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Cure My Disease

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New weekly shot shows promise for diabetes and weight loss

NCT ID NCT06326047

Disease control Sponsor: Novo Nordisk A/S Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 21, 2026 · Updated 3 times

Summary

This study tested a new medicine called NNC0519-0130 in 299 adults with type 2 diabetes. The goal was to see if a once-weekly injection can lower blood sugar and body weight. Participants received up to 7 different doses for about 40 weeks. The results will help find the best dose for future use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

299 people

The number who actually took part.

Started

Mar 2024

Finished

Oct 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Female of non-childbearing potential, or male. * For United States (US) only: Female of childbearing potential using highly effective non-systemic methods of contraception with low user-dependency and willingness to continue using it through-out the study or male. * Age 18-75 years (both inclusive) at the time of signing the informed consent. * Diagnosed with type 2 diabetes mellitus greater than or equal 180 days before screening. * Stable daily dose(s) more than or equal 90 days before screening of the following antidiabetic drug(s) or combination regimen(s) at effective or maximum tolerated dose as judged by the investigator: metformin with or without sodium-glucose co-transporter 2 (SGLT2) inhibitor. * Glycated haemoglobin (HbA1c) of 7.5-10.0% (58-86 millimoles per moles (mmol/mol)) (both inclusive) as assessed by central laboratory at screening. * Body mass index (BMI) greater than or equal 23.0 kilograms per meter square (kg/m\^2). Exclusion Criteria: * Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed. * Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Verified by a fundus examination performed within 90 days before screening or in the period between screening and randomisation. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination. * Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's questionnaire question.

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Conditions

The condition(s) this trial relates to.

type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabetes mellitus type 2

Contacts and locations

Locations

  • 310 Clinical Research

    Inglewood, California, 90301, United States

  • Accellacare Wilmington

    Wilmington, North Carolina, 28401, United States

  • Advanced Med Res Maumee

    Maumee, Ohio, 43537, United States

  • Albion Finch Medical Centre

    Toronto, Ontario, M9V 4B4, Canada

  • Amrita Institute Of Medical Sciences & Research Centre

    Kochi, Kerala, 682041, India

  • Artemis Insitute for Clin Res

    San Diego, California, 92123, United States

  • Asan Medical Center

    Seoul, 05505, South Korea

  • Austin Health, Metabolic Disorders Centre

    Heidelberg Heights, Victoria, 3081, Australia

  • Biopharma Informatic_Houston

    Houston, Texas, 77043, United States

  • Burke Internal Medicine & Research

    Burke, Virginia, 22015, United States

  • Campbelltown Hospital

    Campbelltown, New South Wales, 2560, Australia

  • Care United Research, LLC

    Forney, Texas, 75126, United States

  • Catalina Research Institute, LLC

    Montclair, California, 91763, United States

  • Centennial Medical Group

    Columbia, Maryland, 21045, United States

  • Centricity Research

    Columbus, Georgia, 31904, United States

  • Centricity Research Barrie

    Barrie, Ontario, L4N 7L3, Canada

  • Centricity Research Mirabel

    Mirabel, Quebec, J7J 2K8, Canada

  • Centricity Research Quebec City

    Lévis, Quebec, G6W 0M5, Canada

  • Centricity Research Toronto

    Toronto, Ontario, M4G 3E8, Canada

  • Centricity Research Ville St. Laurent VSL

    Saint-Laurent, Quebec, H4T 1Z9, Canada

  • Chellaram Diabetes Institute

    Pune, Maharashtra, 411021, India

  • Christian Medical College Hospital, Vellore

    Vellore, Tamil Nadu, 632004, India

  • Clinvest Research

    Springfield, Missouri, 65807, United States

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • Cook Street Medical Clinic

    Victoria, British Columbia, V8V 4A1, Canada

  • Diab & Endo Assoc of Stark Co

    Canton, Ohio, 44718, United States

  • Diabetes Research Center, Hyderabad

    Hyderabad, Telangana, 500082, India

  • Diabetes, Thyroid and Endocrine Centre

    Jaipur, Rajasthan, 302006, India

  • Diablo Clinical Research, Inc.

    Walnut Creek, California, 94598, United States

  • Diex Recherche Quebec

    Québec, G1V 4T3, Canada

  • Dr A Jacovides and Partners Inc

    Midrand, Gauteng, 1685, South Africa

  • Dr Pillay's Rooms

    Durban, KwaZulu-Natal, 4450, South Africa

  • Dr T Padayachee

    eMkhomazi, KwaZulu-Natal, 4170, South Africa

  • Eastern Clinical Research Unit Box Hill

    Box Hill, Victoria, 3128, Australia

  • Elite Clinical Trials

    Blackfoot, Idaho, 83221, United States

  • Emeritus Research Melbourne

    Camberwell, Victoria, 3124, Australia

  • Endo And Metab Cons

    Rockville, Maryland, 20852, United States

  • Endocrine Associates Houston

    Houston, Texas, 77004, United States

  • Epic Clinical Research

    Lewisville, Texas, 75057, United States

  • Excel Clinical Network

    Las Vegas, Nevada, 89109, United States

  • First Valley Med Grp Lancaster

    Lancaster, California, 93534, United States

  • Fremantle Hospital

    Fremantle, Western Australia, 6160, Australia

  • Fukuwa Clinic

    Tokyo, 104-0031, Japan

  • Fukuwa Clinic_Internal Medicine

    Tokyo, 104-0031, Japan

  • G.A. Research Associates Ltd.

    Moncton, New Brunswick, E1G 1A7, Canada

  • Illawarra Diabetes Service Clinical Trials & Research Unit

    Wollongong, New South Wales, 2500, Australia

  • Innovative Research of W FL

    Clearwater, Florida, 33756, United States

  • Innovative Research of W Florida Inc.

    Clearwater, Florida, 33756, United States

  • International Research Associates, LLC_Miami

    Miami, Florida, 33183, United States

  • Josha Research

    Bloemfontein, Free State, 9301, South Africa

  • Kangbuk Samsung Hospital

    Seoul, 03181, South Korea

  • Korea University Anam Hospital

    Seoul, 02841, South Korea

  • Lady Hardinge Medical College

    New Delhi, 110001, India

  • Life Care Hospital and Research Centre

    Bangalore, Karnataka, 560092, India

  • Logan Hospital

    Meadowbrook, Queensland, 4131, Australia

  • London Road Diagnostic Clinic and Medical Centre

    Sarnia, Ontario, N7T 4X3, Canada

  • MD Medical Research

    Oxon Hill, Maryland, 20745, United States

  • MS Ramaiah

    Bengaluru, 560054, India

  • Macquarie University - Clinical Trials Unit

    Macquarie Park, New South Wales, 2109, Australia

  • Med Partners, Inc.

    Toluca Lake, California, 91602, United States

  • Mercury Str Med Grp, PLLC

    Butte, Montana, 59701, United States

  • Methodist Medical Center of Illinois

    Peoria, Illinois, 61603, United States

  • Nova Scotia Hlth Halifax

    Halifax, Nova Scotia, B3H 1V7, Canada

  • Nowon Eulji Medical Center, Eulji University

    Seoul, 01830, South Korea

  • OCT Research ULC (dba Okanagan Clinical Trials)

    Kelowna, British Columbia, V1Y 1Z9, Canada

  • OCT Research ULC (dba Okanagan Clinical Trials)

    Richmond, British Columbia, V6V 2L1, Canada

  • Pacific Clinical Studies

    Los Alamitos, California, 90720, United States

  • Palm Research Center Inc-Vegas

    Las Vegas, Nevada, 89148, United States

  • PharmQuest Life Sciences LLC

    Greensboro, North Carolina, 27408, United States

  • Preferred Primary Care Physicians Inc.

    Pittsburgh, Pennsylvania, 15243, United States

  • Preferred Primary Care Physicians, Inc.

    Uniontown, Pennsylvania, 15401, United States

  • Providence Health Partners Ctr

    Dayton, Ohio, 45439, United States

  • Recherche GCP Research

    Montreal, Quebec, H1Y 3H5, Canada

  • Roger Chih Yu Chen

    Sydney, New South Wales, 2148, Australia

  • Royal North Shore Hospital

    St Leonards, New South Wales, 2065, Australia

  • Seoul National University Bundang Hospital

    Seongnam-si, Gyeonggi-do, 13620, South Korea

  • Seth GS Medical College & KEM Hospital

    Mumbai, Maharashtra, 400012, India

  • Soka Sugiura Internal Medicine Clinic

    Soka-shi, Saitama, 340-0015, Japan

  • Southern Adelaide Diabetes & Endocrine Services

    Oaklands Park, South Australia, 5046, Australia

  • TOTALL Diabetes Hormone Institute

    Indore, Madhya Pradesh, 452010, India

  • TPMG Clinical Research

    Newport News, Virginia, 23606, United States

  • Tekton Research

    Irving, Texas, 75039, United States

  • The Royal Melbourne Hospital

    Parkville, Victoria, 3050, Australia

  • The Royal Melbourne Hospital - Diabetes & Endocrinology Department

    Parkville, Victoria, 3050, Australia

  • Tokuyama clinic_Diabetic internal medicine

    Chiba, 261-0004, Japan

  • Tokyo-Eki Center-building Clinic_Internal Medicine

    Tokyo, 103-0027, Japan

  • Torrance Clin Res Inst, Inc.

    Lomita, California, 90717, United States

  • Tristar Clin Investigations, PC

    Philadelphia, Pennsylvania, 19114, United States

  • UCLA Health Southbay Endocrine

    Torrance, California, 90505, United States

  • UT Southwestern Med Center

    Dallas, Texas, 75390, United States

  • University Clin Investigators

    Tustin, California, 92780, United States

  • University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • University of Iowa

    Iowa City, Iowa, 52242, United States

  • University of Sunshine Coast - Vitality Village

    Birtinya, Queensland, 4575, Australia

  • Valley Research

    Fresno, California, 93720, United States

  • Velocity Clin Res Austin

    Austin, Texas, 78759, United States

  • Velocity Clin Res Grants Pass

    Grants Pass, Oregon, 97527, United States

  • Velocity Clin Res San Diego

    La Mesa, California, 91942, United States

  • Velocity Clin Res-Chula Vista

    Chula Vista, California, 91911, United States

  • Velocity Clin Res_Cincinnati

    Cincinnati, Ohio, 45242, United States

  • Velocity Clinical Res-Dallas

    Dallas, Texas, 75230, United States

  • Velocity Clinical Research Abilene

    Abilene, Texas, 79606, United States

  • Velocity Clinical Research Binghamton

    Binghamton, New York, 13905, United States

  • Velocity Clinical Research Lincoln

    Lincoln, Nebraska, 68510, United States

  • Velocity Clinical Research Springdale

    Cincinnati, Ohio, 45246, United States

  • Velocity Clinical Research Westlake

    Los Angeles, California, 90057, United States

  • Western Endocrine Blacktown

    Sydney, New South Wales, 2148, Australia

  • Wharton Medical Clinic Clinical Trials (Hamilton)

    Hamilton, Ontario, L8L 5G8, Canada

  • Wits Bara Clinical Trial Site

    Johannesburg, Gauteng, 2013, South Africa

  • Zenos Clinical research

    Dallas, Texas, 75230, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.