AI coach for diabetes: small study tests personalized insulin advice

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults ≥18years of age * Diagnosis of T1DM for \> 1 year * On MDI using a basal-bolus insulin regime or CSII (insulin pump) for at least 6 month * Structured education done and good ability perform carbohydrates (CHO) counting * HbA1c ≥ 48mmol/mol and ≤ 86mmol/mol * Using insulin carbohydrates ratio (ICR) and insulin sensitivity factor (ISF) to calculate the mealtime bolus * An understanding of and willingness to follow the protocol and sign the informed consent * CBG measurements at least 2 times per day for calibration of the CGM Exclusion Criteria: * Severe episode of hypoglycaemia (requiring 3rd party assistance) in the 6 months prior to enrolment * Diabetic ketoacidosis in the last 6 months prior to enrolment * Impaired awareness of hypoglycaemia (based on Clarke score) * Pregnancy, breastfeeding or intention of becoming pregnant over time of study procedures * Enrolled in other clinical trials * Have active malignancy or under investigation for malignancy * Suspected or diagnosed endocrinopathy like adrenal insufficiency, unstable thyroidopathy, endocrine tumour * Gastroparesis * Autonomic neuropathy * Macrovascular complications (acute coronary syndrome, transient ischaemic attack, cerebrovascular event within the last 12 months prior to enrolment in the study) * Visual impairment including unstable proliferative retinopathy * Reduced manual dexterity * Inpatient psychiatric treatment * Abnormal renal function test results (calculated Glomerular Filtration Rate (GFR) \<40 mL/min/1.73m2) * Liver cirrhosis * Not tributary to optimization to insulin therapy * Abuse of alcohol or recreational drugs * Oral steroids * Regular use of the acetaminophen, beta-blockers or any other medication that the investigator believes is a contraindication to the participant's participation. Participant withdrawal criteria: * Loss of capacity to give informed consent * The subject has a serious event related to study * Cessation of MDI of insulin as usual care for T1DM * Severe hypoglycaemia * Diabetic ketoacidosis * Positive pregnancy test * Terminal illness * Investigators initiated discontinuation of study due to participant or equipment concerns