Hyperinsulinism

This study tests a new medicine called ersodetug for people whose tumors cause dangerously low blood sugar that standard treatments can't control. About 16 adults with insulin-producing tumors will receive the drug alongside their usual care. The main goal is to see if ersodetug …

This study tests whether a low dose of glucagon, given before exercise, can prevent blood sugar drops in adults with type 1 diabetes who use an automated insulin pump. Eighteen participants will exercise after a meal, comparing glucagon to a standard glucose drink. The goal is to…

This study tests a new drug, evexomostat, added to two standard treatments for a common type of advanced breast cancer (HR+, HER2-). The goal is to see if the triple combination is safe and can reduce high blood sugar side effects often caused by the standard drugs. About 52 adul…

This program provides an investigational drug, ersodetug, to people with dangerously low blood sugar caused by certain tumors. It is for those who cannot join a formal clinical trial. The goal is to help control blood sugar levels when standard treatments are not enough.

This study tests a new way to measure the maximum amount of insulin a person's pancreas can produce. Participants first undergo the standard hyperglycemic clamp, then take a single dose of alpelisib and consume a standardized meal to see if the simpler test gives similar results.…

This study tests whether a special PET scan using a radioactive tracer called FDOPA can accurately find and locate focal lesions in the pancreas of infants with congenital hyperinsulinism, a condition causing severe low blood sugar. The goal is to help surgeons remove only the di…

This study offers expanded access to a PET scan using a radioactive tracer called 18F-DOPA to locate small, insulin-producing lesions in the pancreas. It is for patients with congenital hyperinsulinism, Beckwith-Wiedemann syndrome, or insulinoma who have low blood sugar. The goal…

This phase 3 study is testing an improved PET/CT imaging method using a radioactive tracer called 18F-DOPA. Researchers want to see if it can better detect small lesions and reduce image artifacts in patients with conditions like congenital hyperinsulinism, neuroblastoma, neuroen…

This study is testing whether a special PET/MRI scan using 18F-DOPA can accurately locate small, overactive areas in the pancreas that cause too much insulin (hyperinsulinism). The goal is to help doctors decide if surgery can remove just the problem spot, potentially curing the …

This study looks at whether cognitive-behavioral therapy (CBT), exercise training, or both can help prevent type 2 diabetes in teenage girls who are at risk. The researchers want to see if these approaches lower stress, improve mood, boost physical activity, and reduce insulin re…

This study aims to find the genetic causes of primary aldosteronism, a condition where adrenal tumors cause high blood pressure, in Black individuals. Researchers will enroll 1150 participants, including those with difficult-to-control blood pressure or known primary aldosteronis…

This study aims to understand how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medi…

This study looks at how the hormone insulin controls blood sugar and fat in healthy adults and those at risk for type 2 diabetes. Researchers will give participants a single dose of a drug called alpelisib, which blocks some of insulin's effects, to see if the liver can still mak…

This early-stage trial is testing whether a one-week course of diazoxide can reduce the production of new fat in the liver. The study involves 25 adults with obesity, insulin resistance, and fatty liver disease. Participants will take either the drug or a placebo and undergo bloo…

This early-phase study looks at whether adding dapagliflozin, a diabetes drug, to standard chemotherapy changes insulin-related markers in the blood. It involves 20 women with early-stage HER2-negative breast cancer who also have high insulin levels. The goal is to gather safety …

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that may explain why some groups face higher metabolic risks. The goal is to be…

This study looks at how antipsychotic drugs might cause metabolic problems in women by affecting how the brain responds to insulin. Researchers will give 15 healthy women a single dose of the antipsychotic olanzapine and insulin nasal spray, then use brain scans to see changes. T…

This study looks at people with rare genetic changes that affect beta cells, which control blood sugar. Researchers will collect blood samples and optional MRI scans to find biomarkers and understand how these genes change body function. No treatment is given, and participants co…

This observational study at Turku University Hospital will use ultrasound radiomics to compare fetal liver texture between 60 pregnant women with type 1 diabetes and healthy controls. The goal is to see if this noninvasive method can detect signs of fetal hyperinsulinemia (high i…

This study looks at how different treatments for Polycystic Ovary Syndrome (PCOS) affect the heart and blood vessels. Researchers will compare four approaches: a GLP-1 receptor agonist, birth control pills, metformin, and lifestyle changes alone. They will measure changes in hear…