine

    San Ramon, California, 94583, United States

  • PanAmerican Clinical Research - Querétaro - Avenida Antea

    Querétaro, 76100, Mexico

  • Preferred Primary Care Physicians

    Uniontown, Pennsylvania, 15401, United States

  • Preferred Primary Care Physicians, Preferred Clinical Research-St. Clair

    Pittsburgh, Pennsylvania, 15243, United States

  • Pudong New Area People's Hospital Shanghai

    Shanghai, Shanghai Municipality, 201200, China

  • Puerto Rico Health Institute

    Dorado, 00646, Puerto Rico

  • Quality of Life Medical & Research Center

    Tucson, Arizona, 85712, United States

  • Revival Research Institute

    Dearborn, Michigan, 48126, United States

  • Rophe Adult and Pediatric Medicine/SKYCRNG

    Union City, Georgia, 30291, United States

  • Salud Cardiovascular

    Guadalajara, Jalisco, 44860, Mexico

  • Shunde Hospital of Southern Medical Univesity

    Foshan, Guangdong, 528399, China

  • Steel Memorial Yahata Hospital

    Kitakyushu, Fukuoka, 805-8508, Japan

  • Syed Research Consultants Llc

    Sheffield, Alabama, 35660, United States

  • Tekton Research - Wichita

    Wichita, Kansas, 67218, United States

  • The Corvallis Clinic, P.C.

    Corvallis, Oregon, 97330, United States

  • The Fourth Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150001, China

  • The Institute of Medical Science, Asahi Life Foundation

    Chuo-ku, Tokyo, 103-0002, Japan

  • The Jackson Clinic

    Jackson, Tennessee, 38305, United States

  • The Research Center of The Upstate

    Greenville, South Carolina, 29607, United States

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, Jiangsu, 210011, China

  • The Second Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450014, China

  • Tokuyama Clinic

    Mihama-ku,Chiba City, Chiba, 261-0004, Japan

  • Tokyo-Eki Center-building Clinic

    Chuo-ku, Tokyo, 103-0027, Japan

  • Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente

    Guadalajara, Jalisco, 44150, Mexico

  • University Clinical Investigators, Inc.

    Tustin, California, 92780, United States

  • Velocity Clinical Research, Dallas

    Dallas, Texas, 75230, United States

  • Velocity Clinical Research, Huntington Park

    Huntington Park, California, 90255, United States

  • Velocity Clinical Research, Westlake

    Los Angeles, California, 90057, United States

  • Wannan Medical College Yijishan Hospital

    Wuhu, Anhui, 241001, China

  • West China Hospital of Sichuan University

    Chengdu, Sichuan, 610041, China

  • West Orange Endocrinology

    Ocoee, Florida, 34761, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.