Massive diabetes study reveals best meds to pair with metformin

NCT ID NCT01794143

Completed Disease control Sponsor: GRADE Study Group Source: ClinicalTrials.gov ↗

First seen Feb 11, 2026 · Last updated May 24, 2026 · Updated 14 times

Summary

This study compared several common diabetes medications when added to metformin in 7,850 adults with type 2 diabetes. The goal was to see which combination best kept blood sugar under control over time. Participants were followed to see how long their blood sugar stayed below a certain target level.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Albert Einstein College of Medicine

The Bronx, New York, United States
Atlanta VA Medical Center

Decatur, Georgia, United States
Baylor College of Medicine

Houston, Texas, United States
Baylor Endocrine Center

Dallas, Texas, United States
Case Western Reserve University School of Medicine

Cleveland, Ohio, United States
Columbia University Naomi Berrie Diabetes Center

New York, New York, United States
Duke University Medical Center

Durham, North Carolina, United States
Indiana University School of Medicine

Indianapolis, Indiana, United States
International Diabetes Center

Minneapolis, Minnesota, United States
Kaiser Permanente Northwest

Portland, Oregon, United States
Kaiser Permanente of Georgia

Duluth, Georgia, United States
Massachusetts General Hospital

Boston, Massachusetts, United States
MedStar Health Research Institute

Hyattsville, Maryland, United States
Mount Sinai St. Luke's Hospital

New York, New York, United States
Oregon Health and Science University

Portland, Oregon, United States
Pacific Health Research and Education Institute (VA Pacific Islands)

Honolulu, Hawaii, United States
Pennington Biomedical Research Center

Baton Rouge, Louisiana, United States
Seattle Institute for Biomedical and Clinical Research

Seattle, Washington, United States
South Florida VA Foundation (Miami VA)

Miami, Florida, United States
Southwestern American Indian Center

Phoenix, Arizona, United States
State University of New York (SUNY)-Downstate Medical Center

Brooklyn, New York, United States
University of Alabama-Birmingham

Birmingham, Alabama, United States
University of Cincinnati

Cincinnati, Ohio, United States
University of Colorado

Denver, Colorado, United States
University of Iowa

Iowa City, Iowa, United States
University of Michigan

Ann Arbor, Michigan, United States
University of Minnesota

Minneapolis, Minnesota, United States
University of Nebraska

Omaha, Nebraska, United States
University of New Mexico School of Medicine

Albuquerque, New Mexico, United States
University of North Carolina Diabetes Care Center

Durham, North Carolina, United States
University of Texas Health Science Center

San Antonio, Texas, United States
University of Texas-Southwestern Medical Center

Dallas, Texas, United States
Vanderbilt University Medical Center

Nashville, Tennessee, United States
Veterans Medical Research Foundation, San Diego (San Diego VA)

San Diego, California, United States
Washington University School of Medicine

St Louis, Missouri, United States
Yale University School of Medicine

New Haven, Connecticut, United States

Conditions

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COMPARATIVE EFFECTIVENESS OF GLYCEMIA-LOWERING MEDICATIONS TYPE 2 DIABETES